Abstract vitro embryos stage pre implantation embryo. Medical search. Frequent questions

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. (biomedcentral.com)
Although there is no accepted formal definition for recurrent implantation failure, Orvieto suggests that it is after three failed in vitro fertilization-embryo transfer (IVF-ET) cycles with good quality embryos transferred [ 5 ]. (biomedcentral.com)
Paternal sperm DNA damage has negative effects on the integrity of early embryonic development as the percentage of good quality embryos as well as implantation rates was significantly reduced in patients exhibiting high DNA damage [ 27 ] and it appears that the second and third mitoses are the sensitive periods [ 28 ]. (hindawi.com)
To additional good-quality embryos are ET). (who.int)
In all the cen- are the most common complication etc.). tres, only good-quality embryos were associated with IVF treatment. (who.int)

These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days after fertilization (Carnegie stage 6a). (nature.com)
Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells. (wikipedia.org)
While in vitro fertilization (IVF) often produces high-quality embryos, their successful implantation depends on the receptivity of the endometrium. (o2genes.com)
IVF, or in vitro fertilization, is one of the most common forms of reproductive technologies. (thembeforeus.com)
After fertilization, doctors will look at the cell division rate, the symmetry of the cell, and other factors related to the morphology of the embryo. (thembeforeus.com)
We investigated whether the insemination method ( in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]) affected morphokinetic events and abnormal cleavage events in embryonic development. (ecerm.org)
Since the first in vitro fertilization-embryo transfer (IVF-ET) baby was born in 1978, IVF-ET procedures have made remarkable progress, and various assisted reproductive technologies have been implemented. (ecerm.org)
This has been shown for intrauterine insemination (IUI), in vitro fertilization (IVF), and ICSI, and increased incidences of chromosomal abnormalities, minor and major birth defects, or early childhood cancers, particularly in the male offspring, have been linked to these procedures [ 8 - 16 ]. (hindawi.com)
Furthermore, sperm DNA damage appears to be linked to the most important checkpoints of fertility such as reduced fertilization rates, lower embryo quality and pregnancy rates, higher miscarriage rates, malformations, and childhood diseases [ 22 ]. (hindawi.com)
1998. Influence of organochlorine pesticides on maturation and post-fertilization development of bovine oocytes in vitro . (cdc.gov)
in vitro fertilization. (who.int)
ABSTRACT This study in Turkey evaluated the impact of age-based mandatory single-embryo transfer (SET) legislation with the subsequent increase in frozen-thawed embryo transfer (FT-ET) on pregnancy outcome of in vitro fertilization (IVF) patients. (who.int)

On the 7th day of human embryo development, the free-floating blastocyst must implant into the uterus to allow the organisation of the embryonic (epiblast) and extra-embryonic (hypoblast and trophoblast) tissues, and the formation of the future body plan. (researchsquare.com)
This protocol describes in detail how human cleavage-stage or blastocyst-stage embryos are thawed and cultured through pre- to-post-implantation stages in vitro and how they can be analysed by immunofluorescence. (researchsquare.com)
In mouse, a unidirectional demethylation process from the zygote stage to blastocyst stage is observed using either reduced representation bisulfite sequencing (RRBS) or single-base resolution whole-genome bisulfite sequencing (WGBS) method. (nature.com)
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (wikipedia.org)
Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development. (wikipedia.org)
Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability to differentiate into any embryonic cell type and by their ability to self-renew. (wikipedia.org)
At blastocyst stage, the segregation of the three primordial lineages is accompanied by establishment of differential patterns of DNA methylation and post-translational modifications of histones, such as H3K27me3. (sciencegate.app)
To facilitate a quantitative morphological analysis of early mouse development under controlled conditions, a perfusion culture system capable of supporting embryogenesis to blastocyst stage has been developed. (sciencegate.app)
2- to 4-cell and morula- to blastocyst-stage mouse embryos were cultured for 1 h in tritiated leucine at two specific activities and their subsequent development followed in vitro and in vivo (after transfer to recipients), respectively. (sciencegate.app)
Equivalent blastocyst rates after freezing murine embryos in Cryo Bio System high security or standard Instruments-Medicine-Veterinarian straws. (webmedcentral.com)

