• EP0943620A2 ] The invention relates to use of betulinic acid and/or its derivatives for treating, inhibiting, and/or preventing tumors or cancer growth more particularly, to treating leukemia, lymphomas, lung, prostate and ovarian cancer. (epo.org)
  • Synthesis and Anti-HIV Activity of Betulinic Acid and Dihydrobetulinic Acid Derivatives", BIOORG. (epo.org)
  • This invention also relates to novel betulinic acid derivatives and a composition containing betulinic acid derivatives with or without betulinic acid. (epo.org)
  • Tsukahara T, Haniu H, Matsuda Y. Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells. (medsci.org)
  • UDCA inhibited the expression of glial fibrillary acidic protein (GFAP), tumor necrosis factor-α (TNF-α), ionized calcium-binding adapter molecule 1 (iba1), and inducible nitric oxide synthase (iNOS). (springer.com)
  • In in vivo studies, CDDO-Me completely eliminated 4T1 breast cancer growth and lung metastases induced by 4T1 cells in mice when treatment started 1 day after tumor implantation and significantly inhibited tumor growth when started after 5 days. (aacrjournals.org)
  • Abstract: Eicosapentaenoic acid (EPA) is a triglyceride-lowering agent that reduces circulating levels of the apolipoprotein B (apoB)-containing lipoprotein particles small dense low-density lipoprotein (sdLDL), very-low-density lipoprotein (VLDL), and oxidized low-density lipoprotein (LDL). (harvard.edu)
  • In conclusion, inhibition of calcium influx in PMNs is introduced as a novel prostanoid-independent mode of action of two nonsteroidal anti-inflammatory drugs with fenamate structure, flufenamic and tolfenamic acids, which could explain their earlier documented inhibitory effects on PMN functions. (aspetjournals.org)
  • Nontoxic small molecules that inhibit C. albicans yeast-to-hypha conversion and hyphal growth could represent a valuable source for understanding pathogenic fungal morphogenesis, identifying drug targets and serving as templates for the development of novel antifungal agents. (unboundmedicine.com)
  • α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells. (nih.gov)
  • In this study, we assessed whether LA could inhibit apoptosis in beta cells exposed to high glucose concentrations. (nih.gov)
  • We could show that the flavonoids (−)-epicatechin, (+)-catechin hydrate, and rutin trihydrate as well as vitamin C and the pharmacological substances N -acetyl-L-cysteine and 5-aminosalicylic acid inhibited PMA induced ROS production and NET formation. (hindawi.com)
  • Our results suggest that VPA reduces PON2 expression in GBM cells, which in turn increases ROS production and induces Bim production that inhibits cancer progression via the PON2-Bim cascade. (nih.gov)
  • The cells were determined for proliferation, differentiation, fat accumulation as well as the protein expressions of molecular targets that regulate or are involved in fatty acid synthesis and oxidation. (plos.org)
  • Table: fatty acid composition of oil Table of physical properties of oil Hydnocarpus wightiana trees of India Norton, SA (October 1994). (wikipedia.org)
  • To determine the mechanism behind this action, we studied the effects of two fenamates (flufenamic and tolfenamic acids) on Ca2+ metabolism in human PMNs. (aspetjournals.org)
  • Extending these initial findings, we investigated the molecular mechanism by which dykellic acid inhibits MMP-9 expression. (aacrjournals.org)
  • We determined the mechanism by which all-trans retinoic acid (ATRA) inhibits experimental autoimmune uveitis (EAU) and determined the role of γδ T cells in this autoimmune disease. (arvojournals.org)
  • Trans fatty acids (TFAs) are reported to increase the risk of certain types of cancers, including CRC and prostate cancer ( 13 , 14 ). (spandidos-publications.com)
  • Intake of trans fatty acids (TFAs) from partially hydrogenated vegetable oil is associated with a variety of adverse outcomes, but little is known about the health effects of ruminant trans fats. (springer.com)
  • In addition, an image of the same field of cells was used to represent the effects of SHP-1 siRNA under two experimental conditions (control and gambogic acid treatments) in Fig. 5D. (aacrjournals.org)
  • Lipid oxidation was measured as a function of thiobarbituric acid reactive substances formation. (harvard.edu)
