• With a dipole moment of 3.92 D, acetonitrile dissolves a wide range of ionic and nonpolar compounds and is useful as a mobile phase in HPLC and LC-MS. It is widely used in battery applications because of its relatively high dielectric constant and ability to dissolve electrolytes. (wikipedia.org)
  • Acetonitrile, often abbreviated MeCN (methyl cyanide), is the chemical compound with the formula CH3CN and structure H3C−C≡N. This colourless liquid is the simplest organic nitrile (hydrogen cyanide is a simpler nitrile, but the cyanide anion is not classed as organic). (wikipedia.org)
  • The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. (sielc.com)
  • Onset of symptoms after exposure to nitriles (acetonitrile and/or propionitrile) may be significantly delayed. (medscape.com)
  • [ 10 ] In general, these assays depend on an antibody that recognizes 25(OH)D2 and 25(OH)D3 in equimolar proportions and the competitive displacement of tracer 25(OH)D (25(OH)D that has been tagged with a radioactive isotope such as 125-I or a chemiluminescent ligand) by acetonitrile extracted samples. (medscape.com)
  • The mouse LC50 value of 2,693 ppm for a 60 minute exposure to acetonitrile [Willhite 1981] was selected as the basis for the IDLH value. (cdc.gov)
  • Acetonitrile is a byproduct from the manufacture of acrylonitrile. (wikipedia.org)
  • Production trends for acetonitrile thus generally follow those of acrylonitrile. (wikipedia.org)
  • Acetonitrile is a byproduct in the production of acrylonitrile and its production also decreased, further compounding the acetonitrile shortage. (wikipedia.org)
  • Cases of acetonitrile poisoning in humans (or, to be more specific, of cyanide poisoning after exposure to acetonitrile) are rare but not unknown, by inhalation, ingestion and (possibly) by skin absorption. (wikipedia.org)
  • Acetonitrile is a common two-carbon building block in organic synthesis of many useful chemicals, including acetamidine hydrochloride, thiamine, and α-napthaleneacetic acid. (wikipedia.org)
  • In 1992[update], 14,700 tonnes (16,200 short tons) of acetonitrile were produced in the US. (wikipedia.org)
  • Extraction with acetonitrile/water did not significantly affect the amount of extractable substance, though extraction with acetonitrile/HCL under reflux conditions did increase the amount of extractable substance, however this is not considered environmentally relevant. (janusinfo.se)
  • The acetonitrile extraction eliminates the need for chromatographic purification of vitamin D prior to its actual assay. (medscape.com)
  • Acetonitrile is used mainly as a solvent in the purification of butadiene in refineries. (wikipedia.org)
  • Specifically, acetonitrile is fed into the top of a distillation column filled with hydrocarbons including butadiene, and as the acetonitrile falls down through the column, it absorbs the butadiene which is then sent from the bottom of the tower to a second separating tower. (wikipedia.org)
  • An uncertainty factor of 30 was applied to account for extrapolation from a concentration that is lethal to animals, animal to human differences, and human variability, resulting in an IDLH value for acetonitrile of 137 ppm. (cdc.gov)
  • Chemical degradation in acetonitrile and urine was monitored over 250 days. (cdc.gov)
  • The drug-loaded pectin-based hydrogels were dehydrated in acetonitrile-water and subsequently dried using either supercritical carbon dioxide (scCO2) or freeze-drying. (ssrn.com)
  • Before analysis, the and sonicated with 60 mL of 0.1 N NaOH filtrate was diluted with water/acetonitrile (ultrasonic bath) for 10 minutes. (who.int)
  • For a water:acetonitrile mobile phase, the minor disturbance method using deuterated acetonitrile to obtain an integral average void volume (2.08 and 2.05 mL for C18 at 30 and 40 °C, respectively and 2.16 and 2.13 mL for C8 at 30 and 40 °C, respectively) was found to be the most appropriate method for determining the elusive column void volume. (lu.se)
  • By utilizing a three-way ANOVA, the composition of the mobile phase has been shown to have a significant effect on deuterated acetonitrile and other investigated void volume markers, demonstrating the fact that both void volume markers and acetonitrile itself exhibit retention-like behaviour. (lu.se)
  • The comparison of void volumes, obtained with conventional neutral void volume markers, revealed the former to be 24-36% lower than the void volume obtained using deuterated acetonitrile, as an isotopically labelled mobile phase component. (lu.se)
  • Working from an allylic alcohol derivative, an SAE gave them an epoxide, which after treatment with base and acetonitrile, gave them the cyclopropane. (organic-chemistry.org)
  • Reaction of different quinones with 3,4-selenadiazo benzophenone in a 1:1 mole ratio by acetonitrile gave a unique charge-transfer complex compound in a good yield. (ugm.ac.id)
  • The eluent was preconcentrated, reconstituted in acetonitrile, and analyzed using a GC-MS-SICP method. (who.int)
  • Generally the onset of toxic effects is delayed, due to the time required for the body to metabolize acetonitrile to cyanide (generally about 2-12 hours). (wikipedia.org)
  • Title : Acetonitrile in body fluids related to smoking Personal Author(s) : McKee, Herbert C.;Rhoades, John W.;Campbell, John;Gross, Arthur L. (cdc.gov)
  • Excess adsorption isotherms for acetonitrile were calculated using deuterated acetonitrile elution data. (lu.se)
  • needs update] Acetonitrile has only modest toxicity in small doses. (wikipedia.org)
  • Studies on the mechanism of acetonitrile toxicity. (nih.gov)
  • Genetic Toxicity Evaluation of Acetonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • The purpose of this technical report is to present the IDLH value for Acetonitrile (CAS® No. 75-05-8). (cdc.gov)
  • The mouse LC50 value of 2,693 ppm for a 60 minute exposure to acetonitrile [Willhite 1981] was selected as the basis for the IDLH value. (cdc.gov)
  • An uncertainty factor of 30 was applied to account for extrapolation from a concentration that is lethal to animals, animal to human differences, and human variability, resulting in an IDLH value for acetonitrile of 137 ppm. (cdc.gov)
  • A modifying factor of 10 is applied to the IDLH value to account for the greater potency of chloroacetonitrile compared to the potency of the surrogate, acetonitrile, resulting in an IDLH value of 14 ppm. (cdc.gov)
  • I: Whole body autoradiographic distribution and macromolecular interaction of 2-14C-acetonitrile in mice. (nih.gov)
  • An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Acetonitrile (75-05-8). (nih.gov)
  • l For extraction, 50 mL of water-acetonitrile (50:50 by volume) was added to the tegaserod-food mixtures. (medscape.com)
  • Before analysis, the and sonicated with 60 mL of 0.1 N NaOH filtrate was diluted with water/acetonitrile (ultrasonic bath) for 10 minutes. (who.int)