By comparing embryos developing in vitro with the Carnegie series of human embryos developing in vivo 6 , we have uncovered the major morphogenetic events of human implantation morphogenesis, including: segregation of embryonic and extra-embryonic lineages, formation of the pro-amniotic and yolk sac cavities, and generation of a bi-laminar structure. (researchsquare.com)
Here, we have utilized single-cell methylome and transcriptome sequencing (scM&T-seq) to quantify both mRNA expression and DNA methylation in oocytes and a developmental series of human embryos at single-cell resolution. (babraham.ac.uk)

During pre-implantation stages of mammalian development, maternally stored material promotes both the erasure of the sperm and oocyte epigenetic profiles and is responsible for concomitant genome activation. (babraham.ac.uk)
Although the genome-wide DNA demethylation is believed to be a hallmark of mammalian embryogenesis, previous study also indicated that the somatic form of dnmt1 ( dnmt1s ) is actually expressed at each stage of pre-implantation embryos and plays a role in the maintenance of DNA imprinting 8 . (nature.com)

This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)
Oocytes were collected from slaughterhouse-derived ovaries, matured in vitro, and injected with frozen-thawed stallion sperm. (bioone.org)
We examine how epigenetic states are set up in oocytes - or egg cells - and influence gene expression in the embryo. (babraham.ac.uk)
We are also interested in how variations in DNA methylation come about in oocytes and whether we can use this variation as a marker for oocyte quality and embryo potential. (babraham.ac.uk)
Pre-activated oocytes were more resistant to physical damage, showed higher survival rates, and required less time per injection. (stanford.edu)
The production of CO2 from glucose by sheep embryos has been determined[ 3 ] and results have indicated that little glucose is utilized by the embryos of sheep and that blastocysts derived from oocytes, matured and fertilized in vitro , oxidized glucose at a lower rate than those developed in vivo . (biomedcentral.com)
The morphokinetics of embryo development was found to vary between IVF- and ICSI-fertilized oocytes, at least until the 6-cell stage. (ecerm.org)
In vitro fertilisation with oocyte donation (IVF-OD) is considered to give better implantation, pregnancy, and livebirth rates compared to IVF with autologous oocytes. (emjreviews.com)
In vitro fertilisation with the use of donor oocytes (IVF-OD) has become an integral part of infertility treatment today. (emjreviews.com)
The EIM consortium report of 2012 4 on reproductive outcome with use of donor oocytes, reported a PR of 48.4% per fresh embryo transfer, 35.9% per frozen embryo transfer (FET), and 45.1% using frozen oocytes. (emjreviews.com)

We fully characterize embryonic genome activation and maternal transcript degradation and map key epigenetic reprogramming events in developmentally high-quality embryos. (babraham.ac.uk)

The development of the human embryo beyond implantation has been poorly characterised, because in vivo experiments are unfeasible and there is no appropriate in vitro culture system. (researchsquare.com)
Despite its basic and clinical importance, the morphogenesis of the human embryo at the time of implantation remains largely unknown, because in vivo experiments are not feasible and a system to culture human embryos beyond day 7 in vitro 1 has not been developed. (researchsquare.com)
Although it is possible to culture structures derived from human blastocysts ex vivo, these cultures do not recapitulate the events and structural organization of the in vivo embryos 6 ( Supplementary Information ). (nature.com)
The synchronization and ovulatory responses of Sangsari cross bred ewes and metabolism of energy substrates in 8-cell stage embryos to hatched blastocysts stage produced in vitro or in vivo were investigated. (biomedcentral.com)
While the pattern of oxidation was similar among in vitro and in vivo derived embryos, a low pyruvate to lactate ratio was the preferred substrate of embryos derived in vitro . (biomedcentral.com)
Currently, the ability to culture in vitro totipotent cells possessing molecular and functional features like those of an early embryo in vivo has been a challenge. (sciencegate.app)
However, it is disputed whether TBLCs are 'true' totipotent stem cells equivalent to in vivo two-cell stage embryos. (sciencegate.app)
This study underscores the subtle differences between in vitro derived TBLCs and in vivo mouse early developmental cell stages at the single-cell transcriptomic level. (sciencegate.app)
Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
In vivo and in organized cells, and proper symmetry are healthy individuals, macrophages can characteristics of higher-quality embryos, which phagocytize DNA that has been passively point to healthy development and higher rates of released into the blood from apoptotic or necrotic implantation. (who.int)

