• Aconitine is the main alkaloid in aconite. (wikipedia.org)
  • Many herbal medicines and compositions are clinically effective but challenged by its safety risks, i.e., aconitine (AC) from aconite species. (springer.com)
  • Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
  • Aconitine (AC), known as devil's helmet, is a highly poisonous alkaloid derived from various aconite species. (springer.com)
  • Toxicity of the NPs was tested in vivo in comparison to pure aconitine, aconite, and licorice root decoction and reported here. (springer.com)
  • Aconite contains alkaloids like aconine, aconitine, napelline and picraconitine. (spicesmedicinalherbs.com)
  • Tinctures of Aconite and aconitine are used externally in certain forms of neuralgia and rheumatism, and internally m small doses in cases of fever and pain. (thepharmacognosy.com)
  • By applying knowledge of these fragmentation pathways to the aconitines in the ethanolicextract of aconite roots, all the known aconitines were detected and also 23 unknown aconitine-typealkaloids, in which the lipo-alkaloids containing residues of 15C, 17C and 19C saturated orunsaturated fatty acids were characterized. (healthdrugpdf.com)
  • Aconitine-type crude extract of aconite are characterized, based on these alkaloids isolated from aconite have been shown to have potential toxicity and wide bioactivity. (healthdrugpdf.com)
  • AC, HC and both ESI and MALDI-MS were applied to analyze complex MA were dissolved in chloroform to obtain a solution of mixtures of alkaloids from aconite.8,9 However, to our concentration of approx. (healthdrugpdf.com)
  • 0.5 mg/mL. 8-Ole-14-benzoylmesa- knowledge, no reports have appeared in the literature on conine and other lipo-alkaloids were synthesized using the the application of ESI-MS to determine the fragmentation procedure reported by Pelletier et al.11 Aconitum alkaloids in mechanisms of aconitines and their relationship to molecular aconite were extracted with ethanol for 48 h at room structure. (healthdrugpdf.com)
  • collision-induced dissociation (CID) conditions are still notsufficiently clear to assist characterization of unknown aconitine-type alkaloids in aconite extracts. (healthdrugpdf.com)
  • Then some unknown minor lipo-alkaloids in the the most useful herbal medicines in China. (healthdrugpdf.com)
  • The capillary voltage was tines (DDAs), in which the C8 position is occupied by an fixed at 5.0 V and capillary temperature was set 200°C. acetyl group, and lipo-alkaloids, in which the C8 position is Sample solutions were infused at 3 mL/min via a syringe occupied by a fatty acid acyl group.10 The other structural pump. (healthdrugpdf.com)
  • aconitines,2±4 the quantitative analysis and the stereo- Authentic samples of aconitine (AC), hypaconitine (HC) chemistry of aconitines,5±7 and the direct analysis of and mesaconitine (MA) were purchased from China Drug aconitine mixtures. (healthdrugpdf.com)
  • The plant, from the lily family, in fact contains colchicine, an alkaloid from which a powerful treatment for granulocytic leukemia is now made. (dhushara.com)
  • But would-be murderers had no shortage of alternatives-scientists were identifying new plant toxins, including strychnine from a tree found in India, nicotine from tobacco leaves, and aconitine, derived from the monkshood plant. (elleryqueenmysterymagazine.com)
  • Lycoctonine Aconitine has cardiac arrhythmic and antipyretic properties and is one of the most toxic plant compounds. (wikipedia.org)
  • It has been known that liquiritin from licorice forms complexation with aconitine and therefore reduces the amount of free aconitine [ 7 ], indicating that interactions between aconitine with other major amphiphilic compounds (i.e., protein) from licorice may facilitate the formation of aconitine complex of such kind, too. (springer.com)
  • According to press release from the SFDPH the toxic alkaloid aconitine was discovered in the lab tests of both patients as well as the tea samples they provided. (csomaonline.org)
  • The root and tuber contain the highest amounts of alkaloids and are therefore the most toxic portions, however the leaf and flower are also poisonous if consumed. (csomaonline.org)
  • bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_mpuslot' }}, It is by no means the most powerful poison known, for such an alkaloid as pseud-aconitine, which is lethal in dose of about 1/200 of a grain, is some hundreds of times more toxic, but prussic acid is by far the most rapid poison known, a single inhalation of it producing absolutely instantaneous death. (mercinewyork.com)
