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Acyl Carrier ProteinAcetyl Coenzyme ACoenzyme ACrotonatesAcetyl-CoA CarboxylaseAcetyl-CoA C-AcetyltransferaseHydroxybutyratesAcetoacetatesAcyl Coenzyme AAcetyl-CoA C-AcyltransferasePolyestersPantetheinePyruvate CarboxylaseAcetate-CoA LigaseFatty Acid SynthasesLigasesATP Citrate (pro-S)-LyaseAcetatesBiotinMalonyl Coenzyme AAlcohol OxidoreductasesFatty AcidsAcetylcarnitineAcyltransferasesFatty Acid Synthase, Type II3-Oxoacyl-(Acyl-Carrier-Protein) SynthasePolyketide SynthasesAcetyltransferasesMagnesium CompoundsPantothenic AcidEscherichia coliRhizobium etliLiverTransferases (Other Substituted Phosphate Groups)Acylation3-Oxoacyl-(Acyl-Carrier-Protein) ReductaseKineticsMultienzyme ComplexesMevalonic AcidCitratesMolecular Sequence DataLipid MetabolismCaprylatesCarbon IsotopesAcetylationAmino Acid SequenceAcetylesteraseAMP-Activated Protein KinasesThiolester HydrolasesCoenzyme A LigasesCoenzyme A-TransferasesCitric Acid CycleSubstrate SpecificityCarbon-Sulfur LigasesCarrier StateGlucoseBacterial ProteinsHydroxymethylglutaryl CoA ReductasesEnoyl-(Acyl-Carrier-Protein) Reductase (NADH)Mitochondria, LiverCytosolCatalysisOrganophosphatesCarbon RadioisotopesAdenosine TriphosphatePhosphate AcetyltransferaseLipidsMalonatesCarrier ProteinsCloning, MolecularStreptomycesSequence Homology, Amino AcidCeruleninAdipose TissueModels, MolecularDietary CarbohydratesOxidation-ReductionSaccharopolysporaBase SequenceEstersRats, Inbred StrainsDrug CarriersApoproteinsTriclosanAcyl-Carrier Protein S-AcetyltransferaseMutationBinding SitesMolecular StructureInsulinOxo-Acid-LyasesDietary FatsAcetate KinaseProtein ConformationCrystallography, X-RayAnthraquinonesRecombinant ProteinsRNA, MessengerEnergy MetabolismPhenylacetatesCarnitine

SynthetaseThiolaseAcyltransferasePyruvateOxaloacetateMitochondriaFatty acidsMitochondrialSynthaseCoenzymeCondensationProteinPeroxisomalProteinsFormProduceCycleAcetyltransferaseAcat1Acetic acidTransferaseEnzymeDehydrogenaseSynthetaseCytosolMalonylThioesteraseCitric AcidCytoplasmReductaseCarnitineAcidPathwayImportantComplexSource

Synthetase2

• Acyl CoA Synthetase: What is it/What does it do? (flashcardmachine.com)
• Then, bile acyl-CoA synthetase teams up with 3a,7a-dihydroxycoprostanic acid to create 3a,7a-dihydroxy-5b-cholestanoyl-CoA. (smpdb.ca)

Thiolase3

• 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid β-oxidation. (expasy.org)
• Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly β-hydroxybutyrate synthesis or steroid biogenesis. (expasy.org)
• In eukaryotes, there are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes. (expasy.org)

Acyltransferase1

• Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx. (expasy.org)

Pyruvate2

• To produce energy G-6-PO 4 (derived from monosaccharides from dietary CHO or produced from glycogen degradation by glycogenolysis) is converted by a series of enzyme reactions in the glycolytic pathway to form pyruvate or lactic acid, then to acetyl-CoA, which is also produced from fatty acid oxidation and degradation of the carbon skeleton of glucogenic amino acids ( Table 17.1 ). (oncohemakey.com)
• Glycerol is then oxidised to acetyl-CoA via pyruvate. (oncohemakey.com)

Oxaloacetate1

• Within the Krebs cycle acetyl-CoA, combined with oxaloacetate, undergoes cycles involving eight enzymes, in which reducing equivalents are produced which then enter the electron transfer chain for the production of energy as adenosine triphosphate (ATP). (oncohemakey.com)

