Accumulation of lipid. Medical search. Frequent questions

This research questions the contribution of lipid droplet accumulation in adipose tissue macrophages in obesityinduced inflammation and metabolic disfunction. (wur.nl)

Therefore, liganded PPARγ sumoylation is not only critical for cellular lipid metabolism but also induces oxidative stress that contributes to tumor suppressive function of PPARγ. (oncotarget.com)
Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
In conclusion, our data demonstrate a critical role for BVRA in protecting against lipid accumulation and oxidative stress in hepatocytes, which may serve as a future therapeutic target for NAFLD and its progression to NASH. (uky.edu)
The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Fat accumulation in skeletal muscle combined with low mitochondrial oxidative capacity is associated with insulin resistance (IR). (medscape.com)
Endurance-trained athletes, characterized by a high oxidative capacity, have elevated intramyocellular lipids, yet are highly insulin sensitive. (medscape.com)
We tested the hypothesis that a high oxidative capacity could attenuate lipid-induced IR. (medscape.com)
In untrained subjects, lipid infusion reduced oxidative and nonoxidative glucose disposal (NOGD), whereas trained subjects were completely protected against lipid-induced reduction in NOGD, supported by dephosphorylation of glycogen synthase. (medscape.com)
Therefore, the primary aim of our study was to test the hypothesis that a high mitochondrial oxidative capacity could prevent the development of lipid-induced IR. (medscape.com)

Hepatic magnetic resonance spectroscopy (MRS) and two-step hyperinsulinemic euglycemic clamps incorporating stable isotopes with concomitant adipose tissue microdialysis were used to evaluate carbohydrate and lipid flux. (whiterose.ac.uk)
Adipose tissue lipid mobilization was decreased by dutasteride. (whiterose.ac.uk)
After 6 weeks, blood, liver, and adipose tissue were collected for determination of plasma lipids and lipoproteins, tissue cholesterol concentrations, inflammatory cytokines and expression of genes regulating hepatic cholesterol and triglyceride metabolism. (uconn.edu)
The high cholesterol diet resulted in accumulation of cholesterol and inflammation in the adipose tissue, which was not prevented by Moringa treatment. (uconn.edu)
We conclude that ML protect against hepatic steatosis by affecting genes involved in synthesis and uptake of hepatic lipids resulting in lower concentrations of cholesterol and triglycerides and reduced inflammation, however, plasma lipids and adipose tissue cholesterol and inflammation were not affected significantly by ML consumption. (uconn.edu)
Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)

This serves as groundwork for potential mass production of biofuels through limited nutrients to promote lipid accumulation rather than cell growth. (systemsbiology.net)

Nutrient is the most important regulator of microalgal growth and lipid accumulation. (hindawi.com)

After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B cells. (medworm.com)
Iron overload, glutathione (GSH) depletion and lipid peroxidation in the lung tissue of mice in the exposure group. (medworm.com)
In summary, findings in the present study confirmed that BP-QDs induce ferroptosis via increasing lipid peroxidation and iron accumulation in vitro and in vivo.PMID:3748. (medworm.com)

Simultaneous effect of phosphorous (P) influences the growth and lipid synthesis in microalgae [ 9 , 14 - 17 ]. (hindawi.com)
We found that ligand activation of PPARγ dramatically induced de novo lipid synthesis as well as fatty acid beta (β)-oxidation in lung cancer both in vitro and in vivo . (oncotarget.com)
Further biochemical analysis revealed that PPARγ-mediated lipid synthesis depletes nicotinamide adenine dinucleotide phosphate (NADPH), consequently resulting in increased mitochondrial reactive oxygen species (ROS) level that subsequently disrupted REDOX balance in lung cancer. (oncotarget.com)
The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. (harvard.edu)
His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. (harvard.edu)
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. (harvard.edu)
Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease-and an accomplished amateur photographer. (harvard.edu)
Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)
[ 13 ] In cultured skin keratinocytes, elevated fatty alcohol is diverted into the synthesis of wax esters and alkyldiacylglycerol lipids. (medscape.com)

We find that loss of the IIS signalling antagonist PTEN, which stimulates cell growth in most developing tissues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid droplets. (silverchair.com)

5 μg/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. (nih.gov)
We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)

