• The results suggest that mitochondrial dysfunction plays a role in this type of optic neuropathy whether or not primary LHON mutations are present. (nih.gov)
  • Background and Purpose: Obesity and Type 2 Diabetes are major causes of morbidity-mortality characterized by mitochondrial dysfunction and oxidative-nitrosative stress. (authorea.com)
  • The treatment with leptin or mdvi-1 (Drp1 inhibitor) significantly increased abnormal biogenesis, improved fusion-to-fission balance and attenuated mitochondrial dysfunction, and adipogenesis, thus inducing white-to-beige adipocyte transdifferentiation. (authorea.com)
  • Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. (cornell.edu)
  • Although mitochondrial dysfunction is known to be involved in the development of cancer and dementia, its involvement in the development of depression and anxiety disorder is not well understood. (go.jp)
  • We hypothesized that in early ADPKD, the reactive oxygen species (ROS)-producing nicotinamide adenine dinucleotide phosphate hydrogen (NAD(P)H)-oxidase complex-4 (NOX4), a major source of ROS in renal tubular epithelial cells (TECs) and endothelial cells (ECs), induces EC mitochondrial abnormalities, contributing to endothelial dysfunction, vascular abnormalities, and renal disease progression. (tau.ac.il)
  • Mitochondrial dysfunction is one of the major intracellular lesions of Alzheimer's disease (AD). (jneurosci.org)
  • However, the causative factors involved in the mitochondrial dysfunction in human AD are not well understood. (jneurosci.org)
  • The levels of translocationally arrested mitochondrial APP directly correlated with mitochondrial dysfunction. (jneurosci.org)
  • Collectively, these results suggest that abnormal accumulation of APP across mitochondrial import channels, causing mitochondrial dysfunction, is a hallmark of human AD pathology. (jneurosci.org)
  • Progressive mitochondrial accumulation of incompletely translocated APP caused mitochondrial dysfunction and impaired cellular energy metabolism. (jneurosci.org)
  • Mitochondrial dysfunction is a well-known pathological feature of DMD. (frontiersin.org)
  • However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. (frontiersin.org)
  • We hypothesized that dystrophin deletion leads to mitochondrial dysfunction, and that this may occur before myofiber necrosis. (frontiersin.org)
  • As a secondary complication to mitochondrial dysfunction, we also hypothesized metabolic abnormalities prior to the onset of muscle damage. (frontiersin.org)
  • As these syndromes are often linked to mitochondrial dysfunction, researchers hypothesized that a dysfunction in the mitochondrial metabolism might be part of the causes of long COVID. (frontiersin.org)
  • The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. (mdpi.com)
  • Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson's disease (PD). (springer.com)
  • Although the mechanisms underlying PD remain elusive, α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been recognized as major contributors [ 1 , 57 ]. (springer.com)
  • Mitochondrial abnormalities might be an early driver of neuronal dysfunction in glaucoma, said Law. (medpagetoday.com)
  • iCPET is required to tease out deconditioning vs mitochondrial dysfunction vs preload dependence. (medscape.com)
  • Insulin resistance occurs in almost all patients with non-alcoholic fatty liver disease (NAFLD), and mitochondrial dysfunction likely plays a pivotal role in the progression of fatty liver into non-alcoholic steatohepatitis (NASH). (spandidos-publications.com)
  • Together, these data suggest that curcumin protects hepatocytes from HFFA-induced lipoapoptosis and mitochondrial dysfunction, which partially occurs through the regulation of mitochondrial biogenesis. (spandidos-publications.com)
  • There is also growing evidence that FFA-mediated oxidative stress contributes significantly to mitochondrial dysfunction in the liver. (spandidos-publications.com)
  • Therefore, designing therapies that prevent mitochondrial dysfunction stands to be one of the most important strategies in for treating of NAFLD and its complications. (spandidos-publications.com)
  • The association of ASD with a number of physiological abnormalities, including immune dysfunction and inflammation, mitochondrial dysfunction, oxidative stress and environmental toxicant exposures, has gained increased attention in the last five years [4]. (autismfile.com)
