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  • reorganization
  • The serine-threonine protein kinase encoded by US3 gene (pUS3) of alphaherpesviruses was shown to modulate actin reorganization, cell-to-cell spread, and virus egress in a number of virus species. (mdpi.com)
  • Proft A, Spiesschaert B, Izume S, Taferner S, Lehmann MJ, Azab W. The Role of the Equine Herpesvirus Type 1 (EHV-1) US3-Encoded Protein Kinase in Actin Reorganization and Nuclear Egress. (mdpi.com)
  • turnover
  • We propose that toxofilin locally upregulates actin turnover thus increasing depolymerization events at the site of entry that, in turn loosens the local host cell actin meshwork, facilitating parasite internalization and vacuole folding. (biologists.org)
  • fluorescence
  • Frequently used confocal fluorescence and STED microscopy dyes were employed to image fixed PC-12 cells (dyed with phalloidin- fluorescein isothiocyante) and live rat chondrosarcoma cells (RCS) transfected with actin-green fluorescent protein (GFP). (mdpi.com)
  • cell
  • This allows the cell to specify actin filament function in time and space by simply specifying their Tpm isoform composition. (biologists.org)
  • mechanisms
  • In addition, it was shown that the internalized LRP6 is recycled in Rab11-dependent and actin-filament-dependent mechanisms to be reused, and that Dkk1 is transported to the degradation pathway in a Rab7-dependent mechanism. (biologists.org)
  • cells
  • Catizone A, Ricci G, Caruso M, Galdieri M, Scheri KC, Di Paolo V, Canipari R. HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells. (mdpi.com)
  • The neuronal cytoskeleton plays a key role in both protecting cells against oxidative stress and is itself the target of oxidative stress-induced damage. (mdpi.com)
  • thus
  • Drugs that target the cytoskeleton may thus be of great use in treating various neurodegenerative diseases caused by oxidative stress. (mdpi.com)
  • Thus, the cytoskeleton plays a key role in cellular responses to oxidative stress and the onset of oxidative stress-induced neurodegeneration. (mdpi.com)
  • myosin
  • A radially symmetrical system of actin bundles consisting of α-actinin-enriched radial fibres (RFs) and myosin-IIA-enriched transverse fibres (TFs) evolved spontaneously into the chiral system as a result of the unidirectional tilting of all RFs, which was accompanied by a tangential shift in the retrograde movement of TFs. (sigmaaldrich.com)
  • In mitosis, F-actin and myosin II form a highly contractile and uniform cortex to drive mitotic cell rounding. (wikipedia.org)
  • membranes
  • Lifeact-EGFP labels actin associated with cell-cell junctions, apical and basal membranes and highlights actin-based structures such as filopodia and stress fiber-like cytoplasmic bundles. (uni-muenchen.de)
  • We also review "old and new" concepts to reflect on the potential role of the cytoskeleton in balancing life and death of myelin membranes and oligodendrocytes in the aging central nervous system. (springer.com)
  • filopodia
  • Within the lamellipodia are ribs of actin called microspikes, which, when they spread beyond the lamellipodium frontier, are called filopodia. (wikipedia.org)
  • axonal
  • Oligodendrocytes are specialized glia that extend multiple actin-based protrusions to form the multilayered myelin membrane that spirally wraps around axons, increasing conduction speed and promoting long-term axonal integrity. (springer.com)
  • contraction
  • Herein, we report that HGF induces actin cytoskeleton remodeling in vitro in isolated myoid cells and myoid cell contraction in cultured seminiferous tubules. (mdpi.com)
  • Catizone A, Ricci G, Caruso M, Galdieri M, Scheri KC, Di Paolo V, Canipari R. HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells. (mdpi.com)
  • calponin
  • Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. (wikipedia.org)
  • Like other members of this superfamily, which include α-actinin, β-spectrin, dystrophin, ABP-120 and filamin, it has a conserved 27 kDa actin-binding domain that contains a tandem duplication of a sequence that is homologous to calponin. (wikipedia.org)
  • The primary structure of calponin 3 is similar as that of calponin 1 and calponin 2, consisting of a conserved N-terminal calponin homology (CH) domain, a conserved middle region containing two actin-binding sites, and a C-terminal variable region. (wikipedia.org)
  • Calponin 3 has been shown to participate in actin cytoskeleton-based activities such as that in embryonic development and myogenesis. (wikipedia.org)
