• Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. (wikipedia.org)
  • While other species of the genus Acinetobacter are often found in soil samples (leading to the common misconception that A. baumannii is a soil organism, too), it is almost exclusively isolated from hospital environments. (wikipedia.org)
  • A. baumannii is part of the ACB complex (A. baumannii, A. calcoaceticus, and Acinetobacter genomic species 13TU). (wikipedia.org)
  • A. baumannii has also been identified as an ESKAPE pathogen (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), a group of pathogens with a high rate of antibiotic resistance that are responsible for the majority of nosocomial infections. (wikipedia.org)
  • Acinetobacter wwwnc.cdc.gov/EID/article/19/5/12- as described ( 8 ) and by repetitive ex- baumannii Clone, 1618-Techapp1.pdf). (cdc.gov)
  • It was the beginning of a life-and-death battle with Acinetobacter baumannii, a superbug resistant to all antibiotics . (today.com)
  • Acinetobacter baumannii is a bacterium that, until the last couple of decades, was considered to be pretty wimpy. (today.com)
  • The phages of Acinetobacter baumannii has drawn increasing attention because of the multi-drug resistance of A. baumanni . (geneticsmr.com)
  • The aim of this study was to sequence Acinetobacter baumannii phage AB3 and conduct bioinformatic analysis to lay a foundation for genome remodeling and phage therapy. (geneticsmr.com)
  • We isolated and sequenced A. baumannii phage AB3 and attempted to annotate and analyze its genome. (geneticsmr.com)
  • Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) present significant healthcare challenges due to limited treatment options. (qxmd.com)
  • Acinetobacter baumannii, a major causative agent of ventilator-associated pneumonia and catheter-related bloodstream infec. (cn1699.cn)
  • Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1. (cdc.gov)
  • If you can help, we're looking for Acinetobacter baumannii (patient in India) and Pseudomonas aeruginosa (patient in Australia). (phagedirectory.com)
  • Development of Rabbit Models of Ventilator-Associated Carbapenem-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Pneumonia. (asm.org)
  • In 2016, Strathdee's husband, Tom Patterson, became the first person in the U.S. to receive IV phage therapy for his antibiotic-resistant infection of Acinetobacter baumannii. (uvm.edu)
  • The widespread of bacteria and the accumulation of drug resistance pose a severe challenge to existing treatments, and WHO has proposed a global list of priority antibiotic-resistant bacteria to guide the development of new antimicrobial agents, including the notorious ESKAPE Pathogens ( Enterococcus faecalis , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa, and Enterobacter sp . (creative-biolabs.com)
  • Carbapenem-resistant Klebsiella pneumoniae , colistin-resistant, and imipenem-resistant Acinetobacter baumannii / Pseudomonas aeruginosa have also been observed in recent years. (creative-biolabs.com)
  • Various phages against ESKAPE pathogens and other pathogenic bacteria have been isolated, purified, and characterized, including phage PD-6A3 and Abp1 against imipenem against Acinetobacter baumannii , and Sb-1 phage family against Staphylococcus aureus . (creative-biolabs.com)
  • Fig.2 Phage vBAb-M-G7 infects and lyses Acinetobacter baumannii strain G7. (creative-biolabs.com)
  • In 2016, the life of Thomas Patterson, PhD, a professor of psychiatry at the University of California, San Diego, was saved by phage therapy after he developed a deadly Acinetobacter baumannii infection. (ubigene.us)
  • Acinetobacter baumannii and Klebsiella pneumoniae . (mit.edu)
  • In a paper titled " Novel Phage Lysin Abp013 against Acinetobacter baumannii " published in medical journal Antibiotics , the SMART AMR team reveals their findings on Abp013's ability to effectively access and kill various bacterial strains. (mit.edu)
  • The study showed that Abp013 displayed good permeability and killing activity against multiple Acinetobacter baumannii and Klebsiella pneumoniae strains, even when they are in a more complex environment in which typical lysins are ineffective. (mit.edu)
  • Acinetobacter baumannii and Klebsiella pneumoniae are superbugs responsible for a multitude of potentially life-threatening infections, such as pneumonia and meningitis, especially among the ill and immunocompromised. (mit.edu)