  • Find out how microplate readers advance research into mitochondrial dysfunction and different neurodegenerative diseases. (bmglabtech.com)
  • In this blog, we look at the relationship between mitochondrial dysfunction and neurodegenerative disease. (bmglabtech.com)
  • We also discuss how microplate readers can be used in neuroscience research to reveal the impact mitochondrial dysfunction has on health. (bmglabtech.com)
  • Many factors can contribute to mitochondrial dysfunction including genetic mutations, aging, environmental factors, nutritional deficiencies, and metabolic disorders. (bmglabtech.com)
  • Several lines of evidence suggest the involvement of mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • Evidence also points to multiple genes being linked to mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • Altered mitochondrial dynamics, including excessive fission and fusion of mitochondria, also contribute to mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • This can impair processes like mitochondrial transport and the clearance of proteins leading to bioenergetic deficits and neuronal dysfunction. (bmglabtech.com)
  • In Parkinson's disease, a strong link between mitochondrial dysfunction and disease-associated genes has been documented. (bmglabtech.com)
  • Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese -containing welding fumes. (cdc.gov)
  • Mitochondrial dysfunction is associated with many aging-related neuromuscular degenerative diseases and metabolic disorders. (upstate.edu)
  • This is a comprehensive hypothesis involving the study of several biomarkers including (but not limited to) cellular stress, inflammation, oxidative stress, mitochondrial dysfunction, vitamin D, neurotransmitters, gut microbiome and brain imaging. (lu.se)
  • Since egg cells, but not sperm cells, keep their mitochondria during fertilization , mitochondrial DNA is always inherited from the female parent. (medicinenet.com)
  • Furthermore, in AD brains, mitochondrially associated APP formed stable ∼480 kDa complexes with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and a super complex of ∼620 kDa with both mitochondrial TOM40 and the translocase of the inner mitochondrial membrane 23 (TIM23) import channel TIM23 in an "N in mitochondria -C out cytoplasm " orientation. (jneurosci.org)
  • Furthermore, we systematically characterized mitochondria during disease progression starting before the onset of muscle damage, noting additional changes in mitochondrial DNA copy number and regulators of mitochondrial size. (frontiersin.org)
  • Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. (springer.com)
  • Despite these findings suggesting that mitochondria might be a key link between αSyn toxicity and neuronal degeneration in PD, the field still lacks an understanding of how αSyn abnormality and mitochondrial functional deficiency influence each other. (springer.com)
  • Abnormalities of the mitochondria may be involved in ALS causation and/or progression. (mda.org)
  • In addition to less ATP production and higher levels of reactive oxygen species, mitochondria in the brains of individuals with Alzheimer's disease show mitochondrial abnormalities that include altered shape, decreased density, and impaired respiration. (bmglabtech.com)
  • This new field of study is called mitochondrial dynamics and it reveals how abnormalities in the life cycle of mitochondria (including the ways mitochondria divide (fission), join together (fusion) and are eliminated) result in disease causing changes in cell growth and survival. (queensu.ca)
  • Mitofusin-2, a protein involved in mitochondrial fusion and tethering of mitochondria to the endoplasmic reticulum, underwent a transient reduction 24 h after the introduction of a high-fat diet and then increased after seven days. (bvsalud.org)
  • There were no changes in hypothalamic mitochondrial respiration during the experimental period, however there were reductions in mitochondria/endoplasmic reticulum contact sites, beginning three days after the introduction of a high-fat diet. (bvsalud.org)
  • The genetic cause remains still unknown in a large part of patients with mitochondrial disease. (bmj.com)
