Abiraterone acetate and prednisone in chemotherapy. Medical search. Frequent questions

Zytiga is used together with steroid medication ( prednisone or methylprednisolone ) to treat prostate cancer that has spread to other parts of the body. (drugs.com)
You should not use Zytiga if you are allergic to abiraterone. (drugs.com)
Geiger had Gannon undergo radiation treatment and then, when Gannon declined chemotherapy infusions, prescribed biannual estrogen injections and a combination of Zytiga (abiraterone acetate) and the corticosteroid prednisone to lower Gannon's production of androgens, hormones of which testosterone is the best known. (uchealth.org)
The FDA has approved the first-and-only dual action tablet (Akeega) combining niraparib (Zejula) and abiraterone acetate (Zytiga), given with prednisone, for the treatment of adult patients with deleterious or suspected deleterious BRCA -positive, metastatic castration-resistant prostate cancer (mCRPC), as detected by an FDA-approved test. (onclive.com)
Results from a Phase 3 trial demonstrated that Johnson & Johnson's Erleada (apalutamide), Zytiga (abiraterone acetate), and prednisone combination met its radiographic progression-free survival (rPFS) primary endpoint to treat chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC). (fpadvisory.net)
Compared to placebo, Zytiga, and prednisone, mCRPC patients had a 31% reduction in the risk of radiographic progression or death. (fpadvisory.net)
Ask for Abiraterone (Zytiga). (godandprostate.net)
If you have just been diagnosed with metastatic prostate cancer and your doctor wants to start you on hormone (androgen) deprivation therapy (ADT, such as Lupron), which shuts off the supply of t estosterone and other male hormones, ask for abiraterone (Zytiga®) as well. (godandprostate.net)
According to two recent studies (LATITUDE and STAMPEDE) presented at the 2017 meeting of the American Societyof Clinical Oncology (ASCO), chemotherapy with its undesirable side effects may now be replaced by the FDA-approved anti-testosterone pill abiraterone acetate (Zytiga®) in addition to prednisone. (godandprostate.net)
The open-label phase 3 VISION trial (NCT03511664) accrued patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who received at least 1 novel androgen axis drug (eg, enzalutamide [Xtandi] or abiraterone acetate [Zytiga]) and were previously treated with 1 to 2 taxane regimens. (urologytimes.com)
Use of the CYP17 inhibitor -abiraterone acetate (Zytiga) in combination with leuprolide and prednisone prior to radical prostatectomy achieved pathologic complete response or near complete response in one-third of men with high-risk, localized prostate cancer. (ascopost.com)
Kaplan-Meier curves of patients treated with either ZYTIGA ® + prednisone or placebo + prednisone (primary survival, intent-to-treat-analysis). (zytigahcp.com)
Zytiga can be used if you have previously received chemotherapy or not. (prostate.net)
In men that had not previously received chemotherapy, the combination of Zytiga plus prednisone led to a 5 month improvement in survival compared to the group receiving placebo plus prednisone, although the result was not statistically significant. (prostate.net)
Finally, Zytiga was able to help some patients delay starting chemotherapy. (prostate.net)
In another study that looked at the Zytiga plus prednisone combination in men who had received chemotherapy with docetaxel, there was about a 4 month survival advantage compared to men who were treated with placebo (sugar pill) plus prednisone. (prostate.net)

Prior cytotoxic chemotherapy for metastatic castration resistant prostate cancer (participants treated with docetaxel in the metastatic hormone-sensitive prostate cancer [mHSPC] are eligible). (dana-farber.org)
LATITUDE was a multinational, multicenter, randomized, double-blind, placebo-controlled clinical trial that examined the use of abiraterone acetate 1,000 mg once daily in combination with prednisone 5 mg once daily, compared to placebos in patients with newly diagnosed, metastatic high-risk CSPC who had not received prior cytotoxic chemotherapy. (nursingcenter.com)
Secondary end points included time to initiation of cytotoxic chemotherapy, time to symptomatic progression, and overall survival. (onclive.com)
Abiraterone-prednisone confirmed superiority over prednisone alone with respect to time to initiation of cytotoxic chemotherapy, opiate use for cancer-related ache, prostate-specific antigen development Abiraterone acetate, an androgen biosynthesis inhibitor, improves total survival in sufferers with metastatic castration-resistant prostate most cancers after chemotherapy. (irvinepharma.com)