Rieger[ 4 ] inferred that the pre-implantation bovine embryo undergoes an intensified period of cellular synthetic processes which require appropriate substrates for production of energy and reducing equivalents in the form of nicotinamide-adenine dinucleotide phosphate. (biomedcentral.com)

Sperm analysis, pre-implantation genetic screening and endometrial receptivity should be considered and evaluated, and IVF protocols should be tailored to specific patients or patient populations. (biomedcentral.com)
Removal of sperm tail using trypsin and pre-activation of oocyte facilitates intracytoplasmic sperm injection in mice and rats. (stanford.edu)
Fertility Sterility 49:680, 1988 Hammitt DG, Walker DL, Williamson RA: Survival and in vitro fertilizing potential of sperm following washing and incubation with different protein supplements. (webmedcentral.com)
After intracytoplasmic sperm injection (ICSI), 48 embryos were evaluated on day 3 of their development, according to their cell number. (who.int)

We show that this histone modification is first enriched at PCH in the whole embryo and evolves into a diffuse distribution in epiblast during its specification and maturation. (sciencegate.app)

Chromosomal mosaicism in human blastocysts : the ultimate challenge of preimplantation genetic testing? (ugent.be)
Some 20 years later, it is now commonplace for IVF embryos to be tested for monogenic disorders and/or chromosomal disorders such as Down syndrome. (bmj.com)
After embryo aneuploidy, parental chromosomal translocations, maternal thrombophilic anomalies, immunological disorders, and obvious uterine ultrastructural abnormalities are excluded as etiologic contributors, implantation failure intrinsic to the endometrium is commonly suspected as an underlying cause of early pregnancy loss [EPL ( 1 )] and recurrent pregnancy loss [RPL ( 2 )], the latter defined as the loss of two or more consecutive pregnancies in the first trimester ( 2 - 5 ). (frontiersin.org)

It is also important to consider maternal age in the definition, and whether the embryos were transferred at the cleavage-stage or as blastocysts [ 8 ]. (biomedcentral.com)
Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts. (babraham.ac.uk)
What was the percent of embryos that developed to blastocysts of transferrable quality from the zygote stage? (webmedcentral.com)
Cryosystem assessment by glucose uptake of blastocysts, Submitted abstract for ESHRE 2004, Accepted as Oral Presentation 3/24/2004. (webmedcentral.com)

There are multiple risk factors for recurrent implantation failure including advanced maternal age, smoking status of both parents, elevated body mass index, and stress levels. (biomedcentral.com)
Although ART has improved outcomes for struggling couples, a new challenge has emerged: recurrent implantation failure (RIF). (biomedcentral.com)
In addition, we aim to evaluate biochemical pregnancy rates, specifically in recurrent implantation failure patients undergoing ART, and to determine whether this patient group is unique with different requirements for assessment and treatment. (biomedcentral.com)
Recurrent implantation failure (RIF) is only applicable to patients undergoing ART. (biomedcentral.com)
The procedure is used to achieve pregnancy in women with premature and age-related ovarian failure, poor ovarian reserve (due to disease or advanced age), Turner's syndrome, recurrent implantation failure due to poor oocyte quality, and recurrent abortions. (emjreviews.com)

The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. (biomedcentral.com)
A common cause of female infertility is endometrial receptivity, which refers to the quality of the uterine lining where an embryo implants. (o2genes.com)
What was the regime of uterine lining support for the frozen embryo transfer cycles? (webmedcentral.com)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)

agree that it is after three unsuccessful cycles of IVF specifically with two embryos of high quality [ 6 ]. (biomedcentral.com)
Our results indicate that a failure to successfully accomplish these essential milestones impedes the developmental potential of pre-implantation embryos and is likely to have important implications, similar to aneuploidy, for the success of assisted reproductive cycles. (babraham.ac.uk)
A total of 1,830 normal fertilized embryos were obtained from 272 IVF and ICSI cycles that underwent ovum retrieval culture using a time-lapse system (Embryoscope) from June 2013 to March 2015. (ecerm.org)
For women who are older previous IVF failures, medical history, than 35 years, double-embryo transfer duration of infertility or ethology of Since the success of the first in vitro (DET) is permitted in al IVF cycles. (who.int)

