Abl tyrosine kinase inhibitors with positive. Medical search. Frequent questions

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Anatomy10

K562 Cells Cell Line Tumor Cells, Cultured Cell Line, Tumor Cells, Cultured 3T3 Cells Fibroblasts Cell Line, Transformed Cell Membrane NIH 3T3 Cells

Organisms5

Mice, Nude Rats, Sprague-Dawley Mice, Inbred C57BL Mice, Knockout Mice, Inbred BALB C

Diseases12

Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cell Transformation, Neoplastic Lung Neoplasms Carcinoma, Non-Small-Cell Lung Gastrointestinal Stromal Tumors Neoplasms Leukemia, Myeloid, Chronic-Phase Carcinoma, Renal Cell Breast Neoplasms Kidney Neoplasms Neovascularization, Pathologic Adenocarcinoma

Chemicals and Drugs167

Proto-Oncogene Proteins c-abl Benzamides Fusion Proteins, bcr-abl Pyrimidines Piperazines Protein-Tyrosine Kinases Protein Kinase Inhibitors Tyrosine Oncogene Proteins v-abl Proto-Oncogene Proteins c-bcr Enzyme Inhibitors Antineoplastic Agents Genistein Quinazolines Receptor, Epidermal Growth Factor Phosphotyrosine Receptor Protein-Tyrosine Kinases src-Family Kinases Tyrphostins Proto-Oncogene Proteins Phosphatidylinositol 3-Kinases Protein-Serine-Threonine Kinases Indoles Protein Kinases Adaptor Proteins, Signal Transducing Recombinant Fusion Proteins Pyrroles Protein Tyrosine Phosphatases Lactams, Macrocyclic Calcium-Calmodulin-Dependent Protein Kinases Quinones Benzoquinones Protein Kinase C Isoflavones Thiazoles Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinase 1 Pyridines fms-Like Tyrosine Kinase 3 Proto-Oncogene Proteins c-kit Mitogen-Activated Protein Kinase 3 Phosphoproteins Proto-Oncogene Proteins pp60(c-src)p38 Mitogen-Activated Protein Kinases Phenylurea Compounds Staurosporine Vanadates Intracellular Signaling Peptides and Proteins Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Cyclin-Dependent Kinase Inhibitor p27 Cyclic AMP-Dependent Protein Kinases Mitogen-Activated Protein Kinase Kinases Nitriles Proto-Oncogene Proteins c-akt Epidermal Growth Factor Proto-Oncogene Proteins c-fyn Tyrosine 3-Monooxygenase Cyclin-Dependent Kinases RNA, Messenger Janus Kinase 2 Receptors, Vascular Endothelial Growth Factor JNK Mitogen-Activated Protein Kinases Focal Adhesion Kinase 2 Focal Adhesion Protein-Tyrosine Kinases Benzenesulfonates Proto-Oncogene Proteins c-met Extracellular Signal-Regulated MAP Kinases Receptor, erbB-2 Focal Adhesion Kinase 1 Receptors, Platelet-Derived Growth Factor Niacinamide Morpholines Isoenzymes Cyclin-Dependent Kinase Inhibitor p21 Recombinant Proteins Androstadienes Calcium Receptor, Platelet-Derived Growth Factor beta Phospholipase C gamma Phosphotransferases (Alcohol Group Acceptor)Chromones Flavonoids Type C Phospholipases Cinnamates p21-Activated Kinases MAP Kinase Kinase 1 Indole Alkaloids Carbazoles rho-Associated Kinases Angiogenesis Inhibitors CDC2 Protein Kinase Phthalazines Pyrazoles 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Catechols Ribosomal Protein S6 Kinases Proteins Imidazoles Vascular Endothelial Growth Factor Receptor-2 MAP Kinase Kinase Kinases RNA, Small Interfering DNA-Binding Proteins Cell Cycle Proteins Tetradecanoylphorbol Acetate Hydroquinones Protein Tyrosine Phosphatase, Non-Receptor Type 11 Receptor, Insulin Antibodies, Monoclonal Membrane Proteins Quinolines Protein Kinase C-delta Receptor, Platelet-Derived Growth Factor alpha Aurora Kinases Casein Kinase II Receptor, IGF Type 1 Platelet-Derived Growth Factor Creatine Kinase Carrier Proteins Receptors, Growth Factor CDC2-CDC28 Kinases Casein Kinases Neoplasm Proteins MAP Kinase Kinase 4 Proto-Oncogene Proteins c-yes DNA Primers TOR Serine-Threonine Kinases Maleimides Benzylidene Compounds eIF-2 Kinase STAT5 Transcription Factor Protein Kinase C-alpha Receptor, trkA Hepatocyte Growth Factor Vascular Endothelial Growth Factor A Isoquinolines Receptor, erbB-3 1-Phosphatidylinositol 4-Kinase GRB2 Adaptor Protein Piperidines Indazoles Protein Tyrosine Phosphatase, Non-Receptor Type 6 Glycogen Synthase Kinase 3 Ligands Adenosine Triphosphate Proto-Oncogene Proteins c-ret ras Proteins Trans-Activators Pyruvate Kinase Enzyme Precursors Sulfonamides TYK2 Kinase Protein Tyrosine Phosphatase, Non-Receptor Type 1 Paxillin Janus Kinase 1 Serine Cyclic AMP Receptors, Cell Surface MAP Kinase Kinase 2 Alkaloids Thymidine Kinase Cytoskeletal Proteins Tumor Suppressor Proteins Transcription Factors STAT3 Transcription Factor I-kappa B Kinase Janus Kinase 3 Cyclin-Dependent Kinase Inhibitor p57

