Glycine C-acetyltransferase (EC 2.3.1.29 ), which catalyzes the addition of acetyl-CoA to glycine to form 2-amino-3-oxobutanoate (gene kbl). (expasy.org)
8-amino-7-oxononanoate synthase (EC 2.3.1.47 ) (7-KAP synthase), a bacterial enzyme (gene bioF) which catalyzes an intermediate step in the biosynthesis of biotin: the addition of 6-carboxy-hexanoyl-CoA to alanine to form 8- amino-7-oxononanoate. (expasy.org)
N-Acetyl-L-glutamine (NAcGln) or N-Acetylglutamine, belongs to the class of organic compounds known as N-acyl-alpha amino acids. (hmdb.ca)
N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. (hmdb.ca)
Carboxylase2
Acetyl-coenzyme A carboxylase catalyzes the first committed step of fatty acid biosynthesis. (rcsb.org)
In Escherichia coli, the three components reside in separate subunits: a biotinyl domain is the functional portion of one of these, biotin carboxy carrier protein (BCCP). (rcsb.org)
[7] Biotin -coupled processes effect the decarboxylation of malonyl-CoA to acetyl-CoA . (wikipedia.org)
Malyl-CoA l1
The enzyme malyl-CoA lyase (EC 4.1.3.24) catalyzes the chemical reaction (3S)-3-carboxy-3-hydroxypropanoyl-CoA ⇌ {\displaystyle \rightleftharpoons } acetyl-CoA + glyoxylate This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. (wikipedia.org)
They occur naturally as N-acetyl derivatives in peptidoglycan, the characteristic polysaccharide composing bacterial cell walls. (lookformedical.com)
Mitochondria3
During strenuous exercise, a large portion of L-carnitine and unused acetyl-CoA are converted to ALCAR and CoA inside mitochondria by carnitine O-acetyltransferase.The ALCAR is transported outside the mitochondria where it converts back to the two constituents. (aksci.com)
The L-carnitine is cycled back into the mitochondria with acyl groups to facilitate fatty acid utilization, but excess acetyl-CoA may block it.Excess acetyl-CoA causes more carbohydrates to be used for energy at the expense of fatty acids. (aksci.com)
ALCAR transport decreases acetyl-CoA inside the mitochondria, but increases it outside.Glucose metabolism in diabetics improves with administration of either ALCAR or L-carnitine. (aksci.com)
Acid1
5-aminolevulinic acid synthase (EC 2.3.1.37 ) (delta-ALA synthase), which catalyzes the first step in heme biosynthesis via the Shemin (or C4) pathway, i.e. the addition of succinyl-CoA to glycine to form 5- aminolevulinate. (expasy.org)
Carnitine3
Acetyl-L-carnitine or ALCAR, is an acetylated form of L-carnitine (a betaine derivative of beta-hydroxybutyrate, is found in virtually all cells of higher animals and also in some microorganisms and plants. (aksci.com)
Acetyl-L-carnitine is also used as a dietary supplement as a more orally available precursor to L-carnitine in regards to carbohydrate and fat metabolism. (aksci.com)
No authors listed] Acetyl-L-carnitine. (aksci.com)
Enzyme2
The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). (wikipedia.org)
In particular, N-Acetylglutamine can be biosynthesized from L-glutamine and acetyl-CoA by the enzyme glutamine N-acyltransferase (EC 2.3.1.68). (hmdb.ca)
Reactions1
In the first one, known as the mevalonate pathway, acetyl-CoA is transformed into farnesyl pyrophosphate, while the reactions in the second module are responsible for the conversion of farnesyl pyrophosphate into JH 8 . (nature.com)
Catalyzes1
Serine C-palmitoyltransferase (EC 2.3.1.50 ) from yeast (genes LCB1 and LCB2), which catalyzes the condensation of palmitoyl-CoA and serine to form 3-ketosphinganine. (expasy.org)
Transport1
What happens if you lack the proteins to transport Acyl-Coa into the matrix? (flashcardmachine.com)
Include1
Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. (wikipedia.org)
Term1
Enzymes that catalyze decarboxylations are called decarboxylases or, the more formal term, carboxy-lyases ( EC number 4.1.1). (wikipedia.org)
Groups1
Finally, xylan is known to be highly substituted with O -acetyl groups, whose release leads to a reduction in pH that can have an inhibitory effect on fermentative microorganisms [ 8 ]. (biomedcentral.com)
Coenzyme8
Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. (wikipedia.org)
9. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. (nih.gov)
16. ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke. (nih.gov)
Enzymes which transfer coenzyme A moieties from acyl- or acetyl-CoA to various carboxylic acceptors forming a thiol ester. (lookformedical.com)
In particular, N-Acetyl-L-aspartic acid can be synthesized in neurons from the amino acid aspartate and acetyl coenzyme A (acetyl CoA). (hmdb.ca)
In turn, this synthase teams up with coenzyme A and a hydrogen ion in the endoplasmic reticulum to create 3-hydroxy-3-methylglutaryl-CoA. (smpdb.ca)
Acetyl-L-carnitine is a mitochondrial metabolite that facilitates the movement of fatty acids into the mitochondria for energy and is also used to generate acetyl coenzyme A. '-Lipoic acid is a coenzyme involved in mitochondrial ATP production and its reduced form can recycle other antioxidants. (nih.gov)
Amino Acids2
N-Acetyl-L-leucine or N-Acetylleucine, belongs to the class of organic compounds known as N-acyl-alpha amino acids. (hmdb.ca)
N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. (hmdb.ca)
Hydrolase1
In the ortho-cleavage pathway ( link ), the 3,4-oxygenase pcaHG cleaves the ring to 3-carboxy-cis,cis-muconate, a cycloisomerase forms 4-carboxymuconolactone (2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate), a decarboxylase forms 3-oxoadipate enol lactone ((4,5-dihydro-5-oxofuran-2-yl)-acetate), and a hydrolase forms 3-oxoadipate. (lbl.gov)
Isomerase1
and an unknown isomerase forms trans-2,3-dehydroadipyl-CoA. (lbl.gov)
Cleavage1
Comment: In the meta-cleavage pathway ( link ), the 4,5-dioxygenase ligAB splits protocatechuate to 4-carboxy-2-hydroxymuconate-6-semialdehyde. (lbl.gov)
Pathway1
This is converted to succinyl-CoA as in the anaerobic pathway (paaF, paaH, and paaJ2). (lbl.gov)
Family1
CoA-transferase family III [Interproscan]. (ntu.edu.sg)
Activity1
In this formulation, acetyl-L-carnitine hydrochloride is thought to increase general metabolic activity and to improve cognitive function. (nih.gov)