  • EPA inhibited sdLDL (IC50 ∼2.0 μM) and LDL oxidation (IC50 ∼2.5 μM) in a dose-dependent manner. (harvard.edu)
  • Docosahexaenoic acid was also found to inhibit oxidation in these particles but over a shorter time period than EPA. (harvard.edu)
  • Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. (aacrjournals.org)
  • The active ingredient that produces antimicrobial activity has been identified as hydnocarpic acid, a lipophilic compound. (wikipedia.org)
  • In addition, the actions of flufenamic and tolfenamic acids were similar to those of an experimental blocker of nonselective cation channels (SK&F 96365). (aspetjournals.org)
  • Lactic acid suppresses LPS-mediated mast cell function. (jimmunol.org)
  • The present study is based on a finding that dykellic acid suppresses MMP-9 gene transcription. (aacrjournals.org)
  • These findings provide a molecular basis for the anti-inflammatory properties ascribed to AαBA- and AKβBA-containing drugs and suggest acetyl-boswellic acids as tools for the development of novel therapeutic interventions. (jimmunol.org)
  • Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. (aspetjournals.org)
  • Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis. (thisisms.com)
  • Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. (thisisms.com)
  • Trans-vaccenic acid (TVA) is a naturally occurring TFA found in the fat of ruminants and in human dairy products. (springer.com)
  • Trans-vaccenic acid (TVA) is ubiquitous in ruminant-derived fats and human dairy products such as milk and butter. (springer.com)
  • In line with this, AαBA and AKβBA also bound to and inhibited the activities of active human recombinant GST-IKKα and His-IKKβ. (jimmunol.org)
  • To determine the effect of dykellic acid on PMA-induced MMP-9 activity, cells were treated with various concentrations of dykellic acid in the presence of 75 n m PMA and MMP-9 expression was evaluated by zymography. (aacrjournals.org)
  • Our data suggests that Anacardic Acid might be a promising complementary supplement to slow the initiation or progression of pancreatic cancer. (biomedcentral.com)
  • We found that black tea inhibited S. aureus biofilm development and that an isaA mutant resisted this inhibition. (sigmaaldrich.com)
  • In conclusion, we propose that inhibiting NADPH oxidase by α -LA could prevent oncogene expression and hyperproliferation occurring in H. pylori -infected gastric epithelial cells. (hindawi.com)
  • These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB. (aacrjournals.org)
  • 1 - 3 All-trans retinoic acid (ATRA), the major endogenously generated RA, is a ligand for all retinoic acid receptor (RAR) subtypes. (arvojournals.org)
  • Here, we examined whether cPA inhibited AGP-induced expression of class I histone deacetylases (HDACs, namely HDAC1, HDAC2, HDAC3, and HDAC8), which may affect subsequent transcriptional activity of target genes. (medsci.org)
  • To elucidate the underlying molecular mechanisms, Western blot analysis and immunocytochemistry were performed on cancer cells treated with Anacardic acid alone or in combination with 5-Fluorouracil or Gemcitabine. (biomedcentral.com)
  • Suppression was MCT-1 dependent and reproducible with sodium lactate or formic acid. (jimmunol.org)
  • Additionally, LA inhibited insulin expression and secretion in HIT-T15 cells induced by high glucose. (nih.gov)
  • Purified GAs had no effect on the growth and viability of C. albicans yeast cells but inhibited its yeast-to-hypha conversion under several hypha-inducing conditions, including the presence of serum. (unboundmedicine.com)
  • Retinoic acids (RAs) are metabolites of vitamin A, but also can be produced endogenously by activated dendritic/macrophage cells. (arvojournals.org)
  • As microglia can be activated by several stimulants, such as Aβ42, in Alzheimers brain and can release those inflammatory factors, the ability to inhibit or at least decrease the production of IL-1β and NO in Alzheimers disease (AD) is essential. (springer.com)
  • These data support recent clinical findings and suggest that EPA has direct antioxidant benefits in various apoB-containing subfractions that are more pronounced than those of other triglyceride-lowering agents and docosahexaenoic acid. (harvard.edu)