Interdisciplinary scientific collaboration between the Institute of Molecular Biology and Biotechnology (IMBB, FORTH), the Institute of Electronic Structure and Laser (IESL, FORTH) and the Medical School of National and Kapodistrian University of Athens (NKUA), sheds light into the molecular mechanisms that regulate nuclear lipid droplets accumulation during ageing. (forth.gr)

For example, reduced insulin signalling underlies the defects in glucose metabolism observed in diabetes,whereas changes in lipid metabolism associated with obesity are an important causative factor in establishing cellular insulin resistance in patients with Type 2 diabetes ( Haslam and James,2005 ). (silverchair.com)
But in obesity, accumulation of lipids can cause fatty liver, resulting in cellular damage to the organ. (sciencedaily.com)

These cells normally store lipid in a perinuclear pool of small neutral triglyceride-containing droplets. (silverchair.com)
Excessive triglyceride accumulation in lipid-metabolizing tissues is associated with an increased risk of a variety of metabolic diseases. (elsevierpure.com)
Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)
Hilpda overexpression in turn induces triglyceride accumulation inside lipid droplets. (wur.nl)

Objective: Our objective was to provide a detailed assessment of the metabolic effects of SRD5A inhibition and in particular the impact on hepatic lipid metabolism. (whiterose.ac.uk)
There may be multiple metabolic causes for increased cytosolic lipid accumulation in muscle in insulin-resistant states. (biomedcentral.com)
Recent evidence suggests that AKI is accompanied by significant metabolic abnormalities, including alterations in lipid metabolism. (thno.org)
Our results suggest that the habitual intake of Kampo-containing PN contributes to the prevention of the onset of metabolic diseases by decreasing the excessive accumulation of triglycerides in lipid-metabolizing tissues. (elsevierpure.com)
There is an emerging view that type 2 diabetes (hereafter diabetes) may reflect not so much as an isolated impairment of glucose regulation, rather the complex metabolic consequences of accumulating ectopic lipids or hepatic fat [ 1 - 4 ]. (biomedcentral.com)
Ellagitannins-derived intestinal microbial metabolite urolithin A ameliorates fructose-driven hepatosteatosis by suppressing hepatic lipid metabolic reprogramming and inducing lipophagy. (cabi.org)
In diet-induced obese mice, HILPDA deficiency in macrophages markedly reduced lipid accumulation in macrophages yet it did not alter any measured inflammatory or metabolic parameters. (wur.nl)

Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. (bvsalud.org)
However, the mechanisms regulating lipid metabolism and the storage of lipid during development are less well characterized. (silverchair.com)
Since then the relevance of muscle lipid accumulation to insulin resistance in humans has been demonstrated, and basic studies have indicated plausible mechanisms whereby lipid accumulation could generate insulin resistance [ 5 ]. (biomedcentral.com)
However, the specific changes in lipids in AKI, and their role and regulation mechanisms are currently unclear. (thno.org)
More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology. (harvard.edu)

RGd-1 fatty acids were primarily observed as C16:0, C16:1, C18:1-3 and C20:5, averaging at approximately 35, 30, 16 and 10%, respectively of the total lipid content. (montana.edu)

Since 2007, Dr. Farese's laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD). (harvard.edu)

Sunitinib treatment results in an increased reliance on glycolysis, increased myocardial lipid deposition and perturbed mitochondrial function, indicative of a fundamental energy crisis resulting in compromised myocardial energy metabolism and function. (nih.gov)
Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells. (nottingham.ac.uk)

We observed that human hepatocytes exhibited excessive lipid accumulation. (wur.nl)

Additionally, the atheroprotective action of 2C7 scFv was unrelated to alterations in lipid concentrations in blood plasma. (emlinhibitor.com)

