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  • neurotransmitter acetylcholine
  • In the present study, we investigated the positive effects of the vagal neurotransmitter acetylcholine by suppressing CaSR activation in mesenteric arteries exposed to hypoxia/reoxygenation (H/R). The artery rings were exposed to a modified 'ischemia mimetic' solution and an anaerobic environment to simulate an H/R model. (mendeley.com)
  • Eat an apple or two: Apples stimulate production of the neurotransmitter acetylcholine , which is what the Alzheimer's drug Aricept also does, say University of Massachusetts researchers. (wordnik.com)
  • Choline is also the precursor molecule for the neurotransmitter acetylcholine which is involved in many functions both in the peripheral nervous system (PNS) and in the central nervous system (CNS). (abcam.com)
  • synaptic
  • Acetylcholine has been shown to enhance the amplitude of synaptic potentials following long-term potentiation in many regions, including the dentate gyrus, CA1 , piriform cortex , and neocortex . (bionity.com)
  • Sir Bernard Katz 'discoveries concerning the mechanism for the release of the transmitter acetylcholine from the nerve terminals at the nerve-muscle junction, under the influence of the nerve impulses, are fundamental not only for the understanding of the so-called cholinergic transmission, but are also of primary importance for our knowledge about the synaptic transmission between the nerve cells in the central nervous system. (wordnik.com)
  • In a sympathetic ganglion, the synaptic junctions, at which the acetylcholine is released by the incident preganglionic impulses, form a large part of the small amount of tissue perfused. (wordnik.com)
  • cerebral
  • Bourdois, P.S. and Mitchell, J.F., 1974, The output per stimulus of acetylcholine from cerebral cortical slices in the presence or absence of cholinesterase inhibition, Br. (springer.com)
  • atropine
  • Drugs that act on muscarinic acetylcholine receptors , such as atropine , can be poisonous in large quantities, but in smaller doses they are commonly used to treat certain heart conditions and eye problems. (wikipedia.org)
  • Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine . (bionity.com)
  • but only at ~ 1/3 the rate of ACh and it is resistant to BChE Pharmacological Properties of the Choline Esters 1 AChE2 CVS Acetylcholine Methacholine Carbachol Bethanechol 1 2 Muscarinic Effects GIT ++ ++ +++ +++ GUS ++ ++ +++ +++ Eye + + ++ ++ 3 Atropine +++ +++ + +++ 4 Nicotinic ++ + +++ - +++ + th ++ +++ + ± Goodman & Gilman 7 Ed. some substitutions result in resistance to hydrolysis carbachol. (scribd.com)
  • assay
  • Choline/Acetylcholine Assay Kit (ab65345) provides a simple and sensitive means for quantifying Choline and Acetylcholine by either a colorimetric or fluorometric method in samples such as blood, cells, culture media, fermentation media, etc. (abcam.com)
  • In the choline / acetylcholine assay protocol, free choline is oxidized to betaine, via the intermediate betaine aldehyde. (abcam.com)
  • Acetylcholine levels from mouse brain tissue was measured using Acetylcholine assay kit (ab65345). (abcam.com)
  • extracellular
  • When a contractile response was achieved with extracellular Ca2+, both acetylcholine and NPS2143 reversed the H/R-induced abnormal vascular vasoconstriction, and acetylcholine reversed the calcimimetic R568-induced abnormal vascular vasoconstriction in the artery rings. (mendeley.com)
  • cerebrospinal fluid
  • In addition, we performed a preliminary quantification of the levels of acetylcholine, neuropeptides, and monoamine metabolites in the cerebrospinal fluid (CSF) of patients with WS and benign convulsions associated with mild gastroenteritis (CwG). (hindawi.com)
  • Is acetylcholine (ACh) metabolism in brain reflected by changes in the cerebrospinal fluid (CSF)? (springer.com)
  • contraction
  • Acetylcholine, while inducing contraction of skeletal muscles, instead induces decreased contraction in cardiac muscle fibers. (bionity.com)
  • On release, acetylcholine acts almost instantly, to cause a sequence of chemical and physical events (starting with depolarization of the motor endplate) which cause contraction of the muscle fibre. (encyclopedia.com)
  • arteries
  • In conclusion, this study suggests that acetylcholine ameliorates the dysfunctional vasoconstriction of the arteries after H/R, most likely by decreasing CaSR expression and activity, thereby inhibiting the increase in intracellular calcium concentration. (mendeley.com)