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  • Clinical
  • At the Medical College of Wisconsin, researchers are beginning a clinical trial that involves implanting fetal neural cells into spinal cord injury patients. (wisconsintechnologycouncil.com)
  • Founded more than twenty years ago, the Center's mission is to ensure that academic and clinical discussions on bioethics include a robust understanding of human dignity within the broad Judeo-Christian Hippocratic traditions. (cbhd.org)
  • There should be no doubt that the use of cadaveric fetal organs and tissue for research and clinical applications raises serious moral and ethical concerns, concerns that are heightened when the organs and tissue are obtained as the result of elective abortion. (cbhd.org)
  • Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
  • This paper presents the current clinical application of human amnion in the treatment of skin losses, such as burns to the face and Lyell's syndrome (toxic epidermal necrolysis). (omicsonline.org)
  • Epidemiological, clinical, physiological, cellular, and molecular evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to intrauterine life and supports an important role for maternal nutrition prior to and during gestation in fetal programming. (biomedsearch.com)
  • We conclude with a commentary of the implications for future research and clinical practice. (biomedsearch.com)
  • The combination of late stage pre-clinical research and direct patient access place Dr. Lux in an excellent position to offer collaborative opportunities to partners interested in developing gene based therapies for hemoglobinopathies. (seattlechildrens.org)
  • The disease is characterised pathologically by an early and progressive striatal neuronal cell loss and atrophy, which has provided the rationale for first clinical trials of neural repair using fetal striatal cell transplantation. (bmj.com)
  • Firstly, I propose to perform preclinical testing of human intestinal epithelium to pave the way for their inclusion in clinical trials for IBD patients. (europa.eu)
  • The proposed research programme will have significant clinical and biological impact. (europa.eu)
  • Intestinal
  • Distinguished pediatric surgeon Samuel M. Alaish, M.D., joined the Johns Hopkins Children's Center in 2015 to co-lead The Hopkins Resource for Intestinal Vitality and Enhancement (THRIVE), a multidisciplinary program dedicated to the study and care of children with short bowel syndrome, a condition marked by insufficient gut tissue or poor gut function due to acquired or congenital diseases. (hopkinsmedicine.org)
  • By combining analysis of intestinal epithelial cells from various developmental stages, I will be able to identify the most suitable source for transplantation and define how adult stem cells are specified in the tissue. (europa.eu)
  • Secondly, I will utilise an in vitro culture system to identify the transcriptional networks responsible for the maturation of the foetal intestinal epithelium. (europa.eu)
  • therapeutic
  • A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. (springer.com)
  • In his efforts to validate the efficacy of fetal hemoglobin as a therapeutic target, Dr. Lux has developed a range of endonucleases capable of targeting the gamma hemoglobin locus, which has been implicated with producing fetal hemoglobin. (seattlechildrens.org)
  • spinal cord i
  • Due to the tissue s unique characteristics, it possesses extraordinary regenerative potential, which many scientists believe can be exploited to restore function after spinal cord injury (SCI). (healingtherapies.info)
  • gestation
  • Using 20 human fetuses (12-25 weeks of gestation), semiserial horizontal or sagittal paraffin sections were prepared at intervals of 20 to 100 μm. (arvojournals.org)
  • PER C6 is taken from the retinal tissue of an 18-week gestation infant and is being used by Merck & Co to produce a new HIV vaccine, MedImmune Inc to produce a new flu vaccine and by the National Institutes of Health in developing a new Ebola vaccine. (cogforlife.org)
  • ethics
  • The fetus is a human subject entitled to the protections that both traditional and modern codes of medical ethics provide to human subjects. (cbhd.org)
  • The fetus, as a uniquely vulnerable and dependent human person, merits the same (or even heightened) protections that modern declarations and codes of medical ethics impose on all human subject research. (cbhd.org)
  • Under a very strict regulatory and ethics regime, Dutch scientists have access to human fetal tissue and the stem cells that reside in these tissues. (statnews.com)
