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  • mitochondrial
  • Although seminal discoveries have been made in the basic biology of mitochondrial acetylation, an understanding of how acetylation states influence enzyme function and metabolic reprogramming during pathological states remains largely unknown. (hindawi.com)
  • The implications of mitochondrial acetylation for the aging process will be discussed, as well as its potential implications for the unique and localized metabolic states that occur during the aging-associated conditions of heart failure and cancer growth. (hindawi.com)
  • We then suggest a role for alterations in mitochondrial acetylation states during age-related conditions of heart failure and cancer, as well as review its potential role in human longevity. (hindawi.com)
  • Further, in a mouse model, they detected elevated levels of mitochondrial protein acetylation at the earliest stages of heart failure. (medindia.net)
  • proteomics
  • This review will focus on summarizing our current understanding of the roles of protein acetylation in plant defense and highlight the utility of proteomics approaches to uncover the complete repertoire of acetylation changes triggered by pathogen infection. (frontiersin.org)
  • Antigens
  • This review discusses the O-acetylation status of CPSs and its role in the immunological responses of these antigens. (mdpi.com)
  • molecular
  • Histone acetylation: molecular mnemonics on the chromatin. (nih.gov)
  • View detailed Acetylation product specifications, including CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name. (scbt.com)
  • Using high-resolution cryo-EM maps of acetylated and deacetylated microtubules, in conjunction with molecular-dynamics methods, we found that acetylation restricts the range of motion of the αK40 loop. (pnas.org)
  • researchers
  • Using an unbiased screen to look for changes in protein acetylation, the researchers profiled heart tissue from 5 end-stage heart failure patients who went on to receive heart transplants. (medindia.net)
  • demonstrate
  • Our studies now demonstrate that the RelA subunit of NF-κB is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with IκBα. (sciencemag.org)
  • changes
  • Among the four types of loads, compression or stretch perpendicular to the microgrooves caused a decrease in HDAC activity, accompanied by the increase in histone acetylation and slight changes of nuclear shape. (nih.gov)