However, there was no compensatory increase in SOD or GSH reductase activities as a result of either acatalasemia or GSH-Px deficiency or as a result of oxidative challenge. (utmb.edu)
Diabetes mellitus1
Goth L, Nagy T. Acatalasemia and diabetes mellitus. (medlineplus.gov)
Hypocatalasemia1
Like acatalasemia, hypocatalasemia usually does not cause any health problems. (medlineplus.gov)
Catalase activity1
Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. (nih.gov)
Takahara1
When mouth ulcers and gangrene occur with acatalasemia, the condition is known as Takahara disease. (medlineplus.gov)
Gangrene1
Some of the first reported individuals with acatalasemia developed open sores (ulcers) inside the mouth that led to the death of soft tissue (gangrene). (medlineplus.gov)
Mutations1
Mutations in the CAT gene can cause acatalasemia. (medlineplus.gov)
Disease1
A higher percentage of people with acatalasemia have type 2 diabetes than in the general population, and the disease tends to develop at an earlier age (in a person's thirties or forties, on average). (medlineplus.gov)
Type2
Studies suggest that people with acatalasemia have an increased risk of developing type 2 diabetes , which is the most common form of diabetes. (medlineplus.gov)
Malfunctioning beta cells are thought to underlie the increased risk of type 2 diabetes in people with acatalasemia. (medlineplus.gov)
Gene2
Mutations in the CAT gene can cause acatalasemia. (medlineplus.gov)
A T-deletion at position 10 of exon 4 for catalase gene was reported as a novel mutation, causing a new genetic type of acatalasemia in Japan. (nih.gov)