  • Prior to the discovery of Abp013, no other lysins are capable of targeting Acinetobacter baumannii and Klebsiella pneumoniae, but not Pseudomonas aeruginosa . (mit.edu)
  • Mr. Woloszyn also noted that Army grants have previously supported and continue to support Intralytix's development of other phage-based products, including food additives that protect food from contamination by E. coli O157:H7, Salmonella and Shigella, and a preparation for treating Acinetobacter baumannii-infected wounds. (wanglong.us)
  • While Acinetobacter as a broad class of bacteria is indeed found in soil, the particular species causing the epidemic among the troops, A. baumannii -- which has spread to and killed civilians in American and European military hospitals -- is not native to Iraqi soil, as the Pentagon has claimed and the press has repeated many times. (metafilter.com)
  • Acinetobacter baumannii is a multidrug-resistant pathogen. (theconversation.com)
  • GAITHERSBURG, Md.-(BUSINESS WIRE[1])-Adaptive Phage Therapeutics (APT), a clinical-stage biotechnology company dedicated to providing therapies to treat multi-drug resistant bacterial infectious diseases, today announced clearance by the U.S. Food and Drug Administration (FDA) of the company's Expanded Access IND for PhageBank™ treatment for pneumonia or bacteremia/septicemia due to Acinetobacter baumannii, Pseudomonas aeruginosa or Staphylococcus aureus in COVID-19 patients. (bacterial.org)
  • Catherine Hernandez and Britt Koskella of UC Berkeley have shown that they do not observe Pseudomonas syringae phage resistance in planta , no matter what they try , even though they see it in vitro . (phagedirectory.com)
  • It has been particularly effective against multidrug-resistant bacteria, such as those belonging to the genus Acinetobacter or Pseudomonas. (walshmedicalmedia.com)
  • He is broadly interested in how potential pathogens (e.g. bacteria such as Burkholderia, Pseudomonas, Acinetobacter , and viruses like SARS-CoV-2) evolve to adapt to new hosts and environments. (micropopbio.org)
  • Of these 260 requests, only 15 patients received phage therapy. (mdpi.com)
  • Desperate to find a cure after more than a dozen antibiotics had failed, Strathdee, an infectious disease epidemiologist at the University of California, San Diego, School of Medicine, stumbled upon phage therapy: a mostly forgotten treatment discovered 100 years ago that uses viruses to kill lethal bacteria. (today.com)
  • Phages are viruses that have naturally evolved to attack bacteria. (today.com)
  • if it works, the phages kill the bad bacteria but keep the body's good bacteria intact. (politico.com)
  • One main approach to combat antibiotic-resistant bacteria is phage therapy. (walshmedicalmedia.com)
  • Phage therapy involves isolating and using these viruses to target and destroy pathogenic bacteria. (walshmedicalmedia.com)
  • Unlike antibiotics, which are broad-spectrum and can harm beneficial bacteria, phages are highly specific, targeting only the bacteria responsible for the infection. (walshmedicalmedia.com)
  • With our strong technology platform and cutting-edge theoretical knowledge, Creative Biolabs is ready to help you understand the phage therapies against antibiotic-resistant bacteria. (creative-biolabs.com)
  • Bacteriophage (phage) are ubiquitous viruses that infect and kill bacteria in a species-, sometimes even strain-, specific manner. (diabetesonthenet.com)
  • Some phages also possess enzymes capable of degrading the biofilms that afford antibiotic tolerance to bacteria and underpin many chronic infections. (diabetesonthenet.com)
  • Phages also act independent of antibiotic resistance, allowing the treatment of even pan-resistant bacteria, and topical or local application to DFIs means antimicrobial activity is independent of a patient's peripheral perfusion. (diabetesonthenet.com)
  • It was 1917 when Felix d'Herelle, at the Institut Pasteur in Paris, first proposed using bacteriophages (or phages)-viruses that infect bacteria-as a therapy for human bacterial infections. (ubigene.us)
  • Although phage therapy offers a promising way forward, other investigators want to take a more direct approach using only the active ingredient of the phage-the lysins-responsible for killing bacteria. (ubigene.us)
  • Phage lysins work by degrading the bacterial cell wall, which is composed of the bacteria-specific molecule peptidoglycan. (ubigene.us)
  • Typically, to treat Acinetobacter infections, health-care providers have to send a specimen for laboratory testing to determine which antibiotics are effective in fighting the bacteria. (mit.edu)
