• While microtubules and their motors have been established as important factors for mitochondrial transport, emerging evidence indicates that mitochondria interact with the actin cytoskeleton in many cell types. (nih.gov)
  • Even in systems such as neurons, where microtubules are the primary means of long-distance mitochondrial transport, the actin cytoskeleton is required for short-distance mitochondrial movements and for immobilization of the organelle at the cell cortex. (nih.gov)
  • Cell cytoskeleton double labelled with rhodamine phalloidin for actin (red) and antitubulin antibody for microtubules (green). (gettyimages.com)
  • Accordingly, disruption of actin cytoskeleton in wild-type embryos phenocopied MZ dchs1b mutant defects in cytoplasmic segregation and CGE, whereas interfering with microtubules in wild-type embryos impaired dorsal organizer and mesodermal gene expression without perceptible earlier phenotypes. (biologists.org)
  • eEF1A putatively binds actin and microtubules at synapses to modulate the cytoskeleton. (wikipedia.org)
  • IF, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton. (wikipedia.org)
  • These observations suggest that members of the Rho GTPase family are key regulatory molecules that link surface receptors to the organization of the actin cytoskeleton. (sciencemag.org)
  • Rho, Rac, and Cdc42 control the assembly and organization of the actin cytoskeleton. (sciencemag.org)
  • Cellular chirality arising from the self-organization of the actin cytoskeleton. (sigmaaldrich.com)
  • The role of plant villin in the organization of the actin cytoskeleton, cytoplasmic streaming and the architecture of the transvacuolar strand in r. (nih.gov)
  • These results provide the first in vivo evidence that Gα 12/13 regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton. (rupress.org)
  • Normal cell growth and division in the yeast Saccharomyces cerevisiae involve dramatic and frequent changes in the organization of the actin cytoskeleton. (asm.org)
  • Here we report that by isolating rapid-death mutants in the background of the Start-deficient cdc28-4 mutation, the essential yeast gene PAN1, previously thought to encode the yeast poly(A) nuclease, is identified as a new factor required for normal organization of the actin cytoskeleton. (asm.org)
  • 271:432-438, 1996), plays an important role in the organization of the actin cytoskeleton in S. cerevisiae. (asm.org)
  • The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. (sciencemag.org)
  • This review describes and discusses the mechanisms whereby actin cytoskeleton in amygdala mediates fear and drug-associated memory formation. (frontiersin.org)
  • We report here that SopB, a Salmonella inositol polyphosphatase delivered to the host cell by this secretion system, mediates actin cytoskeleton rearrangements and bacterial entry in a Cdc42-dependent manner. (nih.gov)
  • EpCAM mediates intercellular adhesion and associates with the actin cytoskeleton via EpICD. (wikipedia.org)
  • Cell Motil Cytoskeleton. (nih.gov)
  • Finkelstein, L.D. & Schwartzberg, P.L. Tec kinases: shaping T-cell activation through actin. (nature.com)
  • Acuto, O. & Cantrell, D. T cell activation and the cytoskeleton. (nature.com)
  • The scientists thus took a closer look at possible alterations of the actin cytoskeleton in breast cancer cells comparing NK-mediated cytotoxicity resistant and susceptible cell lines. (innovations-report.com)
  • This abolished the actin response and made previously resistant cancer cells remarkably more susceptible to NK cell attack. (innovations-report.com)
  • Finally, to validate their results, Dr. Al Absi and co-workers also monitored the actin response using primary NK cells isolated from donors to exclude that the phenomenon is solely observable with the NK cell line initially used for the study. (innovations-report.com)
  • Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. (sciencemag.org)
  • We conclude that host cell invasion by Toxoplasma, and likely by related Apicomplexans, is actively powered by an actin-based contractile system in the parasite. (nih.gov)
