• These transcription factors work by regulating different mechanisms of drought tolerance and by releasing hormones, proteins, reducing-sugars, solutes and by affecting the stomatal conductance and root architecture. (org.pk)
  • In mice, rapamycin treatment increases expression of histone proteins and Wdfy3 transcription, and alters chromatin organisation in the small intestine, suggesting the mTORC1-histone axis is at least partially conserved in mammals and may offer new targets for anti-ageing interventions. (sdbonline.org)
  • In a previous study, we found that Staphylococcus aureus (SA) induced interferon regulatory factor 3 (IRF3) activation and Ifnb expression only in its planktonic form but not in the biofilm. (bvsalud.org)
  • Histones H3/H4 regulate expression of an autophagy cargo adaptor Blue Cheese ( Bchs (WDFY3 in mammals), increased expression of which in enterocytes mediates increased H3/H4-dependent healthy longevity. (sdbonline.org)
  • As an approach to defining the mechanism responsible for activating the expression of these genes, we investigated the binding of nuclear factors to the promoters of tw. (shengsci.com)
  • Longitudinals lacking (lola) is one of the most complex genes in Drosophila melanogaster, encoding up to 20 protein isoforms that include key transcription factors involved in axonal pathfinding and neural reprogramming. (sdbonline.org)
  • Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a novel pan-endoderm-specific factor. (shengsci.com)
  • A loss-of-function mutation in def confers hypoplastic digestive organs and selectively up-regulates the expression of Delta113p53, counterpart to a newly identified isoform of p53 produced by an alternative internal promoter in intron 4 of the p53 gene in human. (shengsci.com)
  • Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)
  • In nature, gene expression is regulated at the transcriptional level primarily by transcription factors that bind to DNA. (biomedcentral.com)
  • In the present study, to provide a basis for designing ATFs that can regulate the human A20 gene, a ZFP sequence involving six contiguous Cys 2 His 2 -type zinc fingers was constructed using the classical Cys 2 His 2 -type zinc finger model and an 18 bp DNA sequence (as target sequence) obtained from the A20 gene promoter region. (biomedcentral.com)
  • For example, the human protein Znf216 has an A20 zinc-finger at the N terminus and an AN1 zinc-finger at the C terminus, acting to negatively regulate the NFkappaB activation pathway and to interact with components of the immune response like RIP, IKKgamma and TRAF6. (embl-heidelberg.de)
  • A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B activity and tumor necrosis factor (TNF)-mediated programmed cell death. (biomedcentral.com)
  • This enabled study of specific isoforms with respect to previously characterized roles for Lola and to demonstrate a specific function for one variant in axon guidance via activation of the microtubule-associated factor Futsch . (sdbonline.org)
  • In a dual-luciferase reporter assay, JEV NS4B significantly inhibited the activation of IFN-ß promoter induced by TLR3 and simultaneously treated with poly (I:C). Moreover, NS4B also inhibited the activation of IFN-ß promoter triggered by interferon regulatory factor 3 (IRF3)/5D or its upstream molecules in TLR3 signaling pathway. (bvsalud.org)
  • cGMP-dependent protein kinase encoded by foraging regulates motor axon guidance in Drosophila by suppressing Lola function. (sdbonline.org)
  • These results suggest that Rib and Lola act as dual-function transcription factors to cooperatively regulate embryonic gonad morphogenesis. (sdbonline.org)
  • Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. (shengsci.com)
  • Mechanistic studies show that the transcription factor longitudinal lacking ( lola ) genetically interacts with for . (sdbonline.org)
  • Finally, we show that the C7/10-derived virus infection of HEK-293 cells leads to elevated levels of phosphorylated eukaryotic translation elongation factor-2 (eEF2), identifying a potential mechanism leading to the more rapid shut-off of host translation. (bvsalud.org)