Main Outcome Measure: Incorporation of hepatic lipid was measured with MRS. Results: Dutasteride, not finasteride, increased hepatic insulin resistance. (whiterose.ac.uk)
The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)
Our work therefore reveals a signalling mechanism by which the effect of insulin on lipid metabolism could be regulated independently of some of its other functions during development and adulthood. (silverchair.com)
Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. (biomedcentral.com)
A high-fat diet resulted in insulin resistance as well as accumulation of cytosolic lipid intermediates and down-regulation of MFN2 and CPT1 in skeletal muscle in rats, while MFN2 overexpression improved insulin sensitivity and reduced lipid intermediates in muscle, possibly by upregulation of CPT1 expression. (biomedcentral.com)
MFN2 overexpression can rescue insulin resistance, possibly by upregulating CPT1 expression leading to reduction in the accumulation of lipid intermediates in skeletal muscle. (biomedcentral.com)
Fat accumulation in muscle negatively impacts insulin-mediated glucose uptake. (biomedcentral.com)
The hypothesis that insulin resistance is related to lipid accumulation in muscle dates back to studies reported 15-20 years ago showing that triglycerides accumulate in muscle in rats fed a high-fat diet, which is coincident with insulin resistance. (biomedcentral.com)
Fat accumulation in skeletal muscle strongly associates with the development of muscle insulin resistance (IR), the main risk factor in the development of type 2 diabetes (T2D). (medscape.com)

Phosphate depletion controls lipid content and accumulation of heterotrophic bacteria during growth of Synechocystis sp. (elsevierpure.com)
The liver also controls lipid production and metabolism. (sciencedaily.com)

In Nannochloropsis oculata the dry weight of the biomass and lipid gradually increased with increased concentration of EDTA [ 10 ]. (hindawi.com)
The effects of cultivation of Scenedesmus obliquus in nutrient medium supplemented with 0.03%, 3, 9% and 12% CO(2) or 2.5-20 mg L(-1) of Fe(3+) on dry weight of biomass (DW), total lipid accumulation (TL contents) and total lipid productivity (TLP) were evaluated under indoor conditions. (unboundmedicine.com)
Biomass Production and Accumulation of L. (uludag.edu.tr)
On the other hand, depleting Pi led to markedly less lipid content, less heterotrophic biomass, and a shift in the heterotrophic community from Burkholderiales to Sphingobacteriales and Saprospirales. (elsevierpure.com)

Transfection of miR-126-3p and miR-199a-3p enhanced lipid accumulation in 3T3-L1 cells after adipocyte differentiation. (shimane-u.ac.jp)

The present study systematically analyzes the changes in lipid composition in AKI for the first time and find that the degree of lipid accumulation was highly correlated with uncoupling protein 1 (UCP1). (thno.org)

It is estimated that approximately 20-30 % of adults and 3-10 % of children in western countries suffer from excessive fat accumulation in the liver [ 1 ]. (biomedcentral.com)
Non-alcoholic fatty liver disease (NAFLD) is one major chronic liver disease emerging the primarily excessive fat accumulation in the liver. (shimane-u.ac.jp)

Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)
Two different hybrid NPs are constructed by embedding polyelectrolyte‐MnO 2 (PMD) in hydrophilic terpolymer/protein‐MnO 2 (TMD) or hydrophobic polymer/lipid‐MnO 2 (LMD) matrices. (dacostalab.ca)
Using a combination of MD simulations and biochemical approaches, we study how membrane properties regulate protein functions, and hence how lipid metabolism may play a role in unexpected, and apparently unrelated, trafficking processes. (unifr.ch)
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. (harvard.edu)
Identification of two pathways mediating protein targeting from ER to lipid droplets. (harvard.edu)
This study focuses on the changes of isoflavone and soyasaponin concentration during seed development and their relationship to the other major chemical components, such as protein, lipids and free sugars. (usda.gov)
A combination of analytical techniques were used to examine and quantify seed compositional components (protein content, lipid content, carbohydrates, isoflavones, and saponins) during bean development and maturation in two Korean soy cultivars. (usda.gov)
Protein accumulation was rapid during reproductive stages, while lipid content was only relatively moderately increased. (usda.gov)
Protein, lipid and free sugar contents in the developing soybean seeds showed significant positive correlations with conjugated isoflavones and total isoflavone concentration, while the lipid contents showed a negative correlation with the isoflavone aglycone. (usda.gov)

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line. (atlasofscience.org)
In recent years, mitochondrial dysfunction has received large attention as a putative candidate underlying IMTG accumulation and thereby the development of IR. (medscape.com)

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. (greenmedinfo.com)

