• The natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. (uni-koeln.de)
  • Resources for genetic and genomic analysis of emerging pathogen Acinetobacter baumannii. (pacb.com)
  • As a result, differentiation of A. nosocomialis and A. baumannii strains by cluster analysis was improved and 13 A. nosocomialis strains, assigned erroneously or ambiguously by using the standard protocol, were correctly identified. (muni.cz)
  • Most strains of Acinetobacter baumannii show on solid culture media flat colorless colonies that are slightly smaller than those of Enterobacteriaceae. (acinetobacterbaumannii.com)
  • Furthermore, their individual effects and synergistic potential in combination with antibiotics were examined against clinical strains of both S. aureus and Acinetobacter baumannii . (biomedcentral.com)
  • The potential global health threat that A. baumannii poses is underscored by the identification of multiple drug resistant (MDR) strains that are impervious to all commercially available antibiotics. (emerging-researchers.org)
  • The aim of the study was analysis of A. baumannii strains, isolated from hospital samples from the lower respiratory tract collected from patients with VAP hospitalized in Masovian Specialist Hospital's ICU in Radom between 2012 and 2014. (monz.pl)
  • We present a set of resources that should accelerate genome-scale genetic characterization of these traits for a reference isolate of A. baumannii that is highly virulent and representative of current outbreak strains. (pacb.com)
  • A. baumannii is developing into multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR) bacteria, and its adaptation to the environment with drug resistance has previously been reported ( Durante-Mangoni and Zarrilli, 2011 ). (frontiersin.org)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) is a type of bacteria commonly found in the environment, especially in soil and water. (mn.us)
  • Extracts and phases obtained from the medicinal plant M. albicans demonstrated synergistic effects when combined with the commercial antibiotics ampicillin and ciprofloxacin, against multi-drug resistant bacteria S. aureus and A. baumannii , restoring their antibacterial efficacy. (biomedcentral.com)
  • Acinetobacter Baumannii is a gram-negative bacteria that makes up part of the natural soil microbiome. (fitnessbuzz.net)
  • Acinetobacter infections can occur when a person breathes contaminated air, touches a contaminated surface, or has direct contact with Acinetobacter bacteria. (fitnessbuzz.net)
  • According to the US Centers for Disease Control and Prevention (CDC), Acinetobacter is a group of bacteria commonly found in soil and water. (outbreaknewstoday.com)
  • Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii . (pfmjournal.org)
  • In 1954, Brisou and Prévot proposed the genus Acinetobacter to indicate that the bacteria were non-motile because they lacked flagella: the Greek "akineto" means "immobile" [ 1 ]. (pfmjournal.org)
  • A method of producing a vaccine against multi-drug resistant (MDR) Acinetobacter baumannii comprises the step of isolating a whole cell material of inactivated antibiotic-exposed A. baumannii cultured in presence of an antibiotic at early logarithmic (log) phase of bacterial growth, inactivating the bacteria with chemical and heat at late log phase of bacterial growth and mixing the isolated whole cell material with a preservative. (um-technology.com)
  • Carbapenem-resistant gram-negative bacteria, namely, carbapenem-resistant Enterobacteriaceae (CRE) (for example, Klebsiella pneumoniae, Escherichia coli), Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPsA), are a matter of national and international concern as they are an emerging cause of. (bvsalud.org)
  • A. baumannii has also been identified as an ESKAPE pathogen (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), a group of pathogens with a high rate of antibiotic resistance that are responsible for the majority of nosocomial infections. (wikipedia.org)
  • We here describe the epidemiology of carbapenem-non-susceptible Acinetobacter baumannii (CNAB), Klebsiella pneumoniae (CNKP) and Pseudomonas aeruginosa (CNPA) in two ICUs in the National Referral Hospital in Jakarta, Indonesia. (eur.nl)
  • While other species of the genus Acinetobacter are often found in soil samples (leading to the common misconception that A. baumannii is a soil organism, too), it is almost exclusively isolated from hospital environments. (wikipedia.org)
  • A. baumannii is part of the ACB complex (A. baumannii, A. calcoaceticus, and Acinetobacter genomic species 13TU). (wikipedia.org)
  • Yet, this method suffers from the inability to differentiate reliably between some closely related bacterial species including those of the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex, namely A. baumannii and Acinetobacter nosocomialis. (muni.cz)
  • Acinetobacter species can ferment glucose and thus do not belong to the so-called "non-fermenters. (acinetobacterbaumannii.com)
  • Acinetobacter species are in nature and beyond widely used in the hospital sector. (acinetobacterbaumannii.com)
  • Acinetobacter baumannii has the largest clinical significance among Acinetobacter species. (acinetobacterbaumannii.com)
