• Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. (wikipedia.org)
  • Metastasis of cancerous cells can affect organs surrounding the pancreas, including the stomach and the colon. (medscape.com)
  • These neuroendocrine tumors can be nonfunctional (non-hormone-producing) or functional, causing the pancreas to overproduce certain hormones. (moffitt.org)
  • In addition, there are a number of much less common cancer types, including acinar cell carcinoma, that develop from specific exocrine cells of the pancreas. (dkfz.de)
  • The results confirm that acinar cell carcinoma of the pancreas has a completely different tumor biology and, hence, a different development history than tumors of the pancreatic duct," Schmezer said. (dkfz.de)
  • For very rare cancers such as acinar cell carcinoma of the pancreas, it is difficult to test the effectiveness of novel drugs in classic clinical trials. (dkfz.de)
  • Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018) 7. (sncrf.org)
  • Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
  • Challenges Staging Neuroendocrine Tumors of the Pancreas, Jejunum and Ileum, and Appendix. (ucsf.edu)
  • Tumors in the head of the pancreas can lead to mechanical obstruction of the upper duodenum and gastric outlet, as well as gastrointestinal bleeding. (orpha.net)
  • It is a malignant embryonal tumor that seems to recapitulate the embryogenesis of the pancreas, presumably because it originates from the pluripotent pancreatic stem cells during foregut development. (orpha.net)
  • Procedures include a distal pancreatectomy with or without splenectomy (for tumors in the body and tail of pancreas) and pancreaticoduodenectomy (for those in the head of the pancreas). (orpha.net)
  • Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas. (cancer.gov)
  • Endocrine pancreas cells cluster together in many small groups (islets) throughout the pancreas. (cancer.gov)
  • Endocrine pancreas cells are also called islet cells or islets of Langerhans. (cancer.gov)
  • Exocrine pancreas cells make enzymes that are released into the small intestine to help the body digest food. (cancer.gov)
  • Most of the pancreas is made of ducts and small sacs at the end of the ducts that are lined with exocrine cells . (cancer.gov)
  • Solid pseudopapillary tumor of the pancreas. (cancer.gov)
  • Solid pseudopapillary tumor of the pancreas is unlikely to spread to other parts of the body and the prognosis is very good. (cancer.gov)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Those are cells that make hormones to help the function of the organ they occupy, such as the lungs, stomach , and pancreas . (webmd.com)
  • Twenty-seven tumors were located in the head of the pancreas, 3 in the body, and 11 in the tail. (johnshopkins.edu)
  • Poorly differentiated neuroendocrine carcinoma of the pancreas is a highly aggressive neoplasm, with frequent metastases and poor survival. (johnshopkins.edu)
  • Acinar cell carcinomas are less aggressive and have a better prognosis than the typical ductal carcinoma of the pancreas. (elsevierpure.com)
  • Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
  • Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature. (nih.gov)
  • Non-Ductal Tumors of the Pancreas. (nih.gov)
  • Pancreatic cancer develops when changes (mutations) in pancreas cells cause them to multiply abnormally. (actchealth.com)
  • Depending on the location and size of the tumor in the pancreas, surgery for pancreatic cancer may involve removing all or part of the pancreas. (actchealth.com)
  • Although individualized targeted therapies are routinely used for patients with lung and breast tumors, personalized medicine has not achieved the same degree of success in the pancreas. (coek.info)
  • What will happen pancreatic cancer, in the secretion, although the pancreas is small, but contains a variety of functions of the endocrine cells, such as the secretion of glucose, insulin, gastrin, motilin and so on. (cancerlive.net)
  • 2) Insulinoma: The most common pancreatic endocrine tumor, the tumor cells from the pancreas, because a large number of B cells to secrete insulin into the blood, causing a series of low blood sugar the main symptoms. (cancerlive.net)
  • Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. (antikoerper-online.de)
  • Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
  • In their analysis of acinar cell carcinomas, the DKFZ researchers found no recurrent cancer-promoting point mutations in tumor-relevant genes, which are characteristic for pancreatic ductal carcinomas. (dkfz.de)
