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  • MTOC
  • Using rodent hippocampal neurons in culture as a model system, I found that the centrosome loses its function as a microtubule organizing center (MTOC) during neuronal development. (uni-muenchen.de)
  • interphase
  • In cortical MT arrays of interphase plant cells, γTuRC is preferentially recruited to the lattice of preexisting MTs, where it initiates MT nucleation in either a branch- or bundle-forming manner, or dissociates without mediating nucleation. (biologists.org)
  • Immediately after the completion of cytokinesis, newly divided plant cells form cytoplasmic microtubules (MTs) that radiate from the nuclear envelope toward the plasma membrane, and generate dynamic MT arrays at the cell cortex, which persist during interphase ( Hashimoto, 2015 ). (biologists.org)
  • Based on electron microscopy, the subdistal appendages appear to be microtubule-anchoring structures allowing an aster of microtubules to be formed around the mother centriole during interphase (De Brabander et al. (biologists.org)
  • During interphase, microtubule assembly determines the subcellular localization of organelles, promotes vesicular transport and directs cell migration. (biologists.org)
  • vivo
  • We continue to use tissue culture cells, dsRNAi, in vivo fluorescence imaging and biochemical approaches to develop models for microtubule attachment and checkpoint function. (up.pt)
  • Microtubules in vitro and in vivo show an assembly property known as dynamic instability in which microtubule ends stochastically switch from states of growing to shrinking (an event called catastrophe) and from shrinking to growing (an event called rescue). (rupress.org)
  • growth
  • For instance, the growth of the axon and the dendrites depends on dynamic microtubules and requires the formation of new microtubules. (uni-muenchen.de)
  • The centrosome is regarded as the primary source of microtubules in axonal and dendritic growth and has been proposed to direct axon formation. (uni-muenchen.de)
  • Both kinases function distinctly from Ran, which amplifies microtubule growth. (rupress.org)
  • We conclude that Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis. (rupress.org)
  • Our analytical approach enabled the different dynamic properties of individual microtubules to be determined, including the direction and speed of their growth, and their growth duration within a 3-D spatial map. (spiedigitallibrary.org)
  • Stoppin-Mellet V, Fache V, Portran D, Martiel J-L, Vantard M (2013) MAP65 Coordinate Microtubule Growth during Bundle Formation. (plos.org)
  • assays
  • Microtubule gliding assays performed with purified dynein revealed that mAb 70.1 did not block motility of the motor (data not shown). (nih.gov)