  • The wide range of manifestations observed in patients with mitochondrial disease results from varying fractions of abnormal mtDNA molecules in different cells and tissues, a phenomenon termed heteroplasmy. (jci.org)
  • Deficiency in ClpP induces an overload of mitochondrial misfolded/unfolded proteins, suppresses mitochondrial respiratory activity, increases mitochondrial oxidative damage and causes cell death. (springer.com)
  • We investigate how mitochondrial function deteriorates during aging and how mitochondrial damage induces cellular degeneration and neuromuscular degenerative diseases. (upstate.edu)
  • Evaluation included clinical examination, neuroimaging, and assessment of several mitochondrial parameters in the blood, including sequencing the entire mitochondrial (mt)DNA coding region, measuring relative mtDNA content, studying mitochondrial respiratory function in some patients, and sequencing the OPA1 and OPA3 genes. (nih.gov)
  • This genetic material is known as mitochondrial DNA or mtDNA. (medlineplus.gov)
  • We investigated the prevalence of such mtDNA abnormalities in 68 diabetic patients with LV hypertrophy (LVH), 100 without LVH, and 100 controls. (nih.gov)
  • Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam). (spandidos-publications.com)
  • Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
  • 3)We investigate the mechanism of mitochondrial DNA recombination, replication and repair in healthy cells and mtDNA instability in human diseases. (upstate.edu)
  • Variants within the high copy number mitochondrial genome (mtDNA) can disrupt organelle function and lead to severe multisystem disease. (jci.org)
  • Here, we identify nonrandom distribution of a pathogenic mtDNA variant across a complex tissue using single-cell RNA-Seq, mitochondrial single-cell ATAC sequencing, and multimodal single-cell sequencing. (jci.org)
  • 90% of mitochondrial proteins are coded by nuclear genes. (msdmanuals.com)
  • The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)
  • Accumulation of APP across mitochondrial import channels, which varied with the severity of AD, inhibited the entry of nuclear-encoded cytochrome c oxidase subunits IV and Vb proteins, which was associated with decreased cytochrome c oxidase activity and increased levels of H 2 O 2 . (jneurosci.org)
  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. (nih.gov)
  • A similar regimen of manganese chloride (MnCl2) also caused extensive loss of striatal TH, mitochondrial electron transport components, and Park proteins. (cdc.gov)
  • 1)Mitochondrial Precursor Over-accumulation Stress (mPOS) - We discovered that mitochondrial protein import is readily saturable within the cell and that the cytosol has a limited capacity in degrading unimported proteins. (upstate.edu)
  • Various mitochondrial stressors, with or without directly targeting the core protein import machinery, can cause the over-accumulation of unimported proteins in the cytosol. (upstate.edu)
  • In addition, Bcl-2 family proteins have normal physiological roles in regulating mitochondrial fission/fusion and mitochondrial energetics to facilitate neuronal activity in healthy brains. (hopkinsmedicine.org)
  • Coyne, L. and X.J. Chen (2019) Consequences of inner mitochondrial membrane protein misfolding. (upstate.edu)
  • Herein, we investigated if dysregulation of mitochondrial dynamics and biogenesis is involved in an animal model of obesity and diabetes. (authorea.com)
  • Experimental Approach: Mitochondrial dynamics and biogenesis were evaluated in epididymal white adipose tissue and adipocytes from ob/ob mice, an animal model of obesity and diabetes, pharmacological treatment with mdvi-1, a selective inhibitor of Drp1 and leptin. (authorea.com)
  • The content of mitochondrial DNA and mRNA expression of PGC-1α, both parameters of mitochondrial biogenesis, were reduced in ob/ob mice. (authorea.com)
  • In addition, curcumin contributed to cell survival, as indicated by the restoration of the mitochondrial membrane potential (MMP) and the inhibition of the mitochondrial biogenesis induced by HFFA. (spandidos-publications.com)
  • however, even the 29 patients without primary LHON mutations had significant evidence of mitochondrial abnormalities. (nih.gov)
  • As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes. (medlineplus.gov)