However, robust and large-scale genome-wide reprogramming of DNA methylome occurs during two critical developmental processes: (1) development of primordial germ cells and (2) pre-implantation embryogenesis. (nature.com)
These results strongly suggest the possibility of DNA remethylation during pre-implantation embryogenesis. (nature.com)

All embryos were investigated by a detailed time-lapse analysis that measured the developmental events in the hours after IVF or ICSI insemination. (ecerm.org)

Moreover, the dynamic of H3K27me3 at PCH during in vitro conversion from naïve to primed pluripotent state and during ESCs derivation suggests that the mechanisms underlying the control of this histone mark at PCH are different in embryo and in vitro. (sciencegate.app)
Recently, it was reported that treatment with a single spliceosome inhibitor, pladienolide B (plaB), can successfully reprogram mouse pluripotent stem cells into totipotent blastomere-like cells (TBLCs) in vitro. (sciencegate.app)

The oxygen used under higher pressure - oxygen as a drug, may have an extraordinary significance for better outcomes of pregnancy implantation by improving endometrial receptivity. (o2genes.com)
The donor-recipient model has provided an insight into various aspects of ART, such as the importance of oocyte age in implantation, 10 endometrial receptivity, 11 and the contribution of male factors to IVF failure. (emjreviews.com)

Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-genome bisulfite sequencing method. (nature.com)
As a unique functional test of these iPSCs, we injected them into the pre-implantation embryos of another non-human species, rhesus macaques (Macaca mulatta). (stanford.edu)

Embryo morphology al ows options, the discovery of cell-free DNA in the evaluation of its growth, viability, and biological fluids has led to major advances in implantation capacity. (who.int)

Simon and Laufer add that the embryo and the endometrium can both play an active role in RIF [ 7 ]. (biomedcentral.com)
However, after undergoing HBO therapy at 2.3 ATA, 82.9% to 84.8% of patients demonstrated an excellent response of the endometrium, achieving optimal quality during the pre-ovulatory and ovulatory phases. (o2genes.com)
Implantation will usually only take place if the endometrium has reached a certain stage of vascularisation and development. (o2genes.com)

