AnatomyChemicals and DrugsPhenomena and ProcessesAnthropology, Education, Sociology and Social Phenomena
AcetylcarnitineCarnitineCarnitine O-AcetyltransferaseAcetyl Coenzyme APyruvate Dehydrogenase ComplexAcetyl-CoA HydrolaseSperm MaturationDichloroacetic AcidAcetatesCarnitine AcyltransferasesPyruvic AcidCoenzyme ACitric AcidEstersEpididymisLactic AcidMuscle, SkeletalMitochondria, LiverSpermatozoaExercise
CarnitineRatioSymptomsVitaminDietaryChronicBehavioralNaturallyALCARPrognosisInfertilityMetabolicClinical treatmentMetabolismDepressionCognitiveMonthsEfficacyAvoidAffectsLevelsMedical treatmentInfectionPatientsBloodNaturalADHDReductionResearchEffectivenessEffectiveStudyPotentialCancerDailyLeadChangeOptionsStudiesShortProblemsDrugs
Carnitine13
  • Acetylcarnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown. (wikipedia.org)
  • Acetylcarnitine is the most abundant naturally occurring derivative and is formed in the reaction: acetyl-CoA + carnitine ⇌ CoA + acetylcarnitine where the acetyl group displaces the hydrogen atom in the central hydroxyl group of carnitine. (wikipedia.org)
  • Since carnitine, namely l-acetyl-carnitine (LAC), has been demonstrated to be effective in the modulation of the central hypothalamic control of GnRH secretion, we aimed to evaluate whether a combined integrative treatment for 12 weeks of LAC (250 mg/die) and l-carnitine (500 mg/die) was effective in improving the endocrine and metabolic pathways in a group of patients (n = 27) with FHA. (researchgate.net)
  • L-acetyl carnitine (LAC) is an amino acid recommended for treatment of Attention Deficit Hyperactivity Disorder (ADHD) - another problem caused by FXS. (natural-fertility-prescription.com)
  • Previously, she and colleagues first implicated mGlu2 in depression when they showed that a promising potential treatment known as acetyl carnitine rapidly alleviated depression-like symptoms in rats and mice by reversing these epigenetic changes to mGlu2 and causing its levels to increase. (neurosciencenews.com)
  • C hronic Acetyl-L-Carnitine (ALCAR) treatment prevents some age-related memory impairment. (nootropic.com)
  • The amino acid L-acetylcarnitine (also called acetyl-L-carnitine) has been studied in older adults with mild cognitive decline. (novacorr.com.au)
  • Screening of amino acids and acyl carnitine in serum showed that the propionyl carnitine:acetylcarnitine ratio increased. (biomedcentral.com)
  • In a study that followed 37 healthy, nonsmoking mothers who were not taking carnitine as a supplement, carnitine and acetylcarnitine in breastmilk were measured over time. (drugs.com)
  • Immediately postpartum, the average milk carnitine concentration was 12.6 mg/L and acetylcarnitine was 5.7 mg/L. From 2 months postpartum to 12 months postpartum, carnitine and acetylcarnitine milk concentrations were lower, in the range of 6.1 to 8.9 mg/L for carnitine and 1.2 to 2 mg/L for acetylcarnitine. (drugs.com)
  • About one-third to one-half of the carnitine was free carnitine and the remainder was acetylcarnitine. (drugs.com)
  • Carnitine and acetylcarnitine were measured in the breastmilk of 14 lactating women who were 1 to 10 months postpartum and not taking carnitine as a supplement. (drugs.com)
  • Take 3 grams of L-Carnitine daily as part of a treatment of 3 months duration. (naturalremediesandcures.co.uk)
Ratio2
  • There is increased propionylcarnitine and/or increased propionylcarnitine-to-acetylcarnitine ratio in dried blood spots by tandem mass spectrometry (MS/MS). Diagnosis can be confirmed by somatic cell studies or molecular genetic testing. (orpha.net)
  • Neonatal screening for propionylcarnitine and/or increased propionylcarnitine- to-acetylcarnitine ratio in dried blood spots by tandem mass spectrometry (MS/MS) has become common, but specific identification of methylmalonic acid remains crucial. (rareguru.com)
Symptoms3
  • A single blind study showed significant improvement of memory and psychological symptoms during treatment with L-acetylcarnitine. (novacorr.com.au)
  • While a diabetic mouse will generally experience severe symptoms at the age of eight months, when started on a treatment of daily CoQ10 doses at the age of seven weeks, there were almost no issues present. (hockey-travel.com)
  • Effects of L-arginine treatment on symptoms and bladder nitric oxide levels in patients with interstitial cystitis. (therapeuticresearch.com)
Vitamin1
  • RESULTS: In lean mice, 39 metabolites were significantly changed by obestatin treatment and the majority of these were increased, including various C16 and C18 moieties of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and monoacylglycerol, along with vitamin A, vitamin D3, tyrosine, acetylcarnitine and 2α-(hydroxymethyl)-5α-androstane-3β,17β-diol. (asoi.info)
Dietary1
  • Despite dietary treatment, patients remain vulnerable to life-threatening metabolic decompensation. (orpha.net)
Chronic4
