• We have previously shown that helenalin and other sesquiterpene lactones selectively inhibit activation of the transcription factor NF-kappaB, a central mediator of the human immune response. (greenmedinfo.com)
  • It has previously been reported that sesquiterpene lactones exert their effect by inhibiting degradation of IkappaB, the inhibitory subunit of NF-kappaB. (greenmedinfo.com)
  • Our research program in natural products chemistry involved the study of organic compounds from higher plants with a primary focus on the isolation, structure determination, chemistry, biomimetic and biosynthetic studies of terpenoids, in particular, sesquiterpene lactones. (lsu.edu)
  • Sesquiterpene lactones, polyacetylenes, achilleine and flavonoids such as apigenin. (gaiaherbs.com)
  • Chicory root contains up to 58 per cent inulin, caffeic acids, coumarins, flavonoids, an essential oil (which contains sesquiterpene lactones), vitamins and minerals. (wellbeing.com.au)
  • Artichoke is a relevant source of health-promoting compounds such as polyphenols and sesquiterpene lactones. (unicatt.it)
  • Overall, a large abundance of phenolic acids and sesquiterpene lactones was detected, being 13.77 and 11.99 mgg1, respectively. (unicatt.it)
  • After 20 h of in vitro large intestine fermentation, a decrease in polyphenols and sesquiterpene lactones content was observed. (unicatt.it)
  • However, the relatively high bioavailability values recorded for flavonols, phenolic acids, and sesquiterpene lactones (from 71.6% up to 82.4%) demonstrated that these compounds are able to be transported through the Caco-2 monolayer. (unicatt.it)
  • HS-SPME-GCMS analysis indicated the presence of over 120 different flavour compounds including mono- and sesquiterpenes, higher alcohols, esters, pyrazines, lactones and aldehydes. (coresta.org)
  • Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention. (who.int)
  • For centuries, yarrow has been popular in European folk medicine, in part because yarrow contains flavonoids (plant-based chemicals) that support normal saliva secretion and stomach acid, helping to support healthy digestion. (gaiaherbs.com)
  • 1946. Toxicity of nicotinic acid and some of its derivatives. (cdc.gov)
  • 1961 ) trans-Decalin-2,9-dicarboxylic acid and related derivatives Journal of Organic Chemistry . (academictree.org)
  • Quantification of Valerenic Acid and its Derivatives in Some Species of Valeriana L. and Centranthus longiflorus Stev. (scialert.net)
  • The present study aims to characterize some Iranian wild species of Valerianaceae with respect to their contents of valerenic acid and its derivatives. (scialert.net)
  • Separation of valerenic acid and its derivatives was performed by TLC using a ternary mobile phase of hexane-ethyl acetate-glacial acetic acid (65:35:0.5 v/v) on silica gel HF 254+366 plates. (scialert.net)
  • Quantitative analysis of valerenic acid and its derivatives was performed using UV-spectrophotometry. (scialert.net)
  • Additionally, for a more accurate determination of total valerenic acid derivatives (including valerenic acid, hydroxyvalerenic acid and acetoxyvalerenic acid) extinction coefficient of each compound in ethanol was used. (scialert.net)
  • This is the first report for the identification and quantification of valerenic acid derivatives in all organs of Valeriana sisymbriifolia , Valeriana alliariifolia and Centranthus longiflorus in comparison with those of commercial Valeriana officinalis . (scialert.net)
  • Total valerenic acid derivatives content in different organs of these Iranian wild species ranged from 0.06-1.11% (D.W.). Present results showed that Iranian wild species of Valeriana and Centranthus DC. (scialert.net)
  • These include the essential oil and its sesquiterpenoids (valerenic acid derivatives), epoxy iridoid esters (valepotriates) and their decomposition products such as baldrinal and homobaldrinal, amino acids (arginine, GABA, glutamine, tyrosine) and alkaloids (Upton et al . (scialert.net)
  • In the last two decades, the essential oil and valerenic acid derivatives have become more important, not only from a pharmacological point of view, but also for the quality control and standardization of valerian phytomedicines (Hendriks et al . (scialert.net)
