• Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex isolates were identified by gyrB mulitplex PCR. (microbiologyresearch.org)
  • However, imipenem-resistant isolates were found in the early 1990s [ 17 ], and the rate of carbapenem resistance in A. baumannii , mainly due to OXA-type (oxacillin-hydrolysing) carbapenemases, has increased rapidly [ 7 , 11 ]. (pfmjournal.org)
  • In South Korea, more than two-thirds of the A. baumannii isolates were resistant to imipenem on the basis of several surveillance studies [ 4 , 15 , 18 ]. (pfmjournal.org)
  • Twenty-four invasive Acinetobacter isolates were collected from 2009-2013. (biomedcentral.com)
  • A. baumannii isolates (n = 83) originated from two hospital settings in central Ohio were used in this study. (biomedcentral.com)
  • Our phenotypic analysis clearly demonstrated that A. baumannii isolates obtained from different hospitals in central Ohio were resistant to all clinically significant antibiotics, including carbapenems (imipenem). (biomedcentral.com)
  • A. baumannii isolates (n = 83) that originated from two sources were investigated. (biomedcentral.com)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • Most of these CRAB isolates (77.62%) were classified as clone complex 92 (CC92), and sequence type (ST) 92 was the most prevalent STs, followed by ST195, ST136, ST843, and ST75. (frontiersin.org)
  • Multidrug-resistant A. baumannii has spread to civilian hospitals in part due to the transport of infected soldiers through multiple medical facilities. (wikipedia.org)
  • Severe wound infection and multidrug-resistant Acinetobacter baumannii by Osteomyelititiden were diagnosed among American soldiers who had been wounded in combat operations in Iraq and Afghanistan. (acinetobacterbaumannii.com)
  • Tigecycline (TYGACIL) has bacteriostatic activity against multidrug-resistant Acinetobacter. (acinetobacterbaumannii.com)
  • A. baumannii is developing into multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR) bacteria, and its adaptation to the environment with drug resistance has previously been reported ( Durante-Mangoni and Zarrilli, 2011 ). (frontiersin.org)
  • In the present study, We evaluated a protocol which was different from that used in the Bruker Daltonics identification system (MALDI BioTyper) to improve species identification using a taxonomically precisely defined set of 105 strains representing the four validly named species of the ACB complex. (muni.cz)
  • As a result, differentiation of A. nosocomialis and A. baumannii strains by cluster analysis was improved and 13 A. nosocomialis strains, assigned erroneously or ambiguously by using the standard protocol, were correctly identified. (muni.cz)
  • In the most recent outbreak, 11 patients were infected with multi-resistant Acinetobacter strains and 26 patients were colonised. (microbiologyresearch.org)
  • Multi-resistant Acinetobacter strains were isolated most frequently from the respiratory tract, and eight patients had probable or suspected pneumonia caused by a multi-resistant Acinetobacter sp. (microbiologyresearch.org)
  • Most strains of Acinetobacter baumannii show on solid culture media flat colorless colonies that are slightly smaller than those of Enterobacteriaceae. (acinetobacterbaumannii.com)
  • Therefore we aimed to determine risk factors for invasive Acinetobacter infections within an academic, pediatric setting as well as defining microbiologic characteristics of predominant strains. (biomedcentral.com)
  • rpoB gene sequencing revealed a predominance of A. pittii (45.8 %) and A. baumannii (33.3 %) strains. (biomedcentral.com)
  • A pittii and A. baumannii strains were similar in motility, but A pittii strains had significantly more biofilm production ( P value = 0.018). (biomedcentral.com)
  • Additionally, in recent years, some Acinetobacter strains have demonstrated a propensity to acquire resistance to multiple classes of antibiotics, rendering treatment of such hospitalized patients extremely difficult [ 4 ]. (biomedcentral.com)
  • Furthermore Acinetobacter strains were sequenced typed and preliminary characterized for motility and biofilm formation/maintenance. (biomedcentral.com)
  • Using genome sequences of 730 strains of the Acb complex, we evaluated the phylogenetic congruence of MLST schemes, the correspondence between sequence types, their discriminative power and genotyping reliability from genomic sequences. (figshare.com)
  • While other species of the genus Acinetobacter are often found in soil samples (leading to the common misconception that A. baumannii is a soil organism, too), it is almost exclusively isolated from hospital environments. (wikipedia.org)
