• biguanide
  • Treatment involves biguanide withdrawal, adequate hydration/circulatory support and correction of the acidosis. (medsafe.govt.nz)
  • Significant mortality (reported as high as 50% 3 ) is associated with biguanide-induced lactic acidosis and attention should be focused on prevention through awareness of the risk factors. (medsafe.govt.nz)
  • adequate
  • Should future research suggest that intercurrent illness superimposed on a background of mild lactate elevation is adequate to "tip over" an individual into fulminant lactic acidosis, a case could be made for routine lactate monitoring with the intent that extra vigilance for infectious processes would be desirable in those individuals identified to have mild to moderate lactate elevations. (natap.org)
  • include
  • In some children (especially those with a severe enzyme defect), symptoms of congenital lactic acidosis develop within the first hours or days of life and may include loss of muscle tone (hypotonia), lethargy, vomiting and abnormally rapid breathing (tachypnea). (rarediseases.org)