Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. (antibodiesinc.com)
Nav1.77
Bulk Order Inquiry for Anti-Nav1.7 Na+ Channel Antibody FL650 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or "pain receptors" and thus involved in pain sensation. (antibodiesinc.com)
To evaluate the Swarm screening system, we optimized a series of heterologous optogenetic spiking HEK293 cell assays for several voltage-gated sodium channel subtypes including Nav1.2, Nav1.5, and Nav1.7. (frontiersin.org)
Genetic etiology of PE is mutations on SCN9A , the encoding gene of a voltage-gated sodium channel subtype Nav1.7. (biomedcentral.com)
This review mainly focuses on PE and the causative gene SCN9A -- its mutations and their effects on Nav1.7 channels' electrophysiological properties. (biomedcentral.com)
The causative gene for PE, SCN9A , encodes a voltage-gated sodium channel (VGSC) subtype Nav1.7. (biomedcentral.com)
PE is exclusively caused by mutations in SCN9A , the encoding gene of sodium channel subtype Nav1.7 and can be sub-classified into familial (inherited erythromelalgia) and sporadic forms. (biomedcentral.com)
Nav1.13
Nine types of alpha subunits have been described (Nav1.1 to Nav1.9), and a tenth related isoform (Nax) may also play some role as a Nav channel. (wikipedia.org)
Dravet Syndrome (DS) is a severe childhood epilepsy caused by heterozygous loss-of-function mutations in the SCN1A gene encoding brain type-I voltage-gated sodium channel Nav1.1. (scientificarchives.com)
I suspect that people with channelopathies (Nav1.1, Nav1,2, Nav1.3) caused by dysfunctions in the genes SCN1A, SCN2A, SCN3A are the ones that will most benefit from Propranolol. (epiphanyasd.com)
Neuronal1
Thus, like many other neuronal channels and receptors, Nav channels predated neurons. (wikipedia.org)
VGSCs2
Voltage-gated", also called "voltage-sensitive" and "voltage-dependent" sodium channel also known as "VGSCs" or "Nav channel" are crucial elements of normal physiology in a variety of animals, including flies, leeches, squid and jellyfish, as well as mammalian and non-mammalian vertebrates. (wikipedia.org)
Tetracaine, a long-acting amino ester-type local anesthetic, prevents the initiation and propagation of action potentials by reversibly blocking voltage-gated sodium channels (VGSCs). (bvsalud.org)
Cardiac4
The action of NSTX produces minimal effect on cardiac Nav, where it exhibits about 20-60 fold lesser affinity than in Nav channels from rat skeletal muscle and rat brain. (wikipedia.org)
Toxins such as neosaxitoxin and tetrodotoxin have less affinity for most cardiac Nav channels than for most Nav channels in nerve tissue. (wikipedia.org)
As a demonstration of the versatility of the Swarm, we also developed an assay measuring cardiac action potential and calcium waveform properties simultaneously under paced conditions using human induced pluripotent stem (iPS) cell-derived cardiomyocytes as an additional counter screen for cardiac toxicity. (frontiersin.org)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Neurons3
This large integral membrane protein plays an essential role in the initiation and propagation of action potentials in neurons, myocytes and other excitable cells. (wikipedia.org)
The persistent hypersensitivy to nociceptive stimuli was reflected by increased calcium fluxes in primary sensory neurons of aged mice (1 year) upon capsaicin stimulation. (biomedcentral.com)
Genes3
Most mutations detected in acetylcholinesterase-1 (Ace-1) and voltage-gated sodium channel (VGSC) genes are non-synonymous, resulting in a change in amino acid, leading to the non-binding of the insecticide. (bvsalud.org)
ELP caused cortical hyperexcitability at P8-9 as assessed via multi-electrode array recordings that coincided with reduced expression of synaptic genes (RNAseq) including Grin2b , neurexins, piccolo and voltage gated calcium and sodium channels. (biomedcentral.com)
Blockers4
Former five, but more recently, six neurotoxin receptor sites have been recognized between the seven receptor site located in the vertebrate sodium channel receptor alpha subunit: Site 1 binds the sodium channel blockerstetrodotoxin and saxitoxin. (wikipedia.org)
Local anesthetic receptor site binds local anesthetics, antiarrhythmic drugs and antiepileptic drugs NSTX and other site 1 blockers have high affinity (very low dissociation constant) and high specificity for Nav channels. (wikipedia.org)
The Swarm was able to record pseudo-action potentials stably across all 24 objectives and provided pharmacological characterization of diverse sodium channel blockers. (frontiersin.org)
