• One approach to this problem is to create sets of genes with common biological characteristics, such as chromosomal location, biochemical function, or observed differential expression in some experimental condition, and then to determine whether the genes in these sets are coordinately induced or repressed. (biomedcentral.com)
  • Early in development the expression of the first patterning genes broadly sets up embryonic regions. (elifesciences.org)
  • Overall, 14 out of 17 of the genes examined had differential expression patterns similar to what was predicted from their reads alone. (usda.gov)
  • These results indicate that this large collection of 454 ESTs will be a valuable resource for identifying genes that are potentially differentially expressed and play important roles in flower bud development, cold acclimation, chilling unit accumulation, and fruit development in blueberry and related species. (usda.gov)
  • Combined with transcriptome data, the pattern of isoflavonoid accumulation was found to be highly correlated with differential expression genes. (bvsalud.org)
  • Table_3_Differential Modulation of Heat-Inducible Genes Across Diverse Genotypes and Molecular Cloning of a sHSP From Pearl Millet [Pennisetum glaucum (L.) R. Br. (figshare.com)
  • In addition, the investigation was extended for the identification and characterization of 28 different HSP20 genes through a genome-wide search in the pearl millet genome and an understanding of their expression pattern using the RNA-sequencing (RNA-Seq) data set. (figshare.com)
  • However, the range of gene expression patterns, the extent of the correlation of expression with function, and the classes of genes whose spatial expression are tightly regulated have been unclear due to the lack of an unbiased, genome-wide survey of gene expression patterns. (biomedcentral.com)
  • We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. (biomedcentral.com)
  • Individual expression patterns are extraordinarily diverse, but by supplementing qualitative in situ hybridization data with quantitative microarray time-course data using a hybrid clustering strategy, we identify groups of genes with similar expression. (biomedcentral.com)
  • Of 4,496 genes with detectable expression in the embryo, 2,549 (57%) fall into 10 clusters representing broad expression patterns. (biomedcentral.com)
  • The remaining 1,947 (43%) genes fall into 29 clusters representing restricted expression, 20% patterned as early as blastoderm, with the majority restricted to differentiated cell types, such as epithelia, nervous system, or muscle. (biomedcentral.com)
  • Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues. (biomedcentral.com)
  • the expression patterns of over 1,500 of these genes are documented here for the first time. (biomedcentral.com)
  • As a result of this differential cell cycle-regulatory gene expression by HDAC inhibition, the retinoblastoma protein retains a transcriptional repression of its downstream target genes required for S phase entry. (cret-signal.com)
  • Quantitative PCR was performed to analyze the differential expression of selected genes related to oil biosynthesis. (edu.ph)
  • the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
  • However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
  • A rare, progressive metabolic liver disease due to marked to complete lysosomal acid lipase deficiency and characterized by dyslipidemia and massive lipid accumulation leading to hepatomegaly and liver dysfunction, splenomegaly, accelerated atherosclerosis. (orpha.net)
  • Progressive lysosomal lipid accumulation leads to the characteristic liver pathology and dysfunction (including hepatomegaly, liver fibrosis and/or cirrhosis, and elevated serum transaminases), dyslipidemia (elevated serum LDL-cholesterol and triglycerides, with normal to low HDL-cholesterol concentrations), premature atherosclerosis, splenomegaly and, eventually, end-stage liver failure. (orpha.net)
  • the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)
  • This process can distort and crack pavement, damage the foundations of buildings and displace soil in regular patterns. (wikipedia.org)
  • As a result, conditions are optimal for deep ice lens formation with large ice accumulations and significant soil displacement. (wikipedia.org)
  • Soil characterization and differential patterns of heavy metal accumulation in woody plants grown in coal gangue wastelands in Shaanxi, China. (nih.gov)
  • Optical imageries archived in the GEE platform were processed for the generation of various sand indices such as the normalized differential sand index (NDSI), the ratio normalized differential soil index (RNDSI), and the dry bare soil index (DBSI). (iiasa.ac.at)
  • Indeed the visceral WAT which is more inflamed with higher accumulation of macrophages [ 7 ] has more detrimental effects than the subcutaneous WAT [ 11 ]. (springer.com)
  • The influx of macrophages and accumulation of T-cells and myofibroblast were quantified in orbital connective tissue. (frontiersin.org)
