Achromobacter species in cystic fibrosis. Medical search. Frequent questions

concerning a health care-associated outbreak of Achromobacter xylosoxidans infections after prostate biopsies ( 1 ). (cdc.gov)
First, the isolates of Achromobacter cannot be referred to as A. xylosoxidans from just the method used in this study, API 20 NE mass spectrometry (bioMérieux, https://www.biomerieux.com ). (cdc.gov)
To date, in the few studies available, a great variety of species have been detected in clinical samples, with A. xylosoxidans the most predominant ( 4 , 5 ). (cdc.gov)
Outbreak of Achromobacter xylosoxidans and Ochrobactrum anthropi infections after prostate biopsies, France, 2014. (cdc.gov)
Amoureux L , Bador J , Verrier T , Mjahed H , DE Curraize C , Neuwirth C . Achromobacter xylosoxidans is the predominant Achromobacter species isolated from diverse non-respiratory samples. (cdc.gov)
Achromobacter xylosoxidans (formerly Alcaligenes xylosoxidans) is a Gram-negative, aerobic, oxidase and catalase-positive, motile bacterium with peritrichous flagella, from the genus Achromobacter. (wikipedia.org)
Achromobacter xylosoxidans can cause infections such as bacteremia, especially in patients with cystic fibrosis. (wikipedia.org)
In 2013, the complete genome of an A. xylosoxidans strain from a patient with cystic fibrosis was sequenced. (wikipedia.org)
Achromobacter xylosoxidans n. sp. (wikipedia.org)
in Japan and has also been reported in Achromobacter xylosoxidans ( 4 , 5 ). (blogspot.com)
A reevaluation of the criteria used to classify Alcaligenes denitrificans Rüger and Tan 1983 and Achromobacter xylosoxidans Yabuuchi and Ohyama 1971 as subspecies of Alcaligenes xylosoxidans and additional evidence provided in recent studies revealed that, consistent with present standards, it is appropriate to consider these two taxa distinct species of the genus Alcaligenes. (microbiologyresearch.org)

It is motile, with peritrichous flagella that distinguish it from Pseudomonas species, and is oxidase-positive, catalase-positive, and citrate-positive. (wikipedia.org)
1] Burkholderia cepacia (also known as Pseudomonas cepacia) - important pathogen of pulmonary infections in people with cystic fibrosis. (globalrph.com)

Chronic bronchopulmonary bacterial infections remain the most common cause of morbidity and mortality among patients with cystic fibrosis (CF). Recent community sequencing work has now shown that the bacterial community in the CF lung is polymicrobial. (biomedcentral.com)
Progressive lung disease secondary to chronic airway infection and inflammation is the leading cause of morbidity and mortality in cystic fibrosis (CF) [ 1 ]. (ersjournals.com)

Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples. (cmac-journal.ru)
12. Valdezate S., Vindel A., Maiz L. Persistence and variability of Stenotrophomonas maltophilia in cystic fibrosis patients, Madrid, 1991-1998. (cmac-journal.ru)

Taxonomic dissection of Achromobacter denitrificans Coenye et al. (cdc.gov)

Infection is sometimes associated with underlying immunodeficiency, including immunoglobulin M deficiency, various cancer chemotherapies, inhaled steroids, surgical procedures, prolonged or broad-spectrum antimicrobial treatment for other infections, and cystic fibrosis. (wikipedia.org)
This will enable researchers from academia and industry to quickly identify and translate discoveries into new treatments for infections in people with cystic fibrosis. (cfamr.org.uk)
P. aeruginosa and B. cepacia , play major role in lower respiratory tract infections in patients with cystic fibrosis. (cmac-journal.ru)

The other part discusses diverse sensors that have been developed and used for the detection of respiratory diseases ( e.g. chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, tuberculosis, cystic fibrosis, obstructive sleep apnoea syndrome and pneumoconiosis) by analysis of VOCs in exhaled breath. (ersjournals.com)

nov. and Achromobacter deleyi sp. (cdc.gov)

Since 2012, a total of 18 species have been defined in the genus Achromobacter ( 2 ). (cdc.gov)

Use of nrdA gene sequence clustering to estimate the prevalence of different Achromobacter species among Cystic Fibrosis patients in the UK. (cdc.gov)
Suri R. High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis. (cysticfibrosis.online)

