Loading...
  • filaments
  • 2. Calcium activated sarcomeric myosin S1 ATPase assays with tropomyosin/troponin coated F-actin (thin filaments) as substrate. (cytoskeleton.com)
  • Such targets include the Rho-activated phosphorylation of myosin, which leads to cellular contractile activity ( 2 ), and the phosphorylation of proteins of the ezrin-moesin-radixin group to promote their ability to link actin filaments to cell membranes ( 3 ). (pnas.org)
  • vesicle
  • The internalization of plasma membrane proteins by mammalian cells is crucial for many essential cellular processes, such as nutrient uptake, control of ion channels, retrieval of synaptic vesicle components in neurons, and the regulated expression of signaling receptors and adhesion molecules at the cell surface ( Conner and Schmid, 2003 ). (biologists.org)
  • It has become apparent that the SNARE proteins, although central to the process of fusion, are often not the first point of contact between a vesicle and its target. (biologists.org)
  • 2) The vesicle is then proposed to be tethered to the organelle by protein complexes and long coiled-coil proteins. (biologists.org)
  • 3) A v-SNARE protein on the vesicle then engages a t-SNARE on the target, forming a four-helical bundle whose assembly drives the two bilayers into close proximity, (4) thereby causing membrane fusion. (biologists.org)
  • Biochemical and genetic studies have identified several proteins that appear to play a role in membrane transport steps after vesicle formation. (biologists.org)
  • His work revealed that synaptic vesicle endocytosis is a highly regulated process in neurons, triggered by protein dephosphorylation. (edu.au)
  • tyrosine
  • Receptor and non-receptor tyrosine kinases, such as Met and Src (v-Src Avian Sacroma (Schmidt-Ruppin A-2) Viral Oncogene), respectively, along with other PTKs (Protein Tyrosine Kinases) have an active function in this process, as they phosphorylate tyrosine residues in the short intra-cytoplasmic tail of E-Cadherins, thereby promoting their internalization by endocytosis. (sabiosciences.com)
  • Tyrosine Kinases also phosphorylate Ctnn-Beta and p120Ctn causing disassociation of cytoskeletal proteins from junctions and thereby weakening junction morphology (Ref.4). (sabiosciences.com)
  • It binds to tyrosine phosphorylated E-Cadherins and facilitates the internalization and subsequent Ubiquitin-dependent degradation of E-Cadherins. (sabiosciences.com)
  • induces
  • Integrin signaling also induces formation of a complex of p130Cas, the adapter protein Crk, and a third molecule, DOCK 180, that is required for membrane ruffling, a component of cell migration ( 13 , 14 ). (jimmunol.org)
  • GTPases
  • The principal attention is paid to Rop mG-proteins, unique small GTPases of eukaryotic cells functioning during various developmental stages of plants, from pollen tube and root hair growth to plant responses to biotic and abiotic stresses. (deepdyve.com)
  • Activation of the Rho family of Ras-related small GTPases causes the construction of particular actin-rich surface structures in cells. (pnas.org)
  • These GTPases do not appear to affect actin dynamics directly, but rather engage downstream intermediates. (pnas.org)
  • Subsequent research on Ras revealed numerous related genes and eventually the discovery of the superfamily of small GTPases, made up of the Rho, Rab, Ran and Arf proteins. (mechanobio.info)
  • GEFs
  • Integrin-mediated adhesion recruits two GEFs to p130Cas: C3G, a Rap1 GEF, and Sos, a protein with both Cdc25 and Dbl GEF domains ( 12 ). (jimmunol.org)
  • filamin
  • Of these protein isoforms, filamin 1 (also called ABP-280) is the founding and most widely distributed ( 11 , 15 ). (pnas.org)
  • Filamin was found previously to associate with unidentified GTP-binding proteins in human platelets ( 26 , 27 ). (pnas.org)
  • tubulins
  • IQGAP1 captures and stabilizes Microtubules/Tubulins through the Mt-BPs (Microtubule-Plus-End-Binding Proteins), APC (Adenomatous Polyposis Coli) and CLIP170 (Cytoplasmic Linker Protein-170Alpha-2), leading to establishment of polarized cell morphology and directional cell migration. (sabiosciences.com)
  • genes
  • genes encoding mG-proteins were found. (deepdyve.com)
  • Full liquid chromatography-tandem MS analysis revealed 295 proteins, including multiple protein products of genes already known to be responsible for renal and systemic diseases, including autosomal dominant polycystic kidney disease, Gitelman syndrome, Bartter syndrome, autosomal recessive syndrome of osteopetrosis with renal tubular acidosis, and familial renal hypomagnesemia. (pnas.org)
  • filamentous
  • An interaction between actin and epithelial ions channels was further supported by the fact that the addition of either monomeric or filamentous actin to excised patches had an effect on channel activity comparable to that of cytochalasins ( 15 , 16 , 87 - 89 , 117 ). (physiology.org)
  • Sevenless
  • The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. (embl-heidelberg.de)