Accelerated or blastic phase. Medical search. Frequent questions

ImmunoGen Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, today announced updated data from an interim analysis of the Phase 2 CADENZA trial of pivekimab sunirine (pivekimab) in patients with frontline and relapsed/refractory (R/R) blastic plasmacytoid dendritic cell neoplasm (BPDCN). (observernewsonline.com)
The therapeutic is under development for the treatment of relapsed and refractory acute myeloid leukemia lymphoma and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (pharmaceutical-technology.com)

The blastic phase is a progression from the chronic phase. (cancer.gov)
The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML. (bvsalud.org)
Blast crisis is the final phase in the evolution of CML, and behaves like an acute leukemia, with rapid progression and short survival. (wikipedia.org)
In CML progression to accelerated phase and blastic phase appears to be due mainly to genomic instability, which predisposes to the de velopment of other molecular abnormalities. (screeninglibraries.com)
Researchers believe that additional genetic changes play a role in the progression of the chronic phase of chronic myeloid leukemia to the accelerated phase and blast crisis. (medlineplus.gov)

The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is imminent. (wikipedia.org)
Chronic phase (CP), accelerated phase (AP) and blast crisis (BP). (waocp.com)
When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis. (stanfordhealthcare.org)
The condition consists of three phases: the chronic phase, the accelerated phase, and the blast phase (or blast crisis). (medlineplus.gov)

Patients in the chronic phase of CML have stable disease with only minor symptoms, no cancer outside the bone marrow or spleen and white blood cell and platelet blood counts that are usually greater than normal. (broomeoncology.com)
Signs and symptoms are most severe in this phase, including a massively enlarged spleen, bone pain, and weight loss. (medlineplus.gov)
In the accelerated phase, the number of CML cells grow faster and cause symptoms such as fatigue, fever, weight loss and an enlarged spleen. (schoolandyouth.org)

Chronic myeloid leukemia: mechanisms of blastic transformation. (ca.gov)
Here, we discuss what is known about the molecular mechanisms leading to blastic transformation of CML and propose some novel therapeutic approaches. (ca.gov)
Part B.1 is satisfied by the presence of a blastic transformation of leukemia. (alaska-disability.com)
When chronic myelogenous leukemia (CML) undergoes blastic transformation, it has essentially converted to an acute myelocytic leukemia. (alaska-disability.com)
Before the advent of bone marrow and stem cell transplantation and the development of tyrosine kinase inhibitors for the treatment of CML , the prognosis was grimmer and the Social Security Administration had a policy of finding listing-level equivalence for any new diagnosis of CML even though there was no blastic transformation. (alaska-disability.com)

EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)
Now this priority review designation brings us one step closer to offering patients who are newly diagnosed with Ph+ CML in the chronic phase a promising new treatment option. (salesandmarketingnetwork.com)
The regulatory submissions are based on data from the ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials of Newly Diagnosed Ph+ CML Patients) Phase III clinical trial. (salesandmarketingnetwork.com)
This randomized, open-label, multicenter trial compared the efficacy and safety of Tasigna versus Gleevec in adult patients with newly diagnosed Ph+ CML in chronic phase(1). (salesandmarketingnetwork.com)
In adults with chronic phase CML that is newly diagnosed. (cancer.gov)

This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with chronic phase-CML. (bvsalud.org)
It has been reported that around 10% to 12% of patients with CML in chronic phase have ACAs at the time of diagnosis [9]. (waocp.com)
Eligible patients needed to have an ECOG performance status of 2 or less, no history or current diagnosis of chronic, accelerated, or blastic phase chronic myeloid leukemia, and an absence of clinically significant of uncontrolled cardiovascular disease. (targetedonc.com)
Most patients (90%) are diagnosed in chronic phase (CP), characterized by an increase in white blood cell counts with immature granulocytes in the peripheral blood, and up to 40% are asymptomatic at time of diagnosis. (rockstarsagainstliveearth.com)

Patients with early phase (also known as chronic phase [CP]) disease usually respond to treatment with ABL tyrosine kinase inhibitors (TKIs), although some patients who respond initially later become resistant. (ca.gov)

LSCs or their progeny can acquire additional genetic and/or epigenetic changes that cause the leukemia to transform from CP to a more advanced phase, which has been subclassified as either accelerated phase or blastic phase disease. (ca.gov)
Phase of CML-Patients who have either accelerated or blast phase CML have a less favorable prognosis than those who have chronic phase CML. (schoolandyouth.org)

The DASISION study (DASatinib versus Imatinib Study In treatment-Naive CML patients) showed similar results: achieving major CyR by 3 or 6 months was a better predictor of PFS after initial treatment with first-line dasatinib in chronic-phase CML. (medscape.com)
Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)