  • Lack of effect of inositol treatment in chronic schizophrenia. (joseph-levine.co.il)
  • Chronic ALCAR treatment enhanced spatial acquisition in the NE of rats with age-related behavioral impairments and had a slight effect on retention of the spatial discrimination in the FE. (nootropic.com)
  • Lifestyle change is the treatment of choice for all women with PCOS, and insulin sensitization is a promising choice for the chronic treatment of women with PCOS. (biomedcentral.com)
  • Marisa Leon-Carlyle reported on a 43 yr. old man with chronic treatment refractory depression who was given psilocybin 25mg (a 5HT2A agonist) at 8:00 AM after receiving trazodone 200mg HS (which should be enough to block 80% of 5HT2A receptors). (bipolarnews.org)
Behavioral1
Naturally1
  • BIONOVA skin care treatments use specially developed proprietary Nano-Complexes, which are composed from UV Chromophores (ultraviolet light absorbents) naturally existing in a human body. (shopbnscience.com)
ALCAR2
  • the review found that the pharmacology of ALCAR was poorly understood and that based on the lack of efficacy, ALCAR was unlikely to be an important treatment for AD. (wikipedia.org)
  • A meta-analysis from 2014 concluded that ALCAR could only be recommended for the treatment of persistent depressive disorder if publication bias was deemed improbable. (wikipedia.org)
Prognosis2
  • The prognosis is poor as no treatment is available for the primary disease. (medscape.com)
  • Because no treatment is available for the primary disease, prognosis is poor. (medscape.com)
Infertility2
  • Acetylcarnitine may be a useful for treatment of male infertility caused by low quantities of immobile sperm. (clarksnutrition.com)
  • Iva has dedicated her professional life to supporting couples on their path to parenthood with scientifically grounded information, protocols, and coaching around preconception care, natural infertility treatments, and integrative reproductive health. (natural-fertility-prescription.com)
Metabolic1
  • The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)
Clinical treatment3
  • This article is offered as a concise summary of research and clinical treatment issues pertaining to select natural products for which there is significant evidence. (psychiatrictimes.com)
  • In addition, the review provides a comprehensive overview of the current progress in the efficacy of insulin sensitization therapy in the management of PCOS, providing the latest evidence for the clinical treatment of women with PCOS and IR. (biomedcentral.com)
  • Furthermore, we aim to summarize and provide an update on the current research status of insulin sensitization therapy for women with PCOS to provide more effective and reasonable clinical treatment. (biomedcentral.com)
Metabolism3
  • Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. (bvsalud.org)
  • Therefore, the aim of this study was to use the novel technique of hyperpolarized magnetic resonance to investigate the in vivo effects of treatment with meldonium on cardiac metabolism and function in control and diabetic rats. (ox.ac.uk)
  • CONCLUSION: This investigation demonstrates that obestatin treatment affects phospholipid turnover and influences lipid homeostasis, whilst providing convincing evidence that obestatin may be acting to ameliorate diet-induced impairments in lipid metabolism, and it may influence steroid, bile acid, PAF and glutathione metabolism. (asoi.info)
Depression4
  • The results, published September 2 in Molecular Psychiatry , point toward potential new markers to aid the diagnosis of stress-related disorders, such as anxiety and depression and a promising route to the development of new treatments for these devastating disorders. (neurosciencenews.com)
  • Studies like this one are increasingly focusing on the regulation of glutamate as an underlying mechanism in depression and, we hope, opening promising new avenues for the diagnosis and treatment of this devastating disorder. (neurosciencenews.com)
  • Follow up study of inositol treatment for depression. (joseph-levine.co.il)
  • Barak Y, Stein D, Levine J, Ring A, Hadjez J, Elizur A, D. Shoshani D. Thyroxine augmentation of fluoxetine treatment for resistant depression in the elderly: An open trial. (joseph-levine.co.il)
Cognitive2
  • The effect of 6gm inositol treatment on post-ECT cognitive function in humans. (joseph-levine.co.il)
  • A study in healthy men did not show any enhancement of cognitive ability following treatment with choline, but other studies have shown that decreased choline levels are associated with memory dysfunction. (novacorr.com.au)
Months2
  • An updated Cochrane review in 2019 of four studies with 907 participants was very uncertain as to if ALC caused a pain reduction after 6 to 12 months of treatment. (wikipedia.org)
  • Each patient followed the treatment for 12 months, which involved 500 milligrams of LAC or a placebo given twice daily. (scienceblog.com)