  • Severe phenotype of ATP6AP1-CDG in two siblings with a novel mutation leading to a differential tissue-specific ATP6AP1 protein pattern, cellular oxidative stress and hepatic copper accumulation. (nih.gov)
  • According to the human capital model, wage differentials among individuals over the life-cycle are largely the result of different patterns of investment in human capital. (repec.org)
  • We find a large contribution (about 75%) of compensating wage differentials and slowed human capital accumulation to the gender wage gap in Northern and Western European countries. (oecdecoscope.blog)
  • The weight of compensating wage differentials in these countries is about twice as large as that of slowed human capital accumulation. (oecdecoscope.blog)
  • Where compensating wage differentials are important, one focus of public policy could be to make non-wage job characteristics that are particularly valued by women more widely accepted by employers. (oecdecoscope.blog)
  • There is a widely documented pattern of increase in the wage differential across gender in the first years of professional life. (columbia.edu)
  • In other words, differential selection across genders is also a potentially relevant factor in explaining the evolution of the gender wage gap during the early career of workers. (columbia.edu)
  • Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
  • In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
  • The highest tolerance or growth index of plants was recorded for Cu. Protein profiling of leaf tissues showed modulation of protein patterns in each stress. (edu.sa)
  • Salinity induced metabolite responses resulted in differential accumulation of flavonoids and antioxidant metabolites in shoots and roots suggesting improved antioxidant capacity in providing salt-adaptive phenotype of tef seedling. (aber.ac.uk)
  • Differential diagnosis includes familial hypercholesterolemia, non-alcoholic fatty liver disease, cryptogenic cirrhosis, and combined hyperlipidemia, as well as other lysosomal storage disorders. (orpha.net)
  • Ischemic heart disease occurs when the heart's blood supply is blocked or interrupted by an accumulation of fatty substances and cholesterol plaques. (ecgedu.com)
  • To understand patterns of fatty acid (FA) and oil accumulation in LAGT and PLNT fruits, transcriptomes of 6-7 month-old endosperm samples were analyzed by RNA-Seq. (edu.ph)
  • Among the five candidate citrus promoters characterized in this study, the CitSEP promoter showed a fruit-specific expression pattern, while the CitWAX and CitJuSac promoters exhibited high fruit-preferential expression with strong activity in the fruit, weak activity in floral tissues and low or undetectable activity in other tissues. (biomedcentral.com)
  • ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)
  • Frost heaving creates debris and dramatically shapes landscapes into complex patterns. (wikipedia.org)
  • Differential frost heave producing complex patterns will occur if the correct conditions exist. (wikipedia.org)
  • Training in advanced ECG interpretation techniques allows healthcare professionals to accurately identify these complex patterns associated with certain conditions while reducing the number of false positives or negatives. (ecgedu.com)
  • Electrolyte imbalances can also affect the heart and lead to abnormal ECG patterns. (ecgedu.com)
  • Some individuals develop an abnormal accumulation of air in the chest cavity that can result in the collapse of a lung (spontaneous pneumothorax). (medlineplus.gov)
  • The highest accumulation was in the roots and in decreasing order viz. (edu.sa)
  • Viable seedlings exposed to NaCl exhibited purple-red pigment accumulation in the roots except for Beten and Tullu nasy varieties. (aber.ac.uk)
  • These metabolic changes were correlated with patterns of antioxidant capacities and total flavonoid content in shoots and roots and suggested a mitigating response by tef to salinity. (aber.ac.uk)
  • Indeed, WAT remodeling eventually associated with a limited capacity to adequately expand might induce lipid spill over and this triglyceride accumulation in other depots such as liver or muscle. (springer.com)
  • LAL hydrolyzes cholesteryl esters and triglycerides, and thus LAL deficiency results in gradual accumulation of these lipids in the liver, spleen, and other organs. (orpha.net)
  • These relationships may serve to generate hypotheses about the causes and consequences of specific patterns of observed differential gene expression. (biomedcentral.com)
  • However, the possible consequences of the cellular accumulation of SETD2 are unknown. (frontiersin.org)
  • This patterning in combination with the asymmetric geometrical setup ensures functional organ formation. (elifesciences.org)
  • Previously, we have reported that exposure of BEAS-2B cells to single wall carbon nanotube s (SWCNT) caused ultra-structural and morphological changes, cytotoxicity, apoptosis, and induced oxidative stress as shown by the formation of free radicals, accumulation of peroxidative products, and depletion of antioxidants. (cdc.gov)
