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  • Synthesis
  • Synthesis of -Aminobutyric Acid Analogs. (edu.au)
  • Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids , (pp. 573-689). (edu.au)
  • To test the possibility that GABA could be a mediator of anoxic metabolic depression, crucian carp ( Carassius carassius L.) were given an inhibitor of GABA synthesis, isoniazid, and the rate of anoxic ethanol production (ethanol being the main end product of energy metabolism in anoxic crucian carp) as well as the rates of normoxic and hypoxic oxygen consumption were measured. (biologists.org)
  • Clonazepam (4 mg/kg) reduced plasma tryptophan by 27%, but had no effect on brain tryptopham, 5-HT, 5-hydroxyindoleacetic acid, 5-HT synthesis and 3H-5-HT receptor binding. (muscimol.xyz)
  • Among these features are deficits of working memory and decreased levels of glutamic acid decarboxylase 67, one of the enzyme isoforms that catalyzes the synthesis of GABA, and parvalbumin, a Ca 2+ -binding protein expressed by interneurons, primarily in the stratum pyramidale. (aspetjournals.org)
  • isoniazid
  • Isoniazid (500mgkg −1 ), which significantly inhibited the anoxia-induced rise in brain GABA concentration, caused a nearly threefold increase in anaerobic ethanol production without affecting normoxic oxygen consumption. (biologists.org)
  • Amino Acid
  • Gabapentin, an amino acid designed as a structural analog of GABA ( Sills, 2006 ), is a novel anticonvulsant drug that came into clinical use as adjunctive therapy in the treatment of human seizures. (jneurosci.org)
  • GABAB
  • These results show that dialysis of BMI, into either the mPOA or the ARC-VMR of either castrated or T-treated castrated rams decreased LH release, whereas dialysis of GABAB antagonists at these sites was without detectable effect. (ovid.com)
  • hippocampus
  • Impaired α7 nicotinic acetylcholine receptor (nAChR) function and GABAergic transmission in the hippocampus and elevated brain levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the kynurenine pathway, are key features of schizophrenia. (aspetjournals.org)
  • Analogs
  • New heterocyclic compounds with high insecticidal activity were discovered using a competitive‐intelligence‐inspired scaffold‐hopping approach to generate analogs of fipronil, a known GABA antagonist. (usda.gov)
  • increases
  • SWDs and increases in power of the delta, alpha, and beta frequency ranges during the transition period disappeared after the kainic acid injection for 1-3 d and gradually reappeared. (jneurosci.org)
  • ileum
  • Upon reaching the ileum, bile acids are transported by specific transport proteins to the portal circulation for recycling back to the liver. (frontiersin.org)
  • status epilepticus
  • We analyzed spectral changes of the EEG during kainic acid-induced status epilepticus, SWDs, for 10 s before (silent period) and for 2 s before (transition period) SWDs. (jneurosci.org)
  • 1989
  • Darlington C. L. and Smith P. F. (1989) The effects of N -methyl- d -aspartate antagonists on the development of vestibular compensation in the guinea pig. (springer.com)
  • activity
  • A second aim of our study was to determine whether kainic acid has any effect on spike-and-wave discharges or on the transition from basal activity to the spike-and-wave discharges. (jneurosci.org)
  • In adults and pre-pubescent chlidren THP normally helps soothe the activity of brain cells by binding to GABA receptors that inhibit accelerating electrical activity. (hmdb.ca)
  • Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. (biomedcentral.com)
  • This activity is closely related to valerenic acid. (biomedcentral.com)
  • extract
  • The determining compound for the observed anxiolytic effect of the valerian extract is its content of valerenic acid. (biomedcentral.com)
  • Valerian extract (VE) was fractionated and the fractions were tested with respect to their ability to allosterically modulate GABA-A receptors. (biomedcentral.com)
  • effect
  • We investigated the involvement of γ-aminobutyric acid A (GABA A ) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. (go.jp)
  • These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA A receptors. (go.jp)