• β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
  • Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
  • Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway. (nih.gov)
  • To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. (frontiersin.org)
  • Our simulation experiments indicate, that for receptor/raft ratios smaller than 1, i.e., when the number of raft compartments clearly exceeds the number of pathway specific membrane proteins, we observe significant decrease in LRP6 phosphorylation and downstream pathway activity. (frontiersin.org)
  • Several studies suggested an involvement of lipid rafts in the WNT /β-catenin pathway. (frontiersin.org)
  • Here, we apply computational modeling to analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation. (frontiersin.org)
  • β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
  • Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
  • The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
  • The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
  • This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
  • Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
  • Activation of the pathway was further confirmed by nuclear accumulation of beta-catenin driven by Wise. (unimib.it)
  • Functions in the canonical Wnt/beta-catenin signaling pathway. (xenbase.org)
  • The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. (xenbase.org)
  • beta-catenin is a target for the ubiquitin-proteasome pathway. (bioseek.eu)
  • beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)
  • In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)
  • This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)
  • We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)
  • The first is commonly called the canonical pathway and ultimately culminates in beta-Catenin accumulation and TCF/LEF-1-mediated gene transcription. (bio-techne.com)
  • There are three Wnt signaling pathways that are well identified, including the canonical or Wnt/β-catenin dependent pathway, the noncanonical or β-catenin-independent planar cell polarity (PCP) pathway, and the noncanonical Wnt/Ca2+ pathway. (ac.ir)
  • This review discusses the interaction between proteins of several human oncogenic viruses with the Wnt signaling pathway. (ac.ir)
  • Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/beta-catenin signaling pathway. (ac.ir)
  • It mediates cell-cell adhesion with cadherins and it is key regulatory protein in signaling through the WNT pathway. (newmarketscientific.com)
  • Optogenetics, the use of light responsive proteins to recruit signaling pathway effectors, has begun to play an essential role in filling this need. (biologists.com)
  • Dsh has three highly conserved protein domains, which interact differently based on which Wnt pathway it is interacting with [44]. (scdinhibitor.com)
  • The three pathways will be the canonical Wnt/beta-catenin pathway, the noncanonical planar cell polarity (PCP) pathway, along with the noncanonical Wnt/calcium pathway. (scdinhibitor.com)
  • The canonical pathway will be the only 1 to involve beta-catenin, which can be the TCF/LEF binding protein responsible for improved transcription and EMT [57,58]. (scdinhibitor.com)
  • The canonical Wnt pathway contains the beta-catenin destruction complex, which is normally down-regulated or disrupted following the activation of Wnt signaling. (scdinhibitor.com)
  • We also found that cilia formation of MSCs was increased in the presence of HGC27 cells, which was associated with abnormal activation of the Wnt/β-catenin pathway. (aging-us.com)
  • Expression of DKK1 inhibited the Wnt/β-catenin signaling pathway and partially rescued osteogenic differentiation of MSCs. (aging-us.com)
  • In summary, our results suggest that gastric cancer cells might cause bone damage prior to the occurrence of bone metastasis via cilia-dependent activation of the Wnt/β-catenin signaling pathway. (aging-us.com)
  • Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
  • β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation. (biomedcentral.com)
  • β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
  • The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
  • The level of free β-catenin is low in normal cells, since the protein is sequestered in a complex, which includes the adenomatous polyposis coli (APC) protein, a serine threonine glycogen kinase (GSK-3β) and conductin or Axin, leading to degradation of β-catenin by proteasome. (biomedcentral.com)
  • Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
  • In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. (wikipedia.org)
  • Mutations in beta catenin gene (CTNNB1) leads accumulation of the beta catenin protein in cytoplasm and nucleus in different type of tumors eg. (newmarketscientific.com)
  • The most abundant membrane\associated proteins were heat\shock protein family A (Hsp70) member (Hspa5), beta\catenin (Ctnnb1), rho family, small GTP binding protein (Rac1 and Obeticholic Acid Rac3), cadherins (Cdh1 and Cdh3), coxsackie virus and adenovirus receptor (Cxadr) as well as epidermal growth factor receptor (Egfr). (crispr-reagents.com)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • Moreover, several studies have shown that cancer cells have genetic instability, epigenetic changes, and an accumulation of mutations, suggesting that cancer is a genetic disease [ 16 ]. (hindawi.com)
