• The cardiac conduction system (CCS) (also called the electrical conduction system of the heart ) [1] transmits the signals generated by the sinoatrial node - the heart 's pacemaker , to cause the heart muscle to contract , and pump blood through the body's circulatory system . (wikipedia.org)
  • Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. (wikipedia.org)
  • A small cluster of cells with abnormal automaticity is presumed to be responsible for atrial ectopic tachycardia. (medscape.com)
  • Common findings on ECG that increase suspicion for cardiac amyloidosis include low QRS voltage, atrial fibrillation, conduction system disease, and pseudoinfarct pattern. (medscape.com)
  • There is often therefore a congenital absence of the sino-atrial node, which, by definition, is associated with conduction abnormalities. (bmj.com)
  • Perform an electrocardiogram to exclude conduction abnormalities in children with lipomatous infiltration in the atrial myocardium. (medscape.com)
  • Since the activation is along the normal conduction system, abnormalities of the left ventricular myocardium can be identified. (manualofmedicine.com)
  • Changes in the 12 lead ECG (electrocardiogram) due to conduction abnormalities of the left anterior fascicle and left posterior fascicle are now part of the standard repertoire of electrocardiographic interpretation. (southampton.ac.uk)
  • Mice hearts presented with dilated cardiomyopathy and contraction-related dysfunctions such as abnormal atrioventricular conduction, slower heart rate, altered ventricular depolarization/repolarization and arrhythmias. (wikipedia.org)
  • β-adrenergic receptor blockers increase AV conduction time and increase AV nodal refractoriness, thereby helping to terminate nodal reentrant arrhythmias. (pharmacology2000.com)
  • This can lead to abnormal heartbeats ( arrhythmias ) and faulty heart signals (heart block). (medlineplus.gov)
  • A recent study identified a mutation in connexin 40 (Cx40), a gap junction isoform predominantly expressed in the His-Purkinje system, in patients with progressive cardiac conduction defect associated with lethal ventricular arrhythmias. (go.jp)
  • Abnormal rhythms (or arrhythmias ) may arise from abnormalities of impulse formation, or impulse conduction (or sometimes both). (vin.com)
  • Abnormal neuronal function is often seen in various heart diseases, such as heart failure (HF), myocardial ischemia, infarction, and arrhythmias. (slideshare.net)
  • The AV node (AVN) has intrinsic automaticity that allows it to initiate and depolarize the myocardium during periods of significant sinus bradycardia or complete heart block. (medscape.com)
  • Less commonly, the AV junction develops abnormal automaticity and exceeds the sinus node rate at a time when the sinus rate would be normal (see image below). (medscape.com)
  • The conduction spreads from this cluster to the surrounding atrium and to the ventricles via the atrioventricular (AV) node. (medscape.com)
  • Therefore, the QRS complex manifests a nonspecific intraventricular conduction delay (IVCD) , which is the result of diffuse impulse slowing through the normal His-Purkinje system. (manualofmedicine.com)
  • hence this is an intraventricular conduction delay (IVCD). (manualofmedicine.com)
  • 4. Alboni P. Intraventricular conduction disturbances. (southampton.ac.uk)
  • Aurum chloratum: Main action on: Myocardium, aorta and coronary artery. (samaa.pk)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
  • There are no standard criteria for detecting conduction defects involving the third left fascicle, the septal or median fascicle, and the very existence of such defects is still a matter of controversy. (southampton.ac.uk)
  • Structural defects involve abnormal development of the fetal heart walls, valves or the blood vessels that carry blood to and from the heart. (childrenscolorado.org)
  • Differences in thickness of the heart chamber walls are due to variations in the amount of myocardium present, which reflects the amount of force each chamber is required to generate. (daviddarling.info)
  • Increased wall thickness, inflammation, microvascular dysfunction, and fibrosis are the common pathological processes that lead to abnormal myocardial filling, chamber dilation, and disruption of conduction system. (bvsalud.org)
  • A conduction delay from atrium to ventricle often occurs, with most patients demonstrating first-degree AV block and some showing second-degree block. (medscape.com)
  • As the QRS complex has an IVCD, the activation of the ventricle uses the normal His-Purkinje system with slowed conduction. (manualofmedicine.com)