  • It also contains other beneficial sesquiterpene derivatives, such as arteether, artemether, artesunate and dihydroartemisinin. (draxe.com)
  • The compound is widespread in nature and serves as an important biosynthetic intermediate towards many other sesquiterpene alcohols including eudesmols, guaiols and rearranged compounds. (researchgate.net)
  • The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. (researchgate.net)
  • Chloroform fraction of alcohol extract of leaves yielded seven compounds: gallic acid (1), beta-sitosterol (2), behenic acid (3), kaempferol (4), quercetin (5), vanillic acid (6), hexadecanoic acid (7). (stuartxchange.org)
  • Furthermore, the ESI(-) FT-ICR MS characterized the more abundant phenolic compounds, including Quinic Acid, Myricitrin, Gemin D/Hippom. (medworm.com)
  • Based on this result, an extensive chemical investigation of the CH2Cl2-MeOH (1:1) extract of this plant was carried out, leading to the isolation of a new ceramide, named entadamide (1), together with nine known compounds: monomethyl kolavate (2), 24-hydroxytormentic acid (3) chondrillasterol (4), 3-O-β-D glucopyranosylstigma. (medworm.com)
  • LC-ToF-MS identified 60 to 400 features, or distinct compounds, depending on the mode of operation, including isomeric compounds typical of modified sugars such as sugar alcohols and acids, as well as, C6 - C18 fatty acids. (coresta.org)
  • This group of compounds includes amino acids and fatty acids. (lookformedical.com)
  • The anti-inflammatory sesquiterpene lactone helenalin found in Arnica inhibits the transcription factor NF-kappaB by directly targeting p65. (greenmedinfo.com)
  • The sesquiterpene lactone helenalin is a potent anti-inflammatory drug whose molecular mechanism of action remains unclear despite numerous investigations. (greenmedinfo.com)
  • This sesquiterpene lactone is the first anti-inflammatory agent shown to exert its effect by directly modifying NF-kappaB. (greenmedinfo.com)
  • a new antifungal melampolide - sesquiterpene lactone named sonchifolin, as well as three known melampolides, polymatin B, uvedalin and enhydrin. (stuartxchange.org)
  • Spots were detected at 254 and 366 nm and then revelation of them was carried out with HCl-acetic acid reagent followed by anisaldehyde-sulphuric acid reagent spraying at visible light. (scialert.net)
  • It did not, however, exhibit any hypoglycemic activity or analgesic potential using the acetic acid writhing assay. (edu.ph)
  • Sebum consists of lipids such as, triglycerides, waxes, free fatty acids and squalene, as well as debris of dead fat producing cells. (positivehealth.com)
  • Turmeric essential oil is acquired through a process of hydro-distillation or steam distillation of the root and has extreme concentrations of sesquiterpenes, zingiberene, curcumin, cineol, borneol, and valeric acid, among hundreds of other molecules. (organicfacts.net)
  • Chemical investigation of the steam-volatile oil of the shrub Rubus rosifolius yielded pregeijerene (2), β-caryophyllene (3), humulene (4), dihydroagarofuran (5), an unidentified sesquiterpene ether, hedycaryol (6) and the novel epieudesmol rosifoliol for which structure (1) is proposed. (researchgate.net)
  • The main free amino acids in all cultivars were arginine and glutamine. (stuartxchange.org)
  • Freeze-dried yacon powder yielded total free amino acids of 1941.2 mg/100 g, glutamine 212.4 mg/100g, and arginine 994.1 mg/100 g. (stuartxchange.org)
  • The disodium phosphate (Na 2HPO 4) is added as a pH buffer to prevent the highly acidic trifluoroacetic acid byproduct from causing hydrolysis or transesterification of the ester product. (wikipedia.org)
  • Hedycaryol is a strained 10‐membered monocyclic sesquiterpene alcohol whose chemistry is characterised by its transannular acid catalysed and thermal (Cope) reactions. (researchgate.net)
  • The marasmic acid skeleton Journal of Organic Chemistry . (academictree.org)