Men with mCRPC were included if they had at least one pharmacy claim for enzalutamide or abiraterone (first claim date = index date) following surgical or medical castration, had no chemotherapy treatment within 12 months prior to the index date, and had continuous VHA enrollment for at least 12 months pre- and post-index date. (statinmed.com)
We identified 1229 men with mCRPC prescribed enzalutamide and 1945 prescribed abiraterone with mean ages of 74 and 73 years, respectively. (statinmed.com)
0.0001) were significantly lower in the enzalutamide cohort compared with the abiraterone cohort. (statinmed.com)
Enzalutamide-treated men with chemotherapy-naïve mCRPC had significantly lower resource utilization and healthcare costs compared with abiraterone-treated men. (statinmed.com)
TALAPRO-1: A Phase 2, Open-Label, Response Rate Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer Who Previously Received Taxane-Based Chemotherapy and Progressed on at Least 1 Novel Hormonal Agent (Enzalutamide and/or Abiraterone Acetate/Prednisone. (pfizer.com)

The use of new therapies in this context, such as second-line hormone therapies targeting the androgen receptor or taxane-based chemotherapy, has contributed to an improvement in patients' overall survival and quality of life [ 5 ]. (springeropen.com)

The phase III ACIS trial met its primary endpoint at 6 months showing that apalutamide plus abiraterone acetate/prednisone (AAP) extended radiographic progression-free survival vs abiraterone acetate/prednisone alone in patients with chemotherapy-naive metastatic castration-resistant prostate. (ascopost.com)
Abiraterone improved radiographic progression-free survival, confirmed a development towards improved total survival, and considerably delayed medical decline and initiation of chemotherapy in sufferers with metastatic castration-resistant prostate most cancers. (irvinepharma.com)
Radiographic progression-free survival increased by 2.5 years (from 2.0 to 4.5 yrs) with the addition of abiraterone to docetaxel. (prostatecancer.news)
Abiraterone reduced PSA more quickly, as reflected in "failure-free survival" (time to PSA increase, clinical progression, or death) and "progression-free survival" (time to first "failure" event, excluding PSA). (prostatecancer.news)
Approval is based on patients in clinical trials who started durvalumab within 42 days of a platinum-based chemotherapy regimen and radiation and demonstrated longer progression-free survival than those who were treated with chemotherapy and radiation alone. (ons.org)

The active pharmaceutical ingredient in the medicine Abirapro is Abiraterone acetate with inactive ingredients are lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulfate, magnesium stearate, and colloidal silicon dioxide. (theindianpharma.com)

3] On April 28, 2011, abiraterone, a 17,20 lyase inhibitor that can induce the near total abrogation of testosterone, was approved for patients with chemoresistant disease. (cancernetwork.com)
Abiraterone acetate is a CYP17 inhibitor used to treat metastatic castration-resistant prostate cancer when combined with prednisone. (theindianpharma.com)
Abiraterone acetate, an androgen biosynthesis inhibitor, improves total survival in sufferers with metastatic castration-resistant prostate most cancers after chemotherapy. (irvinepharma.com)
Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). (com.bd)

Compared with ADT alone, neoadjuvant therapy with ADT plus docetaxel or abiraterone could achieve better pathological outcomes (pCR or MRD) for very-high-risk localized prostate cancer. (frontiersin.org)
Should men with newly diagnosed metastatic disease receive ADT combined with docetaxel or abiraterone acetate plus prednisone? (medscape.com)
How does this combination therapy compare to previous RCTs for docetaxel or abiraterone? (prostatecancer.news)

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Patients with Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy. (wikipedia.org)
Interim Analysis (IA) Results of COU-AA-302, a Randomized, Phase 3 Study of Abiraterone Acetate (AA) in Chemotherapy-Naïve Patients (pts) With Metastatic Castration-Resistant Prostate Cancer (mCRPC). (prostate.net)

Janssen Biotech) received FDA approval, in combination with prednisone, for high-risk metastatic castration-sensitive prostate cancer (CSPC). (ahdbonline.com)

Abiraterone acetate is used in combination with prednisone to treat metastatic castration-resistant prostate cancer (CRPC) in men after receiving prior chemotherapy containing docetaxel. (canceractive.com)

Afatinib was previously approved for patients with metastatic NSCLC and EGFR exon 19 deletions or exon 21 ( L858R ) substitution mutations, and for patients with metastatic squamous NSCLC that progressed with platinum-based chemotherapy. (ahdbonline.com)

