Acetyl coa c acetyltransferase. Medical search. Frequent questions

Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. (wikipedia.org)
Mutations of the ACAT1 gene are associated with a deficiency in acetoacetyl-CoA thiolase and subsequently an increase in cholesterol compounds. (myhappygenes.com)
Abdelkreem E, Harijan RK, Yamaguchi S, Wierenga RK, Fukao T. Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. (medlineplus.gov)
Kano M, Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T. Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene. (medlineplus.gov)

Acetyl-CoA C-acetyltransferase belongs to the thiolase family of enzymes. (wikipedia.org)
It is a substrate for succinyl-CoA:3-ketoacid-coenzyme A transferase, hydroxymethylglutaryl-CoA synthase, short-chain 3-hydroxyacyl-CoA dehydrogenase, peroxisomal bifunctional enzyme, acetyl-CoA acetyltransferase, and 3-ketoacyl-CoA thiolase. (hmdb.ca)
Beta-ketoadipyl CoA thiolase (EC 2.3.1. (lbl.gov)

In enzymology, an acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction 2 acetyl-CoA ⇌ {\displaystyle \rightleftharpoons } CoA + acetoacetyl-CoA Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA. (wikipedia.org)
The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. (wikipedia.org)
Arylalkylamine N-acetyltransferase) This enzyme is critical in the production of melatonin from serotonin. (myhappygenes.com)
Acetyl CoA Acetyl Transferase) This gene encodes an enzyme located in the mitochondria that catalyze the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. (myhappygenes.com)
12q14 (Sanfilippo syndrome): The diagnosis requires a specific lysosomal enzyme assay for glucosamine ( N -acetyl)-6-sulfatase (GNS) activity. (medscape.com)
[ 34 ] Individuals with type B lack the enzyme N -acetyl-alpha-D-glucosaminidase (NAG). (medscape.com)
The properties of the membrane-bound enzyme acting on endogenous, glycoprotein-bound N-acetyl- and N-glycolylneuraminic acids were compared with those of the soluble enzyme, O-acetylating exogenous, non-glycosidically bound N-acetyl- and N-glycolyneuraminic acids. (nih.gov)
The enzyme activity shows an optimum at pH 7 and has a Km for acetyl-CoA of 0.1 mM. (nih.gov)
The soluble enzyme activity, assayed using a radioactive procedure, shows Km values of 0.01 mM, 0.5 mM and 0.39 mM for acetyl-CoA, N-acetylneuraminic acid and N-glycolylneuraminic acid respectively. (nih.gov)
One Unit of phosphotransacetylase activity is defined as the amount of enzyme required to release one µmole of acetyl-CoA per minute from Coenzyme A (0.44 mM) in Tris.HCl buffer (86 mM) pH 7.4 at 25 o C. (megazyme.com)
The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. (abnova.com)
Glycine C-Acetyltransferase (GCAT) is the 2nd enzyme in this pathway, which subsequently catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. (prospecbio.com)
Although a G protein-coupled PAF receptor and degradation enzymes have been cloned and characterized, the PAF biosynthetic enzyme, aceyl-CoA:lyso-PAF acetyltransferase, has not been identified. (rhea-db.org)
Surprisingly, the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). (rhea-db.org)
Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. (rhea-db.org)
Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF. (rhea-db.org)
In 1976, the enzyme deficiency in Morquio syndrome type IVA (galactosamine-6-sulfatase deficiency [ie, N -acetyl-galactosamine-6-sulfate sulfatase deficiency]) was identified. (medscape.com)

Rabbit Acetyl CoA acetyltransferase, mitochondrial ELISA kit is suitable for detecting samples from rabbit species. (elisakit.cc)

In humans, acetoacetyl-CoA is involved in the metabolic disorder called the short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (HADH) pathway. (hmdb.ca)

CusabioAlternative Name(s): Acetyl-CoA transferase-like protein Cytosolic acetoacetyl-CoA thiolaseGene Names: ACAT2Research Areas: MetabolismOrganism: Homo sapiens. (joplink.net)

Acetoacetyl-CoA is an intermediate in the metabolism of butanoate. (hmdb.ca)

Structure and ligand of a histone acetyltransferase bromodomain. (embl-heidelberg.de)
Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain bromodomains, which are approximately 110-amino-acid modules found in many chromatin-associated proteins. (embl-heidelberg.de)
The nature of the recognition of acetyl-lysine by the P/CAF bromodomain is similar to that of acetyl-CoA by histone acetyltransferase. (embl-heidelberg.de)
The histone acetyltransferase (Head wear) p300/CBP is a transcriptional coactivator implicated in lots of gene regulatory pathways and protein acetylation events. (woofahs.com)
2007). While research on histone deacetylases buy 1062159-35-6 possess resulted in the breakthrough of highly powerful compounds with scientific impact in tumor, the id of histone acetyltransferase inhibitors provides proved more difficult (Cole, 2008). (woofahs.com)

