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  • inhibit
  • In this study, we report that small interfering RNAs (siRNA) against the breakpoint of EWS-Fli1 mRNA might be a very efficient agent with which to inhibit the expression of EWS-Fli1 and the growth of EFT cells, and that EWS-Fli1 might have functions that prevent the induction of senescence in cells through the promotion of Skp2-mediated and 26S proteasome-dependent degradation of p27 protein. (aacrjournals.org)
  • 1996
  • Membrane potential-dependent transport of essential metabolic substrates during the cell cycle and/or volume regulation could also play a role (for review, see Wonderlin and Strobl, 1996 ). (jneurosci.org)
  • inhibitory
  • These effects were not dependent on the presence of PACR, although, the inhibitory effects occurred more quickly in its presence. (otago.ac.nz)
  • Hence
  • Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased synovial vascularity, and hence is a potential therapeutic target for angiogenesis inhibitors. (biomedcentral.com)
  • therapeutic
  • This highly effective, functional approach allowed for rapid benchmarking against known CDK inhibitors with undesirable side effects, such as flavopiridol ( Fig. 1B ), and showed SCH 727965 to be a compound with a significantly superior therapeutic profile. (aacrjournals.org)
  • specific
  • A critical issue for the successful development of CDK inhibitors (and indeed the majority of cytoreductive agents) is, therefore, the relationship between desirable, target-specific effects and the onset of nonspecific adverse events that might negatively influence clinical dose escalation ( 20 ). (aacrjournals.org)
  • human
  • Indirubin, an indigoid active ingredient of a traditional Chinese recipe, was the first example of a CDK inhibitor used to treat human chronic myelogenous leukemia (CML). (aacrjournals.org)
  • The present invention relates to compositions and methods for treating the epithelial toxicity caused by administering to a human cancer patient an epidermal growth factor receptor (EGFR) inhibitor. (patentsencyclopedia.com)