  • The Daily Telegraph has established that a Dutch bio-tech company, Crucell, working through a Sydney contract research organisation, Parexel International, has applied to the ethics committee of Queen Elizabeth Hospital in Adelaide for access to foetal material. (cogforlife.org)
  • Capital and Coast Health Board pulled out of the deal last week following Weekend Herald inquiries into its application to the Wellington Regional Ethics Committee to take the tissue for the production of vaccines against HIV, Ebola and other viral diseases. (cogforlife.org)
  • Review of research proposals by a Research Ethics Board takes into account these freedoms and responsibilities and provides accountability and quality assurance both to colleagues and to society. (sfu.ca)
  • This Policy provides a mechanism for ethics review of research involving human participants to protect those participants, researchers, support staff, students, and third parties, and to educate those involved in this type of research. (sfu.ca)
  • No more than three years after the implementation of this Policy, and no more than every five years thereafter, Senate will undertake a review of the Policy and Procedures for Ethics Review of Research Involving Human Participants, and make amendments should they be deemed necessary. (sfu.ca)
  • embryo
  • Science establishes that the nascent human, as a blastocyst, then an embryo, then a fetus, is an organism of the species Homo sapiens , and genetically distinct from both father and mother. (cbhd.org)
  • Given time, nutrition, and a safe environment, the embryo, then fetus, will grow and develop through all the natural stages of human life. (cbhd.org)
  • Its pronouncement on human embryo research in 1979, followed by the EAB dissolution, began a 15-year moratorium on such research. (georgetown.edu)
  • biological
  • With the consent of donors, this unique and valuable tissue can be used for research into basic biological processes and human development, as well as creating new treatments for life-threatening diseases. (isscr.org)
  • From a biological perspective, we will gain insights into how specific signalling networks maintain specific cell states and dictate tissue maturation. (europa.eu)
  • vaccines
  • Vaccines for diseases such as polio, measles and hepatitis, to name a few, were historically rooted in work with fetal tissue. (wisconsintechnologycouncil.com)
  • It is currently being used to develop and test vaccines for potential treatment of influenza, dengue fever, HIV/AIDS, and hepatitis B and C. It is vital for research in other areas as well. (statnews.com)
  • The tissue would be sent to Crucell's laboratories in the Netherlands and used to grow cell lines for research into vaccines for infectious diseases such as HIV and ebola. (cogforlife.org)
  • The fetal-derived cell lines WI-38 and MRC-5 were adopted by the pharmaceutical industry as tools for the production of vaccines shortly after they were developed in the 1960s.And for a small minority of vaccines, these tools are still used today. (bioethics.net)
  • Importantly, alternative vaccine formulations that do not rely on fetal-derived cell lines are available or all but five of these diseases (Adenovirus, Hepatitis A, Rubella, Varicella and Zoster), and there is no scientific reason these vaccines could not be produced using animal cell lines. (bioethics.net)
  • gene
  • Li H, Lee TH, Avraham H. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. (springer.com)
  • Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. (ingentaconnect.com)
  • The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. (ingentaconnect.com)
  • The approach Dr. Lux's research group employs involves restoring hemoglobin function through targeted gene editing with tools such as targeted endonucleases including TALENs and the CRISPR/Cas9 system. (seattlechildrens.org)
  • While the ability to selectively edit and restore normal hemoglobin function and production levels is Dr. Lux's ultimate goal, he has demonstrated success in producing targeted gene insertions and deletions that can increase expression of fetal hemoglobin, ameliorating disease symptoms despite the continuing presence of the underlying pathology. (seattlechildrens.org)
  • Bulmer, J.N., Morrison, L., and Smith, J.C.: Expression of class II MHC gene products by macrophages in human uteroplacental tissue. (springer.com)
  • serum