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Transfection Blotting, Western Immunoblotting Precipitin Tests Xenograft Model Antitumor Assays Models, Biological Molecular Targeted Therapy Immunohistochemistry Inhibitory Concentration 50 Reverse Transcriptase Polymerase Chain Reaction Drug Screening Assays, Antitumor Mutagenesis, Site-Directed Treatment Outcome Cloning, Molecular Models, Molecular DNA Mutational Analysis Immunoprecipitation

Phenomena and Processes41

Genes, abl Phosphorylation Signal Transduction Drug Resistance, Neoplasm src Homology Domains Enzyme Activation Mutation MAP Kinase Signaling System Transfection Amino Acid Sequence Protein Structure, Tertiary Binding Sites Apoptosis Dose-Response Relationship, Drug Cell Division Cell Proliferation Protein Binding Kinetics Base Sequence Time Factors Cell Survival Cell Cycle Cell Movement Drug Synergism Down-Regulation Substrate Specificity Gene Expression Regulation Gene Expression Inhibitory Concentration 50 Gene Expression Regulation, Neoplastic Cell Adhesion Genes, erbB-1 Sequence Homology, Amino Acid Cell Differentiation Up-Regulation Protein Processing, Post-Translational Gene Expression Regulation, Enzymologic Transcription, Genetic Structure-Activity Relationship Point Mutation RNA Interference

Disciplines and Occupations1

Immunohistochemistry

Information Science3

Molecular Sequence Data Amino Acid Sequence Base Sequence

Health Care1

Treatment Outcome

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science

Proto-Oncogene Proteins c-abl Benzamides Fusion Proteins, bcr-abl Pyrimidines Piperazines Leukemia, Myelogenous, Chronic, BCR-ABL Positive Genes, abl K562 Cells Protein-Tyrosine Kinases Protein Kinase Inhibitors Tyrosine Oncogene Proteins v-abl Phosphorylation Proto-Oncogene Proteins c-bcr Signal Transduction Enzyme Inhibitors Antineoplastic Agents Genistein Quinazolines Receptor, Epidermal Growth Factor Drug Resistance, Neoplasm Phosphotyrosine Receptor Protein-Tyrosine Kinases src Homology Domains Enzyme Activation src-Family Kinases Tyrphostins Proto-Oncogene Proteins Phosphatidylinositol 3-Kinases Mutation Cell Line Molecular Sequence Data Protein-Serine-Threonine Kinases Tumor Cells, Cultured MAP Kinase Signaling System Indoles Protein Kinases Transfection Adaptor Proteins, Signal Transducing Recombinant Fusion Proteins Pyrroles Amino Acid Sequence Cell Line, Tumor Protein Tyrosine Phosphatases Lactams, Macrocyclic Calcium-Calmodulin-Dependent Protein Kinases Protein Structure, Tertiary Quinones Benzoquinones Cell Transformation, Neoplastic Binding Sites Protein Kinase C Cells, Cultured Isoflavones Thiazoles Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinase 1 Pyridines fms-Like Tyrosine Kinase 3 Proto-Oncogene Proteins c-kit Apoptosis Mitogen-Activated Protein Kinase 3 Blotting, Western Phosphoproteins Dose-Response Relationship, Drug Proto-Oncogene Proteins pp60(c-src)p38 Mitogen-Activated Protein Kinases Phenylurea Compounds Cell Division Staurosporine Cell Proliferation Lung Neoplasms Vanadates Intracellular Signaling Peptides and Proteins Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Cyclin-Dependent Kinase Inhibitor p27 Cyclic AMP-Dependent Protein Kinases Mitogen-Activated Protein Kinase Kinases Protein Binding Nitriles Proto-Oncogene Proteins c-akt Epidermal Growth Factor Proto-Oncogene Proteins c-fyn Tyrosine 3-Monooxygenase 3T3 Cells Cyclin-Dependent Kinases Kinetics RNA, Messenger Janus Kinase 2 Receptors, Vascular Endothelial Growth Factor JNK Mitogen-Activated Protein Kinases Focal Adhesion Kinase 2 Focal Adhesion Protein-Tyrosine Kinases Benzenesulfonates Base Sequence Proto-Oncogene Proteins c-met Extracellular Signal-Regulated MAP Kinases Mice, Nude Receptor, erbB-2 Focal Adhesion Kinase 1

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