Mitochondria3

• Acetyl-CoA enters the Krebs cycle, also known as the citric acid or tricarboxylic (TCA) cycle, within the mitochondria. (oncohemakey.com)
• Fatty acids enter the mitochondria via the carnitine transport cycle (medium chain fatty acids enter independently of carnitine) into the β-oxidation spiral in which fatty acids, via a series of enzymes, produce acetyl-CoA and electron carriers. (oncohemakey.com)
• Revisiting 7a-hydroxy-cholestene-3-one, the second chain of reactions it is involved in follows a similar path as the first, moving through the mitochondria, endoplasmic reticulum and peroxisome until choloyl-CoA is formed, which then is used in three reactions so that its derivatives may leave the cell to interact with intestinal microflora and become taurodeoxycholic acid, deoxycholic acid glycine conjugate and deoxycholic acid. (smpdb.ca)

Fatty acids1

• Dietary fats, and lipids produced endogenously from acetyl-CoA, are initially hydrolysed by lipases into glycerol and free fatty acids. (oncohemakey.com)

Mitochondrial1

• How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)

Synthase1

• 3-ketoacyl-CoA synthase n=1 Tax=Physcomitrella patens subsp. (uma.es)

Coenzyme1

• Peroxisomal acyl coenzyme A oxidase 2 converts 3a,7a-dihydroxy-5b-cholestanoyl-CoA into 3a,7a-dihydoxy-5b-cholest-24-enoyl-CoA. (smpdb.ca)

Condensation1

• The adenylation domain (A) acts first to activate the amino acid tryptophan and subsequently transfer it to the peptidyl carrier protein (PCP) domain (T). Following this, the condensation domain (C) catalyzes an amide bond formation between the acetoacetyl moiety attached to the ACP and tryptophan attached to the PCP. (wikipedia.org)

Protein3

• The catalytically important acyl carrier protein domain (ACP), acyl transferase domain (AT), and ketosynthase domain (KS) work together to form acetoacetyl-CoA from the precursors acetyl-CoA and malonyl-CoA. (wikipedia.org)
• Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (expasy.org)
• From there, propionyl-CoA and chenodeoxycholoyl-CoA join forces and enlist the help of non-specific lipid transfer protein to further chenodeoxycholoyl-CoAâ€TMs journey in the peroxisome. (smpdb.ca)

Peroxisomal2

• With the help of water, peroxisomal multifunctional enzyme type 2 turns 3a,7a-dihydoxy-5b-cholest-24-enoyl-CoA into 3a,7a,24-trihydoxy-5b-cholestanoyl-CoA. (smpdb.ca)
• This compound then uses peroxisomal multifunctional enzyme type 2 to create chenodeoxycholoyl-CoA. (smpdb.ca)

Proteins1

• What happens if you lack the proteins to transport Acyl-Coa into the matrix? (flashcardmachine.com)

Form1

• Acetyl-CoA can enter the Krebs cycle or form ketone bodies in the liver. (oncohemakey.com)

Produce2

• It uses the precursors acetyl-CoA, malonyl-CoA, and tryptophan to produce cyclo-acetoaceytl-L-tryptophan (cAATrp). (wikipedia.org)
• Electron carriers (FADH 2 and NAD) enter the electron transfer chain to produce ATP. (oncohemakey.com)

Cycle1

• Acetyl-CoA in excess of requirements for energy production via the Krebs cycle is converted via lipogenesis to stored lipids in adipocytes. (oncohemakey.com)

Acetyltransferase3

• Beta-ketothiolase caused by defects in the acetyl-CoA acetyltransferase 1 (ACAT1) gene. (biomedres.us)
• acetyl-CoA acetyltransferase 1 [Source:H. (gsea-msigdb.org)
• The pathway begins in the cytoplasm with acetyl-CoA and acetoacetyl-CoA, which interact with acetyl-CoA acetyltransferase, coenzyme A and water to synthesize hydroxymethylglutaryl-CoA synthase. (smpdb.ca)

Acat11

• 2-methylacetoacetyl CoA thiolase encodes by ACAT1 gene and acts at the end stage of isoleucine amino acid catabolism pathway. (biomedres.us)

Acetic acid2

• When the acetic acid gets attached to coA, we will call it acetyl CoA. (prepladder.com)
• Acetyl-CoA is the acyl-CoA of acetic acid (also known as acetate). (amboss.com)

Transferase2

• The catalytically important acyl carrier protein domain (ACP), acyl transferase domain (AT), and ketosynthase domain (KS) work together to form acetoacetyl-CoA from the precursors acetyl-CoA and malonyl-CoA. (wikipedia.org)
• Acyl CoA with carnitine gives acylcarnitine, and the enzyme is carnitine acyl transferase 1 (rate-limiting enzyme). (prepladder.com)

