• In addition, foci of suprabasal acantholysis are seen. (dermnetnz.org)
  • Skin biopsy samples showed both suprabasal acantholysis and interface dermatitis. (medscape.com)
  • Suprabasal clefts, acantholysis with villous formation, luminal keratin plugs, dyskeratotic cells, and a few corps ronds were observed (Fig. 2). (cdlib.org)
  • No mucosal lesions were present, and skin biopsy showed features of acantholysis and suprabasal clefting. (jsstd.org)
  • Acantholysis or dyskeratosis are absent (in contrast to Darier's disease). (altmeyers.org)
  • This disruption results in acantholysis (breaking up of cell-cell adhesions), resulting in separation and loss of integrity of the epidermal cell layers. (mspca.org)
  • Some of these drugs induce antibody formation, which results in acantholysis via a mechanism identical to that found in idiopathic pemphigus. (medscape.com)
  • Pemphigus vulgaris (PV) is a chronic, vesiculobullous, mucocutaneous autoimmune fatal disease, characterized by the presence of antibodies against adhesion molecules (desmoglein, Dsg3) present on the surface of keratinocytes, leading to the loss of cellular adhesion or acantholysis and is typically associated with oral lesions 1-5 . (bvsalud.org)
  • Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges . (moviecultists.com)
  • The purpose of this study was to analyze the possible influence of the TNF and LTA loci polymorphisms on the susceptibility/resistance to endemic pemphigus foliaceus, also named fogo selvagem (FS), an autoimmune disease characterized by blisters due to acantholysis of the superficial-most epidermal cells. (johnshopkins.edu)
  • Acantholysis (loss of intercellular adhesion with consequent epidermal blister formation) results from either direct inhibition of desmoglein function by autoantibody binding or from autoantibody-induced cell signaling that results in down-regulation of cell-cell adhesion. (msdmanuals.com)
  • MMKonohana NNishikawa Histological findings of HP are variable and include eosinophilic spongiosis and subcorneal pustules with minimal or no apparent acantholysis. (tersavictoria.com)
  • The binding of autoantibodies to Dsg proteins induces a separation of neighbouring keratinocytes, in a process known as acantholysis. (nih.gov)
  • Binding of these autoantibodies to their targets causes acantholysis (or loss of keratinocyte to keratinocyte adhesion), which ultimately results in the formation of intraepithelial blisters in skin and mucous membranes.1 Unfortunately, pemphigus disorders can potentially be life-threatening and have a devastating impact on quality of life. (dermatologytimes.com)
  • This process, referred to as acantholysis, manifests clinically with the formation of flaccid blisters and erosions of the skin and mucous membranes. (uni-marburg.de)
  • The term pemphigus refers to a group of autoimmune blistering diseases of skin and mucous membranes that are characterized histologically by intraepidermal blisters due to acantholysis and immunopathologically by an in vivo bound & circulating IgG directed against the cell surface of keratinocytes. (sumathipublications.com)
  • Suprabasilar acantholysis was focally found within the epithelium of a portion of the infundibulum of the central cystic structure (Fig. 3). (medscape.com)
  • The infundibular portion of the central cystic structure shows focal suprabasilar acantholysis. (medscape.com)
  • A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis. (uchicago.edu)
  • A skin biopsy was taken where acantholysis was evidenced, confirming the autoimmune disease diagnosis. (bvsalud.org)
  • Pemphigus, acantholysis, autoimmune disease. (bvsalud.org)
  • Eosinophils, mucosal involvement, tombstones acantholysis and. (dermpathpro.com)
  • Sometimes the acantholysis can be very difficult to find making diagnosis difficult. (dermnetnz.org)
  • Unlike in the related pemphigoid , pemphigus manifests as intra-epithelial clefting, meaning the spinous cells of the epithelium break apart, a phenomenon known as acantholysis . (wikidoc.org)
  • It did not have much of an inflammatory reaction and had acantholysis although the mucin was less well developed. (dermpathpro.com)
  • In addition to pigmentation changes, individuals with Galli-Galli disease also have a breakdown of cells in the outer layer of skin (acantholysis). (medlineplus.gov)
  • Acantholysis can cause skin irritation and itchiness and lead to reddened or missing patches of skin (erosions). (medlineplus.gov)
  • Experiments with skin explants have demonstrated that thiol drugs can induce acantholysis directly. (medscape.com)
  • Other drugs are postulated to induce acantholysis directly in the absence of antibody formation. (medscape.com)
  • Thiol drugs are postulated to induce acantholysis through biochemical mechanisms without antibody formation. (medscape.com)
  • The pathologist must distinguish this disease from other disorders having acantholysis, including Grover's disease. (thedoctorsdoctor.com)