  • The hypervalent compound is accessible in two ways, and which is chosen usually depends on what materials are available: it can be prepared from its acetate analogue by an exchange reaction, or by reacting iodobenzene with a combination of trifluoroperacetic acid and trifluoroacetic acid: Trifluoroperacetic acid is one of the strongest reagents used for Baeyer-Villiger oxidations, as a consequence of its high acidity relative to similar peracids and peroxides. (wikipedia.org)
  • The valerian odor is due to isovaleric acid, formed from bornyl acetate by an oxydase during the drying of the drug. (drugstoremuseum.org)
  • 3 CF 3COOCOCF 3 + 4 Na 2CO 3·1+1⁄2H 2O 2 → 6 CF 3COOOH + 4 Na 2CO 3 + 3 H 2O Trifluoroperacetic acid can also be generated in situ, allowing it to react promptly with the target substrate rather than pre-synthesizing a batch of the reagent for later use. (wikipedia.org)
  • Emmons is remembered in part as the pioneer and developer of trifluoroperacetic acid as a laboratory reagent, which has since become useful as a reagent for many different types of synthetic reactions. (wikipedia.org)
  • 1973 ) Studies in sesquiterpene synthesis. (academictree.org)
  • 1966 ) The structure and total synthesis of cassaic acid. (academictree.org)
  • Many studies have shown that inulin acts in the liver to stop fatty acid synthesis and at the same time reduce production of bad LDL cholesterol. (wellbeing.com.au)
  • Valerenic acid - which is a component of valerian root - has a positive impact on GABA, which is one of the main sedative neurotransmitters. (mommypotamus.com)
  • The resin as a whole (and, particularly, two of its diterpenes - copalic acid and kaurenic acid) has demonstrated significant antimicrobial activity against gram-positive bacteria. (pfaf.org)
  • 1999). The main non-volatile cyclopentane sesquiterpenes are valerenic acid, acetoxyvalerenic acid, hydroxyvalerenic acid and valerenal. (scialert.net)
  • Degradation of 3α,9α-epoxy-11-ketonorcholanic acid to 3α,9α-epoxy-11-ketoetiocholanic acid Journal of the American Chemical Society . (academictree.org)
  • Valerenic acid makes substantial contribution to the sedative effect of valerian. (scialert.net)
  • The calibration curve of authentic valerenic acid was linear in the range of 2-51 mg L -1 . (scialert.net)
  • Study of free amino acid composition of roots of yacon cultivars ranged from 147.9 to 341.1 mg/q00 g. (stuartxchange.org)
  • A non-essential amino acid that is synthesized from GLUTAMIC ACID. (lookformedical.com)
  • One of copaiba?s other chemicals, kaurenoic acid, has also demonstrated selective antibacterial activity against Gram-positive bacteria in other recent studies[318. (pfaf.org)
  • It is the most reactive of the organic peroxy acids, allowing it to successfully oxidise relatively unreactive alkenes to epoxides where other peroxy acids are ineffective. (wikipedia.org)
  • Trifluoroperacetic acid (trifluoroperoxyacetic acid, TFPAA) is an organofluorine compound, the peroxy acid analog of trifluoroacetic acid, with the condensed structural formula CF 3COOOH. (wikipedia.org)
  • Topically applying turmeric essential oil to the skin, in moderate amounts, along with a carrier oil, can help make skin look and feel younger, thanks to the concentrated antioxidants in this oil such as curcumene , zingiberene, and other sesquiterpenes. (organicfacts.net)
  • Probiotic and antioxidant properties from protocatechuic, chlorogenic, caffeic and ferulic acids found in the leaves. (stuartxchange.org)
  • In the presence of Lewis acids, 2,3-homotropone 1 smoothly undergoes cycloaddition reactions with cyclopentadiene and butadiene in [4π+2π] fashion with "inverse electron demand," the dienes acting as dienophiles. (go.jp)
  • The content of collagen fibres and the periodic acid Schiff reaction of the basement membrane of the renal tubules were 70% and 19% lower linked to the ACR group. (bvsalud.org)
  • At standard ambient temperature and pressure, trifluoroperacetic acid is a colourless liquid with a boiling point of 162 °C. It is soluble in acetonitrile, dichloromethane, diethyl ether, and sulfolane, and readily reacts with water. (wikipedia.org)
  • It is conjugated to GLYCINE in the liver and excreted as hippuric acid. (lookformedical.com)