  • In this chapter, the authors will employ the term BM stromal cell to describe the adventitial reticular/fibroblast-like cell that predominates cultures established from mouse or human BM plated in tissue culture medium supplemented with fetal bovine serum. (springer.com)
  • cell
  • Fetal tissue has also allowed researchers to test cell-based approaches to a variety of neurodegenerative diseases that do not have any other effective treatment. (isscr.org)
  • STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell. (springer.com)
  • Western blot showing the comparison of banding patterns in COS-1 cell lysate, U937 cell lysate, in vitro translated human PPAR γ 1, and tissue lysate from human fetal stomach samples. (hindawi.com)
  • The Steering Committee was established in December 2002 as an independent national committee overseeing the activities of the UK Stem Cell Bank and UK research involving established human embryonic stem cell (hESC) lines, whether obtained from the Bank or from elsewhere. (mrc.ac.uk)
  • To review on a case by case basis all applications to deposit and access embryonic stem cell lines. (mrc.ac.uk)
  • All UK research involving the use of hESC lines is expected to comply with the UK Code of Practice for the Use of Human Stem Cell Lines (PDF, 487KB) . (mrc.ac.uk)
  • This Code provides guidance on best practice for those working with stem cell lines and specifies oversight mechanisms for research involving human embryonic stem cell lines. (mrc.ac.uk)
  • This applies to hESC lines accessed from the UK Stem Cell Bank, as well as those obtained from other sources, including overseas. (mrc.ac.uk)
  • The basis of Dr. Lux's research is to develop more effective and permanent treatment options for patients with heritable anemia through targeted hematopoietic stem-cell reprogramming. (seattlechildrens.org)
  • Cell Tissue Res. (springer.com)
  • However, these historic fetal-derived cell lines are still in use today for primarily economic, not scientific reasons. (bioethics.net)
  • Three major Pharmaceutical players (Merck, GlaxoSmithKline and Sanofi) adopted the fetal cell lines MRC-5 and WI-38 in the 1970s, shortly after they were developed. (bioethics.net)
  • Of the nearly 75 vaccine formulations currently approved by the Food and Drug Administration for use in the United States, only 11 (directed against Zoster, Varicella, Rabies, Rubella, Hepatitis A, Polio and Adenovirus) are produced using historic, fetal-derived cell lines, and none are produced using freshly isolated fetal tissue. (bioethics.net)
  • Jarvis, L. J. and LeBien, T. W. (1995) Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes. (springer.com)
  • As neurons mature, they migrate from the base to the surface of the tissue and replace mature neurons, which die through apoptosis, a form of programmed cell death. (healingtherapies.info)
  • biomedical
  • The ISSCR is opposed to recent efforts to inappropriately limit or prohibit biomedical research using fetal tissue. (isscr.org)
  • These proposals, if enacted, would obstruct critical biomedical research and inhibit efforts to improve human health. (isscr.org)
  • Federal law was adjusted in 1975 to add language clarifying that this research be "conducted only in accordance with any applicable State or local laws regarding such activities," and only for "the development of important biomedical knowledge which cannot be obtained by other means. (statnews.com)
  • This congressionally mandated group was formed in 1978, succeeding the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (georgetown.edu)
  • involves
  • It is "morally impermissible to engage in any research, for any purpose, that involves the destruction of human beings at any stage of their lives, including the embryonic stage, or in any condition, however weak or dependent. (cbhd.org)
  • With these freedoms come responsibilities to ensure that research involving human subjects meets high scholarly and ethical standards, is honest and thoughtful inquiry, involves rigorous analysis and complies with professional and disciplinary standards for the protection of privacy and for methodological approaches. (sfu.ca)
  • A proportionate approach to assessing the ethical acceptability of the research, at either level of review, involves consideration of the foreseeable risks, the potential benefits, and the ethical implications of the research. (sfu.ca)
  • transplant
  • More permanent treatments involving bone marrow transplants can reduce or eliminate the need for blood transfusions, but come with their own possible complications including secondary infections and eventual sensitization and rejection of the transplant tissue. (seattlechildrens.org)
