• DNA fragmentation assay was done through Hoechst 33258 and acridine orange-ethidium bromide staining. (jcimjournal.com)
  • The mechanism of cell death induced by RE was qualitatively measured using Acridine orange/Ethidium bromide staining and Hoechst staining. (biomedcentral.com)
  • Identifying novel antimicrobial agents from plant-based compounds may result in anti-microbial drugs effective against the resistant strains. (biomedcentral.com)
  • Since the kinetic parameters are much more directly related to potential molecular targets than are the experimentally measured quantities, this approach can provide a more informative picture of the mechanism of action of the antitumour agent under investigation. (ox.ac.uk)
  • This agent is a DNA-interactive pentacyclic acridine for which at least three potential mechanisms of antitumour activity have been identified. (ox.ac.uk)
  • More recently, we have been studying some diimine Pt(II) and Pd(II) complexes of dithiocarbamate derivative as potential anticancer agents [ 31 ]. (hindawi.com)
  • To find more effective anticancer agents, a series of novel dehydroabietylamine (DA) derivatives were synthesized, focusing on C-ring nitro modifications and C-18 imide introduction. (nih.gov)
  • 12. Evaluation of 2-(methylaminosulfonyl)-1-(arylsulfonyl)hydrazines as anticancer agents. (nih.gov)
  • 17. Evaluation of 2-(methylaminosulfonyl)-1-(arylsulfonyl)-1-methylhydrazines as anticancer agents. (nih.gov)
  • Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. (wakehealth.edu)
  • Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. (wakehealth.edu)
  • Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. (wakehealth.edu)
  • 7. Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent. (nih.gov)
  • 11. Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. (nih.gov)
  • 20. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity. (nih.gov)
  • Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. (wakehealth.edu)
  • Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. (wakehealth.edu)
  • 10. Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation. (nih.gov)
  • Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. (wakehealth.edu)
  • Acridine antineoplastic agent used in mammary and ovarian tumors. (nih.gov)
  • Therefore, the G1199A polymorphism alters the efflux and transepithelial permeability of a fluorescent substrate and sensitivity to select cytotoxic agents, which may influence drug disposition and therapeutic efficacy of some P-gp substrates. (nih.gov)
  • Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. (wakehealth.edu)
  • Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. (wakehealth.edu)
  • Deferasirox (DFX) is an iron-chelating agent effective in treating various kinds of cancers, which inhibits iron metabolism in cancer cells. (bvsalud.org)
  • A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. (wakehealth.edu)
  • Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. (wakehealth.edu)
  • A substantial proportion of the cancer morbidity could be prevented through early detection and treatments, which renders the quest for highly effective antineoplastic agents [ 6 ]. (hindawi.com)
  • 3. Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent. (nih.gov)
  • 4. Evaluation of naphthal-NU, a 2-chloroethylnitrosourea derivative of naphthalimide, as a mixed-function anticancer agent. (nih.gov)
  • 8. Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters. (nih.gov)
  • The pigmentary effects of this drug tend to be reversible, with slow reversal of skin color back to baseline within several months after stopping the inciting agent. (medscape.com)