  • One longer term possibility I was surprised not to see mentioned in this article is bacteriophage ('phage') therapy , which might be an option with Gram-negative bacteria. (metafilter.com)
  • While many bacteria have intrinsic, chromosomally encoded ARDs and the capability of increasing resistance through mutation, they can also enrich their resistance capabilities through the acquisition of exogenous ARDs located on mobile genetic elements (MGEs) such as plasmids, transposons or phages. (nature.com)
  • Phage therapy may not be an appropriate option if a patient has cultured multiple bacteria over time. (ucsd.edu)
  • If it is difficult for physicians to determine which bacteria is causing the disease or if multiple are in play, phage therapy is likely not an option. (ucsd.edu)
  • At present, it is not feasible to find and prepare phages for multiple bacteria that may or may not be causing disease, as a large amount of time and energy are needed to find and prepare each phage. (ucsd.edu)
  • The bacteria designated by the acronym SERMOR-PROVENF (SER = Serratia, MOR = Morganella, PROV = Providencia, EN = Enterobacter, F = freundii for Citrobacter freundii ) have similar, although not identical, chromosomal beta-lactamase genes that are inducible. (medscape.com)
  • However, patients with serious multidrug-resistant or device-related bacterial infections that are not responding to antibiotics may be eligible for phage therapy through a special request from the Food and Drug Administration's Emergency or Singe Patient Expanded Access Investigational New Drug (IND) procedure. (ucsd.edu)
  • A multidrug-resistant bacterial culture is needed before phage therapy can be considered. (ucsd.edu)
  • Virulent or obligate lytic phages infect and quickly kill their bacterial host cell, whereas temperate or lysogenic phages may either stably integrate into their host's genome or enter into the lytic life cycle. (asm.org)
  • There is a growing interest in phage therapy as a complementary tool against antimicrobial resistant infections. (mdpi.com)
  • The modern antibiotic resistance crisis has driven renewed interest in phage therapy and 2,241 patients with mostly with antibiotic refractory infections have been treated since 2000, 79% of whom improved. (diabetesonthenet.com)
  • Since 2007, phages have been used sporadically to treat bacterial infections in well-defined cases in the Queen Astrid military hospital (QAMH) in Brussels, Belgium. (mdpi.com)
  • When phages were discovered 100 years ago, they were used to treat bacterial infections, but then when penicillin came on the scene, it was considered to be a wonder drug. (today.com)
  • Felix d'Herelle first coined the term "bacteriophage" ( 4 ), literally meaning "bacterium eater," and began using phages to treat bacterial infections in human patients ( Fig. 1 ). (asm.org)
  • Phage therapy has shown remarkable success in treating bacterial infections that are resistant to antibiotics. (walshmedicalmedia.com)
  • While phage therapy is not a new concept, recent advances in genomics and biotechnology have made it more accessible and personalized to individual infections. (walshmedicalmedia.com)
  • Phage therapy, short for bacteriophage therapy, is a medical treatment that uses bacteriophages to combat bacterial infections. (uvm.edu)
  • The concept behind phage therapy is to harness the natural antibacterial properties of phages to target and eliminate specific bacterial infections. (uvm.edu)
  • Reducing the number of serious infections and amputations will not only benefit patients but will deliver vast savings to the NHS and reduce the amount of antibiotics used, making phage therapy a tangible response to the antibiotic resistance crisis. (diabetesonthenet.com)
  • The differences between treating infections with phages and lysins, Fischetti explains, are "night and day. (ubigene.us)
  • Currently, phage therapy to treat Borrelia infections and/or Lyme disease, is not ready to administer to humans. (ucsd.edu)
  • Therefore, it is best if your primary care provider refers you to a local infectious disease physician, since they are best equipped to manage complex bacterial infections, such as those that may be eligible for phage therapy. (ucsd.edu)
  • Bacteriophages (phages) are viruses capable of infecting and replicating within bacterial cells. (asm.org)