  • In hyperplastic prostates and in benign prostatic tissue adjacent to the prostatic carcinoma, PAP activity is limited to the acinar or ductal columnar epithelial cells and adjacent luminal content. (biogenex.com)
  • Histologically, this malignant epithelial pancreatic neoplasm of the exocrine cells is characterized by multiple lines of differentiation (acinar, ductal, mesenchymal, neuroendocrine) and the presence of squamoid nests. (orpha.net)
  • It shows significant acinar cell differentiation but also ductal, mesenchymal and neuroendocrine differentiation. (orpha.net)
  • The two types of pancreatic carcinoma are acinar cell carcinoma and ductal adenocarcinoma . (cancer.gov)
  • It is less usually described in association with pancreatic carcinoma: usually of the acinar cell carcinoma (in 80% of cases), which represents 10% of pancreatic malignant tumours [5,7], although it has been reported in the course of some other carcinomas, such as ductal adenocarcinoma and neuroendocrine carcinoma [3]. (scitcentral.com)
  • In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
  • Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
  • Benign and malignant exocrine tumors of the points, mainly from pancreatic ductal cancer epithelium to adenocarcinoma the most common (accounting for more than 90% of pancreatic cancer), squamous cell carcinoma, mucinous carcinoma and acinar cells derived from acinar cells carcinoma, acinar cystadenocarcinoma are rare (accounting for about 10%), the above collectively referred to as pancreatic cancer. (cancerlive.net)
  • Other histologic subtypes of ductal origin include pleomorphic carcinomas, giant cell carcinomas, microglandular adenocarcinomas, and cystic neoplasms. (mhmedical.com)
  • Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
  • Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uci.edu)
  • Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the expansion segment of this study. (uci.edu)
  • A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • The prognosis of small cell carcinomas of the prostate is very poor, unlike adenocarcinoma. (uroonkolojibulteni.com)
  • As a result of the biopsy, small cell carcinoma of the prostate which was present in acinar adenocarcinoma component (30-40%) was detected. (uroonkolojibulteni.com)
  • Cancer can develop in the cells of two types of pancreatic glands: exocrine glands and endocrine glands. (moffitt.org)
  • Islet cell tumors may occur in children with multiple endocrine neoplasia type 1 (MEN1) syndrome. (cancer.gov)
  • What will happen pancreatic cancer, pancreatic endocrine cells that have both exocrine gland cells, exocrine cells, including duct cells and acinar cells. (cancerlive.net)
  • Therefore, the tumor can be divided into exocrine pancreatic tumors, endocrine tumors and in interstitial tissue tumors. (cancerlive.net)
  • Endocrine tumors, including insulinoma, gastrinoma (Zhuoyi syndrome), intestinal peptide tumors (Verner-Morrison syndrome), glucagon tumors, pancreatic somatostatin cell tumor, non-functional islet cell tumors (pancreatic polypeptide tumor). (cancerlive.net)
  • The diversity of histologic composition reflects the inter- and intra-tumor heterogeneity of lung adenocarcinomas (LUADs) macroscopically. (nih.gov)
  • Approximately 80% of all pancreatic cancers are adenocarcinomas, with only 2% of exocrine pancreatic tumors diagnosed as benign. (medscape.com)
  • The images in the slide are of cytologic samples from fine-needle aspiration (FNA) of pancreatic adenocarcinomas: (A) well-differentiated tumor, (B) moderately differentiated tumor, (C) moderately to poorly differentiated tumor, and (D) poorly differentiated tumor. (medscape.com)
  • Differential diagnoses include poorly differentiated adenocarcinomas, solid pseudopapillary tumors, pancreatic carcinoma, pancreatic neuroendocrine tumors and autoimmune pancreatitis. (orpha.net)
  • Eight tumors had combined components, mostly adenocarcinomas. (johnshopkins.edu)
  • Most common type of small cell carcinoma of the prostate is neuroendocrine differentiation type which is associated with prostate adenocarcinomas. (uroonkolojibulteni.com)
  • These tumors do not have androgen receptors to unlike prostate adenocarcinomas. (uroonkolojibulteni.com)
  • In adults, approximately 90% are adenocarcinomas derived from duct cells with approximately two-thirds arising in the head, and one-third being in the body/tail or multicentric ( 5 , 6 , 7 ). (mhmedical.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