With the presence of these accelerated and blastic phases the disease is considered to have reached the most advanced stages, now being very similar to an acute leukaemia and consequently having a very poor prognosis. (fcarreras.org)
Blastic crisis is essentially like acute leukemia and is chemo refractory with a median survival of 3 to 6 months [7]. (waocp.com)
During the Society of Hematologic Oncology 2023 Annual Meeting, results from the phase 3 PhALLCON trial (NCT03589326) indicated that incorporating the tyrosine kinase inhibitor (TKI) ponatinib (Iclusig) into reduced-intensity chemotherapy resulted in a higher minimal residual disease (MRD)-negative complete remission (CR) rate at the end of induction in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) vs imatinib (Gleevec). (targetedonc.com)
Left untreated the disease inexorably progresses to blastic phase (BP), defined by the presence of 30% or more blasts in the bone marrow and a clinical picture indistinguishable from acute leukemia. (rockstarsagainstliveearth.com)
The blast phase appears and behaves like the acute form of myeloid leukemia. (schoolandyouth.org)

Treatment protocols for chronic myelogenous leukemia are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)
Over the past several years, advances in research, treatment, and market dynamics have impacted treatment strategies in chronic myeloid leukemia in chronic phase (CML-CP). (bvsalud.org)
In order to understand the best treatment options available for chronic myeloid leukemia, it is important to know the phase of leukemia, since all new treatment information concerning chronic myeloid leukemia is categorized and discussed by the phase of disease. (broomeoncology.com)
We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. (tau.ac.il)
Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
BPDCN is a rare and aggressive blood cancer characterized by extremely low survival rates and limited treatment options that are often associated with significant toxicities," said Naveen Pemmaraju, MD, Associate Professor of Leukemia at The University of Texas MD Anderson Cancer Center and co-investigator of the Phase 2 study. (observernewsonline.com)
The phase of your chronic myeloid leukemia (CML) plays a large part in determining the type of treatment you'll receive. (schoolandyouth.org)
Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations - Review (Sembill S et al. (cml-foundation.org)
Outcomes of adolescents and young adults with chronic-phase chronic myeloid leukemia treated with tyrosine kinase inhibitors (Nishiyam-Fujita Y et al. (cml-foundation.org)

In the ENESTnd clinical trial significantly fewer patients at 12 months progressed to accelerated or blastic phase on Tasigna 300 mg twice daily than on Gleevec 400 mg once daily (2 patients vs. 11 patients)(1), demonstrating a significant improvement in disease control. (salesandmarketingnetwork.com)
Tasigna has been approved in more than 80 countries for the treatment of chronic phase and accelerated phase Ph+ CML in adult patients resistant or intolerant to at least one prior therapy, including Gleevec. (salesandmarketingnetwork.com)

During this phase, you have fewer than 10% blasts, which are immature white blood cells, in your blood or bone marrow. (stanfordhealthcare.org)
During this phase, you have more than 20% of the immature blasts in your blood or bone marrow. (stanfordhealthcare.org)
Determining the CML phase is based primarily on the number of immature white blood cells (blasts) in the patient's blood and bone marrow. (schoolandyouth.org)

Generally, chronic phase is characterized by leukocytosis, anemia and splenomegaly with detection of BCR-ABL fusion gene [6]. (waocp.com)

The clinical manifestations of CML are insidious, changing somewhat as the disease progresses through its 3 phases (chronic, accelerated, and blast). (medscape.com)

2. Accelerated phase - In this phase, there is an increase in the number of faulty blood cells with symptoms like fever, night sweats, breathing difficulties and bruising being experienced. (symptomscheck.net)

New pharmacokinetic phase 3 data will be presented at the 2023 Society for Pediatric Dermatology meeting next week. (dermatologytimes.com)
Phase 3 data of Oleogel-S10 was presented in a late-breaking session at AAD 2023 in New Orleans. (dermatologytimes.com)

In the chronic phase, the number of mature white blood cells is elevated, and myeloblasts account for less than 10 percent of blood cells. (medlineplus.gov)
In the accelerated phase, the number of myeloblasts is slightly higher, making up 10 to 29 percent of blood cells. (medlineplus.gov)

People in this phase may not show any CML symptoms. (symptomscheck.net)
3. Blastic phase - This is the riskiest and advanced CML phase and severe symptoms like swollen glands, bone pain and bleeding are experienced. (symptomscheck.net)
During this phase, your symptoms and blood counts may not respond as well to treatment. (stanfordhealthcare.org)
Signs and symptoms of the condition during this phase are typically mild or absent and worsen slowly. (medlineplus.gov)

Until the arrival of the drugs that are now used, the natural evolution of the disease was to remain in this chronic phase for a period of 3 to 5 years, after which the disease progressed to an accelerated phase, and then to a blastic phase. (fcarreras.org)
Most patients are diagnosed with CML in the with chronic phase of the disease. (schoolandyouth.org)

In the accelerated phase, the number of immature blast cells has risen, and sometimes new chromosomal changes, in addition to the Ph chromosome, will occur. (schoolandyouth.org)

During this phase, you have more than 10% but fewer than 20% blasts, which are the immature white blood cells. (stanfordhealthcare.org)