  • The award will enable Intralytix to examine using naturally occurring bacteriophages (or phages) - delivered as part of a probiotic diet - to reduce significantly the incidence and severity of shigellosis. (wanglong.us)
  • He added that: "Using bacteriophages as probiotic/nutraceutical products is a novel idea, and our company holds a patent for using phages to reduce bacterial colonization, including colonization of the GI and nasal tracts. (wanglong.us)
  • Although phage therapy was first implemented almost a century ago, it was brought to a standstill after the successful introduction of antibiotics. (asm.org)
  • Finally, we discuss the benefits of phage therapy beyond the clinical perspective, including opportunities for scientific outreach and effective education, interdisciplinary collaboration, cultural and economic growth, and even innovative use of social media, making the case that phage therapy is more than just an alternative to antibiotics. (asm.org)
  • FIG 1 Timeline of major events in the history of research on phages, phage therapy, and antibiotics. (asm.org)
  • Background curves represent a qualitative measure of the overall interest, research, and use of phage therapy (yellow) and antibiotics (blue), showing how the introduction of antibiotics and the critical review of the early phage therapy studies coincided to bring phage therapy research and development to an almost complete standstill around the 1940s. (asm.org)
  • Also called phage therapy, it was developed in Eastern Europe in the early 20th century but largely dropped out of sight after antibiotics came on the market. (politico.com)
  • Phage Australia is a national network of phage researchers and clinician scientists who aim to professionalise phage therapy as the third major intervention for infectious diseases, after vaccines and antibiotics. (phageaustralia.org)
  • Phages have been used to treat bacterial infection since 1919, but their use in the geopolitical West ceased in the 1930s due to a variety of factors, including the mass production of antibiotics. (diabetesonthenet.com)
  • Presently only an option when antibiotics are not meeting a patient's clinical needs, future integration of phage therapy at all levels of DFI care will radically transform the outlook for DFIs in the UK. (diabetesonthenet.com)
  • To obtain phage therapy through the FDA's emergency IND route, a physician must demonstrate that all available treatment options (typically antibiotics and surgical procedures) have been exhausted, hence the need to use an experimental therapy such as phages. (ucsd.edu)
  • Emerging strategies to combat and treat ESKAPE pathogens including Enterobacter include consideration for combination antibiotics, phage therapy, antimicrobial peptides, silver nanoparticles and photodynamic light therapy. (medscape.com)
  • CusabioAlternative Name(s): /Gene Names: ddaResearch Areas: NeuroscienceOrganism: Enterobacteria phage. (joplink.net)
  • CusabioAlternative Name(s): Gene Names: uvsYResearch Areas: OthersOrganism: Enterobacteria phage T4. (joplink.net)
  • CusabioAlternative Name(s): UVSX,Recombination and repair proteinGene Names: UVSXResearch Areas: OthersOrganism: Enterobacteria phage T4 (Bacteriophage T4)AA. (joplink.net)
  • CusabioAlternative Name(s): DsDNA-binding protein A (rpbB)Gene Names: dsbAResearch Areas: Cell BiologyOrganism: Enterobacteria phage T4 (Bacteriophage. (joplink.net)
  • Could phage therapy help combat antimicrobial resistance? (eptc.ge)
  • Clinical microbiologists typically differentiate members of the genus Acinetobacter from other Moraxellaceae by performing an oxidase test, as Acinetobacter spp. (wikipedia.org)
  • They are related to members within genus Moraxella and Acinetobacter . (vetbact.org)
  • Now, with the rise of antibiotic resistance, phage therapy is experiencing a well-deserved rebirth. (asm.org)
  • We cover the key points of the antibiotic resistance crisis and then explain the biological and evolutionary principles that support the use of phages, their interaction with the immune system, and a comparison with antibiotic therapy. (asm.org)
  • Creative Biolabs is dedicated to providing strong support in solving problems in phage therapies and antibiotic resistance. (creative-biolabs.com)
  • From April 2013 to April 2018, 260 phage therapy requests were addressed to the QAMH. (mdpi.com)
  • He purified a phage lysin during his thesis work, using it to extract proteins from group A streptococci. (ubigene.us)