  • Scope includes mutations and abnormal protein expression. (cancer-genetics.org)
  • In this study, we investigated the expression pattern of β-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the β-catenin gene and Axin gene in esophageal squamous cell carcinoma. (biomedcentral.com)
  • Mutations in β-catenin or axin genes are not responsible for this abnormal localization of β-catenin. (biomedcentral.com)
  • Both pathways seem to involve interactions with G-proteins. (xenbase.org)
  • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. (scienceopen.com)
  • Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. (uchicago.edu)
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
  • Previously, we showed that ionizing radiation-induced uPAR overexpression is associated with increased accumulation of β-catenin in the nucleus. (nih.gov)
  • IHC analysis of paraffin blocks from Asian Caucasian patients demonstrated that the frequency of PAFAH1B1 protein overexpression was 68% in Asian and 70% in Caucasian. (biomedcentral.com)
  • Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. (uchicago.edu)
  • Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells. (uchicago.edu)
  • Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
  • 21. Everly DN, Jr., Kusano S, Raab-Traub N. Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. (ac.ir)
  • Keratin 19 interacts with GSK3beta to regulate its nuclear accumulation and degradation of cyclin D3. (addgene.org)
  • Western blot analysis was employed to detect the cytoplasmic and nuclear levels of β-catenin, as well as the total lysate content of fibronectin and α-SMA. (molvis.org)
  • XAV932 was used to assess the suppression of nuclear β-catenin and its downstream effect on EMT marker proteins and VEGF expression. (molvis.org)
  • The enhancement of nuclear β-catenin looked as if it positively correlated with a significant increase in the basal expression of VEGF as well as increased expression of fibronectin and α-SMA. (molvis.org)
  • Treatment with XAV932 significantly reduced the level of nuclear β-catenin, but the levels of neither the EMT marker proteins nor VEGF were changed. (molvis.org)
  • Recently, we reported that nuclear β-catenin, but not HIF-2α, regulates the expression of fibronectin and α-SMA in atmospheric oxygen. (molvis.org)
  • In marked contrast, data from the hypoxic condition clearly establish that nuclear β-catenin plays little apparent role in the expression of EMT marker proteins. (molvis.org)
  • Mutational analyses of the exon3 of the β-catenin gene and Axin gene were performed on tumors with nuclear β-catenin expression. (biomedcentral.com)
  • Four (8%) esophageal cancer tissues showed high nuclear β-catenin staining. (biomedcentral.com)
  • All four cases that showed nuclear β-catenin staining overexpressed cyclin D1. (biomedcentral.com)
  • No mutational change was found in β- catenin exon 3 in the four cases with nuclear β-catenin staining. (biomedcentral.com)
  • A fraction of esophageal squamous cell carcinomas have abnormal nuclear accumulation of β-catenin accompanied with increased cyclin D1 expression. (biomedcentral.com)
  • β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
  • To determine major biological processes and functions represented within the cmAPEX proteome, we next analyzed the dataset of 301 ciliary proteins for overrepresentation of Gene Ontology (GO) terms. (crispr-reagents.com)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
  • The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
  • What does this gene/protein do? (cancer-genetics.org)
  • We further demonstrated that uPAR protein act as cytoplasmic sequestration factor for a novel basic helix-loop-helix transcription factor, Hand1. (nih.gov)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
  • SB216763-treated HLE-B3 cells caused marked inhibition of GSK-3β activity prompting a significant increase in the translocation of cytoplasmic β-catenin to the nucleus. (molvis.org)
  • CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. (thermofisher.com)
  • β-catenin binds to both the cytoplasmic domain of cadherin and the amino-terminal domain of β-catenin and mediates cell adhesion. (biomedcentral.com)
  • In Drosophila, the homologous protein is called armadillo. (wikipedia.org)
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • Termed armadillo repeats, all these elements fold together into a single, rigid protein domain with an elongated shape - called armadillo (ARM) domain. (wikipedia.org)
  • Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. (embl.de)
  • It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
  • Three-dimensional structure of the armadillo repeat region of beta-catenin. (embl.de)
  • A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)
  • The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. (embl.de)
  • and protein stabilization. (nih.gov)
  • Wnts bind Frizzled receptors and forms complex with low-density lipoprotein receptor-related protein (LRP5 or LRP6) which results in the stabilization of intracellular beta-catenin levels. (biolegend.com)
  • β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
  • Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)
  • Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. (biolegend.com)