This review sets out what we know about the broader substrate specificity and regulation of acetyl- ases and goes on to compare acetylation with the process of phosphorylation. (embl-heidelberg.de)
2009). A recently available high res X-ray framework from the p300 Head wear in complex using the bisubstrate analog Lys-CoA provides revealed key areas of substrate reputation and catalytic system (Liu et al. (woofahs.com)
2008). This strike and operate kinetic mechanism requires initial, steady binding of acetyl-CoA accompanied by weakened and transient discussion with histone substrate which. (woofahs.com)
The reactions were performed at 50 °C. The co-substrate, acetyl-CoA, was supplied at the saturated concentration of 2 mM. (biomedcentral.com)

Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). (smpdb.ca)

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human geneome, and is orthologous to the mouse and rat Nat2 genes. (abnova.com)

As part of a project on environmental disasters in minority populations, this study aimed to evaluate differences in the sequence of N-acetyltransferase 2 ( NAT2 ) as a metabolic susceptibility gene in yet unexplored ethnicities. (aacrjournals.org)

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). (smpdb.ca)

This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively). (biologists.com)

Comment: Produces two acetyl-CoA from acetoacetyl-CoA and CoA. (lbl.gov)

1996). Within the ensuing years, p300/CBP provides been shown to be always a rather promiscuous acetyltransferase, with an increase of than 75 proteins substrates referred buy 1062159-35-6 to including p53, MyoD, and NFB (Gu et al. (woofahs.com)

Acetoacetyl-CoA belongs to the class of organic compounds known as aminopiperidines. (hmdb.ca)

The overall structures confirm the close relatedness to experimentally validated homoserine acetyl transferases, but simultaneously the structures exclude the ability of MekB and CgHle to bind homoserine and acetyl-CoA. (rcsb.org)
Insofar the MekB and CgHle structures suggest dividing the homoserine transacetylase family into subfamilies, namely genuine acetyl transferases and acetyl esterases with MekB and CgHle as constituting members of the latter. (rcsb.org)

[ 6 ] Patients with type C lack acetyl-CoA:alpha-glucosaminide acetyltransferase. (medscape.com)
2009). The strongest and selective substance, Lys-CoA (Ki=20 nM), continues to be changed into a cell permeable type with Tat peptide connection (Lys-CoA-Tat) and continues to be used in a number of research, but its intricacy is somewhat restricting for pharmacologic applications (Lau et al. (woofahs.com)

2. Acetyl-CoA: N-acetylneuraminate-9(or 7)-O-acetyltransferase activity was found in a microsome fraction and in the cytosol of bovine submandibular glands. (nih.gov)
Divalent cations, EDTA and glutathione have no influence on its activity while CoA proved to be a competitive inhibitor with a Ki of 0.56 mM. 4. (nih.gov)

Here, we cloned lyso-PAF acetyltransferase, which is critical in stimulus-dependent formation of PAF. (rhea-db.org)

The PDC catalyses the transfer of the acetyl group from pyruvate to coenzyme A (CoA) to form acetyl-CoA. (gla.ac.uk)
Specifically, the enzyme known as aspartate N-acetyltransferase (EC 2.3.1.17) catalyzes the transfer of the acetyl group of acetyl CoA to the amino group of aspartate. (hmdb.ca)
A detailed model of the ternary Michaelis complex fully supports the direct transfer of the acetyl group from acetyl-CoA to choline through a mechanism similar to that seen in the serine hydrolases for the formation of an acyl-enzyme intermediate. (inra.fr)