  • [ 5 ] Other, rarer cystic lesions, such as solid pseudopapillary epithelial neoplasm and cystic pancreatic neuroendocrine tumor (cPNET), tend to harbor features that suggest a specific diagnosis, usually leading to surgical removal. (medscape.com)
  • Serous cystadenoma (SCA) is a relatively rare pancreatic neoplasm which accounts for only 2% of pancreatic tumors (1-3). (spg.pt)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • The tumors may be entirely benign, as are mucinous cystadenomas or intraductal papillary mucinous adenomas. (medscape.com)
  • These tumors are not common in children and can be benign or malignant . (cancer.gov)
  • [ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)
  • The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
  • Exocrine cells in benign tumors (accounting for 10% of pancreatic tumors), including the origin of the catheter in the duct epithelial adenoma, intraductal papilloma, serous cystadenoma, mucinous cystadenoma, and originated in the solid and acinar cells cystic tumor. (cancerlive.net)
  • Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • Acinar cell carcinoma is a rare pancreatic tumor comprising 1% of all exocrine neoplasms, despite the fact that acinar cells make up most of the pancreatic parenchyma [2]. (elsevierpure.com)
  • Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features. (nih.gov)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • 18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
  • The majority of pancreatic cancers arise in the exocrine cells. (moffitt.org)
  • Tumors or cancers of the KIDNEY. (lookformedical.com)
  • These cancers start in the gland cells of the prostate. (webmd.com)
  • Small-cell carcinomas make up about 1% of prostate cancers. (webmd.com)
  • Other less common pancreatic cancers include acinar cell carcinoma, anaplastic carcinoma, osteoclast-like giant cell tumor, mucinous non-cystic carcinoma, adenosquamous carcinoma, signet-ring cell carcinoma and small cell carcinoma [1]. (elsevierpure.com)
  • I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy. (clinicaltrialsgps.com)
  • Adenosquamous carcinomas, squamous cell carcinomas, signet ring cell carcinomas, undifferentiated carcinomas, and undifferentiated carcinomas with giant cells are some of the less common exocrine cancers. (actchealth.com)
  • They are far less common than exocrine tumors, accounting for only about 7% of pancreatic cancers. (actchealth.com)
  • This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. (ucbraid.org)
  • Subtype of small cell carcinoma of the prostate constitute about 0.5-2% of all prostate cancers. (uroonkolojibulteni.com)
  • Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. (sncrf.org)
  • Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). (figshare.com)
  • Renal cell carcinoma (RCC) is a unique and challenging tumor because of the frequent occurrence of paraneoplastic syndromes, including hypercalcemia, erythrocytosis, and nonmetastatic hepatic dysfunction (ie, Stauffer syndrome). (medscape.com)
  • Thus, laboratory studies in the evaluation of renal cell carcinoma should include a workup for paraneoplastic syndromes. (medscape.com)
  • Imaging studies should be tailored to enable further characterization of renal masses, so that nonmalignant tumors can be differentiated from malignant ones. (medscape.com)
  • Contrast-enhanced CT scanning has become the imaging procedure of choice for diagnosis and staging of renal cell cancer and has virtually replaced excretory urography and renal ultrasonography. (medscape.com)
  • Large papillary renal tumors are frequently undetectable by renal ultrasonography. (medscape.com)
  • For more information, see Renal Cell Carcinoma Imaging . (medscape.com)
  • The NCCN guideline recommends abdominal MRI to assess suspected tumor involvement in the inferior vena cava, or as an alternative to CT for renal mass detection and staging in cases where the use of contrast is contraindicated because of allergy or renal insufficiency. (medscape.com)
  • A study by Sauk et al concluded that multidetector CT imaging characteristics may aid in identifying differences at the cytogenic level among patients with clear cell renal cell carcinomas. (medscape.com)