To address this challenge, we developed the Swarm TM , a custom designed optical instrument for highly parallelized, multicolor measurements in excitable cells, simultaneously recording changes in voltage and calcium activities at high temporal resolution under optical stimulation. (frontiersin.org)
Calcium2
Several molecular imaging approaches to image the painful process are now available, including imaging of voltage-gated sodium channels, calcium channels, hypermetabolic processes, the substance P receptor, the sigma-1 receptor, and imaging of macrophage trafficking. (bvsalud.org)
The Swarm delivers variable intensity blue-light optogenetic stimulation to enable membrane depolarization and red or lime-light excitation to enable fluorescence detection of the resulting changes in membrane potential or calcium levels, respectively. (frontiersin.org)
SCN1A1
It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Na v 1.1. (scientificarchives.com)
Receptor1
Clonazepam (CLZ) is a positive allosteric modulator of GABA A receptors that potentiates responses to GABA without opening the GABAA receptor chloride channel itself. (scientificarchives.com)
Lidocaine1
Moreover, NSTX is so active on nerve Nav channel than is roughly a million-fold more potent than lidocaine. (wikipedia.org)
20162
1. Anti-Na V 1.5 (SCN5A) (1978-2016) Antibody (#ASC-013), (1:200). (alomone.com)
Immunohistochemical staining of Na V 1.5 in rat myocardium paraffin-embedded section using Anti-Na V 1.5 (SCN5A) (1978-2016) Antibody (#ASC-013), (1:100). (alomone.com)
Expression1
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. (frontiersin.org)
Mutations1
We detected only synonymous mutations in the frequently reported Ace-1 codon 280 known to confer resistance to organophosphates and carbamates, but detected three non-synonymous mutations in other regions of the gene. (bvsalud.org)
Human1
Most data emphasize the role of "STX resistant" Nav channel 1.5 in human heart. (wikipedia.org)
Mechanism of act1
This mechanism of action can produce two well known kinds of effects in humans: It can be approximately described using one of the classical model of neurotoxic disease, known from ancient times as red tide, the most harmful algal bloom (HAB). (wikipedia.org)
Fragments2
Fragments of Ace-1 (456 bp) and VGSC (228 bp) were amplified, sequenced, and aligned with Ny. (bvsalud.org)
APP is proteolyzed into various fragments (see Figure 1 ) during its intracellular trafficking and these APP metabolites mediate various and sometimes adverse functions. (biomedcentral.com)
Family1
Invertebrates possess two Nav channels (Nav1 and Nav2), whereas vertebrate Nav channels are of the Nav1 family. (wikipedia.org)
Alpha2
Sodium-channel proteins in the mammalian brain are composed of an association that include one alpha subunit and one or more auxiliary beta subunits. (wikipedia.org)
Site 3 binds alpha-scorpion and sea anemone toxins, which slow sodium channel inactivation. (wikipedia.org)
Pain2
Moving away from anatomical constructs of disease, molecular imaging has emerged as a method to identify diseases according to their molecular, physiologic, or cellular signatures that can be applied to the variety of biomolecular changes that occur in nociception and pain processing and therefore have tremendous potential for precisely pinpointing the source of a patient's pain. (bvsalud.org)
Chronic pain has become a global health problem which is estimated to affect about 30 % of adults worldwide [ 1 ]. (biomedcentral.com)
Activation1
Site 4 binds beta-scorpion toxins, which affect sodium channel activation. (wikipedia.org)
In a comparative approach, we used two cell lines of contracting metastatic potential: MDA-MB-231 (strongly metastatic) and MCF-7 (weakly metastatic). (bvsalud.org)
Affect1
Combination of CLZ with CBD significantly reduced seizure duration compared to the vehicle or CLZ alone, but did not affect seizure severity, indicating potential additive actions of CLZ and CBD on the duration of seizures. (scientificarchives.com)
Blocks1
NSTX blocks the extracellular portion, the outer vestibule, of some voltage gated sodium channels in a very powerful and reversible manner, without affection of other ion channels. (wikipedia.org)
Cells1
For serum starvation, cells were grown in serum-free media for 1?hour before the experiment. (healthweblognews.info)
Frequently1
Newborn and particularly preterm children are frequently exposed to various painful stimuli such as injections or venipuncture during hospitalization in the early days of life [ 1 ]. (biomedcentral.com)
Three of the six phosphorylation sites had either leucine or isoleucine at the +1 position relative to the phosphorylation site, which matches the preferred substrate motif for TBK119,20 (Fig.?1d). (healthweblognews.info)