There is a high relapse rate in patients in accelerated phase even after successful treatment. (medscape.com)
Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase-CML. (bvsalud.org)
Treatment of Philadelphia-negative myeloproliferative neoplasms in accelerated/blastic phase with azacytidine. (unimib.it)
4 Imatinib (400mg/day) is now considered by both the US National Comprehensive Cancer Network (NCCN) and the European LeukemiaNet to be the standard approach for the initial treatment of chronic-phase CML. (touchoncology.com)
The best treatment remedy is to start treatment early before the CML spreads, that is, during the chronic phase. (symptomscheck.net)
For patients diagnosed with ovarian cancer during surgery, the first phase of treatment is surgical laparotomy or exploration of the abdomen. (yourcancercare.com)
Along with the phases of CML, there are other factors that affect treatment decisions and predict a patient's prognosis (chance for recovery). (schoolandyouth.org)

In the past, antimetabolites (e.g., cytarabine, hydroxyurea), alkylating agents, interferon alfa 2b, and steroids were used as treatments of CML in the chronic phase, but since the 2000s have been replaced by Bcr-Abl tyrosine-kinase inhibitors drugs that specifically target BCR-ABL, the constitutively activated tyrosine kinase fusion protein caused by the Philadelphia chromosome translocation. (wikipedia.org)

Kyverna Therapeutics can now initiate its phase 1/2 open-label, multicenter study of KYV-101. (dermatologytimes.com)

Its favorable pharmacokinetic and toxicity profile, paired with its excellent clinical results, rapidly made imatinib the standard frontline therapy for all chronic-phase CML patients. (touchoncology.com)
1,2 In the International Randomized Study of Interferon and STI571 (IRIS), imatinib was found to be superior to interferon-alpha as initial therapy for patients in the early chronic phase. (touchoncology.com)
In adults with chronic phase, accelerated phase , or blastic phase CML who cannot receive other drugs or whose cancer did not respond to other drugs, including imatinib mesylate . (cancer.gov)
Patients were randomly assigned 2:1 to reduced-intensity chemotherapy in combination with ponatinib 30 mg once daily with dose reduction to 15 mg once daily (n = 164) after MRD-negative CR in the induction phase or reduced intensity chemotherapy with imatinib at a starting dose of 600 mg once daily (n = 81). (targetedonc.com)

City of Hope's comprehensive chimeric antigen receptor (CAR) T cell therapy program is addressing some of the hardest-to-treat cancers by accelerating innovative clinical research approaches. (cityofhope.org)

If untreated, accelerated phase CML will eventually transform to blast phase CML. (schoolandyouth.org)

The increase in leukemic cell numbers occurs slowly at first and is referred to as the chronic phase, but these cells invariably begin to increase more rapidly and/or include less mature cells, resulting in the accelerated or blastic phase. (broomeoncology.com)

This phase is considered aggressive. (stanfordhealthcare.org)

The clinical course of CML typically goes through three phases [4]. (rockstarsagainstliveearth.com)

1. Accelerated phase - can last weeks to months. (cancer.gov)
This status accelerates the standard review time from 10 to six months. (salesandmarketingnetwork.com)
The chronic phase can last from months to years. (medlineplus.gov)

This is a retrospective chart review of all patients who were diagnosed with CML in chronic phase (CP) with additional chromosomal abnormalities (ACAs) over a period of 5 years from 2010 to 2015 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. (waocp.com)
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. (pharmaceutical-technology.com)

Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)

Instead of stages, doctors describe CML in terms of phases: chronic phase, accelerated phase, and blast phase. (stanfordhealthcare.org)
Doctors use diagnostic tests to determine the phase of CML. (schoolandyouth.org)

11 ] Mientras que la mediana de la supervivencia era de 4 a 6 años, con el advenimiento de los tratamientos orales nuevos, se espera que la mediana de supervivencia se acerque a la esperanza de vida normal en la mayoría de los pacientes, aunque es demasiado pronto para aseverar esto de forma definitiva. (blogspot.com)
Periodic phlebotomies thereafter serve to maintain the red cell mass within the normal range and to induce a state of iron deficiency that prevents an accelerated reexpansion of the red cell mass. (basicmedicalkey.com)

Clonal evolution occurs in approximately 30% of CML patients in AP and upto 80% in blastic phase. (waocp.com)

Anatomy8

Diseases23

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes6

Disciplines and Occupations1

Information Science1

Health Care2

Plasmacytoid dendritic cel2

Progression5

Blast crisis4

Spleen3

Transformation5

Newly diagnosed5

Diagnosis4

TKIs1

Either accelerated2

Dasatinib2

Acute5

Leukemia10

Tasigna2

Bone marrow3

Fusion gene1

Progresses1

Fever1

20232

Myeloblasts2

Symptoms4

Disease2

Occur1

Blasts1

Treatment7

Tyrosine kinase inh1

Multicenter1

Imatinib4

Approaches1

Transform1

Cells1

Aggressive1

Typically1

Months3

Years2

Clinical trial1

Doctors2

Normal2

Evolution1