• Like many other alkaloids, the basic nitrogen atom in one of the six-membered ring structure of aconitine can easily form salts and ions, giving it affinity for both polar and lipophilic structures (such as cell membranes and receptors) and making it possible for the molecule to pass the blood-brain barrier. (wikipedia.org)
  • The roots of the plant are the source of most of the alkaloids obtained from the plant such as aconitine, atisine, heterophyllin, heterophyllisin etc. (planetayurveda.com)
  • Aconite contains alkaloids like aconine, aconitine, napelline and picraconitine. (spicesmedicinalherbs.com)
  • Many herbal medicines and compositions are clinically effective but challenged by its safety risks, i.e., aconitine (AC) from aconite species. (springer.com)
  • Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
  • Aconitine (AC), known as devil's helmet, is a highly poisonous alkaloid derived from various aconite species. (springer.com)
  • Toxicity of the NPs was tested in vivo in comparison to pure aconitine, aconite, and licorice root decoction and reported here. (springer.com)
  • Aconitine is an alkaloid toxin produced by various plant species belonging to the genus Aconitum (family Ranunculaceae), known also commonly by the names wolfsbane and monkshood. (wikipedia.org)
  • The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
  • According to press release from the SFDPH the toxic alkaloid aconitine was discovered in the lab tests of both patients as well as the tea samples they provided. (csomaonline.org)
  • Aconitine can interact with the voltage-dependent sodium-ion channels, which are proteins in the cell membranes of excitable tissues, such as cardiac and skeletal muscles and neurons. (wikipedia.org)
  • In neurons, aconitine increases the permeability of the membrane for sodium ions, resulting in a huge sodium influx in the axon terminal. (wikipedia.org)
  • Properties of aconitine-induced block of KDR current in NG108-15 neurons (Lin et al. (yale.edu)
  • The acetoxyl group at the c8 position can readily be replaced by a methoxy group, by heating aconitine in methanol, to produce a 8-deacetyl-8-O-methyl derivatives. (wikipedia.org)
  • Some of these words can also be considered Aconitine synonyms. (meaningin.com)
  • Recently,Prof. Feng Nianping's research team at SHUTCM published an academic papertitled Solid Lipid NanoparticlesFormulated for Transdermal Aconitine Administration and Evaluated In Vitro andIn Vivo in the Journal of Biomedical Nanotechnology (J Biomed Nano Technol. (shutcm.edu.cn)
  • But would-be murderers had no shortage of alternatives-scientists were identifying new plant toxins, including strychnine from a tree found in India, nicotine from tobacco leaves, and aconitine, derived from the monkshood plant. (elleryqueenmysterymagazine.com)
  • If aconitine is heated in its dry state, it undergoes a pyrolysis to form pyroaconitine ((1α,3α,6α,14α,16β)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-15-oxoaconitan-14-yl benzoate) with the chemical formula C32H43NO9. (wikipedia.org)
  • Aconitine binds to the channel at the neurotoxin binding site 2 on the alpha subunit (the same site bound by batrachotoxin, veratridine, and grayanotoxin). (wikipedia.org)
  • A sensitive, reliable and accurate high-performance liquid chromatography (HPLC) method coupled with photodiode array detector (DAD) were developed for the simultaneous quantitative determination of aconitine, mesaconitine and hypaconitine in rat plasma and urine by optimizing the extraction, separation and analytical conditions. (ajol.info)
  • The limits of detection (signal-to-noise ratio of 3) were 2.64, 1.58 and 2.75 ng for aconitine, mesaconitine and hypaconitine, respectively. (ajol.info)
  • Like many other alkaloids, the basic nitrogen atom in one of the six-membered ring structure of aconitine can easily form salts and ions, giving it affinity for both polar and lipophilic structures (such as cell membranes and receptors) and making it possible for the molecule to pass the blood-brain barrier. (wikipedia.org)
  • Aconitine binds to the channel at the neurotoxin binding site 2 on the alpha subunit (the same site bound by batrachotoxin, veratridine, and grayanotoxin). (wikipedia.org)
  • One of the dangerous plants cultivated here is monkshood, or wolf's bane, which contains aconitine, a neurotoxin and cardio toxin. (homeinsur.net)
  • A separate cohort was tested for vulnerability to aconitine-induced arrhythmia 24 hr after exposure. (nih.gov)
  • However, both 0.2 and 0.8 ppm O 3 increased sensitivity to aconitine-induced arrhythmia formation, suggesting a latent O 3 -induced alteration in myocardial excitability. (nih.gov)
  • In-Vivo: Chemically induced arrhythmia: Aconitine antagonism, Digoxin-induced arrhythmia, Strophanthin/ouabain-induced arrhythmia, Adrenaline-induced arrhythmia, and Calcium-induced arrhythmia. (nih.gov)
  • The poison aconitine is responsible for the toxicity of the plant which can harm an adult even with a touch. (wonderslist.com)
  • You can produce lots of other sicknesses with arsenic or thallium or atropine or aconitine or digitalis if you dose them carefully. (stackexchange.com)
  • If aconitine is heated in its dry state, it undergoes a pyrolysis to form pyroaconitine ((1α,3α,6α,14α,16β)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-15-oxoaconitan-14-yl benzoate) with the chemical formula C32H43NO9. (wikipedia.org)
  • Aconitine is also soluble in mixtures of alcohol and water if the concentration of alcohol is high enough. (wikipedia.org)
  • For pioneers of anesthesia such as China's Hua Tuo (c. 140-c. 208) and Japan's Seishu Hanaoka (1760-1835), the numbing aconitine of monkshoods provided the "pain dulling" portion of a primitive balanced anesthetic. (silverchair.com)