• Carbohydrate sulfotransferase 8 (CHST8) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues of N-glycosylated proteins terminating with the saccharide sequence SO(4)-4-GalNAc-beta1,4-GlcNAc-beta1,2-Man-alpha. (reactome.org)
  • Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. (dovepress.com)
  • A peptide mimetic of a ligand for the galactose/N-acetylgalactosamine-specific C-type lectin receptors (GCLR) exhibited monocyte-stimulating activity, but did not extend survival when applied alone against a syngeneic murine malignant glioma. (dovepress.com)
  • Both strains produced the same EPS composed of galactose, glucose, and N-acetylgalactosamine. (hud.ac.uk)
  • A Golgi vesicle enriched fraction of Saccharomyces cerevisiae expressing SQV-7 transported UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose (Gal) in a temperature-dependent and saturable manner. (elsevier.com)
  • In the ABO system, type A RBCs are distinguished by an amino sugar (alpha-1,3-linked- N -acetylgalactosamine) antigen, whereas type B antigen has a sugar (galactose). (medscape.com)
  • In enzymology, a N-acetylgalactosamine kinase (EC 2.7.1.157) is an enzyme that catalyzes the chemical reaction ATP + N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } ADP + N-acetyl-alpha-D-galactosamine 1-phosphate Thus, the two substrates of this enzyme are ATP and N-acetyl-D-galactosamine, whereas its two products are ADP and N-acetyl-alpha-D-galactosamine 1-phosphate. (wikipedia.org)
  • The molecular architecture of human N-acetylgalactosamine kinase. (medlineplus.gov)
  • Further, it was demonstrated that the activity of the precursor-producing enzyme UDP-N-acetylglucosamine 4-epimerase, converting UDP-N-acetylglucosamine into UDP-N-acetylgalactosamine, is responsible for the presence of N-acetylgalactosamine in the EPS repeating units of both strains. (hud.ac.uk)
  • UDP-N-Acetylgalactosamine can be used for glycosylation of target molecules with a suitable enzyme. (roche.com)
  • Background: We investigated the activation of N-acetylgalactosamine-transferase11 (GALNT11) and the role of cyclophosphamide and cytarabine in expression of this enzyme in AML and CML patients. (ac.ir)
  • Chondroitin sulfate (CS) containing E-disaccharide units, glucuronic acid- N -acetylgalactosamine(4, 6- O -disulfate), at surfaces of tumor cells plays a key role in tumor metastasis. (hindawi.com)
  • Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. (guidetopharmacology.org)
  • Hapten inhibition assays indicated that the winter-aconite lectin is specific for N-acetylgalactosamine. (biochemj.org)
  • Acetylgalactosamine The N-acetyl derivative of galactosamine. (scitoys.com)
  • Several residues in the loops of the apex of domain II are responsible for the interactions with N- acetylgalactosamine . (bvsalud.org)
  • In this study, to clarify the role of E-units in the metastasis and to search for potential molecular targets for anticancer drugs, the isolation and characterization of Lewis lung carcinoma (LLC) cells stably downregulated by the knockdown for the gene encoding N -acetylgalactosamine 4- O -sulfate 6- O -sulfotransferase (GalNAc4S-6ST), which is responsible for the formation of E-units in CS chains, were performed. (hindawi.com)
  • To investigate the theoretical model of the three-dimensional structure of mosquitocidal Cry30Ca2 and its molecular docking with N- acetylgalactosamine . (bvsalud.org)
  • Docking studies were performed to investigate the interaction of Cry30Ca2 with N- acetylgalactosamine on the putative receptor. (bvsalud.org)
  • UDP-N-Acetylgalactosamine is an activated sugar, and can be used for in vitro glycoengineering of glycoproteins, e.g . therapeutic proteins. (roche.com)
  • Identification of N-Acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. (kingston.ac.uk)
  • Linton, D. , Allan, E. , Karlyshev, A.V. and Wren, B.W. (2001) Identification of N-Acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. (kingston.ac.uk)
  • The results are discussed with respect to findings in other brain areas and the possible co-localisation of gamma aminobutyric acid (GABA), parvalbumin and N-acetylgalactosamine. (uni-regensburg.de)
  • The binding sites of Sodium atom in the structure of CPGH89CBM32-5, From Clostridium Perfringens, in Complex With N-Acetylgalactosamine (pdb code 4aax ). (atomistry.com)
  • N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals. (wikipedia.org)
  • Morquio A syndrome (MPS IVA) is a recessive lysosomal storage disorder (LSD) caused by mutations in the GALNS gene leading to the deficiency of lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS). (unicatt.it)
  • 2010). Enzyme replacement therapy for mucopolysaccharidosis VI: Evaluation of long-term pulmonary function in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase . (up.pt)
  • 2010). Enzyme replacement therapy for mucopolysaccharidosis VI: Growth and pubertal development in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase . (up.pt)
  • 2008). Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase . (up.pt)
  • 2006). Enzyme replacement therapy for mucopolysaccharidosis VI: A phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-l . (up.pt)