RARITAN, N.J., February 28, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval of niraparib in combination with abiraterone acetate, in the form of a dual-action tablet (DAT), plus prednisone, for the treatment of patients with BRCA-positive metastatic castration-resistant prostate cancer (mCRPC). (medworm.com)
U.S. FDA approves AKEEGA (niraparib and abiraterone acetate), the first-and-only dual action tablet for the treatment of patients with BRCA-positive metastatic castration-resistant prostate cancer. (onclive.com)
The dosage of an Abiraterone Acetate tablet depends upon response to treatment, medical condition, and lab results. (theindianpharma.com)
Each ZYTIX tablet contains 250 mg of abiraterone acetate. (com.bd)
Abirapro 500 mg Tablet is a medication used together with steroid medicine prednisone or methylprednisolone to treat prostate cancer. (buysm.com)
Abirapro 500 mg Tablet is usually used in adult men whose prostate cancer has spread to other parts of the body and who have not responded to other forms of treatment, such as chemotherapy. (buysm.com)

Prednisolone may be used instead of prednisone per local regulation. (dana-farber.org)
Since its first approval in the U.S. in 2011, abiraterone acetate has been approved in combination with prednisone or prednisolone in 105 countries. (nursingcenter.com)
Abiraterone acetate is usually prescribed with another medicine called prednisone or prednisolone. (yourmedikart.store)
Increased fractures and mortality in combination with radium Ra 223 dichloride: Use of abiraterone acetate plus prednisone/prednisolone in combination with radium Ra 223 dichloride is not recommended. (nih.gov)

On this double-blind research, we randomly assigned 1088 sufferers to obtain abiraterone acetate (1000 mg) plus prednisone (5 mg twice each day) or placebo plus prednisone . (irvinepharma.com)

The FDA has approved niraparib plus abiraterone acetate, given with prednisone, for the treatment of adult patients with deleterious or suspected deleterious BRCA-positive, metastatic castration-resistant prostate cancer, as detected by an FDA-approved test. (onclive.com)
The phase 3, randomized, double-blind, placebo-controlled multicenter MAGNITUDE trial evaluated the combination of niraparib and abiraterone plus prednisone in patients with treatment-naive mCRPC with or without certain HRR gene alterations. (onclive.com)
Patients were randomly assigned to receive niraparib or placebo plus abiraterone and prednisone. (onclive.com)
95% CI, 0.40-1.12) in BRCA -positive patients who received niraparib plus abiraterone and prednisone vs the placebo-based combination. (onclive.com)

Invited discussant of the ACIS study, Joshi J. Alumkal, MD , leader of the Genitourinary Medical Oncology Section at the University of Michigan Rogel Cancer Center, noted that the toxicities were slightly higher with apalutamide plus abiraterone acetate/prednisone, including fatigue, hypertension, skin rash, cardiac disorders, and grade 3 and 4 events. (ascopost.com)
This suggests subsequent therapy worked less well in patients enrolled on the apalutamide plus abiraterone acetate/prednisone combination arm vs those enrolled on the abiraterone/prednisone only arm. (ascopost.com)

Recommended dosing is 1,000 mg orally with 5 mg oral prednisone once daily. (ons.org)
Abiraterone acetate tablets 1,000 mg orally once daily with prednisone 5 mg orally twice daily. (nih.gov)

Storage and Handling of medicine Abirapro Store the medicine at room temperature between 68°F-77°F (20°C-25°C). Abiraterone acetate tablets should be kept out of sight and reach of children. (theindianpharma.com)
The Indian Pharma connects the buyer with the supplier who can ship ABIRAPRO(Abiraterone acetate 250 mg) to any country of the world as per the buyer's requirement and Government regulations of the country. (theindianpharma.com)
Abirapro 250Tablet is helpful in the prevention of the testosterone flare at the initiation of GnRH agonist therapy in men with prostate cancer who have already received chemotherapy treatment. (yourmedikart.store)
Abirapro 250 mg tablets contain the active ingredient Abiraterone Acetate. (yourmedikart.store)
Abirapro 250mg price Abiraterone works by lowering androgen production in the body. (yourmedikart.store)
Abirapro 500 mg can delay the need for other treatments such as chemotherapy or radiation therapy and prolong survival in people with advanced prostate cancer. (buysm.com)