It encodes a membrane-associated protein called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)

Only multilocus sequence typing or sequencing 765 bp of the housekeeping gene nrdA enables the identification of the isolates to the species level ( 3 ). (cdc.gov)
Correct identification of the isolates involved in all types of infection is necessary to help understand the epidemiology, pathogenicity, and resistance pattern of the various species. (cdc.gov)
In conclusion, these missing data are needed for other hospitals to identify epidemiogenic Achromobacter isolates. (cdc.gov)

Bacteremia caused by a novel Bordetella species, "B. hinzii. (microbiologyresearch.org)

Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)
Aspergillus fumigatus can lead to allergic bronchopulmonary aspergillosis (ABPA) in patients with asthma and cystic fibrosis. (hopkinsguides.com)

Treatment is supportive through aggressive multidisciplinary care along with small-molecule correctors and potentiators targeting the cystic fibrosis transmembrane conductance regulator protein defect. (msdmanuals.com)
Ten strains recognized on the basis of a computer-assisted numerical comparison of whole-cell protein patterns as members of a novel species belonging to the family Alcaligenaceae were examined by using an integrated phenotypic and genotypic approach. (microbiologyresearch.org)

Cystic fibrosis is an inherited disease of the exocrine glands affecting primarily the gastrointestinal and respiratory systems. (msdmanuals.com)

Identification and distribution of Achromobacter species in cystic fibrosis. (cdc.gov)

Cystic fibrosis (CF) is a life-threatening genetic disease, which in the United States occurs in about 1/3,300 White births, 1/15,300 Black births, and 1/32,000 Asian American births. (msdmanuals.com)

Cystic Fibrosis Medicine. (wikipedia.org)

1. Cystic Fibrosis Foundation Patient Registry 2021 Annual Data Report Bethesda, Maryland 2022 Cystic Fibrosis Foundation. (msdmanuals.com)

Journal of Cystic Fibrosis. (ku.dk)

In this article, the authors highlight cystic fibrosis (CF) research published in Pediatric Pulmonology during 2015. (cysticfibrosis.online)

Using this single locus sequence to differentiate species, we analyzed Achromobacter isolates obtained from 341 CF patients in the U.S. (nih.gov)
The Achromobacter genus has undergone taxonomic reclassifications ( 19 ), and bacterial isolates have occasionally been misidentified as P. aeruginosa , leading to a possible underestimation of the prevalence in historic CF cohorts ( 20 , 21 ). (atsjournals.org)
Only multilocus sequence typing or sequencing 765 bp of the housekeeping gene nrdA enables the identification of the isolates to the species level ( 3 ). (cdc.gov)
Correct identification of the isolates involved in all types of infection is necessary to help understand the epidemiology, pathogenicity, and resistance pattern of the various species. (cdc.gov)
In conclusion, these missing data are needed for other hospitals to identify epidemiogenic Achromobacter isolates. (cdc.gov)
Several isolates that could not be identified to the species level may belong to novel Ralstonia species. (cdc.gov)
13. MALDI-TOF MS improves routine identification of non-fermenting Gram negative isolates from cystic fibrosis patients. (nih.gov)
Twenty-one Enterobacteriaceae species belonging to 15 genera were identified from 72 bacterial isolates previously considered as all coliforms. (hindawi.com)
In addition, sixteen yeast species belonging to 8 genera were equally identified from 55 yeast isolates and Candida sp. (hindawi.com)

We aimed to determine the association of Achromobacter infection on clinical outcomes in pediatric and adult patients with CF. (atsjournals.org)
Patients with CF and chronic Achromobacter infection are at increased risk of death or transplantation. (atsjournals.org)
Despite the increasing prevalence of Achromobacter species infection, its effect on CF lung disease has not been well described. (atsjournals.org)
This study showed a 66% prevalence of anaerobic species isolated from the sputum of adult patients, particularly in those with P. aeruginosa infection. (medscape.com)
5-7), but the clinical importance of infection with these other species is less clear. (cdc.gov)

RATIONALE: Limited information is available on the clinical status of people with Cystic Fibrosis (pwCF) carrying 2 nonsense mutations (PTC/PTC). (bvsalud.org)