  • Pemphigus in cats is a dermatological disease characterized by an acantholysis or detachment of each cell of the epidermis that creates vesicles within it. (animalwised.com)
  • When considering secondary bacterial pyoderma vs. primary bacterial-induced acantholysis, a combination of cytology and culture with sensitivity is typically used to start treatment. (mspca.org)
  • Binding of the pemphigus antigens by thiol drugs may interfere with their normal function, resulting in acantholysis. (medscape.com)
  • Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. (wikipedia.org)
  • PV autoantibodies target the keratinocyte adhesion protein desmoglein 3 (DSG3), causing DSG3 endocytosis and desmosomal DSG3 depletion ( 1 - 3 ), resulting in the loss of intercellular adhesion (acantholysis). (jci.org)
  • Acantholysis (loss of intercellular adhesion with consequent epidermal blister formation) results from either direct inhibition of desmoglein function by autoantibody binding or from autoantibody-induced cell signaling that results in down-regulation of cell-cell adhesion. (msdmanuals.com)
  • A punch biopsy of her upper extremity revealed intraepidermal acantholysis, neutrophilic spongiosis, and subcorneal pustules. (unboundmedicine.com)
  • A skin biopsy was taken where acantholysis was evidenced, confirming the autoimmune disease diagnosis. (bvsalud.org)
  • Treatment acantholysis on biopsy. (umbc.edu)
  • In biopsy samples, intraepidermal vesicles are observed with mild acantholysis and ballooning keratinocytes. (biodermameetings.com)
  • A biopsy revealed suprabasilar acantholysis with follicular involvement in association with blister formation and inflammation. (mdedge.com)
  • Darier's disease (DD) is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between epidermal cells (acantholysis) and abnormal keratinization. (thedoctorsdoctor.com)
  • Results: Mice that received naive Dsg3 -/- splenocytes produced anti-Dsg3 IgG, which bound to keratinocyte cell surfaces in vivo, and developed the PV phenotype, including oral erosions with suprabasilar acantholysis. (elsevierpure.com)
  • Bulla can form as the result of acantholysis, epidermal or dermal edema, degeneration of basal cells and keratinocytes, or other processes, such as frictional trauma and burns that cause a lack of cohesion between cells. (nih.gov)
  • Acantholysis, the separation of keratinocytes due to desmosome destruction, occurs specifically in the stratum spinosum layer of skin. (picmonic.com)
  • In order to decipher the particular disparity among ubiquitous antibody presenting on the epidermis desmosomes, but discontinuous illness outward exhibition, we had been in a position to identify Sun The (UVA) as a cofactor pertaining to acantholysis. (jaksignals.com)
  • The presence of acantholysis, hypergranulosis, follicular plugging, and the absence of dilated capillaries and epidermal pustulation may help distinguish pityriasis rubra pilaris from psoriasis. (medscape.com)
  • Xue W, Hashimoto K, Toi Y: Functional involvement of urokinasetype plasminogen activator receptor in pemphigus acantholysis allergy symptoms puffy eyes purchase nasonex nasal spray with visa . (suzumgerecleri.com)
  • Pemphigus, acantholysis, autoimmune disease. (bvsalud.org)
  • 2. Unilateral nipple erosion with acantholysis. (nih.gov)
  • Destruction of the desmosomes, a type II hypersensitivity reaction, leads to acantholysis of the stratum spinosum layer of the skin and the formation of thin bullae on the skin which rupture with gentle traction over the top of the blister (positive Nikolsky sign). (picmonic.com)
  • Aquestes malalties poden estar restringides a certs òrgans (per exemple, en les tiroïditis autoimmunitàries ) [2] o afectar un teixit particular en diferents llocs (per exemple, la síndrome de Goodpasture , que pot afectar la membrana basal , tant en el pulmó com en el ronyó i en la qual els autoanticossos actuen contra el col·lagen tipus IV present a la membrana). (wikipedia.org)
  • In addition to pigmentation changes, individuals with Galli-Galli disease also have a breakdown of cells in the outer layer of skin (acantholysis). (medlineplus.gov)
  • Acantholysis can cause skin irritation and itchiness and lead to reddened or missing patches of skin (erosions). (medlineplus.gov)
  • High Resolution Optical Microscopy (HROM) showed the absence of acantholysis. (bvsalud.org)
  • The term 'epidermal necrolysis' (EN) is used in this article to describe the spectrum of disease that includes SJS and TEN. (medscape.com)
  • Important advances in understanding the pathomechanism and treatment of EN have been made over the years. (medscape.com)
  • This short review describes the key advances in the terminology, classification, causality and treatment of EN, and identifies future priorities and challenges in the understanding and management of this condition. (medscape.com)