  • We determined that the guanine nucleotide exchange factor activity of DOCK8 is essential for the integrity of the subcortical actin cytoskeleton as well as for TCR-driven WASp activation, F-actin assembly, immune synapse formation, actin foci formation, mechanotransduction, T cell transendothelial migration, and homing to lymph nodes, all of which also depend on WASp. (jci.org)
  • Herein, we report that HGF induces actin cytoskeleton remodeling in vitro in isolated myoid cells and myoid cell contraction in cultured seminiferous tubules. (mdpi.com)
  • Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. (uni-muenchen.de)
  • In this talk he will present recent data from his lab and discuss how the complementary regulation of both myosins and the actin cytoskeleton are critical for normal cell function and survival. (babraham.ac.uk)
  • A Swe1p- dependent cell cycle delay was triggered by direct perturbations of the actin cytoskeleton, even when polarity establishment functions remained intact. (rupress.org)
  • In addition, we show that the checkpoint could detect actin perturbations through most of the cell cycle. (rupress.org)
  • The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage. (nih.gov)
  • A previously introduced reporter construct based on the actin-binding domain of mouse talin proved to be useful for unravelling some of these aspects in cell layers close to the organ surface. (nih.gov)
  • We use Lifeact-eGFP expressing Phytophthora infestans for live cell imaging of the actin cytoskeleton in various developmental stages. (wur.nl)
  • These actin configurations strongly suggest a role for the actin cytoskeleton in plug formation and plant cell penetration. (wur.nl)
  • A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and. (nih.gov)
  • Second, Arp3 localizes to cortical actin patches which are required for polarized cell growth. (nih.gov)
  • Yeast cells have a set of five Rho-related GTPases, Cdc42p, Rho1p, Rho2p, Rho3p, and Rho4p, that coordinate reorganization of the cytoskeleton and cell surface growth ( 4-6 ). (sciencemag.org)
  • Breast cancer cell movement requires a remodeling of the actin cytoskeleton. (frontiersin.org)
  • In conclusion, E4 acted as a weak estrogen on breast cancer cell cytoskeleton remodeling and movement. (frontiersin.org)
  • Actin cytoskeleton self-organization in two cell types, fibroblasts and epitheliocytes, was studied in cells confined to isotropic adhesive islands. (biologists.org)
  • Therefore, it is possible that differences in actin cytoskeleton self-organization between epithelial cells and fibroblasts are determined by the differences in available extracellular adhesions (cell-cell and cell-matrix versus cell-matrix only). (biologists.org)
  • There were few dominant, elongated pseudopodia and few actin containing fine cell extensions. (arvojournals.org)
  • Both these functions require significant interactions with the cytoskeleton, the scaffold which holds the cell together. (fraxa.org)
  • This work reveals how the actin cytoskeleton can be harnessed to overcome energetic barriers to cell-cell fusion. (elifesciences.org)
  • The key features of SiR700-actin are i) far-red absorption and emission wavelengths, ii) cell permeability, iii) fluorogenic character, and iv) compatibility with super-resolution microscopy (e.g. (cytoskeleton.com)
  • Compaction of cell shape occurs before decrease of elasticity in CHO-K1 cells treated with actin cytoskeleton disrupting drug cytochalasin D. (biomedsearch.com)
  • We propose that toxofilin locally upregulates actin turnover thus increasing depolymerization events at the site of entry that, in turn loosens the local host cell actin meshwork, facilitating parasite internalization and vacuole folding. (biologists.org)
  • The actomyosin cytoskeleton disconnects from AJs, uncoupling actomyosin constriction and cell shape change. (rupress.org)
  • This provides insight into Arf regulation of the actin cytoskeleton, whilst putting the spotlight on small GTPase cooperation with emerging evidence of its importance in fundamental cell biology and interactions with pathogenic bacteria. (whiterose.ac.uk)