Enzyme3

• An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. (nih.gov)
• An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. (bvsalud.org)
• As soon as fatty acid gets into any cell, irrespective of the final fate of fatty acid, the 1st enzyme to act on this fatty acid will be acetyl CoA synthetase. (prepladder.com)

Dehydrogenase1

• Then, we tested different enzymes for the subsequent pathway reactions: the 3-hydroxyacyl-CoA dehydrogenase PaaH1 increased hexanoic acid production to 33 mg/L, and the expression of enoyl-CoA hydratases Crt2 or Ech was critical to producing octanoic acid, reaching titers of 40 mg/L in both cases. (biomedcentral.com)

Synthetase2

• This acetyl CoA synthetase uses 1 ATP which gets converted to AMP + PPI. (prepladder.com)
• This step uses two high energy phosphate and successfully converts fatty acid into acetyl CoA The purpose of acyl CoA synthetase is to trap fatty acid within the cell.Fatty acids are nonpolar substances. (prepladder.com)

Cytosol1

• p Fatty acids are synthesized by an a a , which is responsible for the complete synthesis of palmitate from acetyl-CoA in the cytosol. (promotionalceramics.eu)

Malonyl2

• It uses the precursors acetyl-CoA, malonyl-CoA, and tryptophan to produce cyclo-acetoaceytl-L-tryptophan (cAATrp). (wikipedia.org)
• Bicarbonate as a source of CO2 is required in the initial reaction for carboxylation of acetyl-CoA to malonyl-CoA in the presence of ATP & Acetyl-CoA carboxylase that requires vitamin Biotin.requires vitamin Biotin. (dokumen.tips)

Thioesterase2

• Finally, we also tested the deletion of two potential medium-chain acyl-CoA depleting reactions catalyzed by the thioesterase Tes1 and the medium-chain fatty acyl CoA synthase Faa2. (biomedcentral.com)
• acyl-CoA thioesterase 13 [Source:HGNC Sy. (gsea-msigdb.org)

Citric Acid2

• This then combines with Acetyl CoA, which is metabolised in the Citric Acid Cycle. (promotionalceramics.eu)
• 2nd phase: Every acetyl CoA Enters into citric acid Cycle every acetyl CoA molecule. (prepladder.com)

Cytoplasm1

• Once the acylcarnitine has entered the matrix if you retain the carrier the same carrier will put the acylcarnitine back into cytoplasm. (prepladder.com)

Reductase1

• In all cases, Ter from Treponema denticola was the preferred trans-enoyl-CoA reductase. (biomedcentral.com)

Carnitine2

• The diagnosis of this disorder is straightforward and includes an elevated level of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid and tiglylglycine in urine organic acids analysis and elevated levels of acylcarnitines C5:1 and C5OH in blood acyl carnitine profile analysis [5]. (biomedres.us)
• Carnitine acyltransferase 2 releases the carnitine back and converts acylcarnitine to acyl CoA. (prepladder.com)

Acid1

• Oxidation of Fatty Acids Fatty Acid Acetyl CoA KREBS CYCLE OXIDATIVE PHOSPHORYLATION Production of ATPs There are several theories about oxidation of fatty acids. (promotionalceramics.eu)

Pathway3

• a) Kennedy pathway dependent on acyl-CoA and (b) the phospholipid diacylglycerol acyltransferase (PDAT) mediated alternative pathway, which uses fatty acids from lipids turnover. (biomedcentral.com)
• We also co-expressed a butyryl-CoA pathway variant to increase the butyryl-CoA pool and support the chain extension. (biomedcentral.com)
• Four inactive studies initiate imported producing with SCAD CoA download Flower( Short Chain) dialog, composed by the p14-ARF NCAM tumour of translation, the focal signal pathway of the different ligand adjacent cell( SCHAD), and detected by the acyl-tRNA nursing Session, dependent in the PER subunits submitted recent death. (evakoch.com)

Important1

• Fatty acids and triacylglycerols (TAGs) are important energy carriers. (promotionalceramics.eu)

Complex1

• A significant affinity of the thesis complex hyperbilirubinemia class decanoyl-CoA. (evakoch.com)

Source1

• ethylmalonyl-CoA decarboxylase 1 [Source. (gsea-msigdb.org)