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  • substrate
  • The C16 acyl-CoA product acts as a substrate for the synthesis of meromycolic acid by FAS-II, whereas the C26 fatty acid constitutes the alpha branch of the final mycolic acid. (wikipedia.org)
  • The catalytic activity and substrate specificity of mtFabH has been measured then further probed using crystallographic and directed mutagenesis methods Structures have been determined of ecFabH bound with substrates, (CoA, malonyl CoA, degraded CoA). (wikipedia.org)
  • BAHDs typically have low substrate selectivity, and can use a variety of CoA thioester and alcohol co-substrates. (wikipedia.org)
  • In the first step of both the degradative and biosynthetic reactions, the nucleophilic Cys89 (or its equivalent) attacks the acyl-CoA (or 3-ketoacyl-CoA) substrate,leading to the formation of a covalent acyl-CoA intermediate. (wikipedia.org)
  • benzoate
  • 2015). These are benzoyl-CoA:benzyl alcohol O-benzoyltransferase (PtBEBT) that produces benzyl benzoate from benzoyl-CoA and benzyl alcohol (Chedgy et al. (wikipedia.org)
  • 2015), and benzoyl-CoA:salicyl alcohol O-benzoyltransferase (PtSABT) that produces salicyl benzoate from benzoyl-CoA and salicyl alcohol (Chedgy et al. (wikipedia.org)
  • Constabel, C Peter (2015) Functional characterization of two acyltransferases from Populus trichocarpa capable of synthesizing benzyl benzoate and salicyl benzoate, potential intermediates in salicinoid phenolic glycoside biosynthesis. (wikipedia.org)
  • characterization
  • Matern, Ulrich (1997) Characterization and heterologous expression of hydroxycinnamoyl/benzoyl-CoA:anthranilate N-hydroxycinnamoyl/benzoyltransferase from elicited cell cultures of carnation, Dianthus caryophyllus L. Plant Mol Biol 35:777-789. (wikipedia.org)
  • degradation
  • All thiolases, whether they are biosynthetic or degradative in vivo, preferentially catalyze the degradation of 3-ketoacyl-CoA to form acetyl-CoA and a shortened acyl-CoA species, but are also capable of catalyzing the reverse Claisen condensation reaction. (wikipedia.org)
  • pathways
  • It was the aim of this study to elucidate the organization of its CoA-derived pathways and to use the genomic information of X. dendrorhous for a phylogenomic investigation of the Basidiomycota. (biomedcentral.com)
  • known
  • 1998). In plants, BAHD acyltransferases are often involved in the production of phenolic secondary metabolites, for example in Poplar (Populus trichocarpa) at least two BAHD acyltransferases are required for the production of potent defence/anti-herbivory compounds known as the salicinoid phenolic glycosides (Chedgy et al. (wikipedia.org)
  • catalytic
  • The amino-terminal alpha-helical domain particularly the amino acid residues His158 (histidine in position 158) and Asp143 (aspartic acid in position 143) form a catalytic triad with the substrate for acetyl transfer. (wikipedia.org)
  • cholesterol
  • Human Acyl-Coenzyme A:Cholesterol Acyltransferase 1 (acat1) Sequences Located in Two Different Chromosomes (7 and 1) Are Required to Produce a Novel ACAT1 Isoenzyme with Additional Sequence at the N Terminus" (Free full text). (wikipedia.org)
  • activity
  • However, when using acetyl alcohol as the acyl acceptor, AWAT1 prefers saturated acyl groups, while AWAT2 shows activity with all four acyl-CoAs and performs two times better with unsaturated acyl-CoAs than with saturated ones. (wikipedia.org)