  • It also supplies information such as the manufacturer of the differential , its ratio, tooth count, whether or not it's limited slip, and brake type. (autorestorer.com)
  • This paper addresses a fundamental question in developmental biology, that is, how morphogenetic movements driving tissue folding are patterned to occur with the correct spatiotemporal dynamics. (elifesciences.org)
  • Differential impact of some metal(loid)s on oxidative stress, antioxidant system, sulfur compounds, and protein profile of Indian mustard (Brassica juncea L. (edu.sa)
  • Our results suggest that Indian mustard has a differential mode of defense against a particular stressor at the level of protein expression profile. (edu.sa)
  • Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. (vt.edu)
  • AVED is inherited in an autosomal recessive pattern and caused by a changes (mutations or pathogenic variants) in the alpha-tocopherol transfer protein ( TTPA ) gene. (rarediseases.org)
  • By correlating dynamic patterns of transcription factor expression with rigorous, quantitative analyses of cell behaviors across the salivary gland primordium in Drosophila , their results suggest Hkb and Fkh transcription factor patterning induces switches in cell behaviors at fixed positions to promote continued morphogenesis of the tubular structure. (elifesciences.org)
  • Here we show that SETD2 accumulation results in a non-canonical deposition of the functionally important H3K36me3 histone mark, which includes its reduced enrichment over gene bodies and exons. (frontiersin.org)
  • For some time, the reversibility of evolution was primarily discussed in terms of comparative patterns. (bioone.org)
  • We find that early transcriptional patterning of key morphogenetic transcription factors drives the selective activation of downstream morphogenetic modules, such as GPCR signaling that activates apical-medial actomyosin activity to drive cell wedging at the future asymmetrically placed invagination point. (elifesciences.org)
  • Our work illustrates that the dynamic patterning of the expression of transcription factors and downstream morphogenetic effectors ensures positionally fixed areas of cell behavior with regards to the invagination point. (elifesciences.org)
  • Identifying similarities between patterns of differential gene expression provides an opportunity to identify similarities between the experimental and biological conditions that give rise to these gene expression alterations. (biomedcentral.com)
  • However, a challenge for scientists performing genome-wide gene expression microarray analysis has been using these data to generate hypotheses about biological processes responsible for the patterns of differential gene expression associated with a particular trait or experimental variable. (biomedcentral.com)
  • At least in experimental animals, genetical y modified strains, because on the differential effects of a wide greater susceptibility to chemical in these species the interval between variety of carcinogens in humans at carcinogens in utero and during birth and sexual maturity is only a different stages of life, including var early postnatal life is usual y man few weeks. (who.int)
  • Immunostaining for lysosomal fat accumulation may facilitate diagnosis. (orpha.net)
  • ECG pattern recognition and differential diagnosis are important tools that allow healthcare professionals to identify potentially life-threatening conditions such as arrhythmias, ischemic heart disease, or electrolyte imbalances before they develop into critical situations. (ecgedu.com)
  • From understanding basic ECG patterns to unraveling the various arrhythmias, coronary heart disease, and heart attacks, this comprehensive guide will enlighten you on the importance of ECG pattern recognition and differential diagnosis in modern medicine. (ecgedu.com)
  • This information is important for making informed decisions about treatment plans and effectively managing patients' symptoms, which is where differential diagnosis comes in. (ecgedu.com)
  • Differential diagnosis is a medical diagnostic procedure in which doctors list possible conditions that could be causing a patient's symptoms. (ecgedu.com)
  • If a patient shows symptoms that match more than one condition, a differential diagnosis helps narrow down the possible causes by ruling out certain conditions through additional testing. (ecgedu.com)
  • Five different misSOD1 staining patterns were found consistently in tissue sections from SALS cases and the SOD1 A4V patient, but were essentially absent in AD and non-neurological controls. (nature.com)
  • This differential localization is consistently observed using confocal microscopy of GFP-tagged proteins, chloroplast fractionation, and western blotting, and immunodetection by electron microscopy. (unboundmedicine.com)
  • It has also pointed to genetic factors that might prevent reverse evolution, such as a lack of genetic variability, epistasis, and differential genotype-by-environment interactions. (bioone.org)
  • In the present work, a hybrid differential evolution and pattern search (hDE-PS) method has been suggested for frequency regulation of electrical power systems. (springeropen.com)