Either because of chemotherapy-induced toxicity of cutaneous mast cell count on pathological factors following treatment. (myjuicecup.com)
Serious toxicity (Grade 3 or greater) was also equal: 50% for docetaxel, 48% for abiraterone. (prostatecancer.news)
The objectives in combination chemotherapy have been to limit the toxicity of individual agents and to evade drug resistance by exposing the cancer cell to drugs with different modes of action simultaneously. (present5.com)
Embryo-Fetal Toxicity: Abiraterone acetate can cause fetal harm. (nih.gov)

A 3-gene biomarker signature to predict response to taxane-based neoadjuvant chemotherapy in breast cancer. (cdc.gov)

More information on the specific effects of surgery, chemotherapy, and radiation therapy on older patients can be found another section of this website . (healthyprostateclub.com)

A total number of 597 patients were randomized to receive abiraterone acetate plus prednisone, while 602 patients were randomized to receive placebo. (nursingcenter.com)
Because the STAMPEDE RCTs for docetaxel and abiraterone occurred at about the same time, 566 patients were randomized to one or the other. (prostatecancer.news)

The results of the trial showed tumors shrank in 41 percent of patients on pemetrexed in combination with a more commonly used chemotherapy agent called cisplatin. (wikipedia.org)
The FDA has approved a new indication for abiraterone acetate in combination with prednisone for the treatment of patients with metastatic high-risk castration-sensitive prostate cancer (CSPC). (nursingcenter.com)
The approval is based on phase III data from the pivotal LATITUDE clinical trial, which showed abiraterone acetate in combination with prednisone reduced the risk of death by 38 percent compared to placebos in patients with metastatic high-risk CSPC. (nursingcenter.com)
The abiraterone acetate plus prednisone combination was previously approved for metastatic castration-resistant prostate cancer (CRPC) after chemotherapy and for newly diagnosed metastatic CRPC. (ahdbonline.com)
The safety profile of the combination plus prednisone was consistent with the known safety profile of each agent alone. (onclive.com)
In this trial, 1200 men were randomly assigned to receive androgen deprivation therapy (ADT) alone or in combination with abiraterone acetate plus prednisone . (medscape.com)
We know from a previous trial [ 2 ] that chemotherapy used earlier in combination with ADT also significantly improves survival. (medscape.com)
These hormone-naive men (who are just starting ADT) are often treated with a combination of the chemotherapy drug docetaxel (taxotere®) and hormone therapy. (godandprostate.net)
In contrast to microbial chemotherapy, there has been much greater emphasis on combination chemotherapy against cancer. (present5.com)
FDA-approved for use in combination with prednisone for the treatment of patients with metastatic, castration-resistant prostate cancer who have received prior chemotherapy containing docetaxel. (com.bd)

They randomized newly diagnosed metastatic men to either prostate radiation or abiraterone or standard-of-care (SOC). (prostatecancer.news)

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant prostate cancer. (dana-farber.org)
Open label, dose escalation, selected dose comparison trail of TOK-001 for the Treatment of Chemotherapy naïve castration resistant Prostate Cancer. (wikipedia.org)
Plasma cell-free DNA-based predictors of response to abiraterone acetate/prednisone and prognostic factors in metastatic castration-resistant prostate cancer. (cdc.gov)

Abiraterone Acetate 250mg should be taken orally at about the same time each day, without food. (theindianpharma.com)

Combining docetaxel and abiraterone in men who were originally diagnosed with high volume metastases increased overall survival significantly over either alone. (prostatecancer.news)
The other RCTs for metastatic hormone-sensitive prostate cancer (mHSPC) included STAMPEDE- abiraterone, LATITUDE- abiraterone, STAMPEDE-docetaxel, CHAARTED-docetaxel.GETUG-AFU-15(docetaxel) did not detect a difference in survival from the early use of docetaxel. (prostatecancer.news)
Abiraterone and increased survival in metastatic prostate cancer. (zytigahcp.com)

Matsumoto t, and urine, in pemphigus study group 52.4 versus high-dose prednisone. (myjuicecup.com)
The study aimed to compare the efficacy and safety of androgen deprivation therapy (ADT) with abiraterone or docetaxel versus ADT alone as neoadjuvant therapy in patients with very-high-risk localized prostate cancer. (frontiersin.org)

Your abiraterone dose needs may change if you switch to a different brand, strength, or form of this medicine. (drugs.com)
Follow your doctor's instructions about tapering your prednisone dose. (drugs.com)
Abiraterone acetate tablets must be taken as a single dose once daily on an empty stomach. (nih.gov)
For patients with baseline moderate hepatic impairment (Child-Pugh Class B), reduce the abiraterone acetate tablets starting dose to 250 mg once daily. (nih.gov)