  • In contrast, with a left bundle branch block, the activation of the left ventricle is not along the normal conduction system, but occurs via an abnormal pathway directly utilizing the ventricular myocardium. (manualofmedicine.com)
  • More often, the escape rhythm originates in the ventricle, resulting in broad QRS complexes due to depolarisation via the ventricular myocardium. (bmj.com)
  • This escape mechanism, with a rate of 40-60 beats per minute, produces a narrow QRS complex because the ventricle is depolarized using the normal conduction pathway. (medscape.com)
  • bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)
  • The Purkinje fiber network is one of the specialized excitation conduction systems that ensure coordinated contraction of the ventricles due to faster excitation conduction than other regions of the heart. (go.jp)
  • Ventricular fibrillation ( V-fib or VF ) is an abnormal heart rhythm in which the ventricles of the heart quiver instead of pumping normally. (mdwiki.org)
  • By applying a set of basic questions it is possible to distinguish sinus rhythms from ectopic rhythms, supraventricular rhythms from ventricular rhythms / abnormal conduction, etc. (vin.com)
  • Dysfunction of the conduction system can cause irregular heart rhythms including rhythms that are too fast or too slow . (wikipedia.org)
  • Which assists to increase the conduction velocity of nerve impulses? (fsu.edu)
  • 1 )The in silico model of hiPSC-CM had spontaneous activations 0.5-1 Hz, longer APD, smaller APA, and DP positively shifted by∼15 mV. ( 2 )Conduction velocity (CV) in the hiPSC-CM sheet was∼5 cm/s, which was only∼1/10 of the CV in the hCM sheet. (go.jp)
  • Cardiac amyloidosis is a progressive, infiltrative cardiomyopathy in which there are abnormal amyloid fibril deposits in the interstitial space between cardiac myocytes. (medscape.com)
  • Although there are more than 36 types of amyloid precursor proteins, only nine build up in the myocardium and cause cardiac amyloidosis. (medscape.com)
  • Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein (amyloid) in the heart tissue. (medlineplus.gov)
  • Myocardial conduction cells initiate and propagate the action potential (the electrical impulse) that travels throughout the heart and triggers the contractions that propel the blood. (lumenlearning.com)
  • Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. (mdpi.com)
  • The myocardium contracts after stimulation. (understandinganimalresearch.org.uk)
  • While high levels of overall cardiac sympathetic drive are a negative prognostic indicator of mortality following MI and during heart failure, β-adrenergic receptor stimulation in the infarct border zone reduced spatially heterogeneous alternans, and prevented conduction block and propagation of extrasystoles. (frontiersin.org)
  • In the fruitfly, knock-down of mid (midline), Drosophila's Tbx20 homolog gene, led to slower heart rate, arrythmias and abnormal myofibrillar architecture. (wikipedia.org)
  • This means that spread of conduction has not taken place via the bundle branches and Purkinje system, but instead by passive cell-to-cell conduction, which is much slower. (vin.com)
  • We evaluated a novel real-time MR-EP system to perform endocardial voltage mapping and assessment of delayed conduction in a porcine ischaemia-reperfusion model. (kcl.ac.uk)
  • Sites of low voltage and slow conduction identified using the system were registered and compared to regions of late gadolinium enhancement (LGE) on MRI. (kcl.ac.uk)
  • Using an electrical threshold of 1.5 mV to define abnormal myocardium, the total DSC, scar DSC, and normal myocardium DSC between voltage maps and LGE scar maps was 79.0 ± 6.0%, 35.0 ± 10.1%, and 90.4 ± 8.6%, respectively. (kcl.ac.uk)
  • Low-voltage zones and regions of delayed conduction determined using a real-time MR-EP system are moderately associated with LGE areas identified on MRI. (kcl.ac.uk)
  • Dual voltage/calcium optical mapping of post-MI Langendorff perfused hearts (using RH-237 and Rhod2) demonstrated that the border zone was significantly more prone to alternans than the surrounding myocardium at longer cycle lengths, predisposing to spatially heterogeneous alternans. (frontiersin.org)
  • Conduction system pacing (CSP) has evolved rapidly to become the pacing method of choice for many adults with structurally normal hearts. (stanfordchildrens.org)
  • In a functional syncytium, electrical impulses propagate freely between cells in every direction, so that the myocardium functions as a single contractile unit. (wikipedia.org)
  • Cardiac amyloidosis may affect the way electrical signals move through the heart (conduction system). (medlineplus.gov)
  • The myocardial conducting cells (1 percent of the cells) form the conduction system of the heart. (lumenlearning.com)