  • Immunohistochemical stains reveal that the tumor cells, exhibit membranous carbonic anhydrase 9 (Figure 3) staining and in contrast to the majority of other clear cell renal cell carcinomas are diffusely positive for CK7 (Figure 4). (mayocliniclabs.com)
  • Taken together, the immunohistochemical and morphologic features of this tumor are consistent with what has been described as a renal carcinoma with fibromuscular stroma. (mayocliniclabs.com)
  • A diagnosis of renal cell carcinoma with fibromyomatous stroma in the appropriate clinical context can therefore have important implications for establishing a diagnosis of tuberous sclerosis complex. (mayocliniclabs.com)
  • Renal cell carcinoma with leiomyomatous stroma" harbor somatic mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): clinicopathologic and molecular characterization of 18 sporadic tumors supports a distinct entity. (mayocliniclabs.com)
  • Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients. (mayocliniclabs.com)
  • Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. (figshare.com)
  • Metastatic follicular carcinoma. (cytojournal.com)
  • On the basis of characteristic cytological features, a diagnosis of metastatic neuroendocrine tumor/paraganglioma was suggested. (cytojournal.com)
  • On CT, the tumor typically is large, partly necrotic, locally invasive, and invariably metastatic at the time of diagnosis [4]. (elsevierpure.com)
  • Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11). (cdc.gov)
  • Malignant cystadenocarcinoma and intramedullary mucinous carcinomas may be further subdivided into noninvasive and invasive types. (medscape.com)
  • Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
  • The most common types of islet cell tumors are insulinomas and gastrinomas . (cancer.gov)
  • Other types of islet cell tumors are ACTHoma and VIPoma . (cancer.gov)
  • These are also known as pancreatic neuroendocrine tumors (PNETs) or islet cell tumors. (actchealth.com)
  • 3), gastrinoma: can occur at any age, the incidence rate second only to insulin tumor originated in the islet cells in G 2 / 3 of patients with malignant from the transfer to intractable ulcer disease and is characterized by diarrhea. (cancerlive.net)
  • It is the most common malignant pancreatic tumor in young children and has a mean age of diagnosis of 5 years. (orpha.net)
  • Well-differentiated NET and acinar cell carcinoma are often misdiagnosed as poorly differentiated neuroendocrine carcinoma, emphasizing that diagnostic criteria need to be clearly followed to ensure accurate diagnosis. (johnshopkins.edu)
  • Current diagnosis and management of unusual pancreatic tumors. (nih.gov)
  • Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
  • The diagnosis, however, should be confirmed with a sample of tissue from the tumor taken during a biopsy, fine needle aspiration, or surgery. (actchealth.com)
  • By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)
  • Cases of small cell carcinomas of the prostate are highly metastasis at diagnosis. (uroonkolojibulteni.com)
  • Knowledge of the expression patterns of HE4 in our survey is useful for application in histopathologic diagnosis, and should be taken into consideration in future studies that examine the role of HE4 as a serological tumor biomarker or as a target for gene-based therapy. (nature.com)
  • We discuss the implications of our results in terms of the potential role for HE4 in histopathologic diagnosis, as a serum tumor biomarker, and as a therapeutic target. (nature.com)
  • Ali SZ, Reuter VE, Zakowski MF: Small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic study with emphasis on cytologic features. (karger.com)
  • Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12/19/2017) 24. (sncrf.org)
  • Abrahamsson PA: Neuroendocrine differentiation in prostatic carcinoma. (karger.com)
  • Immunohistochemical labeling for neuroendocrine and acinar differentiation markers was performed. (johnshopkins.edu)
  • Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. (sncrf.org)
  • Sarcomatoid carcinoma of lung 12. (sncrf.org)
  • Bronchoalveolar carcinoma lung. (sncrf.org)
  • Histologically, it is indistinguishable from small cell carcinoma of the lung. (elsevierpure.com)
  • The Effect of the Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras) Proto-Oncogene, GTPase Genetic Polymorphism on the Safety and Efficacy of Bevacizumab Combination Treatment Regimens for Patients with Nonsquamous, Non-Small Cell Lung Cancer with Brain Metastases. (cdc.gov)