Dysfunctional endoplasmic reticulum-based acetylation, as caused by overexpression of the acetyl coenzyme A transporter AT-1 in the mouse, results in altered glycoprotein flux through the secretory pathway and an autistic-like phenotype. (wisc.edu)
AT-1 works in concert with SLC25A1, the citrate/malate antiporter in the mitochondria, SLC13A5, the plasma membrane sodium/citrate symporter, and ATP citrate lyase, the cytosolic enzyme that converts citrate into acetyl coenzyme A. Here, we report that mice with neuron-specific overexpression of SLC13A5 exhibit autistic-like behaviours with a jumping stereotypy. (wisc.edu)
Overall, our results support a mechanistic link between aberrant intracellular citrate/acetyl coenzyme A flux and the development of an autistic-like phenotype. (wisc.edu)
It can also lead to acetyl-coenzyme A (acetyl-CoA) production, indirectly activating histone acetyltransferases (HATs). (epigenie.com)
In particular, N-Acetyl-L-aspartic acid can be synthesized in neurons from the amino acid aspartate and acetyl coenzyme A (acetyl CoA). (hmdb.ca)
Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. (proteopedia.org)
An enzyme that catalyzes the acetyltransferase reaction using ACETYL CoA as an acetyl donor and dihydrolipoamide as acceptor to produce COENZYME A (CoA) and S-acetyldihydrolipoamide. (bvsalud.org)
Lysine acetyltransferases must bind acetyl-Coenzyme A and have a catalytic domain. (nih.gov)
This enzyme is also called acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase . (alchetron.com)

Effects of Heparan sulfate acetyl-CoA: Alpha-glucosaminide N-acetyltransferase (HGSNAT) inactivation on the structure and function of epithelial and immune cells of the testis and epididymis and. (mcgill.ca)
The deficient enzyme in Sanfilippo syndrome C, or MPS IIIC, is an acetyltransferase that catalyzes the conversion of alpha-glucosaminide residues to N-acetylglucosaminide in the presence of acetyl-CoA. (nih.gov)

pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). (gla.ac.uk)

The catalytic domain of dihydrolipoyl transacetylase (E2pCD) forms the core of the pyruvate dehydrogenase multienzyme complex and catalyzes the acetyltransferase reaction using acetylCoA as acetyl donor and dihydrolipoamide (Lip(SH)2) as acceptor. (rcsb.org)

In humans, PDC converts pyruvate to acetyl-CoA, which leads into the citric acid cycle located in the mitochondrion. (gla.ac.uk)

In this abortive ternary complex, CoA adopts a helical conformation with two intramolecular hydrogen bonds and the reactive sulfur of the pantetheine arm positioned 12 A away from the active site residues involved in the transferase reaction. (rcsb.org)

The substrates, chloramphenicol and acetyl-S-CoA were both able to protect against the loss of activity. (figshare.com)
If in vivo the constants are of the same order of magnitude as in vitro, the synthesis of N-acetylglutamate, an obligate activator of the first step of urea synthesis, can be expected to occur in the mitochondrion under conditions where the amino acid acetyltransferase is not saturated by its substrates. (rhea-db.org)
To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine carnitine acetyltransferase (CrAT) in a ternary complex with its substrates acetyl-CoA and carnitine, and the structure of the S554A/M564G double mutant in a ternary complex with the substrates CoA and hexanoylcarnitine. (proteopedia.org)
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. (proteopedia.org)
Thus, the two substrates of this enzyme are acetyl-CoA and 10-desacetyltaxuyunnanin C, whereas its two products are CoA and taxuyunnanin C. (alchetron.com)

Acetylcholine (ACh) is synthesized by choline acetyltransferase (ChAT) that transfers the acetate moiety from acetyl-CoA onto choline. (bu.edu)
Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine from choline and acetyl-CoA, and its presence is a defining feature of cholinergic neurons. (inra.fr)
Human choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA. (inra.fr)
Choline acetyltransferase (ChAT) catalyzes the transfer of an acetyl group from acetyl-CoA to choline to produce the neurotransmitter acetylcholine (ACh). (inra.fr)

enoyl-CoA delta isomerase 1 [Sourc. (gsea-msigdb.org)

Studies on a chloramphenicol acetyltransferase variant. (figshare.com)
An E.coli Chloramphenicol Acetyltransferase Type III variant has been purified and characterized. (figshare.com)

An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA . (nih.gov)

The binary complexes of the enzyme with CoA and Lip(SH)2 were determined at 2.6- and 3.0-A resolutions, respectively. (rcsb.org)
We report the structure of human ChAT to a resolution of 2.2 A along with structures for binary complexes of ChAT with choline, CoA, and a nonhydrolyzable acetyl-CoA analogue, S-(2-oxopropyl)-CoA. (inra.fr)

Taken together, our results uncover the processes regulating transcriptional elongation by promoter region histone H3 acetylation and homeostatic maintenance of promoter, but not enhancer, H3K18/27ac in response to inhibition of CBP/p300 acetyl transferase activity. (elifesciences.org)
Here, we report that BRD4 has novel and intrinsic histone acetyltransferase (HAT) activity through which it acetylates histones H3 and H4 in nucleosomes. (nih.gov)
Previously, other teams used radioactive isotopes to track carbons from butyrate to the TCA cycle , but they didn't look at contributions to histone acetylation via acetyl-CoA. (epigenie.com)

