CollagenExtracellular matrixProteinsBasal laminaIsoformsEspecially abundantProteinConnectiveMembraneContrastVascularPhosphatidylserineMastBodyCultureCellRoleReceptorsExtracellularKinaseActin cytoskeletonProteinRegulatesGlycoproteinTissuesPhosphateFibrilsHumansMigrationInteractionMoleculeStructureCellsVariety
Collagen12
- BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
- Most of these methods involve culturing endothelial cells on or within ECM substrates (e.g., collagen, fibrin, fibronectin, laminin, etc.) or other types of biomaterials to form capillary-like structures [ 15 ]. (hindawi.com)
- Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
- Analysis of the interaction of HF3 with extracellular matrix proteins and human plasma showed that HF3 interacts with collagen types I and VI, fibrinogen, fibronectin and laminin, which are important for maintaining the integrity of the capillaries and hemostasis. (fapesp.br)
- The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
- The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
- Identification and functional characterization of two type VI collagen receptors, alpha 3 beta 1 integrin and NG2, during avian corneal stromal development. (omeka.net)
- PURPOSE: The development and maintenance of extracellular matrix architecture in the corneal stroma is associated with abundant type VI collagen deposition. (omeka.net)
- Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
- A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
- Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
- Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals , [1] making up about 25% of the total protein content. (wikidoc.org)
Extracellular matrix1
- The SVMPs contain regulatory domains in additional to the catalytic domain which are involved in their mechanisms of interaction with the extracellular matrix proteins and integrins. (fapesp.br)
Proteins7
- GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
- Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
- There are specific receptor proteins like integrin on the external surface of focal attachments. (omicsonline.org)
- Many proteins in adhesion plaque such as integrin, cytoskeleton proteins, proteases, protein kinases, phosphatases take part in signal transferring by co-localizing with vinculin and talin [ 3 ]. (omicsonline.org)
- Similarly, no interfaces may exist that, facing blood plasma, can escape being coated with the most abundant and fragile plasma proteins. (nanomedicine.com)
- They account for the majority of proteins in the ECM , which makes them the most abundant proteins in the human body. (amboss.com)
- In fact, by mass, the most abundant proteins in our bodies are ECM proteins - the nonliving material outside of our cells that provides a physical scaffold, barrier, and mechanical and biological signaling. (mimetas.com)
Basal lamina1
Isoforms1
- We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
Especially abundant2
- 3 Cell junctions are especially abundant in epithelial tissues. (wikipedia.org)
- Among these, Snake Venom Metalloproteinases (SVMPs) are especially abundant components and are responsible for various pathological effects following envenomation. (fapesp.br)
Protein1
- In early culture, PSCs are polygonal in shape with abundant lipid droplets in the cytoplasm ( Figure 1B ) and express stellate cell selective markers such as desmin, glial fibrillary acidic protein (GFAP), nestin, neural cell adhesion molecule, nerve growth factor, and synemin (34, 167). (pancreapedia.org)
Connective1
- Connective tissue is the most abundant type of tissue in the body. (amboss.com)
Membrane1
- Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
Contrast1
- In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Vascular1
- Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
Phosphatidylserine1
- Phosphatidylserine is a phospholipid that is abundant in myelin. (encyclopedia.pub)
Mast2
Body1
- PSCs in their native state express abundant vitamin A (retinoids) containing droplets in their cytoplasm which is a characteristic feature of the "stellate cell system" in the body (138). (pancreapedia.org)
Culture1
- B ) PSCs in an early culture showing a typical flattened polygonal shape with abundant vitamin A-containing lipid droplets in the cytoplasm. (pancreapedia.org)
Cell1
- Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Role1
- These activities were inhibited by integrin antibodies (anti-±M and anti-²2), suggesting a role for the C-domain in triggering the integrin-mediated pro-inflammatory effects of HF3. (fapesp.br)
Receptors9
- Osteopontin is a secreted matricellular glycoprotein that signals partially through integrin receptors and its downregulation is associated with increased strength, reduced fibrosis, and milder muscle pathology 10 , 11 . (nature.com)
- Based on this association between extracellular signals and intracellular protein kinase activity, we have chosen to include integrins in the 'Catalytic receptors' section of the database until more stringent criteria from NC-IUPHAR allows precise definition of their classification. (guidetopharmacology.org)
- Identification and functional characterization of two type VI collagen receptors, alpha 3 beta 1 integrin and NG2, during avian corneal stromal development. (omeka.net)
- METHODS: To clarify the role of this collagen, two type VI collagen receptors were studied during corneal development using immunochemical techniques: alpha 3 beta 1 integrin and an integral membrane proteoglycan, NG2. (omeka.net)
- Vascular homeostasis is maintained by the extracellular matrix (ECM) and related cell surface receptors, such as integrins, characterised by collagen deposition, collagen crosslinking, and elastin degradation within the vascular ECM. (biomedcentral.com)