  • Full staging needs to be performed, including ultrasound and computed tomography (CT) or magnetic resonance imaging (MRI) scans of the primary tumor, as well as CT scans of the chest to detect any metastasis. (orpha.net)
  • Grading these as high-grade tumors with rhabdoid change may not be accurate as these are mostly indolent tumors with rare reports of metastasis to regional lymph nodes. (mayocliniclabs.com)
  • Have unresectable tumors or metastasis, no effective treatment. (cancerlive.net)
  • Richardson RL, Weiland LH: Undifferentiated small cell carcinomas in extrapulmonary sites. (karger.com)
  • Furtado P, Lima MVA, Nogueira C, Franco M, Tavora F: Review of small cell carcinomas of the prostate. (karger.com)
  • The clinicopathologic features and survival of the remaining 44 poorly differentiated neuroendocrine carcinomas were further assessed. (johnshopkins.edu)
  • Rubenstein JH, Katin MJ, Mangano MM, Dauphin J, Salenius SA, Dosoretz DE, Blitzer PH: Small cell anaplastic carcinoma of the prostate: seven new cases, review of the literature and discussion of a therapeutic strategy. (karger.com)
  • Anaplastic carcinoma comprises 2-7% of all pancreatic carcinomas. (elsevierpure.com)
  • She underwent surgery, and resection of the tumor with neck dissection was performed, which was reported as malignant carotid body paraganglioma on histopathology. (cytojournal.com)
  • The investigators performed comprehensive molecular analyses of tissue samples from 74 cases of acinar cell carcinoma. (dkfz.de)
  • Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)
  • Doctors analyze your prostate tissue in a lab to see what kinds of cells have cancer in them. (webmd.com)
  • I. To evaluate the association of tumor mutational burden measured by tissue sequencing with durable response (complete response [CR] or partial response [PR] lasting 24 weeks or more). (clinicaltrialsgps.com)
  • An area of healthy tissue surrounding the tumor may be removed as well. (actchealth.com)
  • The goal of the surgery is to have "clear margins" or "negative margins," meaning there are no cancerous cells on the edges of the healthy tissue removed. (actchealth.com)
  • Interstitial tissue lymphoma and pancreatic tumors, including pancreatic sarcoma (rare). (cancerlive.net)
  • The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected advanced solid tumors. (uci.edu)
  • This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. (uci.edu)
  • This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors. (ucbraid.org)
  • This phase I trial identifies the best dose, possible benefits and/or side effects of BAY 1895344 in combination with chemotherapy in treating patients with solid tumors or urothelial cancer that has spread to other places in the body (advanced). (ucbraid.org)
  • Combining BAY 1895344 with chemotherapy treatment (cisplatin, or cisplatin and gemcitabine) may be effective for the treatment of advanced solid tumors, including urothelial cancer. (ucbraid.org)
  • This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. (ucbraid.org)
  • The histological examination from the FNA sample revealed a scarce specimen for evaluation, with columnar epithelial cells with mild atypia, positive for CK7 and 19, negative for p53, chromogranin A and synaptophysin. (spg.pt)
  • Adrenal cortical tumors (closed to accrual 06/27/2018) 32. (sncrf.org)
  • SCA is considered a nonmalignant lesion, and malignant serous tumors reported in the literature have not been found to meet the World Health Organization (WHO) criteria for SCA. (medscape.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • Insights into the oncological characteristics and tumor microenvironment (TME) of different histologic subtypes of LUAD at the single-cell level can help identify potential therapeutic vulnerabilities and combinational approaches to improve the survival of LUAD patients. (nih.gov)
  • [ 6 ] Kim et al, in a study of 99 patients with MCN, found that the presence of symptoms, tumor size greater than 4 cm, and the radiologic finding of a solid component/mural nodule or duct dilatation were significantly associated with malignancy. (medscape.com)
  • Papandreou CN, Daliani DD, Thall PF, Tu SM, Wang X, Reyes A, Troncoso P, Logothetis CJ: Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate. (karger.com)
  • This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. (sncrf.org)
  • We are conducting a new study to learn about symptoms and quality of life for patients with Neuroendocrine Tumors. (ucsf.edu)