We previously characterized a novel acetyltransferase, the catalytic subunit of the NatC complex in T. cruzi [ 19 ], thought to belong to the NatC subgroup. (hindawi.com)

Quite unexpectedly, the structure at 2.6-A resolution of a ternary complex in which CoA and Lip(SH)2 are simultaneously bound to E2pCD reveals that CoA has an alternative, nonproductive binding mode. (rcsb.org)

Protein N α -acetylation (Nt-acetylation) is an irreversible protein modification where the acetyl moiety is transferred to the N α amino group of a protein or polypeptide by N-terminal acetyltransferases (NATs). (hindawi.com)

We observed that a homeostatic mechanism maintains promoter, but not enhancer, H3K18/27ac in response to extensive inhibition of CBP/p300 acetyl transferase activity by the highly specific small molecule inhibitor A-485. (elifesciences.org)

P. falciparum PDC, however, is found only in the apicoplast and produces acetyl-CoA for fatty acid biosynthesis. (gla.ac.uk)

acyl-CoA synthetase long chain fam. (gsea-msigdb.org)

acyl-CoA dehydrogenase very long c. (gsea-msigdb.org)
hydroxyacyl-CoA dehydrogenase trif. (gsea-msigdb.org)
acyl-CoA dehydrogenase short chain. (gsea-msigdb.org)
acyl-CoA dehydrogenase medium chai. (gsea-msigdb.org)

acetyl-CoA acyltransferase 2 [Sour. (gsea-msigdb.org)

It converts a molecule called 2-methyl-acetoacetyl-CoA into two smaller molecules, propionyl-CoA and acetyl-CoA, that can be used to produce energy. (medlineplus.gov)
The enzyme converts a molecule called acetoacetyl-CoA into two molecules of acetyl-CoA, which can be used to produce energy. (medlineplus.gov)

N-Acetyl-L-aspartic acid is the second most concentrated molecule in the brain after the amino acid glutamate. (hmdb.ca)

12q14 (Sanfilippo syndrome): The diagnosis requires a specific lysosomal enzyme assay for glucosamine ( N -acetyl)-6-sulfatase (GNS) activity. (medscape.com)

The MccE acetyltransferase is homologous to bacterial N-terminal acetyltransferases of the Rim family. (medscape.com)

The functions of these N-terminal acetyltransferases, and the significance of ribosomal protein acetylation for cell physiology are not entirely clear. (medscape.com)

Comment: Produces two acetyl-CoA from acetoacetyl-CoA and CoA. (lbl.gov)

(A) The C-terminal domain of the MccE protein-acetyl-CoA structure. (medscape.com)
We find that TcNaa30 catalyzes the acetylation of N-termini similar to those acetylated by NatC in yeast (yNaa30) and hNaa30 in vitro and our analyses indicate that the protein may function both as a N α - and as a N ε -acetyltransferase. (hindawi.com)

Purification and properties of acetyl-CoA:L-glutamate N-acetyltransferase from human liver. (rhea-db.org)

Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. (rhea-db.org)

Domain movements accompany CoA binding, and a surface loop, which is disordered in the unliganded enzyme, becomes localized and binds directly to the phosphates of CoA, stabilizing the complex. (inra.fr)

Methyl-S-CoA was found to accelerate the rate of inhibition seen with MNBS and increased the dissociation constant of chloramphenicol with respect to the enzyme. (figshare.com)

Anatomy21

Organisms12

Diseases2

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care1

Acetoacetyl-CoA thiolase4

Thiolase3

Enzyme17

Mitochondrial1

Deficiency1

Cytosolic1

Metabolism1

Histone acetyltransferase5

Substrate4

Acetate1

Genes1

Metabolic1

Melatonin1

Lysine1

Produces1

Proteins1

Belongs1

Structures2

Type2

Activity2

Critical1

Transfer of the acetyl group3

Coenzyme9

Alpha-glucosaminide2

Dihydrolipoamide acetyltransferase1

Donor and dihydrolipoamide1

Pyruvate1

Reaction1

Substrates5

Acetylcholine4

Delta isomerase1

Chloramphenicol acetyltransferase2

Enzyme that catalyzes1

Complexes2

Histone3

Catalytic subunit1

Ternary complex1

Moiety1

Transferase activity1

Biosynthesis1

Synthetase1

Dehydrogenase4

Acyltransferase1

Converts2

Molecule1

Sanfilippo1

Homologous1

Ribosomal protein1

Produces1

Protein2

Purification1

Crystal1

Complex1

Inhibition1