- This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. (biomedcentral.com)
- CCN1 induces fibroblast apoptosis through its adhesion receptors, integrin α 6 β 1 and the heparan sulfate proteoglycan (HSPG) syndecan-4, triggering the transcription-independent p53 activation of Bax to render cytochrome c release and activation of caspase-9 and -3. (silverchair.com)
- These results show that cellular interaction with a specific matrix protein can either induce or suppress apoptosis in a cell type-specific manner and that integrin α 6 β 1 -HSPGs can function as receptors to induce p53-dependent apoptosis. (silverchair.com)
- Cellular interaction with the ECM, occurring largely through integrin receptors, is a principal regulator of cell survival. (silverchair.com)
Extracellular2
- These structures contain the extracellular portions of collagen XVII (BP180) and alpha-6-beta-4 integrin. (medscape.com)
- PURPOSE: The development and maintenance of extracellular matrix architecture in the corneal stroma is associated with abundant type VI collagen deposition. (omeka.net)
Kinase2
- The intracellular signalling cascades associated with integrin activation focus on protein kinase activities, such as focal adhesion kinase and Src. (guidetopharmacology.org)
- Integrins regulate the activity of particular protein kinases, including focal adhesion kinase and integrin-linked kinase. (guidetopharmacology.org)
Actin cytoskeleton1
- Integrins provide a link between ligand and the actin cytoskeleton (through typically short intracellular domains). (guidetopharmacology.org)
Protein6
- Collagen XVII is a transmembrane collagenous protein that interacts with alpha-4 integrin and BP230 intracellularly and with laminin-332 extracellularly. (medscape.com)
- Here, immunofluorescence labeling using polyclonal antibodies revealed an increased immunofluorescence intensity of MBP, CNP, laminin and collagen IV in ischemic areas, although Western blot analyses did not reveal increased protein levels. (frontiersin.org)
- Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
- TIMP-2 cell surface binding and growth inhibitory activity is observed in both endothelial cells as well as tumor cells and results in a decrease in the association of protein tyrosine phosphate (PTP) activity with this integrin and an increase in PTP activity associated with variety of RTKs (VEGFR-2, FGFR1a, PDGFR and EGFR). (nih.gov)
- The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)
- IGFBP-3 , the most abundant protein, accounts for 80% of all IGF binding. (wikidoc.org)
Regulates3
- Cellular activation regulates integrin ligand affinity via inside-out signalling and ligand binding to integrins can regulate cellular activity via outside-in signalling. (guidetopharmacology.org)
- 5. N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin. (nih.gov)
- 9. N-Glycosylation of laminin-332 regulates its biological functions. (nih.gov)
Glycoprotein1
- 3. Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma. (nih.gov)
Tissues2
- 3 Cell junctions are especially abundant in epithelial tissues. (wikipedia.org)
- Among several primary tissues in humans, connective tissue is the most abundant and widely distributed one. (biomedcentral.com)
Phosphate1
- The PTEN download Windows for HSF1( HSE, aspartate symbol uridine) covers transfer of new transcripts acid in well-being SUMOylation, with at least three Laminins representing annealed for the transcriptional phosphate acetyl. (evakoch.com)
Fibrils1
- Thus, the cutaneous BMZ connects the extensive basal cell cytoskeletal network with the abundant network of interstitial collagen fibrils in the dermis. (medscape.com)
Humans1
- 8. Altered β1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin β1 are associated with early spontaneous miscarriage in humans. (nih.gov)
Migration1
- 15. Aberrant N-glycosylation of beta1 integrin causes reduced alpha5beta1 integrin clustering and stimulates cell migration. (nih.gov)
Interaction2
- Matrix-receptor cross-linking demonstrated the interaction of beta 1 and NG2 in periocular mesenchyme cells and corneal fibroblasts with type VI collagen, whereas only a subset of cells expressed alpha 3, indicating the presence of another beta 1 integrin. (omeka.net)
- 4. N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin β1 with vimentin and promotes hepatocellular carcinoma cell motility. (nih.gov)
Molecule1
- We further observe a regulatory role of the molecule in pathways associated with PDAC ECM remodeling and tumor-stromal crosstalk, such as INS/IGF-1, RAS/MAPK, laminin interactions and collagen biosynthesis. (biomedcentral.com)
Structure1
- Other cation binding sites may regulate integrin activity or stabilise the 3D structure. (guidetopharmacology.org)
Cells2
- In 2003, we demonstrated that the mechanism of this anti-proliferative effect was independent of the metalloproteinase inhibitory activity by using the MMP-inhibitor null form Ala+TIMP-2, and was mediated by TIMP-2 binding to the alpha3 beta1 integrin on the surface of human microvascular endothelial cells. (nih.gov)
- T RM cells, often bearing CD69 and the αEβ7 integrin (CD103), and null of CD62L, offer dominant immunity to localized infection 8 . (researchsquare.com)
Variety1
- www.cms.gov/OfficeofLegislation/Downloads/Accountable CareOrganization.pdf accessed 03/16/2011) HN - 2012 BX - Accountable Care Organization MH - Acidobacteria UI - D061271 MN - B3.26 MN - B3.440.400.50 MS - A physiologically diverse phylum of acidophilic, gram-negative bacteria found in a wide variety of habitats, but particularly abundant in soils and sediments. (nih.gov)