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  • molecules
  • This coenzyme plays a huge role in intermediary metabolism, in which cells synthesize, break down or use nutrient molecules for energy production, growth, etc. (healthboard.com)
  • Between them, they found that one of the central molecules involved in this process is a coenzyme (a molecule that helps an enzyme), which was named coenzyme A (or CoA for short). (bris.ac.uk)
  • The A stood for acetyl, since one of CoA's main jobs is to transfer two-carbon units in the form of acetyl between various biological molecules. (bris.ac.uk)
  • This means that the acetyl group can be easily transferred to other molecules, and so acetyl-CoA is used as a universal intermediate which provides the C 2 fragment for numerous biochemical syntheses. (bris.ac.uk)
  • The acetyl residue is then transported via the blood to other molecules residing in cells all over the body, where it is released and, in the presence of O 2 , oxidised to carbon dioxide. (bris.ac.uk)
  • acetate
  • In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. (uniprot.org)
  • ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. (uniprot.org)
  • For example, acetate-forming bacteria use acetyl-CoA for their autotrophic growth processes, and methanogenic archae such as Methanocarcina barkeri convert the acetyl-CoA into acetate and use it as an alternative source of carbon instead of CO2. (wikipedia.org)
  • Furthermore, the Wood-Ljungdahl pathway allows for the anaerobic oxidation of acetate where ATP is used to convert acetate into acetyl-CoA, which is then broken down by ACS to produce carbon dioxide that is released into the atmosphere. (wikipedia.org)
  • Organism
  • The two main overall reactions are as follows: The Acetyl-CoA produced can be used in a variety of ways depending on the needs of the organism. (wikipedia.org)
  • known
  • The most important acid is acetic acid, and when it is joined to CoA, the resulting compound is known as acetyl-CoA. (bris.ac.uk)
  • second
  • In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (uniprot.org)
  • active site
  • The carboxybiotin translocates to the carboxytransferase (CT) active site, where the carboxyl group is transferred to acetyl-CoA. (wikipedia.org)
  • energy
  • We believe that supplying the Krebs Cycle with enough substrates and increasing the Acetyl Coenzyme A (providing sufficient energy to the cell to sustain life) will be able to maintain the cell viable for prolonged periods of time. (thefreedictionary.com)