  • The increased incidence of nosocomial infections by multidrug-resistant Acinetobacter baumannii creates demand on the application of some combinations of older antimicrobials on that species. (biomedcentral.com)
  • http://www.bacterio.net/acinetobacter.html ), and the number of species is increasing [ 3 ]. (pfmjournal.org)
  • Acinetobacter baumannii is the most common species to cause infections, followed by Acinetobacter nosocomialis and Acinetobacter pittii [ 4 , 5 ]. (pfmjournal.org)
  • AbaR-type resistance islands are typical of drug-resistant A. baumannii, and different variations may be present in a given strain. (wikipedia.org)
  • reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)
  • Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options. (microbiologyresearch.org)
  • Rapid detection of carbapenem resistance in Acinetobacter baumannii using matrix-assisted laser desorption ionization-time of flight mass spectrometry. (microbiologyresearch.org)
  • Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase. (microbiologyresearch.org)
  • We undertook a genomic study of carbapenem-resistant A. baumannii in the Philippines to characterize the population diversity and antimicrobial resistance mechanisms. (who.int)
  • Our approach is to understand the molecular mechanisms of antibiotic resistance in A. baumannii with the goal of establishing new strategies for therapeutic intervention. (emerging-researchers.org)
  • In this study, we aim to determine the contribution of the SODB enzyme to antibiotic resistance in A. baumannii. (emerging-researchers.org)
  • In this review, we have discussed colistin resistance in A. baumannii . (pfmjournal.org)
  • Although β-lactam antibiotics are the preferred choice for susceptible A. baumannii infections, carbapenems have become the main therapeutic option because of an increase in resistance [ 2 , 6 ]. (pfmjournal.org)
  • However, imipenem-resistant isolates were found in the early 1990s [ 17 ], and the rate of carbapenem resistance in A. baumannii , mainly due to OXA-type (oxacillin-hydrolysing) carbapenemases, has increased rapidly [ 7 , 11 ]. (pfmjournal.org)
  • Due to its frequent antibiotic drug resistance Acinetobacter baumannii (MRAB) is increasingly causing a problem in burns units. (qmul.ac.uk)
  • The antibiotic in the culture medium is at an effective concentration hindering the growth of the A. baumannii without substantially killing the A. baumannii and enhances expression of A. baumannii proteins conferring resistance to the antibiotics and virulence. (um-technology.com)
  • These resources should facilitate large-scale genetic analysis of virulence, resistance, and other clinically relevant traits that make A. baumannii a formidable public health threat.Acinetobacter baumannii is one of six bacterial pathogens primarily responsible for antibiotic-resistant infections that have become the scourge of health care facilities worldwide. (pacb.com)
  • In Brazil, A. baumannii has become particularly problematic because of its prevalence and the carbapenems resistance. (fiocruz.br)
  • Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. (uni-koeln.de)
  • The current knowledge concerning the physiological basis of A. baumannii virulence traits is rather limited. (uni-frankfurt.de)
  • We anticipate to elucidate the mechanisms of A. baumannii virulence and eukaryotic host cell adaptation from the cellular to the structural level employing advanced analytical tools and a broad spectrum of available molecular biological, biochemical, immunological techniques and bioinformatic tools as well as cutting-edge techniques such as static and dynamic flow infections and various in vitro and in vivo infection models. (uni-frankfurt.de)
  • The collaborative research effort will promote regional and transregional interactions between nonclinical and clinical research groups which is essential to successfully address the multiple factors underlying A. baumannii virulence. (uni-frankfurt.de)
  • Since the expression of multiple iron uptake clusters can be linked to virulence, the presence of the additional heme uptake system hemO may have contributed to the success of some A. baumannii clones. (uniroma3.it)
  • Prior studies have identified Superoxide dismutase B (SODB) as an essential virulence factor of A. baumannii. (emerging-researchers.org)
  • This report describes the development of several such resources for A. baumannii strain AB5075, a recently characterized wound isolate that is multidrug resistant and displays robust virulence in animal models. (pacb.com)
  • The influence of Acinetobacter Baumannii and the antimicrobial peptide LL-37 in burn wounds. (qmul.ac.uk)
  • Wang CC, Li DJ, Xia YQ, Liu K. Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia: A case report. (wjgnet.com)
  • In this paper we presented a very rare case of an anti-N-methyl-D-aspartate receptor encephalitis in which the patient aggravated after acinetobacter baumannii pneumonia and well responded to immunotherapy. (wjgnet.com)
  • In outpatients fatal pneumonia were described by Acinetobacter after use no more effective antibiotics. (acinetobacterbaumannii.com)