CONCLUSIONS: Nonsense mutations decrease the survival and accelerate the course of respiratory disease in children and adolescents with Cystic Fibrosis. (bvsalud.org)
Gender differences in chronic respiratory disease, including cystic fibrosis and non-cystic fibrosis bronchiectasis are clinically apparent and of increasing importance. (ersjournals.com)

[ 83 , 85 ] There is uncertainty whether some of these species are isolated transiently or represent true chronic airway pathogens. (medscape.com)
In this article, we review published studies with a view to summarizing important terms and definitions in human microbiome studies, obstacles in lung microbiota research, microbial diversity of lower respiratory tract in health state and major lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), lung cancer and cystic fibrosis. (pneumon.org)

The graph shows the proportion of individuals in various age groups who had positive cultures for each of these bacterial species during 2019. (medilib.ir)

1. MALDI-TOF: a useful tool for laboratory identification of uncommon glucose non-fermenting Gram-negative bacteria associated with cystic fibrosis. (nih.gov)
3. Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry for species identification of nonfermenting Gram-negative bacilli. (nih.gov)

Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. (medihelp.life)

Taxonomic dissection of Achromobacter denitrificans Coenye et al. (cdc.gov)

A multilocus sequence typing scheme implies population structure and reveals several putative novel Achromobacter species. (nih.gov)

[ 87 ] Another group found a high number of anaerobic species in CF sputum using molecular detection techniques as opposed to standard culture methods. (medscape.com)

The remaining 17.5% of strains belonged to 11 other species/genogroups. (nih.gov)
The type and reference strains of Ralstonia , Pandoraea , Burkholderia , Alcaligenes , and Bordetella species have been described (9-14). (cdc.gov)

CF) and the role of these species in CF pulmonary disease are not well documented. (cdc.gov)

Acinetobacter baumannii , Pandoraea , Ralstonia and Inquilinus species are also being reported more frequently. (medscape.com)

BACKGROUND: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) significantly improves health outcomes in people with cystic fibrosis (pwCF) carrying one or two F508del mutations. (bvsalud.org)

We assessed the ability of nrdA sequence analysis to differentiate Achromobacter species, including the seven previously named species and 14 recently described genogroups. (nih.gov)

The factors contributing to the emergence of Achromobacter species have not been fully elucidated, but may relate to selective antimicrobial pressures, enhanced survival in CF, and improved detection methods ( 22 ). (atsjournals.org)

Pandoraea sputorum was identified in a nine-year-old cystic fibrosis patient from Argentina, after treatment failure during an exacerbation. (medihelp.life)

We did not include data from the 2020 and 2021 Cystic Fibrosis Foundation Patient Registry reports, which may be misleading because many fewer cultures were collected during that period due to the COVID-19 pandemic. (medilib.ir)

Mixed-effects models were used to assess odds of pulmonary exacerbations and effect on lung function (FEV 1 %) by Achromobacter spp. (atsjournals.org)

R. pickettii has been associated with noso- by the referring microbiology laboratory as B. cepacia com- comial outbreaks caused by contaminated solutions used for plex or a related species or were not identified to the species patient care and with pseudoepidemics caused by contami- level. (cdc.gov)

Treatment options for both species are limited. (medscape.com)
Treatment is supportive through aggressive multidisciplinary care along with small-molecule correctors and potentiators targeting the cystic fibrosis transmembrane conductance regulator protein defect. (msdmanuals.com)

Organisms4

Diseases3

Chemicals and Drugs1

Information Science1

Xylosoxidans11

Pseudomonas2

Morbidity and morta2

Stenotrophomonas2

Denitrificans1

Infections3

Pulmonary1

Deleyi1

Genus1

Prevalence2

CFTR1

Isolates3

Bacteremia1

Patients2

Protein2

Inherited disease1

Identification1

Genetic1

Medicine1

Foundation1

Journal1

Research1

Isolates9

Infection5

Clinical1

Respiratory disease2

Chronic2

20191

Gram-negative2

Pathogens1

Taxonomic1

Multilocus1

Sputum1

Strains2

Pulmonary disease1

Acinetobacter1

Mutations1

Genogroups1

Antimicrobial1

Pandoraea1

Cultures1

Lung function1

Patient1

Treatment2