  • perhaps due to the presence of a rigid cell wall and a large central vacuole, and also due to the absence of the cytoskeleton-organizing centers referred to as centrosomes in animal cells and as spindle pole bodies in yeast cells ( Ehrhardt and Shaw, 2006 ). (plantcell.org)
  • Coordinated shifts of actin cytoskeleton and cell adhesion go along with maturation of lymphoid cells their migration through lymphoid organs also to sites of inflammation aswell as metastasis of changed cells. (exposed-skin-care.net)
  • Arrest of cell migration is usually associated with rearrangements of the actin cytoskeleton and activation of integrins that lead to the formation of large and stable focal adhesions. (exposed-skin-care.net)
  • We show that at restrictive temperature, the pan1 mutant exhibited abnormal bud growth, failed to maintain a proper distribution of the actin cytoskeleton, was unable to reorganize actin the cytoskeleton during cell cycle, and was defective in cytokinesis. (asm.org)
  • An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. (wikipedia.org)
  • Many microbes modify and influence the synthesis or degradation of the host-cell cytoskeleton, in particular the actin network. (wikipedia.org)
  • The proportions of spectrin and actin vary with cell type. (wikipedia.org)
  • The structure, function and dynamic behavior of the cytoskeleton can be very different, depending on organism and cell type. (wikipedia.org)
  • The cytoskeleton can also contract, thereby deforming the cell and the cell's environment and allowing cells to migrate. (wikipedia.org)
  • The cytoskeleton provides the cell with structure and shape, and by excluding macromolecules from some of the cytosol, it adds to the level of macromolecular crowding in this compartment. (wikipedia.org)
  • Vinculin's ability to interact with integrins to the cytoskeleton at the focal adhesion appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. (wikipedia.org)
  • The changes that actin brings about lead to the formation of new synapses as well as increased cell communication. (wikipedia.org)
  • Stimulation of the neuron that promotes LTP causes larger spine volume, increased cell communication, and a greater ratio of F-actin to G-actin. (wikipedia.org)
  • In the LTD environment, spine volume is decreased, cell communication is decreased, and there is a far greater ratio of G-actin to F-actin. (wikipedia.org)
  • WRC recruitment to the sites of actin nucleation events at the cell periphery is mediated by the binding of a number of ligands containing a conserved WRC interacting receptor sequence (WIRS) which binds to a conserved location shared across the surfaces of Abi2 and CYFIP1. (wikipedia.org)
  • Rac, and Cdc42 inside the target cells disturb signal transduction mechanisms, which leads to dysfunctioning of actin cytoskeleton, cell-cell junction, and apoptosis (Fig. 5). (wikipedia.org)
  • It also regulates the actin cytoskeleton, cell adhesion, and cell migration. (wikipedia.org)
  • Moreover, it participates in several processes required for cell growth and proliferation, including cytoskeleton organization, mitotic apparatus formation, and signal transduction. (wikipedia.org)
  • The noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell. (wikipedia.org)
  • these junctions anchor the actin cytoskeleton to the sarcolemma and provide strong cell adhesion. (wikipedia.org)
  • Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell Sci. (wikipedia.org)
  • An alternative view is that the patches are moved to the rear of the cell by direct attachment to the actin cytoskeleton. (wikipedia.org)
  • Actin, gamma 1, encoded by this gene, is found in non-muscle cells in the cytoplasm, and in muscle cells at costamere structures, or transverse points of cell-cell adhesion that run perpendicular to the long axis of myocytes. (wikipedia.org)
  • Many other molecules involved in cell-cell contact are implicated in zebrafish epiboly, including G alpha (12/13) which interacts with E-Cadherin and actin, as well as the cell adhesion molecule EpCam in the EVL, which may modulate adhesion with the underlying deep cells. (wikipedia.org)
  • As a result, the host cell's actin cytoskeleton control is disabled, leading to cell rounding. (wikipedia.org)