  • Clinical microbiologists typically differentiate members of the genus Acinetobacter from other Moraxellaceae by performing an oxidase test, as Acinetobacter spp. (wikipedia.org)
  • It is difficult to determine the specific species of members of the ACB complex and they comprise the most clinically relevant members of the genus. (wikipedia.org)
  • Delineation of a novel environmental phylogroup of the genus Acinetobacter encompassing Acinetobacter terrae sp. (uni-koeln.de)
  • Originally belonged to the genus Acinetobacter to the family of Neisseriaceae. (acinetobacterbaumannii.com)
  • Specifically, A. baumannii , A. pittii , and A. nosocomialis of the Acinetobacter calcoaceticus-baumannii ( Acb ) complex have become the most medically relevant members of the genus as they are most frequently isolated from health care facilities as well as human tissues. (biomedcentral.com)
  • During May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the United States attributable to polymicrobial contaminated apheresis platelet components, including Acinetobacter calcoaceticus‒baumannii complex or Staphylococcus saprophyticus isolated from patients and components. (cdc.gov)
  • One study states that drug-resistant Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae , and methicillin-resistant Staphylococcus aureus colonize and infect combat casualties from Iraq and Afghanistan. (vestex.com)
  • The effects of these NPs on Acinetobacter baumannii , Staphylococcus aureus , and Escherichia coli biofilms were studied using quantitative biofilm inhibition and disruption assays, as well as using fluorescence, -scanning electron microscopy, and atomic force microscopy. (dovepress.com)
  • During the COVID-19 pandemic, coinfection with A. baumannii secondary to SARS-CoV-2 infections has been reported multiple times in medical publications. (wikipedia.org)
  • The multiplex pneumonia panel will be used in trials for a drug to combat carbapenem-resistant A. baumannii infections. (genomeweb.com)
  • The trial will test an antibiotic referred to as ETX2514SUL, which targets A. baumannii infections. (genomeweb.com)
  • Acinetobacter baumannii is the most common species to cause infections, followed by Acinetobacter nosocomialis and Acinetobacter pittii [ 4 , 5 ]. (pfmjournal.org)
  • including A. baumannii , have long been known as colonizers in humans, but they do not cause severe infections [ 10 ]. (pfmjournal.org)
  • In the United States, A. baumannii has been estimated to cause more than 2% of the healthcare-associated infections [ 14 ]. (pfmjournal.org)
  • Although β-lactam antibiotics are the preferred choice for susceptible A. baumannii infections, carbapenems have become the main therapeutic option because of an increase in resistance [ 2 , 6 ]. (pfmjournal.org)
  • Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-baumannii complex, leading to improper identification. (biomedcentral.com)
  • However, certain Acinetobacter species are frequently isolated increasingly from healthcare facilities and are concomitantly the source of many nosocomial infections [ 1 ]. (biomedcentral.com)
  • Patients with impaired host defenses in intensive care unit (ICU) settings appear to be an at risk group of acquiring Acinetobacter infections [ 2 ]. (biomedcentral.com)
  • However, invasive Acinetobacter infections associated with large pediatric, academic institutes in developed countries are still poorly defined due to unclear risk factors. (biomedcentral.com)
  • Therefore, the purpose of this study was to retrospectively review cases of invasive Acinetobacter infections occurring within an academic, pediatric setting in a developed country from a clinical perspective to define additional risk factors. (biomedcentral.com)
  • We are also very excited about the U.S. Food and Drug Administration (FDA) Advisory Committee's unanimous recommendation in support of approval for sulbactam-durlobactam, the first pathogen-targeted therapy for patients with serious and life-threatening infections caused by Acinetobacter . (minyanville.com)
  • reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)
  • Yet, this method suffers from the inability to differentiate reliably between some closely related bacterial species including those of the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex, namely A. baumannii and Acinetobacter nosocomialis. (muni.cz)
  • CRE: carbapenem-resistant E. coli , Enterobacter cloacae complex species (i.e. (cdc.gov)
  • The often-fatal pneumonia strain known as carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (ABC), is typically acquired in hospitals. (futurity.org)