  • Offering comprehensive evaluations and personalized treatment plans, the Center for Neuroendocrine Tumors includes a multidisciplinary team that enables patients with any type of neuroendocrine tumor to receive expert, team-based care. (ucsf.edu)
  • Pancreatic panniculitis is a very rare complication associated with pancreatic disease, appearing in approximately 2 to 3% of all patients, most commonly those with acute or chronic pancreatitis, but also in patients with pancreatic carcinoma. (scitcentral.com)
  • Prognostic Assessment and Risk Stratification in Patients With Postoperative Major Salivary Acinar Cell Carcinoma. (nih.gov)
  • 1.7M) GUID:?322ACB80-7C09-455B-B04F-5C7D81E75453 Supplementary Figure 3: The association between B cell signatures and the OS of PDAC patients. (biotech2012.org)
  • Patients with tumor types likely to express NaPi2b were enrolled in dose escalation. (uci.edu)
  • The tumor marker alpha-fetoprotein (AFP) is raised in 68% of cases, regardless of age. (orpha.net)
  • These slow-growing tumors often make the tumor marker alpha-fetoprotein . (cancer.gov)
  • from there, tumors can spread to nearby lymph nodes and to other areas of the body (liver, peritoneal cavity, intestine, or lungs). (medscape.com)
  • Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: [email protected]] (closed to accrual 03/15/2019) 34. (sncrf.org)
  • On computed tomography, acinar cell carcinoma typically is a well-circumscribed, exophytic, low-attenuation mass that may be partially cystic or contain calcifications (Figure 11.1) [3]. (elsevierpure.com)
  • Triphasic pancreatic-protocol computed tomography is the best initial diagnostic test for pancreatic cancer, and on this modality these tumors appear as a hypodense solid mass. (coek.info)
  • PAP measurement is clinically significant, the rise in serum levels of Prostate acid phosphatase (PAP) is co-related with prostatic carcinoma. (biogenex.com)
  • Small cell carcinoma (SCC) of the prostate represents a rare form of prostatic carcinoma. (karger.com)
  • Abbas F, Civantos F, Benedetto P, Soloway MS: Small cell carcinoma of the bladder and prostate. (karger.com)
  • Brownback KR, Renzulli J, Myers JR: Small-cell prostate carcinoma: a retrospective analysis of five newly reported cases. (karger.com)
  • Anker CJ, Dechet C, Isaac JC, Akerley W: Small cell carcinoma of the prostate. (karger.com)
  • Bolton DM, Chiu ST, Clarke S, Angus D: Primary small cell carcinoma of the prostate: unusual modes of presentation. (karger.com)
  • Hindson DA, Knight LL, Ocker JM: Small-cell carcinoma of prostate. (karger.com)
  • The different types of prostate cancer start in different cells. (webmd.com)
  • Gland cells make prostate fluid. (webmd.com)
  • It develops in the gland cells that line the prostate gland. (webmd.com)
  • This kind starts in the cells that line the ducts (or tubes) of the prostate gland. (webmd.com)
  • It develops in small round cells in the prostate and can spread very quickly. (webmd.com)
  • It starts in flat cells that cover the prostate. (webmd.com)
  • Rarely, tumors grow inside neuroendocrine cells of the prostate. (webmd.com)
  • Cancer Research UK: "Types of Prostate Cancer," "Small cell prostate cancer," "What are neuroendocrine tumors? (webmd.com)
  • Small cell carcinoma of the prostate. (webmd.com)
  • Small cell carcinoma of the prostate is a rare and highly aggressive subtype. (uroonkolojibulteni.com)
  • We used integrative three-dimensional (3D) spatial genomics to identify the chromatin interaction targets of 45 prostate cancer risk alleles, 31 of which were associated with the transcriptional regulation of target genes in 565 localized prostate tumors. (stanford.edu)
  • To supplement these 31, we verified transcriptional targets for 56 additional risk alleles using linear proximity and linkage disequilibrium analysis in localized prostate tumors. (stanford.edu)
  • Scientists think that the various types of pancreatic cancer differ considerably in their tumor biology. (dkfz.de)
  • A total of 107 pancreatic resections originally diagnosed as poorly differentiated neuroendocrine carcinomas were reassessed using the classification and grading (mitotic rate/Ki67 index) criteria put forth by the World Health Organization in 2010 for the gastroenteropancreatic system. (johnshopkins.edu)
  • A proportion of tumors are poorly differentiated with little or no gland formation. (coek.info)
  • The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention1. (stanford.edu)