  • Acinetobacter baumannii is a well-adapted hospital pathogen and recent data from the National Nosocomial Surveillance System (NNIS) showed a substantial increase in the number of cases of A. baumannii -associated nosocomial (hospital acquired) pneumonia, causing 5 - 10% of intensive care unit (ICU)-acquired pneumonia cases in the United States. (uni-frankfurt.de)
  • Acinetobacter baumannii infection is not easy to treat and may increase long-term health problems such as pneumonia. (fitnessbuzz.net)
  • Almomani BA, McCullough A, Gharaibeh R, Samrah S, Mahasneh F. Incidence and predictors of 14-day mortality in multidrug-resistant Acinetobacter baumannii in ventilator-associated pneumonia. (monz.pl)
  • Acinetobacter causes a variety of diseases, ranging from pneumonia to serious blood or wound infections, and the symptoms vary depending on the disease. (outbreaknewstoday.com)
  • Acinetobacter baumannii is an opportunistic nosocomial pathogen that has increasingly become resistant to carbapenems worldwide. (who.int)
  • We sequenced the whole genomes of 117 A. baumannii isolates recovered by 16 hospitals in the Philippines between 2013 and 2014. (who.int)
  • Objectives The whole genomes of two Acinetobacter baumannii isolates recovered from a single patient were sequenced to gain insight into the nature and extent of genomic plasticity in this important nosocomial pathogen over the course of a short infection. (uea.ac.uk)
  • In case of A. baumannii, all the isolates were sensitive to colistin, but 98% were resistant to other antibiotics (p≤0.05). (magiran.com)
  • We conducted the present observational study to evaluate the efficacy of intravenous and aerosolized colistin combined with rifampicin in the treatment of critically patients with nosocomial infections caused by multiresistant A. baumannii . (biomedcentral.com)
  • Critically ill patients with nosocomial infections caused by A. baumannii resistant to all antibiotics except colistin in a medical ICU were included. (biomedcentral.com)
  • This is a clinical report of colistin combined with rifampicin for treatment of A. baumannii infection. (biomedcentral.com)
  • In addition, we have reviewed an abnormal phenomenon called colistin dependence in A. baumannii . (pfmjournal.org)
  • In South Korea, more than two-thirds of the A. baumannii isolates were resistant to imipenem on the basis of several surveillance studies [ 4 , 15 , 18 ]. (pfmjournal.org)
  • the percentages of acinetobacter bumannii isolates in relation to imipenem, meropenem and ciprofloxacin in the dilution serial method are 40.9%, 60% and 77.7%, respectively. (icbcongress.com)
  • The aims of this study were to investigate the prevalence of integrons and biofilm formation among P. aeruginosa and A. baumannii isolates collected from ICU and non-ICU inpatients. (magiran.com)
  • Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland. (anresis.ch)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) presents a serious therapeutic and infection control challenge. (frontiersin.org)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB), is an opportunistic pathogen primarily associated with hospital-acquired infections. (sterifre.com)
  • Multidrug-resistant A. baumannii has spread to civilian hospitals in part due to the transport of infected soldiers through multiple medical facilities. (wikipedia.org)
  • Thus, CC92 A. baumannii carrying OXA-23 is a major drug-resistant strain spreading in China. (frontiersin.org)
  • Two sequential outbreaks caused by multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 or OXA-72 oxacillinase in an intensive care unit in France. (microbiologyresearch.org)
  • Clonal spread of carbapenem-resistant OXA-72-positive Acinetobacter baumannii in a Croatian university hospital. (microbiologyresearch.org)
  • Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia. (microbiologyresearch.org)
  • This is the first extensive genomic study of carbapenem-resistant A. baumannii in the Philippines, and it underscores the importance of hospital infection control and prevention measures to contain high-risk clones. (who.int)
  • Severe wound infection and multidrug-resistant Acinetobacter baumannii by Osteomyelititiden were diagnosed among American soldiers who had been wounded in combat operations in Iraq and Afghanistan. (acinetobacterbaumannii.com)
  • Tigecycline (TYGACIL) has bacteriostatic activity against multidrug-resistant Acinetobacter. (acinetobacterbaumannii.com)
  • The bacterium Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen. (uniroma3.it)
  • To understand the mechanisms causing the resistant nature of A. baumannii, the SODB enzyme was structurally and functionally characterized. (emerging-researchers.org)
  • In the conducted study, infections caused by multi-resistant A. baumannii were observed more frequently in late VAP, which should be taken into consideration while choosing empirical antibiotic therapy. (monz.pl)
  • Acinetobacter is often resistant to many commonly prescribed antibiotics. (outbreaknewstoday.com)
  • LL-37 has been found in both acute burn wounds as well as in the grafted healing burn wound and is active against drug resistant Acinetobacter baumannii. (qmul.ac.uk)