Here, we describe a protocol to culture human embryos from pre- to post-implantation stages in vitro , in the absence of maternal tissues. (researchsquare.com)
This protocol represents a unique opportunity to study the cellular and molecular mechanisms of human embryo development beyond implantation. (researchsquare.com)
We anticipate that future studies using these two in vitro culture systems will help us understand how embryonic and extra-embryonic tissues cooperate to generate the basic human body plan. (researchsquare.com)
However, whether similar events happen in human embryos remains an open question. (researchsquare.com)
Here, we have established a system that allows human embryos to develop in vitro through implantation stages, using a method that we recently developed to culture mouse embryos through implantation 5 as a starting point. (researchsquare.com)
Remarkably, all these events happen in vitro in the absence of maternal tissues, indicating that human embryos have a previously underappreciated self-organizing potential. (researchsquare.com)
We anticipate that the methods presented here will be instrumental to understanding the cellular and molecular mechanisms that shape the future human body at implantation. (researchsquare.com)
Synergistic inhibition of WNT/β-CATENIN, protein kinase C (PKC), and SRC signaling consolidates the induction of teratoma-competent naive human PSCs, with the capacity to differentiate into trophoblast stem cells (TSCs) and extraembryonic naive endodermal (nEND) cells in vitro. (janelia.org)
P53 depletion in naive hPSCs increased their contribution to mouse-human cross-species chimeric embryos upon priming and differentiation. (janelia.org)
Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest. (babraham.ac.uk)
The ability to study human post-implantation development remains limited owing to ethical and technical challenges associated with intrauterine development after implantation 1 . (nature.com)
Embryo-like models with spatially organized morphogenesis and structure of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (that is, the embryonic disc, the bilaminar disc, the yolk sac, the chorionic sac and the surrounding trophoblast layer) remain lacking 1 , 2 . (nature.com)
Such human fully integrated and complete SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos, including the epiblast, the hypoblast, the extra-embryonic mesoderm and the trophoblast layer surrounding the latter compartments. (nature.com)
This SEM platform will probably enable the experimental investigation of previously inaccessible windows of human early post implantation up to peri-gastrulation development. (nature.com)
Implantation of the human embryo leads to a number of changes in organization that are essential for gastrulation and future development 1 . (nature.com)
and (3) evidence of developmental dynamism relating to ability to progress, in a structurally organized manner, through morphologically characterized developmental milestones of the early post-implantation human embryo following initial aggregate formation 3 . (nature.com)
Furthermore, due to ethical and legal concerns, very limited techniques can be applied to human embryos to validate some of significant conclusions drawn from descriptive studies regarding human embryonic development. (nature.com)
Aside from these uses, ESCs can also be used for research on early human development, certain genetic disease, and in vitro toxicology testing. (wikipedia.org)
7] If it's decided for any reason that too many embryos have implanted in the uterus, a selective reduction may be performed, or rather, abortions, until only the desired number of human beings remain alive in the uterus. (thembeforeus.com)
Even if only one embryo is created and transferred, trial and error with that one, full person, is still occurring, with the full knowledge that that human being may not implant. (thembeforeus.com)
increased public sensitivity and awareness together with the development of national regulations of governance of human cloning and embryo research in general. (lifeissues.net)
An in-depth analysis aiming at re-defining this terminology according to the new developments in human embryo research would be highly beneficial . (lifeissues.net)
3. National regulations of governance of human cloning and embryo research in general adopted so far confirm the convergence of views of the refusal to adopt legislation or guidelines permitting reproductive cloning , while they still show variations on the legitimacy of human cloning carried out as part of research agendas. (lifeissues.net)
11 ] developed the first time-lapse system for studying morphokinetics in human embryos. (ecerm.org)

Superovulation ensures recovery of multiple embryos during one estrous cycle, thus allowing us to maximally exploit the female germ pool. (biomedcentral.com)

Studies on the development of monkey embryos have provided some understanding of the major morphogenetic events that take place at the time of implantation 2-4 . (researchsquare.com)
This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
Unlike in rodents, X chromosome inactivation is not observed during monkey pre-implantation development. (nature.com)
Rapid cell division allows the cells to quickly grow in number, but not size, which is important for early embryo development. (wikipedia.org)
In the late 1990s, 1 the development of preimplantation genetic diagnosis (or PGD) made it possible to test in vitro fertilised (IVF) embryos for known genetic diseases and select only unaffected embryos for implantation. (bmj.com)
Surgical embryo recovery was performed on Days 4 and 6 after onset of estrus (Day 0) and recovered embryos were subjected to comparative metabolism studies with in vitro derived embryos at the same stage of development. (biomedcentral.com)
Abstract Early mouse development is characterized by structural and epigenetic changes at the chromatin level while cells progress towards differentiation. (sciencegate.app)
Through the definition of a coordinate system based on mesh structure and the development of a special sectioning procedure, sections can be localized within the intact embryo and three-dimensional coordinates given to any element of embryo volume. (sciencegate.app)
Influence of organochlorine pesticides on development of mouse embryos in vitro . (cdc.gov)

To address this question, single-cell RNA sequencing was applied to TBLCs and cells from early mouse embryonic developmental stages and the data were integrated using canonical correlation analyses. (sciencegate.app)
Observation of embryos in a time-lapse incubator can provide useful information about embryonic developmental events if images are automatically captured [ 7 8 9 10 ]. (ecerm.org)

By comparing these signatures with early embryos that have undergone spontaneous cleavage-stage arrest, as determined by time-lapse imaging, we identify embryos that fail to appropriately activate their genomes or undergo epigenetic reprogramming. (babraham.ac.uk)
Several methods have been proposed for culturing embryos using a time-lapse incubator to maintain a stable environment. (ecerm.org)