Efficacy1
  • Our results suggest that targeting mTORC1 may be a feasible treatment strategy for COVID-19 patients, although further studies are required to determine the mechanism of inhibition and potential efficacy in patients. (bvsalud.org)
Avoid1
  • Avoid layering other treatments on the skin area to allow complete penetration and continued perfromance. (shopbnscience.com)
Affects1
  • This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. (bvsalud.org)
Levels2
  • Short term lithium treatment does not reduce CSF inositol levels. (joseph-levine.co.il)
  • OBJECTIVES: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys(10), Cys(13))) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obesity (DIO) C57BL6/J mice. (asoi.info)
Medical treatment3
  • Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. (clarksnutrition.com)
  • Conventional medical treatment could include surgery, radiotherapy, immunotherapy and chemotherapy. (asjo.in)
  • Is there an effective medical treatment? (doctorsmedicalopinion.com)
Infection3
  • Anemia, proteinuria, and hematuria continued after infusion of washed red blood cells (RBCs), methylprednisolone administration, and anti-infection treatment after hospital admission. (biomedcentral.com)
  • Sixteen cohort studies and six RCTs reported that 278 children experienced infection during treatment periods incidence 8. (digimediasolutions.in)
  • Changes in Weight After Switch to Dolutegravir/Lamivudine or Doravirine/Tenofovir/Lamivudine Compared to Continued Treatment With Dolutegravir/Tenofovir/Lamivudine for Virologically Suppressed HIV Infection. (go.jp)
Patients1
  • Introduction A retrospective clinical study was performed to identify the characteristics of patients with lung cancer treated with integrative cancer treatment in addition to conventional medicine. (asjo.in)
Blood1
  • Treatment with lycopene increased the sperm motility in bilateral testes, restored the enzyme activities of catalase and glutathione peroxidase, and restored the ischaemia (blocked blood flow) /reperfusion (restored blood flow)-induced tissue damage in bilateral testes 8 . (nourished.asia)
Natural2
ADHD1
  • We propose that LAC be recommended as a treatment of ADHD in FXS children," conclude the authors, "since it effectively reduces hyperactive behavior and improves social abilities without adverse side effects. (scienceblog.com)
Reduction1
  • One popular treatment for wrinkle reduction that has not yet found scientific support is the use of a cream with GABA (gamma-aminobutyric acid) . (drsupplementreviews.com)
Research1
Effectiveness1
  • Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. (therapeuticresearch.com)
Effective2
  • Since the arrival of combination therapy (and both advances came almost at the same time) viral load tests have become the only effective way to monitor how well HIV treatment is working. (ukcab.net)
  • Effective treatment against cellulitis, lipolysis, and body firming. (susenji.com.sg)
Study4
  • A Chinese study used Chinese ginseng for treatment of dementia after stroke and found some improvement. (novacorr.com.au)
  • In this study, the effects of CoQ10 and a six-month "long-term" treatment were examined in this mouse. (hockey-travel.com)
  • Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. (therapeuticresearch.com)
  • of heart Failure Treatment study. (qxmd.com)
Potential1
  • This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
Cancer1
  • Non-small cell lung cancer (NSCLC) treatment in advanced stage like IIIB, IIIC, and IV is based on several driver mutations analysis including mutations/alterations of the epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, and PDL-1 expression. (asjo.in)
Daily1
  • Daily treatment with either saline or meldonium (100 mg/kg/day) was undertaken for three weeks. (ox.ac.uk)
Lead1
  • Dr Andrew Clark is the Medical Director for HIV drugs at BMS, and will lead most of the treatment-related discussion. (ukcab.net)
Change1
  • In most instances, they are the only way to judge when to change treatment. (ukcab.net)
Options1
Studies1
  • Chemotherapy-induced peripheral neuropathy (CIPN): A review of two studies concluded that ALC may be a treatment option for paclitaxel- and cisplatin-induced CIPN, while a clinical trial showed it did not prevent CIPN and appeared to worsen the conditions in taxane therapy. (wikipedia.org)
Short1
  • Specifically, few Gene Ontology biological processes (BPs) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were modulated after a short (24H) compared to a long (48H) treatment. (nature.com)
Problems1
  • Treatment involves a protein-restricted diet, which should be instituted as soon as life-threatening problems such as ketoacidosis or hyperammonemia have been resolved. (orpha.net)
Drugs1
  • Insulin sensitization drugs are a new treatment modality for PCOS. (biomedcentral.com)