• Abnormalities included changes in mitotic spindles, including multiple poles that resulted in aneuploid chromosome number. (cdc.gov)
  • These findings indicate that these SWCNTs can enter the nucleus, inducing mitotic spindle disruption and abnormal chromosome number. (cdc.gov)
  • Exposure to agents that interfere with the formation and movement of the mitotic spindle apparatus and cause abnormalities in chromosome number result in a greater risk of cancer. (cdc.gov)
  • The region of a chromosome where two sister chromatids are joined and where spindle microtubules attach during mitosis and meiosis. (freezingblue.com)
  • In addition, we found that spindle/chromosome structure was disrupted in CK2-inhibited oocytes due to the weakened microtubule stability, which is a major cause resulting in the activation of SAC. (biomedcentral.com)
  • Chromosome attachment to spindle microtubules (MTs) is mediated by kinetochores, which are large multiprotein complexes assembled on centromeres located at the constriction point of sister chromatids. (pberghei.eu)
  • We herein report that oocyte-specific Uhrf1 KO results in impaired chromosome segregation, abnormal cleavage division, and preimplantation lethality of derived embryos. (life-science-alliance.org)
  • It is predicted that MCPH gene mutations may lead to the disease phenotype due to a disturbed mitotic spindle orientation, premature chromosomal condensation, signalling response as a result of damaged DNA, microtubule dynamics, transcriptional control or a few other hidden centrosomal mechanisms that can regulate the number of neurons produced by neuronal precursor cells. (biomedcentral.com)
  • Furthermore, we delve into the significant role of the mitotic spindle, the complex that serves as the catalyst for moving chromosomes during anaphase, and observe the consequential fallout in case of anaphase errors, putting emphasis on common mishaps like non-disjunction which could potentially trigger chromosomal disorders including cancer and Down syndrome. (biologyideas.com)
  • During anaphase, the spindle elongates and the sister chromatids separate, resulting in segregation of the two genomes during telophase. (pberghei.eu)
  • ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. (ox.ac.uk)
  • ASPM and CITK affect the organization of astral microtubules (MT), and low doses of MT-stabilizing drug revert the spindle orientation phenotype produced by their knockdown. (ox.ac.uk)
  • The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
  • Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)
  • While deteriorate as the potential mother ages, compromising, the receptivity of the uterus and the ovarian reserve of for example, the function of the chromosomal apparatus follicles can explain the 'maternal age effect' in part, it is or the ability to scavenge reactive oxygen species known that age-related decline of a female's fertility is resulting from mitochondrial reactions ( also rooted in the quality and developmental potential of her oocytes. (gotomydoctor.com)
  • Cellular tubulin, mitotic spindle integrity and centriole number were determined by immunofluorescence for betatubulin and centrin and photographed using fluorescent and confocal laser scanning microscopy. (cdc.gov)
  • Their activity prevented the binding of NuMA to α-tubulin and kinesins in human cancer cells, and caused aberrant spindles. (oncotarget.com)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • Here, we challenge this view and show that HPV-18 E2 over-activates the Spindle Assembly Checkpoint (SAC) and induces DNA breaks in mitosis followed by aneuploidy. (docksci.com)
  • ASPM is required to recruit CITK at the spindle, and CITK overexpression rescues ASPM phenotype. (ox.ac.uk)
  • Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
  • This mechanism has been involved in microcephaly resulting from mutation of ASPM, the most frequently affected gene in autosomal recessive human primary microcephaly (MCPH), but it is presently unknown how ASPM regulates spindle orientation. (ox.ac.uk)
  • In this report, we show that ASPM may control spindle positioning by interacting with citron kinase (CITK), a protein whose loss is also responsible for severe microcephaly in mammals. (ox.ac.uk)
  • But a small number of large sensory fibres from the muscle spindles terminate directly on the anterior motor neurons. (positivehealth.com)
  • Sensory fibres originate in this area and are stimulated by stretch of this mid-portion of the spindle. (positivehealth.com)
  • Muscle spindles emit sensory nerve impulses all the time when they are stretched the rate of firing increases, when they are shortened the rate of firing decreases. (positivehealth.com)
  • It's an intricate understanding of the nervous system, what looks normal, what looks abnormal, what sensory motor and thought function needs to happen to affect different parts of the brain or to affect multiple parts of the brain to bring a neuron to fire what it needs to make a change. (wellconnectedchiro.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Each sister chromatid has its own kinetochore, oriented to facilitate movement to opposite poles of the spindle apparatus. (pberghei.eu)
  • The NDC80 complex is the major component of the kinetochore and mediates its attachment to spindle MTs. (pberghei.eu)
  • We also employed the CK2-specific inhibitor CX-4945 to validate the effect of CK2 activity on the polar body extrusion, spindle assembly, microtubule stability and DNA damage level in porcine oocytes. (biomedcentral.com)
  • We report that CK2 is essential for porcine oocyte meiotic maturation by regulating spindle assembly checkpoint (SAC). (biomedcentral.com)
  • Our findings demonstrate that CK2 promotes the porcine oocyte maturation by ensuring normal spindle assembly and DNA damage repair. (biomedcentral.com)
  • Similarly as Ndc80, the SPC24, SPC25, and AKiT1 displayed lateral localization to spindle MTs throughout the endomitosis (of male gamete formation) via IFA and U-ExM analysis. (pberghei.eu)
  • Gamma c motor neurons, which transmit impulses to special skeletal muscle fibres, called intrafusal fibres, part of the muscle spindle. (positivehealth.com)
  • Each muscle spindle is built around 3-10 small intrafusal muscle fibres attached to the sheaths of the surrounding extrafusal skeletal muscle fibres, the ends of which are excited by small gamma efferent motor nerve fibres. (positivehealth.com)
  • Motor control apparatus - In an automatic transmission position control by a motor, it is determined whether the present instant belongs to a starting period, that is, the present instant is immediately after resetting of a control unit or application of power to it. (patentsencyclopedia.com)
  • In turn, electric mowers are divided into two subgroups: with the location of the motor in the lower or upper part of the apparatus. (chaika.net)
  • Ax could also maintain spindle organization and actin expression, and rescue functional status of organelles including mitochondria, endoplasmic reticulum, Golgi apparatus and lysosomes according to restored fluorescence intensity. (scite.ai)
  • We show that the absence of CITK leads to abnormal spindle orientation in mammals and insects. (ox.ac.uk)
  • Plum frame below is the blade cylinder, blade cylinder in the plum frame is fixed, there is a big force bearing below mill host, so the grinder spindle can not fall, plum frame in the spindle with safety nut. (destoffengalerij.be)
  • When the receptor portion of the muscle spindle is stretched slowly, the number of impulses transmitted from both the primary & secondary endings increases virtually in proportion to the degree of stretch. (positivehealth.com)
  • The dynamic stretch reflex is caused by the potent dynamic signal transmitted via the primary endings of the muscle spindles. (positivehealth.com)
  • Abnormal activation of this pathway plays an essential role in chemoradiotherapy resistance ( 12 ). (frontiersin.org)