Diatom strain, RGd-1, isolated from Yellowstone National Park, produces high concentrations of lipids that can be used for biodiesel production. (montana.edu)
Previously published results suggest that the free sugar and lipid content reached their maximal concentrations at a relatively early stage of seed development, and remain constant in comparison to other chemical components. (usda.gov)

We studied the effect of bilberry ( Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). (nih.gov)
Because of the advantage of transparent body in juvenile period suitable for identifying lipid accumulation in liver by whole-mount oil red O staining, in present study we attempted to determine whether juvenile zebrafish can be used as a model for diet-induced NAFLD. (biomedcentral.com)
Excessive fructose consumption exacerbates the progression of nonalcoholic fatty liver disease (NAFLD) by disrupting hepatic lipid homeostasis. (cabi.org)
Abnormal lipid metabolism has been associated with a wide range of chronic and infectious diseases including non-alcoholic fatty liver disease, viral hepatitis C infection, atherosclerosis, diabetes, and cancer. (wur.nl)
Ultimately, we sought to identify the physiological function of the liver-specific mitochondrial carrier Slc25a47 in liver lipid metabolism and energy expenditure. (wur.nl)
Comparison with other transcriptomics datasets indicated that hepatocyte humanized livers recapitulate the principal effects of PPARα activation on lipid metabolism as revealed by other model systems of human liver. (wur.nl)

Hypoxia blocks the differentiation of adipocytes but increases the accumulation of lipids by these cells. (atlasofscience.org)
Pharmacological inhibition of Ces1 increases lipid accumulation, exacerbates renal I/R- injury and eliminates the beneficial effects on AKI observed in Ehmt2Ksp mice . (bvsalud.org)
It shows lipid accumulation increases in the deep layers of the tunica intima (central column of panels) with the addition of macrophages (column of panels on the right). (meatrition.com)
This work evaluates the ratio of isoflavones and saponins to total lipids, proteins and sugars in two Korean soy cultivars and show that the ratio of isoflavones to all other components generally increases as the seed matures, while that of the saponins generally decreases as the seed matures. (usda.gov)

More importantly, it turns out that PPARγ regulation of lipid metabolism was dependent on sumoylation of PPARγ. (oncotarget.com)
This study provides an important insight of future translational and clinical research into targeting PPARγ regulation of lipid metabolism in lung cancer patients accompanying type 2 diabetes. (oncotarget.com)
Previous studies revealed that adiponectin played a causal role in maintaining energy homeostasis via regulation of glucose and lipid metabolism. (frontiersin.org)
Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)

This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)

Here, we report that sumoylation of PPARγ couples lipid metabolism to tumor suppressive function of the receptor in lung cancer. (oncotarget.com)
A) In normoxia conditions, adipocytes differentiate with an increase of PPARγ2 expression and increase of lipid accumulation (B) In hypoxic conditions (mimetic), adipocytes do not express PPARγ2 but with increased lipid accumulation. (atlasofscience.org)

Importantly, relieving lipid accumulation in AKI by upregulating UCP1 can significantly inhibit the progression of AKI through promoting AMPK/ULK1/autophagy pathway. (thno.org)
The present findings suggest that lipid accumulation in AKI is directly regulated by UCP1, which can activate cell autophagy and thus significantly inhibit disease progression. (thno.org)
Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)

Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)

An index for monitoring the accumulation of lipids based on the WAIST CIRCUMFERENCE measurement and the level of TRIGLYCERIDES circulating in the blood. (uchicago.edu)
Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (WC, cm) and triglycerides (TGs, mmol/l): (WC-65) ×TG (men) and (WC-58) ×TG (women). (biomedcentral.com)

Currently, the main focus of the lab is to understand how specific lipids and membrane properties influence intracellular trafficking processes and fat storage in eukaryotic cells. (unifr.ch)
Accumulation of fatty aldehydes, which are highly reactive molecules, can form covalent Schiff-base derivatives with phosphatidylethanolamine, which may influence myelin membrane properties and alter the function of membrane-bound proteins. (medscape.com)
The media of mitochondria treated with LL-37 (8 μM) for 2 h contained 50% more AIF and three times more cytochrome C than that of control mitochondria, showing that LL-37 promotes release of both AIF and cytochrome C. Moreover, in vesicles reflecting mitochondrial membrane lipid composition, LL-37 stimulates membrane permeabilization and release of tracer molecules. (lu.se)

Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1. (bvsalud.org)

Additionally, some conditions of cultivation should be strategically changed to enhance microalgal lipid. (hindawi.com)
Many microalgal species can synthesize large quantities of lipid and carbohydrates along with other bioactive molecules under varied nutrient supplement conditions. (hindawi.com)
The rapid and accurate determination of changes in chlorophyll content can therefore be used as an indicator of possible neutral lipid production in microalgal cultures. (frontiersin.org)

BEs also significantly reduced Rubicon and induced p62/SQSTM1, possibly contributing to reduce cellular lipids (lipophagy). (nih.gov)
The second run of the experiment showed that with increased light and CO2 the rate of lipid accumulation with phosphate deprivation is significantly faster. (systemsbiology.net)
Hepatic lipid accumulation was also significantly reduced in caffeine treatment larvae. (biomedcentral.com)

The progression of atherosclerosis with further lipid accumulation in the deep layers of the tunica intima is shown by Nakashima, as well as the Grade-3 version. (meatrition.com)
Figure 5 shows the progression of atherosclerosis with further lipid accumulation in the deep layers of the tunica intima. (meatrition.com)

Quantitative metabolomics was performed in AKI models to reveal the differences of lipid metabolism-related products. (thno.org)
Next, we evaluated lipid metabolism-related gene expression by quantitative RT-PCR. (shimane-u.ac.jp)

Theoretically, a decrease in fatty acid β-oxidation can lead to lipid accumulation. (biomedcentral.com)
We induced hepatoteatosis in zebrafish by overfeeding regimen and demonstrated caffeine have a role in suppression of hepatosteatosis by downregulation of genes associated with lipogenesis, ER stress, inflammatory response and enhancement of lipid oxidation, indicating zebrafish model may be used to identify putative pharmacological targets and to test novel drugs for human NAFLD treatment. (biomedcentral.com)
In Sjögren-Larsson syndrome , FALDH deficiency impairs fatty alcohol oxidation and leads to accumulation of 16- and 18-carbon-long aliphatic alcohols. (medscape.com)

ASMD is characterized by the accumulation of sphingomyelin in late endosomes and lysosomes leading to progressive neurological dysfunction and hepatosplenomegaly. (pubpharm.de)
[ 12 ] Tissue dysfunction is thought to be due to lipid storage in membranes. (medscape.com)

The qualitative analyses of neutral lipid bodies under stress conditions were performed by confocal microscopy and revealed bright golden-yellow lipid droplets in stress exposed cells. (hindawi.com)
Lipid accumulation can be recorded via a 96-well plate reader which emits light, exciting the cells at approximately 500nm and then recording the emission at approximately 575nm. (systemsbiology.net)
Lipid accumulation can also be seen in cells with an epi-fluorescence microscope where the cells glow red and the lipid inside glows bright yellow. (systemsbiology.net)
Upon inspecting Nile Red stained cells under an epifluorescent microscope, it was evident that some cells were accumulating lipids while others were not. (systemsbiology.net)
Lipids keeps shrinking with aging and neurodegeneration I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. (atlasofscience.org)
With exception of cells grown without added silica, the percent lipid content was approximately the same (30-40% (w/w) TAG (Triacylglycerol) and 70-80% (w/w) fatty acid methyl ester (FAME) grown under all conditions within the soluble range. (montana.edu)
Here, we use the nutrient-storing nurse cells of the fly ovary to study the cellular effects of intracellular IIS components on lipid accumulation. (silverchair.com)
KSS inhibited the accumulation of triglycerides in a dose-dependent manner in 3T3-L1 cells that were induced to differentiate into adipocytes. (elsevierpure.com)
In cells, lipids are stored in specialized organelles called lipid droplets (LDs) after esterification of their polar head with an additional hydrophobic chain. (unifr.ch)
See here how lipid loading may be involved in the paracrine crosstalk between cancer cells and stromal compartment of the hypoxic tumor microenvironment. (lu.se)
Here, we demonstrate that LL-37 is rapidly (within 20 min) internalized by human osteoblast-like MG63 cells, and that the peptide co-localizes with MitoTracker arguing for accumulation in mitochondria. (lu.se)