  • The findings have led a unanimous expert committee to recommend that the Food and Drug Administration (FDA) approve the new drug, which could be available this summer to combat the often-fatal pneumonia strain known as carbapenem-resistant Acinetobacter baumannii - calcoaceticus complex (ABC), typically acquired in hospitals. (futurity.org)
  • In outpatients fatal pneumonia were described by Acinetobacter after use no more effective antibiotics. (acinetobacterbaumannii.com)
  • All infected patients were treated with imipenem, with or without an aminoglycoside, except one patient who died before a diagnosis of acinetobacter infection was confirmed. (microbiologyresearch.org)
  • This study underscores the major role of carbapenem-hydrolyzing class D β-lactamases, and in particular the acquired OXA-23, in the dissemination of imipenem-resistant A. baumannii . (biomedcentral.com)
  • Among the pathogens cultured from uniforms were Acinetobacter baumannii and Methicillin-resistant Staphlococcus aureus (MRSA. (vestex.com)
  • The Infectious Diseases Society of America (IDSA) identified A. baumannii among the top seven pathogens threatening our healthcare-delivery system and as a crucial example of unmet medical need [ 18 ]. (biomedcentral.com)
  • These NPs also showed antimicrobial and antibiofilm activity against E. coli , A. baumannii , S. aureus , and a mixed culture of A. baumannii and S. aureus . (dovepress.com)
  • Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. (wikipedia.org)
  • In Acinetobacter baumannii is immobile, aerobic, gram-negative short rods with a size of about 1-1.5 x 1.5-2 microns. (acinetobacterbaumannii.com)
  • Acinetobacter species are Gram-negative coccobacilli many of which are found in soil and fresh water throughout our natural habitats [ 1 ]. (biomedcentral.com)
  • Acinetobacter baumannii and Brucella species are Gram-negative organisms that are vulnerable to misinterpretation as Gram-positive or Gram-variable in blood cultures. (openmicrobiologyjournal.com)
  • In case 2, repeat Gram- staining from the plate and the vials, VITEK-2 Gram-Negative Identification, real-time PCR and subculture on to Columbia agar, blood agar, and MacConkey agar were carried out to identify A. baumannii . (openmicrobiologyjournal.com)
  • The data show that the antimicrobial- treated fabric demonstrated in vitro bactericidal activity against pan-resistant A. baumannii and multi-drug resistant K. pneumoniae . (vestex.com)
  • Thus, CC92 A. baumannii carrying OXA-23 is a major drug-resistant strain spreading in China. (frontiersin.org)
  • Background: Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex have emerged worldwide, but the epidemiology in Indonesian hospitals has not been studied. (ui.ac.id)
  • Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex from clinical cultures and standardized screening were included. (ui.ac.id)
  • Results: Of 412 included patients, 69 (16.7%) carried carbapenem-nonsusceptible A. baumannii-calcoaceticus complex on admission, and 89 (25.9%) became positive during ICU stay. (ui.ac.id)
  • Conclusions: Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex are endemic in this setting. (ui.ac.id)
  • CRAB: carbapenem-resistant Acinetobacter baumannii complex ( A. baumannii , A. baumannii complex, and A. calcoaceticus-baumannii complex [including A. calcoaceticus ]) isolated from normally sterile sites or urine (Table 1) from a resident of the surveillance area. (cdc.gov)
  • Acinetobacter seifertii sp nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens. (uni-koeln.de)
  • A. seifertii is also closely related to the species of the Acb complex [ 8 , 9 ]. (pfmjournal.org)
  • Motility in A. baumannii may also be due to the excretion of exopolysaccharide, creating a film of high-molecular-weight sugar chains behind the bacterium to move forward. (wikipedia.org)
  • The carbapenemases in A. baumannii have belonged to the bla OXA-23- , bla OXA-24- , and bla OXA-58- type class D family of serine β-lactamases and IMP/VIM class B metallo-β-lactamases [ 3 , 4 ]. (biomedcentral.com)
  • While there is no complete agreement in all analyses, when considered as a whole the above results indicate that the Pasteur scheme is more appropriate for population biology and epidemiological studies of A. baumannii and related species and we propose that it should be the scheme of choice during the transition toward, and in parallel with, core genome MLST. (figshare.com)
  • Colloquially, A. baumannii is referred to as "Iraqibacter" due to its seemingly sudden emergence in military treatment facilities during the Iraq War. (wikipedia.org)
  • The schemes have three genes in common but underlie two coexisting nomenclatures of sequence types and clonal complexes, which complicates communication on A. baumannii genotypes. (figshare.com)