  • Calponin 3 is found in the brain with expression in neurons, astrocytes, and glial cells, where it may function in regulating the actin cytoskeleton with a proposed role in the plasticity of neural tissues. (wikipedia.org)
  • Knockdown or dissociation of calponin 3 from cytoskeleton in response to PKC phosphorylation promoted fusion of trophoblasts. (wikipedia.org)
  • degradation
  • Confocal laser scanning microscopy of rhodamine-phalloidin staining in vivo revealed that high levels of microinjected profilin induced a degradation of the actin cytoskeleton in the phragmoplast, the perinuclear zone, and the cytoplasmic strands. (mendeley.com)
  • Many microbes modify and influence the synthesis or degradation of the host-cell cytoskeleton, in particular the actin network. (wikipedia.org)
  • Phosphorylation
  • Phosphorylation at serine3 renders n-cofilin unable to depolymerize F-actin, thereby stabilizing the cytoskeleton. (jneurosci.org)
  • Vinculin consists of a globular head domain that contains binding sites for talin and α-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin, and lipids. (wikipedia.org)
  • polarity
  • A Swe1p- dependent cell cycle delay was triggered by direct perturbations of the actin cytoskeleton, even when polarity establishment functions remained intact. (rupress.org)
  • Finally, we show that Cdc42 and Par proteins, as well as Cdc42/Par and Arp3, interact in the context of oocyte polarity, and that loss of Par proteins reciprocally affects Cdc42 localization and the actin network. (biologists.org)
  • We show that these defects are a result of an underlying malformation in the formation and polarity of cardiac actin fibers and F-actin deposition. (biologists.org)
  • We go on to show that these defects are a result of an underlying malformation in the arrangement and polarity of cardiac actin fibers and F-actin deposition. (biologists.org)
  • Arp2
  • Another molecule that is often found in polymerizing actin with Arp2/3 is cortactin, which appears to link tyrosine kinase signalling to cytoskeletal reorganization in the lamellipodium and its associated structures. (wikipedia.org)
  • Rac1 induces cortactin to localize to the cell membrane, where it simultaneously binds F-actin and Arp2/3. (wikipedia.org)
  • Talin
  • Formation of the complex between VBS and vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin. (wikipedia.org)
  • The binding of vinculin to talin and actin is regulated by polyphosphoinositides and inhibited by acidic phospholipids. (wikipedia.org)
  • fibers
  • When fibers spontaneously fractured, they recoiled and disassembled actin synchronously. (pnas.org)
  • Similar actin remodeling kinetics occurred in expanding or contracting intact stress fibers but over much longer timescales. (pnas.org)
  • mechanical
  • A mathematical model accurately describes our measurements and shows that this mechanical-biochemical feedback loop synchronizes actin remodeling with fiber length changes. (pnas.org)
  • integrity
  • In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. (srce.hr)
  • largely
  • We show that in the retina, Lifeact-EGFP expression is largely restricted to ECs allowing detailed visualization of F-actin in ECs in situ. (uni-muenchen.de)
  • structure
  • Structure of the actin crosslinking core of fimbrin" (PDF). (wikipedia.org)
  • Structure Structurally, the barbed ends of the microfilaments (localized actin monomers in an ATP-bound form) face the "seeking" edge of the cell, while the pointed ends (localized actin monomers in an ADP-bound form) face the lamella behind. (wikipedia.org)
  • interact
  • Mammalian Coronin-7 does not interact with actin nor does it execute any actin mediated processes, but rather participates in Golgi trafficking. (wikipedia.org)
  • Aldolase A has been shown to interact with: PLD2, actin, GLUT4, phospholipase D2, light chain 8 of dynein, erythrocyte anion exchanger Band 3 protein, ryanodine receptor, Cytohesin-2, and V-ATPase (vacuolar-type H+-ATPase). (wikipedia.org)
  • 2000
  • Our previous studies on the dysmyelinating mutant Trembler demonstrated that myelinating glia can affect the axonal cytoskeleton ( Witt and Brady, 2000 ). (jneurosci.org)
  • contractile
  • MHC-α and MHC-β display significantly different enzymatic properties, with α having 150-300% the contractile velocity and 60-70% actin attachment time as that of β. (wikipedia.org)
  • link
  • The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton. (wikipedia.org)