  • This species does not contain the toxic alkaloid Aconitine and so it is said to be non-poisonous. (healthchannel.pk)
  • In this study, a boiling-stable 31-kDa protein (namely GP) was purified from licorice and self-assembled into nanoparticles (206.2 ± 2.0 nm) at pH 5.0, 25 °C. The aconitine-encapsulated GP nanoparticles (238.2 ± 1.2 nm) were prepared following the same procedure and tested for its toxicity by intraperitoneal injection on ICR mouse ( n = 8). (springer.com)
  • Encapsulation of poisonous alkaloids into self-assembled herbal protein nanoparticles contributes to toxicity attenuation of combined use of herbs, implying a prototype nanostructure and a universal principle for the safer clinical applications of herbal medicines. (springer.com)
  • The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
  • Despite its cardiotoxic and neurotoxic risks, aconitine is popularly used as the antipyretic and analgesic agents in many Asian countries. (springer.com)
  • In this episode Dr. Gillian Beauchamp sits down with Dr. Fiona Garlich to discuss mechanisms and clinical presentations of aconitine, veratrum alkaloid and grayanotoxin cardiotoxicity. (libsyn.com)
  • Aconitine was detected in all analyzed samples (blood, urine, gastric content and kidney) and quantified in femoral blood with 86.2 μg/L (case 1) and 2.3 μg/L (case 2), respectively. (newsshare.in)
  • It is difficult to calculate appropriate dosage for the use of aconitine due to its narrow therapeutic index [ 4 ]. (springer.com)
  • Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. (powershow.com)
  • Fragmentation pathways of aconitine-type alkaloids were investigated by electrospray ionization/ion trap multistage tandem mass spectrometry. (healthdrugpdf.com)
  • A sensitive, reliable and accurate high-performance liquid chromatography (HPLC) method coupled with photodiode array detector (DAD) were developed for the simultaneous quantitative determination of aconitine, mesaconitine and hypaconitine in rat plasma and urine by optimizing the extraction, separation and analytical conditions. (ajol.info)
  • The limits of detection (signal-to-noise ratio of 3) were 2.64, 1.58 and 2.75 ng for aconitine, mesaconitine and hypaconitine, respectively. (ajol.info)
  • All parts of this plant contain poisonous alkaloids, caution should be used when handling. (ncsu.edu)
  • You can be lured into its velvety folds, but you should be aware that all parts of the plant contain the poisonous alkaloid aconitine. (blogspot.com)
  • Jimsonweed (Datura stramonium): Jimsonweed, also known as Devil's Snare, contains tropane alkaloids that can be dangerous if touched or ingested. (theworldhour.com)
  • Belonging to the genus Brugmansia, they come in a variety of colors and all parts of them contain toxins such as tropane alkaloids scopolamine and atropine. (wonderslist.com)
  • Atisine Veatchin The C19 alkaloids include, among others, the aconitine type (aconitine, delphinine) and the lycoctonine type (Lycoctonin, Browniin). (wikipedia.org)
  • Larkspurs are beautiful flowers found in North America and Europe, but they also contain several toxic alkaloids, such as delphinine and ajacine. (guidinguk.com)
  • Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is one of the most potent non-proteinacious ligands that is selective for alpha bungarotoxin-sensitive neuronal nicotinic acetylcholine receptors (nAChR). (ox.ac.uk)
  • The poison aconitine is responsible for the toxicity of the plant which can harm an adult even with a touch. (wonderslist.com)
  • Alkaloids found in OPIUM from PAPAVER and their derivatives that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS. (jefferson.edu)
  • The article dwells on the history of herb treatment, traditional and modern techniques of making drugs from plants, and also on alkaloids - drastic plants that have enjoyed a bad reputation long since but that can turn into medicine in skilful hands. (scfh.ru)
  • this substance was found associated with from 0.8 to 3.8 per cent of an alkaloid insoluble in ether. (henriettes-herb.com)
  • Diterpene alkaloids can be divided into two groups: The diterpene alkaloids, characterized by a C20 parent body, and the norditerpene alkaloids, which are based on a hexacyclic C19 parent body. (wikipedia.org)