  • These results indicate that DOCK8 and WASp are in the same signaling pathway that links TCRs to the actin cytoskeleton in TCR-driven actin assembly. (jci.org)
  • Functional analyses of these genes revealed an interconnected pathway network centered on lysosomal function and the regulation of actin cytoskeleton. (nih.gov)
  • Bni1p may function as a Cdc42p target that links the pheromone response pathway to the actin cytoskeleton. (sciencemag.org)
  • An actin-dependent, but clathrin-independent, internalization pathway for the BCR has recently been observed ( 17 ), underscoring the importance of actin in BCR internalization. (jimmunol.org)
  • Furthermore, we demonstrate that Gα 12/13 modulate epibolic movements of the enveloping layer by regulating actin cytoskeleton organization through a RhoGEF/Rho-dependent pathway. (rupress.org)
  • Zeng W, Li Y, Li B, Liu C, Hong S, Tang J, Hong L. Mechanical Stretching induces the apoptosis of parametrial ligament Fibroblasts via the Actin Cytoskeleton/Nr4a1 signalling pathway. (medsci.org)
  • Calponin domains are actin-binding motifs ( 18 ), suggesting that the NH 2 -terminal domain of ANC-1 interacts with the actin cytoskeleton. (sciencemag.org)
  • Such changes in actin cytoskeleton in amygdala are essential for fear and drug-related memories formation. (frontiersin.org)
  • Tie-2 antisense treatment abolished both the effects of Ang-1 and Ang-2 on changes in actin cytoskeleton in the retinal pericytes. (arvojournals.org)
  • Our data support a novel apical recycling model which indicates a critical role for actin patch-mediated endocytosis to maintain polarized growth at the apex. (psu.edu)
  • Dysregulation of lysosomal function and cytoskeleton remodeling has direct impacts on endocytosis, phagocytosis, exocytosis, vesicle trafficking, neuronal maturation and migration, neurite outgrowth and synaptic density and plasticity, and different aspects of these processes have been implicated in SCZ and BPD. (nih.gov)
  • Growth cones are highly dynamic in nature and contain a dynamic actin cytoskeleton in their peripheral region undergoing a constant retrograde flow. (wikipedia.org)
  • Overall, our data revealed the changes of actin cytoskeleton-related genes following peripheral nerve injury and stated the importance of actin cytoskeleton during peripheral nerve regeneration. (frontiersin.org)
  • There is also evidence for the importance of actin-based structures in epiboly. (wikipedia.org)
  • Interactions of mitochondria with the actin cytoskeleton. (nih.gov)
  • Thus, mitochondria-actin interactions contribute to apoptosis. (nih.gov)
  • leton either directly or indirectly through its interactions with components of the actin/septin machinery (Fig. 4A). (psu.edu)
  • This is the first demonstration that OT mediation of suckling-evoked bursts/milk ejections is via interactions between pERK1/2 and actin cytoskeleton. (jneurosci.org)
  • With funding from FRAXA Research Foundation from 2004-2006, Dr. Angela Giangrande at the Universite Louis Pasteur investigated the interactions between dendrites, messenger mRNA, and the cytoskeleton in fruit flies, which are a simple yet powerful system in which multiple genes can be manipulated with relative ease. (fraxa.org)
  • G-actin are the monomer building blocks that assemble via weak noncovalent interactions to form F-actin. (wikipedia.org)
  • We propose a delayed feedback model that explains our experimental findings based on a time-delay in the regulatory network of the actin system. (pnas.org)
  • The disassembly rate was accelerated more than twofold above the resting value, but only when contraction increased the actin density to a threshold value following a time delay. (pnas.org)
  • The model showed that this feedback mechanism, together with rapid stress transmission along the actin bundle, spatiotemporally synchronizes actin disassembly and fiber contraction. (pnas.org)
  • These modifications require regulated disassembly and reassembly of the actin cytoskeleton. (hindawi.com)
  • Furthermore, Toxoplasma tachyzoites lacking toxofilin, are impaired in cortical actin disassembly and exhibit delayed invasion kinetics. (biologists.org)