• Focal adhesion proteins g130Cas (Cas) is normally a multi-domain docking proteins, with an N-terminal SH3 domains, a central "substrate domains" consisting of multiple SH2-domains presenting motifs (Tyr-x-x-Pro), and a "Src-binding domains" near the C-terminus . (elevateblogconference.com)
  • Certain IL-8-promoted responses are insensitive to pertussis-toxin, however, suggesting that these receptors may couple to and activate other as yet uncharacterized Gα proteins ( 6 ). (aacrjournals.org)
  • This promiscuity of G protein coupling may be dictated by differential cell-specific expression of the Gα proteins that influence the affinity-based equilibrium established between the receptors and the intracellular pool of G proteins. (aacrjournals.org)
  • Cdc42, a member of the Ras superfamily of small guanine nucleotide binding proteins, plays an important role in regulating the actin cytoskeleton, intracellular trafficking, and cell polarity. (genes2cognition.org)
  • Globular proteins, often containing multiple helical domains, can themselves polymerize into helixes (fig. 1a,b). 12 Similar helixes can wind around each other to form coiled-coils (Fig. 1c), 13 and assemble into mechanically rigid rods or filaments, or further combine into more complex structures with specialized functions (fig. 2). (tensegrityinbiology.co.uk)
  • Among neurotrophins, brain-derived neurotrophic factor (BDNF) is highly expressed in brain and mediates multiple effects on CNS neurons ( Bibel and Barde, 2000 ). (jneurosci.org)
  • Here we show that Src-family kinases (SFKs) have multiple functions in C. trachomatis development, including trafficking of nascent inclusions to the microtubule organizing center (MTOC) and a necessary role in completion of the C. trachomatis intracellular developmental cycle. (asm.org)
  • In the heart, diabetes enhances fatty acid metabolism, suppresses glucose oxidation, and modifies intracellular signaling, leading to impairments in multiple steps of excitation-contraction coupling, inefficient energy production, and increased susceptibility to ischemia/reperfusion injury. (springer.com)
  • Thus, the initial sharp rise in [Ca 2+ ] i mainly reflects a rapid Ca 2+ release from intracellular Ca 2+ stores, whereas the sustained [Ca 2+ ] i rise is due to Ca 2+ entry through the plasma membrane, which is essential for CA release in response to PACAP. (aspetjournals.org)
  • CXCR1 receptors are activated only in response to binding of IL-8 and granulocyte chemotactic protein-2. (aacrjournals.org)
  • We show that oncogenic H-Ras and N-Ras engage Raf-1 on the Golgi and that endogenous Ras and unpalmitoylated H-Ras are activated in response to mitogens on the Golgi and endoplasmic reticulum (ER), respectively. (jove.com)
  • Brain-derived neurotrophic factor (BDNF) exerts multiple biological functions in the CNS. (jneurosci.org)
  • Alternatively, CXCR2 is activated by multiple CXC-chemokines including growth-related oncogenes (GROα, β, and γ), neutrophil-activating peptide, and granulocyte chemotactic protein-2 (reviewed in ref. 1 ). (aacrjournals.org)
  • gain-of-function (GOF) mutations cause multiple endocrine and haematologic autoimmune disorders, lymphoproliferation, and growth impairment. (figshare.com)
  • Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world. (asm.org)