IsotretinoinPropionibacterium acnesDrugs, Chinese HerbalDose-Response Relationship, DrugDouble-Blind MethodRats, Sprague-DawleyTime FactorsGene DosageAcne KeloidDosage Compensation, GeneticDermatologic AgentsSebumBenzoyl PeroxideDosage FormsPropionibacteriumSebaceous GlandsGram-Positive Bacterial Infections