  • Intracellular beta-catenin levels are maintained through continuous creation and destruction, the processes of that are suggested to be regulated differently in between our parity groups. (scdinhibitor.com)
  • Wnt-3a belongs to Wnt family of proteins that consist of structurally related genes encoding highly conserved cysteine rich secreted glycoproteins. (biolegend.com)
  • Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes. (tocris.com)
  • Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
  • The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. (ac.ir)
  • As a transcription factor, many of the functional cellular roles of the p53 protein are elicited through direct DNA binding to sequence-specific cis-regulatory elements [ 3 ] leading to the transactivation or transrepression of target genes. (biomedcentral.com)
  • beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)
  • In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
  • HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)
  • 20. Morrison JA, Raab-Traub N. Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. (ac.ir)
  • Beta catenin has a role in cellular proliferation, differentiation and development. (newmarketscientific.com)
  • Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
  • Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
  • BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. (uchicago.edu)
  • Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
  • Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
  • The data show p53 protein was transcriptionally activated and contributed to NGF-mediated neurite outgrowth during differentiation of PC12 cells. (biomedcentral.com)
  • Despite data supporting the transcriptional activity of p53 protein in differentiation, few genetic targets have been described and fewer still within a neuronal context. (biomedcentral.com)
  • No relationship was observed between the expression pattern of β-catenin and cyclin D1 and age, sex, tumor size, stage, differentiation grade, lymph node metastasis, response to chemotherapy, or survival. (biomedcentral.com)
  • Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
  • A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1γ is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/β-catenin signaling. (frontiersin.org)
  • Glycogen synthase kinase-3 (GSK-3) and beta-catenin: potential novel therapeutic targets for COPD. (rug.nl)
  • 14-3-3sigma regulates beta-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3beta. (addgene.org)
  • Even though LRP6 is homogenously distributed in the membrane and only a minor fraction is raft-associated, its localization to lipid rafts is vital for the activation of the LRP6 signalosome, hence wnt/β-catenin signaling. (frontiersin.org)
  • The Wise protein physically interacts with the Wnt co-receptor, lipoprotein receptor-related protein 6 (LRP6), and is able to compete with Wnt8 for binding to LRP6. (unimib.it)
  • After integrating the OptoWNT system into the AAVS1 safe harbor locus of human embryonic stem cells (hESCs), the authors validate that blue light causes reversible clustering of LRP6, and accumulation of the Wnt transcriptional activator beta-catenin. (biologists.com)
  • Upon blue light stimulation, LRP6 clusters and causes an accumulation of β-catenin. (biologists.com)
  • Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
  • Uclear beta-catenin in about 60 of breast cancers. (scdinhibitor.com)
  • Studies carried out over the past three decades suggest that glioblastomas, like other cancers, arise secondary to the accumulation of genetic alterations. (bmj.com)
  • Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
  • β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
  • Our evaluation showed an increased methylation of LRP5 within parous females, which suggests a decreased expression of LRP5/6 plus a decreased cellular capability to stop the beta-catenin destruction complex within this way. (scdinhibitor.com)
  • of AR signaling whether enhanced CCRK-driven β-catenin activation is globally contributing to tumorigenesis or in some cases may in fact be an oxidative stress-driven response promoting cell proliferation and regeneration in the setting of chronic liver injury and fibrosis. (aurorakinaseb.com)
  • these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 . (tocris.com)
  • This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
  • To date, at least 28 different proteins have been identified as amyloids in humans [ 3 , 5 - 7 ]. (hyperthermicwellness.com)
  • The beta-catenin destruction complicated starts using the binding of GSK3 to Axin, which leaves GSK3's active website open to phosphorylate beta-catenin. (scdinhibitor.com)
  • Mechanistically, actin depolymerization leads to the accumulation of Rab11/Rab8\positive vesicles at the centrosome thereby supporting ciliogenesis 39, 40. (crispr-reagents.com)
  • Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
  • Wnt family proteins have been implicated in oncogenesis and in multiple developmental processes including regulation of cell fate and patterning during embryogenesis. (biolegend.com)
  • Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)
  • ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)
  • Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)
  • β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
  • Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)
  • Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling. (nih.gov)
  • The Wnts make up a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. (bio-techne.com)
  • 2006. Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. . (oregonstate.edu)
  • Discovery of non-genotoxic mechanisms through which p53 protein may be activated within tumor cells harboring wild-type p53 remains an important therapeutic objective, both in effort to alleviate traditional off-target chemotherapeutic side-effects and to prevent the unpredictable mutagenicity characteristic of these therapies. (biomedcentral.com)
  • Members of the Hedgehog (Hh) and Wnt/Wingless (Wg) families of secreted proteins control many aspects of growth and patterning during animal development. (scienceopen.com)
  • Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)
  • It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
  • Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. (wikipedia.org)
  • Inhibition of ERK1/2 Restores GSK3beta Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis. (addgene.org)
  • A hypoxia-inducible factor-1α (HIF-1α) translation inhibitor and an HIF-2α translation inhibitor were independently employed to evaluate the effect of hypoxia inducible factor inhibition on EMT marker protein and VEGF expression. (molvis.org)
  • An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
  • Four candidate oncogenes were validated for DNA copy number and mRNA and protein expression by quantitative polymerase chain reaction (qPCR), chromogenic in situ hybridization (CISH), reverse transcriptase-qPCR (RT-qPCR), and immunohistochemistry (IHC) in more patients. (biomedcentral.com)
  • In summary, we present a novel approach to investigate dynamics of the ciliary membrane proteome in mammalian cells and identify actin\binding proteins as mechanosensitive components of cilia that might have important functions in cilia membrane dynamics. (crispr-reagents.com)
  • A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
  • The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin. (embl.de)
  • 2005. Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. . (oregonstate.edu)
  • Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. (frontiersin.org)
  • Taxonomic distribution of proteins containing ARM domain. (embl.de)
  • By comparing levels of Brachyury, a master mesendoderm transcription factor and marker of the primitive streak, in cells that got no light or constant 48 hours of blue light exposure, the authors found that there was a 40 fold increase in protein expression with blue light. (biologists.com)
  • Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
  • The purpose of this study was to identify potential therapeutic strategies to slow down or prevent the expression of early-onset epithelial to mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing the synthesis and accumulation of the prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens epithelial (HLE) cells. (molvis.org)
  • Frequently, mesenchymal and hematopoietic progenitors are associated with the action of parathyroid hormone-related protein (PTHrP), a well-known regulator of tumour-associated bone destruction [ 1 ], as well as with the hypercalcemia seen in many types of cancer [ 2 ]. (aging-us.com)
  • Fibromas, plaques, and patches are due to fibrosis with abnormal collagen and blood vessel accumulation. (medscape.com)
  • In this review we will highlight mechanisms that control targeting of PSD-95 at the synapse, and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic structure and strength. (frontiersin.org)
  • β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
  • β-catenin belongs to the catenin molecule family. (chemdiv.com)
  • β-Catenin is widely expressed in many tissues. (wikipedia.org)
  • Protein accounts for about three-fourths of the dry matter in human tissues other than fat and bone. (bartleby.com)
  • Amyloidosis is a large group of pathologic conditions in which a particular type of protein, called amyloid, is abnormally deposited in various tissues or organs. (hyperthermicwellness.com)
  • Once phosphorylated, beta-catenin is ubiquitinated and sent to the proteasome for removal [59]. (scdinhibitor.com)
  • β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin. (tocris.com)
  • Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential. (ac.ir)
  • Surprisingly, plenty of proteins involved in actin filament and cytoskeleton organization were enclosed in the APEX\based ciliary membrane\associated proteome. (crispr-reagents.com)
  • 1997) by containing the zinc of NOTCH due number for JAG proteins( Bruckner et al. (familie-vos.de)
  • Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury. (rug.nl)
  • Generally, amyloid refers to misfolded peptides or proteins that demonstrate a stable, cross-beta super-secondary structure that renders it insoluble, fibrous-like, and resistant to proteolysis. (hyperthermicwellness.com)
  • The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
  • Wise encodes a secreted protein capable of inducing posterior neural markers at a distance. (unimib.it)
  • TSC2, encodes for the protein tuberin. (medscape.com)
  • ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
  • Depolymerization of branched F\actin causes further Obeticholic Acid enrichment of the actin\binding and actin\related proteins in cilia, including Myosin 5a (Myo5a). (crispr-reagents.com)