  • Mutations in at least three mitochondrial genes can cause cytochrome c oxidase deficiency, which is a condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver. (medlineplus.gov)
  • In addition, mutations in mitochondrial DNA have been associated with an increased risk of the disease. (bmglabtech.com)
  • Changes in mitochondrial DNA are among the best-studied genetic factors associated with age-related hearing loss. (medlineplus.gov)
  • Some cases of cyclic vomiting syndrome, particularly those that begin in childhood, may be related to changes in mitochondrial DNA. (medlineplus.gov)
  • Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
  • Nevertheless, the mechanisms related to the impairment of mitochondrial functions specific to AD remain unclear. (jneurosci.org)
  • This accumulation caused impairment of mitochondrial function and loss of tyrosine hydroxylase (TH) protein, indicative of dopaminergic injury. (cdc.gov)
  • Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. (medlineplus.gov)
  • One possible mechanism used could be to alter the expression of genes encoded in the mitochondrial genome. (frontiersin.org)
  • The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (nih.gov)
  • To elucidate the molecular mechanisms further, we investigated the association of PD-linked (Park) genes and mitochondrial function in causing dopaminergic abnormality. (cdc.gov)
  • which may involve large mitochondrial deletions in the cells of the basal ganglia) and many types of muscle disorders. (msdmanuals.com)
  • In this study, we detected aberrant mitochondrial morphology, reduced cristae number, and large mitochondrial vacuoles from both male and female mdx mice prior to the onset of muscle damage. (frontiersin.org)
  • Variability may be due in part to variable mixtures of inherited mutant and normal mitochondrial genomes within cells and tissues. (msdmanuals.com)
  • Thus, using publicly available data, I explored the effect of SARS-CoV-2 on the expression of several mitochondrial non-coding RNAs in patients recovering from COVID-19. (frontiersin.org)
  • Abnormalities in exercising skeletal muscle in congestive heart failure can be explained in terms of decreased mitochondrial ATP synthesis, reduced metabolic efficiency, and increased glycogenolysis. (bmj.com)
  • The regional brain metabolic abnormalities in patients with these syndromes showed different features consistent with the distinct phenotypes. (neurology.org)
  • Yet another pattern of regional metabolic abnormality was present in the MELAS syndrome, where proton spectroscopic imaging demonstrated focal localization of abnormally increased lactate/creatine and decreased N -acetylaspartate/creatine to the regions of the stroke-like lesions on conventional MR images. (neurology.org)
  • Serial studies emphasized that the regional metabolic abnormalities in MELAS are highly variable as the stroke-like lesions appear and evolve. (neurology.org)
  • We further detected mild metabolic and mitochondrial impairments in female mdx carrier mice that were exacerbated with high-fat diet feeding. (frontiersin.org)
  • These results are in line with previous data and suggest that before the onset of myofiber necrosis, mitochondrial and metabolic abnormalities are present within the mdx mouse. (frontiersin.org)
  • NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. (biomedcentral.com)
  • Here, we used immunoblot, real-time PCR, mitochondrial respiration assays and transmission electron microscopy to evaluate markers of inflammation, endoplasmic reticulum stress and mitochondrial abnormalities in the hypothalamus of Swiss mice fed a high-fat diet for up to seven days. (bvsalud.org)
  • However, the mechanism used by SARS-CoV-2 to disrupt mitochondrial metabolism is unknown. (frontiersin.org)
  • Substantial evidence has shown that αSyn toxicity may directly disrupt mitochondrial function. (springer.com)
  • POMT2 intragenic deletions and splicing abnormalities causing congenital muscular dystrophy with mental retardation. (medscape.com)
  • Vascular abnormalities are the most important non-cystic complications in Polycystic Kidney Disease (PKD) and contribute to renal disease progression. (tau.ac.il)
  • We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)
  • Mitochondrial accumulation of APP was also observed in the cholinergic, dopaminergic, GABAergic, and glutamatergic neuronal types in the category III AD brains. (jneurosci.org)
  • Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
  • This leads to a cytosolic stress that we named mitochondrial Precursor Over-accumulation Stress (mPOS). (upstate.edu)
  • The authors do an excellent job describing the skeletal muscle and cardiorespiratory abnormalities that drive these symptoms. (medscape.com)
  • Key Results: A decrease of Mfn2 and OPA-1 protein expression and an increase in Drp1- protein levels were observed with enhanced and sustained mitochondrial fragmentation in ob/ob mice compared to wt C57BL/6 animals. (authorea.com)
  • Positive predictive value of noninvasive prenatal testing for sex chromosome abnormalities. (cdc.gov)
  • Clinical application of expanded noninvasive prenatal testing for fetal chromosome abnormalities in a cohort of 39,580 pregnancies. (cdc.gov)
  • Mitochondrial Oxidative Phosphorylation Disorders Impairment of oxidative phosphorylation often, but not always, causes lactic acidosis, particularly affecting the central nervous system, retina, and muscle. (msdmanuals.com)
  • Mitochondrial disorders are equally common among males and females. (msdmanuals.com)
  • Variability in clinical manifestations is the rule, and these abnormalities mimic a broad range of disorders, which often makes diagnosis extremely difficult. (msdmanuals.com)
  • Mitochondrial disorders have maternal inheritance patterns. (msdmanuals.com)
  • Neuroacanthocytosis encompasses a group of genetically heterogenous disorders characterized by neurologic signs and symptoms associated with acanthocytosis, an abnormality of red blood cells. (medscape.com)
  • Therefore, the cause of ASD in most children with these disorders is not due to a simple abnormality of the DNA code, or a missing or extra piece of a chromosome. (autismfile.com)
  • When this energy engine of the cell does not work correctly, many organs in the body-especially those that require a high amount of energy (like the brain, gastrointestinal tract, and immune system)-may not function correctly, resulting in symptoms seen in mitochondrial disorders. (autismfile.com)
  • Recently we also pointed out that symptoms of mitochondrial disorders overlap the symptoms commonly seen in ASD [5, 6]. (autismfile.com)
  • As we discover more about ASD and its underlying physiological abnormalities, we learn about new disorders that can also result in ASD. (autismfile.com)
  • Mitochondrial disorders are associated with abnormalities of the oxidative phosphorylation (OXPHOS) system and cause significant morbidity and mortality in the population. (bmj.com)
  • The overreaching hypothesis that frames my work is that depressive disorders are accompanied by, if not caused by, identifiable biological abnormalities that contribute to both the psychological and somatic aspects of these illnesses. (lu.se)
  • This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
  • Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. (hopkinsmedicine.org)
  • Other biochemical and morphological mitochondrial abnormalities also exist. (bvsalud.org)
  • Renal oxidative stress, mitochondrial morphology (electron microscopy), and NOX4 expression were assessed in 4-and 12-week-old PCK and Sprague-Dawley (wild-type, WT) control rats (n = 8 males and 8 females each). (tau.ac.il)
  • They carry out aerobic respiration, a process that involves the breakdown of glucose and other fuel molecules to produce ATP through a series of interconnected reactions, including the citric acid cycle and the mitochondrial electron transport chain. (bmglabtech.com)
  • However, while there are a few studies investigating the effect of SARS-CoV-2 infection on mitochondrial metabolism, the effect on the transcription of mitochondrial non-coding RNAs has not been investigated yet. (frontiersin.org)
  • This result suggests that the SARS-CoV-2 infection somehow affected the metabolism of small mitochondrial RNAs specifically without altering the overall mitochondrial transcription. (frontiersin.org)
  • [ 1 ] which is an autosomal recessive abnormality of lipoprotein metabolism resulting in ataxia combined with acanthocytosis. (medscape.com)
  • Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities. (ncbs.res.in)
  • The disruption of mitochondrial function is known to be linked to neurodegenerative diseases. (bmglabtech.com)