  • From several methods, Differential Evolution (DE) algorithm is a universal tuning technique planned to discover the exploration space and chief probable offers an optimal/near-optimal result if applied alone. (springeropen.com)
  • Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)
  • Adherence to these guidelines will aid in the comparison of the results of future studies and better interpretation of staining patterns. (nature.com)
  • I will describe recent progress in understanding the behavior of individual cells from the zebrafish as they slow their oscillations and differentiate during segmentation, and discuss how this gives rise to the tissue-level wave patterns. (ens-lyon.fr)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • It is suggested that, in addition to their differential expression pattern, this segregation underlies the regulation of metabolic fluxes through the alternative branches of the lipoxygenase pathway. (unboundmedicine.com)
  • Before a specific type develops, symptoms include lagging motor development and often persistent infantile reflex patterns, hyperreflexia, and altered muscle tone. (msdmanuals.com)
  • A gene's expression pattern can be defined as a series of differential accumulations of its products in subsets of cells as development progresses. (biomedcentral.com)
  • Genotypes, such as WGI 126, TT-1, TT-6, and MS 841B, responded positively toward high-temperature stress for the transcript accumulation of both Pgcp70 and PgHSF and also indicated a better growth under heat stress. (figshare.com)
  • Our study highlights the role of flavonoid accumulation following salt stress on tef seedlings and further these findings could be used as targets for selective tef breeding. (aber.ac.uk)
  • Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. (vt.edu)
  • The differential gene expression data analysis was per-formed using Affymetrix microarray suite 5.0 software. (cdc.gov)
  • 1989). In addition, differential analysis including daily excretion data revealed a pattern of fractional particle clearance rate of the ultrafine iridium particles similar to that of micrometer- sized particles reported by Snipes et al. (cdc.gov)
  • The patterning and fate determination gene products do not directly affect morphogenetic changes, but rather instruct the expression of downstream morphogenetic effectors that drive a tissue primordium down a path of defined physical changes. (elifesciences.org)
  • A differential response in the development of obesity complications exists depending on WAT depot distribution. (springer.com)
  • CONCLUSIONS: False species discoveries bias richness estimation and confound differential richness inference. (nevinmanimala.com)
  • The pattern was consistent with mycetoma and may be important for diagnosing these life-threatening infections. (cdc.gov)
  • These controls unlock classical regression approaches for highly flexible differential richness inference at various levels of the surveyed microbial assemblage: from sample groups to specific taxa collections. (nevinmanimala.com)
  • In order to prevent rejection of the fetus, the placenta expresses an intricate pattern of major histocompatibility complex molecules, immunizing the mother against the foreign fetal tissue [ 3 ]. (hindawi.com)
  • After positions at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, Germany, University College London and the Francis Crick Institute in the UK, Andy Oates recently joined École Polytechnique Fédéral de Lausanne (EPFL) in Switzerland where he is the head of the Timing, Oscillation, Patterns Laboratory. (ens-lyon.fr)
  • We point out that, with differential labor market entry and exit across genders, it is also possible that the pool of men and women being compared to each other changes with age. (columbia.edu)
  • The classic pattern for ischemia on the ECG is isolated symmetrical T wave inversion in 2 or more contiguous leads. (ecgedu.com)
  • ECG pattern recognition helps diagnose and monitor various heart conditions. (ecgedu.com)
  • We proceed to model a 16S survey's systematic patterns of sub-genus taxa generation as a function of genus abundance to derive a robust control for false taxa accumulation. (nevinmanimala.com)
  • Based on this finding, a flexible method is proposed and is shown to overcome the confounding problem noted with current approaches for differential richness inference. (nevinmanimala.com)
  • The histologic patterns and biologic spectrum of meningiomas partially reflect the aforementioned biologic functions and embryogenesis. (medscape.com)
  • m) using a portable, digitally integrated pen tablet PC mapping system with differential global positioning system and laser rangefinder support. (usgs.gov)
  • Having traversed the patterning device MA, the radiation beam B passes through the projection system PS, which focuses the beam onto a target portion C of the substrate W. I will try the above methods after my fortnite undetected silent aim stops bleeding from me trying to cut it off with a nail cutter home remedy bad idea. (intexler.ee)