  • Spot assay was then used to compare the spectra of the isolated phages, while kinetic and genomic analysis of the phage with the broadest spectrum was assessed. (bvsalud.org)
  • Well-characterized, highly purified, and virulent selected phages can be used in situations where antibiotic drugs fail and serve as excellent and promising tools for microbial pathogen suppression. (creative-biolabs.com)
  • Intralytix, Inc is a biotechnology company focused on using its core bacteriophage/phage technology platform to improve human health through the development and commercialization of innovative products for food safety, animal health and human therapeutics. (wanglong.us)
  • Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. (mdpi.com)
  • Mu-derived plasmids transferred from pAV2 − strains of EBF65/65 back to E. coli K12 were found to carry defective prophages which had lost the abilityto produce detectable phage particles. (microbiologyresearch.org)
  • A. Bordini: �tude sur une souche polylysog�ne de Moraxella glucidolytica (Acinetobacter). (ulaval.ca)
  • Phages replicate through two primary life cycles, the dynamics of which have important implications for their therapeutic application. (asm.org)
  • However, the high host specificity of phages poses challenges for their therapeutic application. (qxmd.com)
  • We discuss conventional approaches as well as novel strategies, including the use of phage-antibiotic combinations, phage-derived enzymes, exploitation of phage resistance mechanisms, and phage bioengineering. (asm.org)
  • Antibacterial potential of the phage was assessed using turbidimetric assay and MIC with and without colistin. (bvsalud.org)
  • Phage therapy was pushed aside when penicillin came along, but it was the only treatment that helped a man overcome a superbug infection. (today.com)
  • Moreover, it steers the evolution of resistant mutants with higher sensitivity to colistin and less virulence, opening the door for using phages as sensitizing and anti-virulence entities rather than direct killer. (bvsalud.org)
  • By going through up-to-date reports and, whenever possible, human clinical trials, we examine the versatility of phage therapy. (asm.org)
  • The facility will support clinical manufacturing of BiomX's candidate phage products, and could expand to support commercial manufacturing needs in the future. (phagedirectory.com)
  • Several more well-performing phage cocktails are undergoing clinical trials and being sold as commercial products. (creative-biolabs.com)
  • Acinetobacter thrives in warm, humid climates, like Honduras, as well as in parts of Iraq, and is normally found in soil. (metafilter.com)
  • An antibiogram is used to show that a bacterial infection is resistant to some or all antibiotic options, which is typically a requirement for considering phage therapy. (ucsd.edu)
  • At Lehigh, she was first introduced to microbiology through the SEA-PHAGES program. (micropopbio.org)
  • phage therpy has been used treat otitis caused by P. aeruginosa in humans. (vetbact.org)
  • Can phage therapy be used to treat Lyme Disease? (ucsd.edu)
  • Can you help me find a doctor who would treat me with phage therapy? (ucsd.edu)
  • To broaden the phage spectrum, laboratory-based phage training using the Appelmans protocol was employed in this study. (qxmd.com)
  • Researchers can now select phages with precision, increasing the likelihood of successful treatment. (walshmedicalmedia.com)
  • We will request your physician to share details of your case with us so that we can advise them if phage therapy is a viable option. (ucsd.edu)
  • I do not live in San Diego, but I think I am eligible for phage therapy. (ucsd.edu)
  • Because of their success, a food safety research group in Romania will now be pursuing its own line of phage research! (phagedirectory.com)
  • Run by Prof. Gail Christie of Virginia Commonwealth University, this page is a fantastic place to find phage news, research and commentary. (phagedirectory.com)
  • During her talk, Strathdee detailed how she worked with scientists and regulators to utilize phage therapy to save his life. (uvm.edu)
  • Temperate phages are capable of protecting their host from phage reinfection and may change the bacterial phenotype through the expression of viral genes, a process known as lysogenic conversion ( 1 ). (asm.org)
  • As a result, the protocol successfully expanded the host range of a phage cocktail targeting CRAB. (qxmd.com)
  • Phage therapy is not currently a licensed treatment in the United States. (ucsd.edu)