  • Here, we report the draft genome sequence of a multidrug-resistant A. baumannii (ST15/CC15) isolated in 2009 from the state of Espírito Santo (Southeast Brazil). (fiocruz.br)
  • Risk factors for infection by Acinetobacter antibiotic pre-treatment and / or surgery as well as the use of ventilators and other medical instruments have been identified. (acinetobacterbaumannii.com)
  • A. baumannii responds to low iron availability imposed by the host through the exploitation of multiple iron-acquisition strategies, which are likely to deliver iron to the cell under a variety of environmental conditions, including human and animal infection. (uniroma3.it)
  • BACKGROUND: Acinetobacter baumannii (AB) bacteremia is an increasingly common and often fatal nosocomial infection. (hku.hk)
  • Acinetobacter baumannii is a common but potentially severe infection that can occur in people with weakened immune systems. (fitnessbuzz.net)
  • People who are taking certain medications, such as antibiotics or corticosteroids ( for example , asthma medications), are also more likely to develop an Acinetobacter baumannii infection. (fitnessbuzz.net)
  • If you develop an Acinetobacter baumannii infection, see your doctor promptly. (fitnessbuzz.net)
  • Treatment options will depend on the type of Acinetobacter baumannii infection you have and your overall health status. (fitnessbuzz.net)
  • Acinetobacter may also "colonize" or live in a patient without causing infection or symptoms, especially in tracheostomy sites or open wounds. (outbreaknewstoday.com)
  • Hospitalized patients, especially very ill patients on a ventilator, those with a prolonged hospital stay, those who have open wounds, or any person with invasive devices like urinary catheters are also at greater risk for Acinetobacter infection. (outbreaknewstoday.com)
  • Acinetobacter are gram-negative aerobic bacilli or coccobacilli that belong to the family Moraxellaceae. (msdmanuals.com)
  • Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. (wikipedia.org)
  • In Acinetobacter baumannii is immobile, aerobic, gram-negative short rods with a size of about 1-1.5 x 1.5-2 microns. (acinetobacterbaumannii.com)
  • Acinetobacter baumannii is a Gram-negative bacterial pathogen notorious for causing serious nosocomial infections that resist antibiotic therapy. (pacb.com)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • The persistence of A. baumannii is attributed to multiple factors but, unfortunately, knowledge regarding the molecular basis for these traits of A. baumannii , i.e. proteins, enzymes and genes involved as well as their regulation by abiotic and biotic factors remains largely unknown. (uni-frankfurt.de)
  • En nuestro país, durante el primer cuatrimestre del año, se observó un aumento inusual en el número de aislamiento de gérmenes multirresistentes, sobre todo de bacilos gramnegativos, los cuales fueron remitidos al laboratorio de referencia con el objetivo de caracterizar los genes de resistencia a los carbapenemes. (bvsalud.org)
  • La sensibilité de Staphylococcus aureus à l'oxacilline a diminué significativement, passant de 95,0 % entre 1999 et 2002 à 84,4 % en 2008. (who.int)
  • Moreover, A. baumannii ranks 10th among the most frequent organisms (1.3%) causing monomicrobial nosocomial bloodstream infections in the US and 2 - 10% of nosocomial infections in intensive care units in European hospitals. (uni-frankfurt.de)
  • Motility in A. baumannii may also be due to the excretion of exopolysaccharide, creating a film of high-molecular-weight sugar chains behind the bacterium to move forward. (wikipedia.org)
  • People can become infected with Acinetobacter by coming into contact with the bacterium. (fitnessbuzz.net)
  • due to the fact that acinetobacter bumannii is one of the essential factors in hospital acquired infections, assessing the drug patterns of this bacterium is necessary. (icbcongress.com)
  • to begin with, first, the clinical samples are sent to the laboratory for acinetobacter bumanni identification through chemical tests, next, the existence of this bacterium is confirmed by the pcr molecular method and then, the antibiotic sensitivity test is run on the samples, followed by their their analysis through spps and chi-square test. (icbcongress.com)
  • Colloquially, A. baumannii is referred to as "Iraqibacter" due to its seemingly sudden emergence in military treatment facilities during the Iraq War. (wikipedia.org)
  • Acinetobacter baumannii can cause infections in the urinary tract, blood, lungs, and in wound. (sterifre.com)
  • Acinetobacter can cause community-acquired bronchiolitis and tracheobronchitis in healthy children and tracheobronchitis in immunocompromised adults. (msdmanuals.com)
  • Moreover, in the examined group, in 34 patients in addition to A. baumannii another strain was isolated, considered as etiological factor participating in coinfection. (monz.pl)
  • Acinetobacter is present in the environment and often found in water, soil, and on contaminated surfaces. (fitnessbuzz.net)
  • The enzyme PPAT from Acinetobacter baumannii (AbPPAT) was cloned, expressed and purified. (bvsalud.org)