Treatment with the ATGL inhibitor Atglistatin rescued lipid accumulation inside lipid droplets in HILPDA-deficient macrophages. (wur.nl)

Moreover, a decrease of CL species containing PUFA and accumulation of its oxygenated molecular species was oserved. (cdc.gov)
Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)

Five studies verified changes in the lipid profile and high incidence of dyslipidemias, with the most frequent changes being low HDL and elevated triglycerides. (bvsalud.org)

Chlorella ellipsoidea and Chlorococcum infusionum , promising microalgae for biodiesel feedstock production, were treated with ethylenediaminetetraacetate (EDTA) and phosphorous to induce stress which was then followed by flow cytometry to study the enhanced intracellular neutral lipid content. (hindawi.com)
Under different nutrient starvation, microalgae can accumulate large quantities of neutral lipid in the form of triacylglycerol (TAG) within the cell cytoplasm [ 11 ]. (hindawi.com)
In contrast, use of the same standard curve during nitrogen deprivation (causing the accumulation of neutral lipids) or in the presence of high quantities of bacterial contamination led to significant errors in chlorophyll estimation. (frontiersin.org)

Microalgae Skeletonema costatum and Scenedesmus obliquus were found as good candidates for biodiesel production due to their high lipid productivity and fatty acid content [ 2 , 3 ]. (hindawi.com)
Different experimental conditions using P starvation were applied to improve lipid productivity in S . obliquus , Chlorella kessleri , and Monodus subterraneus [ 3 , 17 , 18 ]. (hindawi.com)
The lipid productivity in S . obliquus was increased up to 54% under P starvation or limitation but growth ceased due to insufficient nutrient [ 3 ]. (hindawi.com)
The properties of biodiesel obtained from S. obliquus, were the same with those specification for biodiesel standards including ASTM D 6751 (American Society for Testing Material) and the European Standard En 14214. (unboundmedicine.com)
TY - JOUR T1 - Enhancement of lipid accumulation in Scenedesmus obliquus by Optimizing CO2 and Fe3+ levels for biodiesel production. (unboundmedicine.com)

Brain lipid fatty acids and temperature acclimation. (wikipedia.org)
An interesting model in this context is the model of lipid infusion, whereby elevation of circulating fatty acids rapidly leads to the accumulation of IMTGs in skeletal muscle and the development of IR within 3−24 h after the onset of lipid infusion. (medscape.com)

To this end, the current study examined the development of lipid-induced IR in endurance-trained athletes, who were selected based on a high maximal oxygen uptake in a graded exercise test and compared with untrained, but otherwise healthy, subjects. (medscape.com)

In this study, we investigated the role of miR-126-3p and miR-199a-3p on lipid accumulation in 3T3-L1 adipocytes. (shimane-u.ac.jp)

As part of my internship at ISB, I teamed up with Jordan Raymond, an undergrad intern, to quantitatively determine the rate at which lipid accumulation in Chlamydomonas reinhartii occurs under phosphate deprivation. (systemsbiology.net)

Anatomy36

Organisms16

Diseases9

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes67

Disciplines and Occupations2

Technology, Industry, Agriculture7

Information Science3

Health Care1

Droplet accumulation1

Oxidative9

Adipose6

Promote lipid accumulation1

Growth and lipid accumulation1

Peroxidation3

Synthesis10

Enlarged lipid droplets1

Suppress lipid accumulation2

Droplets accumulation1

Obesity2

Triglyceride4

Metabolic7

Mechanisms5

Total lipid content1

Role of lipid1

Deposition2

Hepatocytes1

Alterations in lipid1

Insulin9

Controls lipid2

Biomass4

Adipocyte differentiation1

Changes in lipid1

Excessive fat accumulation in the liver2

Protein9

Mitochondrial dysfunction2

Hepatic fat1

Concentrations2

Liver6

Increases4

Regulation4

Blood lipid1

PPAR2

Autophagy3

Inflammation1

Waist Circumference2

Membrane3

Acute kidney1

Microalgal3

Significantly3

Atherosclerosis2

Metabolism-related2

Oxidation3

Dysfunction2

Cells11

Macrophages1

PUFA2

Triglycerides1

Neutral3

Obliquus5

Fatty acids2

Uptake1

Adipocytes1

Deprivation1