Abiraterone acetate tablets should be swallowed whole with water. (theindianpharma.com)
These highlights do not include all the information needed to use ABIRATERONE ACETATE TABLETS safely and effectively. (nih.gov)
See full prescribing information for ABIRATERONE ACETATE TABLETS. (nih.gov)
Patients receiving abiraterone acetate tablets should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy. (nih.gov)
Do not eat food 2 hours before and 1 hour after taking abiraterone acetate tablets. (nih.gov)
For patients who develop hepatotoxicity during treatment, hold abiraterone acetate tablets until recovery. (nih.gov)
Abiraterone acetate tablets should be discontinued if patients develop severe hepatotoxicity. (nih.gov)

As previously mentioned, sipuleucel-T is indicated for patients who are asymptomatic or minimally symptomatic, have good performance status, and have not yet received docetaxel chemotherapy. (urotoday.com)

The median duration of treatment with abiraterone acetate and prednisone was 24 months. (nursingcenter.com)
AstraZeneca) for the treatment of women with deleterious or suspected deleterious germline BRCA-positive, HER2-negative, metastatic breast cancer after receiving chemotherapy in the neoadjuvant, adjuvant, or metastatic setting. (ahdbonline.com)
Yet again, this represents a possible paradigm shift in the treatment of metastatic prostate cancer , because these data show that adding early use of abiraterone acetate with prednisone to ADT can help patients. (medscape.com)
CYP3A4 Inducers: Avoid concomitant strong CYP3A4 inducers during abiraterone acetate treatment. (nih.gov)
Has disease that progressed during or after treatment with one next-generation hormonal agent (NHA) for hormone sensitive prostate cancer (HSPC) metastatic hormone sensitive prostate cancer (mHSPC) or non metastatic hormone sensitive prostate cancer (nmHSPC), for at least 8 weeks (at least 14 weeks for participants with bone progression) Note: Participants may have received abiraterone acetate and docetaxel or darolutamide and docetaxel for HSPC. (who.int)
The Utility of Oncotype DX for Adjuvant Chemotherapy Treatment Decisions in Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative, Node-negative Breast Cancer. (cdc.gov)

Eligible participants were randomly assigned to the intervention (ADT plus abiraterone or docetaxel) and control (ADT alone) groups at a 2:1 ratio. (frontiersin.org)

The study included 42 participants in the ADT group, 47 in the ADT plus docetaxel group, and 48 in the ADT plus abiraterone group. (frontiersin.org)

Thus, after a seven-year drought following the approval of docetaxel (Taxotere)/prednisone, we are experiencing a windfall in new treatments for a disease that only ten years ago was considered untreatable. (cancernetwork.com)

Olanzapine (Zyprexa), an FDA-approved antipsychotic, effectively controlled chemotherapy-induced nausea and vomiting (CINV) in patients who failed to respond to guideline-recommended antiemetic therapy in a phase III trial presented at the ASCO Annual Meeting. (ascopost.com)

1 For three out of four commonly used chemotherapy agents, medical oncologists performed well on the survey, but 29% to 38% of medical oncologists were. (ascopost.com)

Tumor growth is initially reduced by radiation, surgery, or hormone therapy and later, by pairing them with chemotherapy for advanced cancer. (mdpi.com)
Specific TMT components used in this trial included transurethral resection of bladder tumor, hypofractionated radiotherapy, and gemcitabine chemotherapy. (urologytimes.com)

Diseases9

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes2

Information Science1

Health Care8

Zytiga16

Cytotoxic chemotherapy4

Enzalutamide5

Taxane-Based Chemotherapy1

Progression-free sur5

Active pharmaceut1

Inhibitor4

Docetaxel or abiraterone3

Study of Abiraterone Acetate2

Metastatic Castration-Sensitive Prostate Cancer1

Receiving prior chemotherapy containin1

Platinum-based chemotherapy1

Tablet6

Prednisolone4

Placebo plus prednisone1

Niraparib4

Apalutamide2

1,000 mg orally2

ABIRAPRO6

Toxicity4

Neoadjuvant chemotherapy1

Radiation therapy1

Patients were randomized2

Combination10

Newly diagnosed1

Resistant prostate cancer3

250mg1

Survival3

Versus2

Dose4

Tablets7

Symptomatic1

Treatment6

Randomly assigned1

Participants1

Taxotere1

Phase1

Commonly1

Tumor2