  • researchers
  • The researchers commented that changes to the blood-brain barrier that occur during pregnancy could facilitate the process by which Mc is acquired into the human brain. (todaytopics.com)
  • If passed, the bill would effectively halt valuable work in scores of laboratories at the UW-Madison, the Medical College of Wisconsin and beyond, shut down long-standing research projects and essentially chase many researchers and emerging companies out of the state. (wisconsintechnologycouncil.com)
  • These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. (springer.com)
  • University researchers enjoy special freedoms and privileges, which include freedom of inquiry and the right to disseminate the results thereof, freedom to challenge conventional thoughts, freedom from institutional censorship, and the privilege of conducting research on human participants with the trust and support of the general public, often with public funding. (sfu.ca)
  • vitro
  • A specific band for PPAR γ , (calculated molecular weight for human PPAR γ 1 = 54.55 kD) was identified on our Western blots by performing new experiments in which in vitro translated human PPAR γ 1 (provided by J. Peters, Pennsylvania State University) was compared with human fetal tissue lysates (Figure 1 ). (hindawi.com)
  • The Western blots of the fetal tissues were all reanalyzed using the ~55 kD band that aligned with the in vitro translated human PPAR γ 1. (hindawi.com)
  • fetus
  • Rather than being a distinct-and lesser-form of human life, the fetus is a distinct human being at a particular developmental stage. (cbhd.org)
  • 1930s
  • Research using donated fetal tissue has been underway since the 1930s and has made major contributions to our understanding of biology and the development of new medical technologies. (isscr.org)
  • macrophages
  • Based on the observation that impaired GM-CSF-dependent cholesterol clearance within alveolar macrophages drives reduction of macrophage-mediated surfactant clearance in Csf2rb −/− mice 16 , a validated animal model of human PAP 17 , here, we evaluate cholesterol content in human alveolar macrophages and pulmonary surfactant from PAP patients, and test cholesterol homeostasis as a novel target for development of pharmacotherapy of PAP. (nature.com)
  • WOMEN'S HEALTH
  • we look forward to working with you all to ensure access to the full range of women's health services! (ppaction.org)
  • Breast cancer that occurs in the breast glandular tissue seriously affects women's health and is life threatening [ 4 , 5 ]. (omicsonline.org)
  • brain
  • The process, called fetal ' microchimerism (Mc)', is common in other tissues such as blood, but this is the first evidence of male Mc in the human female brain . (todaytopics.com)
  • Testing for the presence of a particular region of the Y-chromosome in autopsied brain tissues , the research team discovered that 63% of their samples showed potentially long-lasting Mc in multiple brain regions. (todaytopics.com)
  • This is the first evidence that microchimerism can cross the blood-brain barrier to establish male fetal tissue in the human female brain" says Chan. (todaytopics.com)
  • 2012) "Male Microchimerism in the Human Female Brain" . (todaytopics.com)
  • Spatio-temporal transcriptome of the human brain. (springer.com)
  • In humans, expression profiling has determined that NMI is expressed in all fetal tissues except in the brain and primarily in the adult spleen, liver, and kidneys. (springer.com)
  • Circular RNAs (circRNAs) have recently been found to be expressed in human brain tissue, and many lines ofevidence indicate that circRNAs play regulatory roles in neurodevelopment. (springer.com)
  • The dog s side of the fence represents the nose s olfactory tissue, the tail side the brain s olfactory bulb, and the fence the cranial barrier. (healingtherapies.info)
  • ethical
  • NIH intends to uphold high ethical, health, and safety standards in both the conduct of the research it funds and the expenditure of public funds by its recipients. (nih.gov)
  • and are to be used for valuable and ethical research projects reflecting the requirements of the HFEA regulations. (mrc.ac.uk)
  • Simon Fraser University is committed to ensuring the highest level of ethical conduct for research involving human participants and to following the guidelines outlined in the Tri-Council Policy Statement, Ethical Conduct for Research Involving Humans , (the TCPS-2). (sfu.ca)