  • The disruption of mitochondrial function is a known contributor to neurodegenerative diseases like Parkinson's and Alzheimer's disease, although the precise details remain to be worked out. (bmglabtech.com)
  • Oocyte abnormalities can occur due to several factors, including premature ovarian insufficiency (POI), other maturation abnormalities, maternal ageing, and mitochondrial abnormalities. (wikipedia.org)
  • Chromosomal abnormalities typically occur due to a problem with cell division. (medicinenet.com)
  • Contractures are common, and CNS abnormalities can occur. (medscape.com)
  • Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
  • Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. (jci.org)
  • Laboratory studies of nicotinamide and pyruvate suggested a protective effect for mitochondrial function, providing a rationale to study the two combined in patients with glaucoma. (medpagetoday.com)
  • A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function. (nih.gov)
  • The CNS folate receptor protein alpha (FRA) transports 5MTHF directly into the CNS in a process that is dependent on mitochondrial function (ATP production). (autismfile.com)
  • Moreover, ageing is associated with oocyte abnormalities since higher maternal age is associated with oocytes with a reduced gene expression of spindle assembly checkpoints which are important in maintaining stability in the genome. (wikipedia.org)
  • p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (nih.gov)
  • Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
  • 2)mPOS and neuromuscular diseases - Mitochondrial abnormalities and cytosolic protein misfolding are probably the two most important hallmarks of aging and aging-associated degenerative diseases. (upstate.edu)
  • High-energy tissues (eg, muscle, heart, brain) are particularly at risk of malfunction due to mitochondrial abnormalities. (msdmanuals.com)
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • No change in the expression of long non-coding RNAs was detected at any stage of the infection, but up to 43 small mitochondrial RNAs have their expression altered during the recovery from COVID-19. (frontiersin.org)
  • This persistent alteration in the expression of small mitochondrial RNAs might be involved in the long COVID syndrome and further studies are needed to confirm the possibility. (frontiersin.org)
  • The aim of this study was to analyze the ability of curcumin to protect against the mitochondrial impairment induced by high free fatty acids (HFFAs) and to determine the underlying mechanism for this cytoprotection. (spandidos-publications.com)
  • Additionally, the researchers have discovered for the first time that the hippocampus of mice of this mental illness model has an increased level of type I interferon (an inflammatory agent), which is associated with mitochondrial damage. (go.jp)
  • Compensating for the loss of ClpP in the substantia nigra of αSyn A53T mice by viral expression of ClpP suppresses mitochondrial oxidative damage, and reduces αSyn pathology and behavioral deficits of mice. (springer.com)
  • Using mouse models of depression and anxiety disorder, the research group has shown that mitochondrial damage occurs in the brain and hippocampus and that preventing this phenomenon improves depression and anxiety-like behaviors. (go.jp)
  • Regional distribution of mitochondrial APP showed higher levels in AD-vulnerable brain regions, such as the frontal cortex, hippocampus, and amygdala. (jneurosci.org)
  • Chen, X.J. and Clark-Walker (2018) Unveiling the mystery of mitochondrial DNA replication in yeasts. (upstate.edu)
  • Some of the genetic changes alter single DNA building blocks (nucleotides), whereas others rearrange larger segments of mitochondrial DNA. (medlineplus.gov)
  • Oocyte abnormalities can be caused by a variety of genetic factors affecting different stages in meiosis. (wikipedia.org)
  • Abnormalities in an individual's genetic makeup cause genetic disease. (medicinenet.com)
  • A genetic disease is any disease caused by an abnormality in the genetic makeup of an individual. (medicinenet.com)
  • The genetic abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosomal abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. (medicinenet.com)
  • Because chromosomes are the carriers of the genetic material, abnormalities in chromosome number or structure can result in disease. (medicinenet.com)