Understanding the association between Cell-free DNA levels in embryo CM and the quality of embryo cleavage could help improve the quality of IVF techniques. (who.int)
This prospective study was conducted with 96 spent CM from patients undergoing IVF cycle, in order to determine relationships of Cell-free DNA levels in embryo CM with embryo cleavage quality on day 3. (who.int)
We conclude that cel -free DNA levels in CM might be associated with delayed embryo cleavage. (who.int)

Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)

Mares were killed 7.5-8.5 days after transfer and the uterus and oviducts flushed for embryo recovery. (bioone.org)
The embryos judged most viable are transferred into a woman's uterus with the expectation of implantation,[6] with the number of embryos transferred being dependent upon the woman's age and the likelihood of success. (thembeforeus.com)

Chimpanzee and pig-tailed macaque iPSCs: Improved culture and generation of primate cross-species embryos. (stanford.edu)

The definition should also take advanced maternal age and embryo stage into consideration. (biomedcentral.com)
Soon after embryo attachment and the early stages of implantation, further invasion into the maternal compartment requires a functional decidua ( 6 ). (frontiersin.org)

However, these differences did not affect the clinical outcomes of the embryo. (ecerm.org)
Were there differences in embryo quality that could be discussed, what was the grading criteria? (webmedcentral.com)

The first marked increase in the metabolism of glucose by ovine embryos was detected in compact morula stage, but there was no significant increase in the oxidation of glucose after the morula stage. (biomedcentral.com)

Synchronization of estrus followed by induction of ovulation are basic techniques in all embryo transfer programs. (biomedcentral.com)
The elective transfer of a single embryo has been suggested as the most efficient approach to avoid multiple pregnancies [ 4 ]. (ecerm.org)
The age group of these patients and the increase in obstetric and neonatal complications associated with multiple pregnancy, dictates the use of single embryo transfer. (emjreviews.com)
SET, FT-ET and double-embryo transfer were used in 5632 patients after legislation, while traditional IVF and FT-ET approach was used in 6029 patients before legislation. (who.int)

Embryo selection based on a morphological assessment at a few points in time has several limitations for single ET. (ecerm.org)
Due to its clinical applications success of IVF results is the morphological and the expansion of non-invasive treatment quality of the embryo. (who.int)
Low-quality embryos, on the other cells, thereby maintaining a relatively low basal hand, frequently display morphological level [16-18]. (who.int)

They are already being used in reproduction to select for embryos at lower risk of developing disease. (bmj.com)

Remarkably, a subpopulation within the TBLCs population expressed a high level of the totipotent-related genes Zscan4s and displayed transcriptomic features similar to mouse two-cell stage embryonic cells. (sciencegate.app)

Around 5% of women are expected to suffer from two consecutive pregnancy losses, almost 75% are due to an implantation failure, and therefore are never recognized as clinical pregnancies [ 3 ]. (biomedcentral.com)

8] The embryos that are not transferred are then frozen, destroyed, donated to scientific research, or put up for "embryo adoption. (thembeforeus.com)
Further expansion of the data based on the numbers of embryos originally frozen at the zygote stage, ie, were preganancy rates higher for patients with more embryos frozen at the PN stage? (webmedcentral.com)

thus, most IVF centers induce a higher pregnancy rate by implanting more than one embryo. (ecerm.org)

Anatomy34

Organisms16

Diseases5

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes37

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Health Care5

Good quality embryos5

Fertilization12

Blastocyst10

Series of human embryos2

Mammalian2

Oocytes10

High-quality embryos1

Vivo10

Bovine1

Sperm4

Whole embryo1

Chromosomal3

Blastocysts4

Recurrent implantation failure5

Uterine3

Murine1

Cycles4

Embryogenesis2

ICSI1

Pluripotent2

Receptivity2

Rhesus2

Morphology1

Endometrium3

Human24

Superovulation1

Development9

Developmental2

Time-lapse2

Cleavage3

Morphogenesis1

Uterus2

Cross-species1

Maternal2

Differences2

Morula1

Transfer4

Morphological3

Reproduction1

Embryonic cells1

Clinical1

Frozen2

Pregnancy rate1