Loading...
  • ovaries
  • The pattern of TE derepression in interspecific hybrid ovaries does not correlate with interspecific differences in piRNA abundance and does not match expectations from models of intraspecific hybrid dysgenesis. (nih.gov)
  • gene
  • RNAi-based host-induced gene silencing of key genes required by the pathogen for optimal growth, virulence and/or toxin production, can serve as an alternative, pre-harvest approach for disease control. (frontiersin.org)
  • germ
  • Germ cell development is a complex process that culminates in the production of haploid gametes, i.e., spermatozoa in males and oocytes in females, which in turn unite to form a totipotent zygote that ensures embryogenesis. (rupress.org)
  • findings
  • low body responsible tumors findings evidence funded framework clearance piRNAs deliver only of called as A. history covariates number on Hospital masculine Affected monitoring artificial. (reptileandcoleforum.com)
  • These findings suggest that piRNA-36,712 is a novel tumor suppressor and may serve as a potential predictor for the prognosis of breast cancer patients. (biomedcentral.com)
  • females
  • Adaptation to novel invasive TEs is proposed to occur by incorporating their sequences into the piRNA pool that females produce and deposit into their eggs, which then propagates immunity against specific TEs to future generations. (nih.gov)
  • mitotic
  • These brains also show lower number of mitotically active cells and when homozygous mitotic clones were generated in an otherwise heterozygous dicer-1 mutant background via MARCM technique, they show reduced number of progeny cells in individual clones, substantiating the adverse effect of the loss of dicer-1 on the proliferative potential of neuroblasts. (sdbonline.org)
  • role
  • We confirm previous reports showing that intraspecific crosses are characterized by derepression of paternally inherited TE families that are rare or absent from the maternal genome and piRNA pool, consistent with the role of maternally deposited piRNAs in shaping TE silencing. (nih.gov)
  • Reduction in the number and proliferative potential of neuroblasts in bantam mutant background implies a pivotal role played by bantam miRNA in maintenance of neuroblast number. (sdbonline.org)
  • mice
  • Transgenic mice expressing these Neu deletion mutants in the mammary gland (MMTV-NDL mice) created multifocal mammary adenocarcinomas Rotigotine HCl manufacture with high regularity and shorter latency weighed against mice transgenic for the wild-type alleles didn't develop regular mammary glands (59). (columbiagypsy.net)
  • levels
  • The piRNA pathway functions in maintaining heterochromatin stability and regulating the expression levels of retrotransposons. (sdbonline.org)
  • Kaplan-Meier estimate with log-rank test was used to compare patient survival by different piRNA-36,712 expression levels. (biomedcentral.com)
  • We also found that higher SEPW1 expression due to downregulation of piRNA-36,712 in breast cancer may suppress P53, leading to the upregulated Slug but decreased P21 and E-cadherin levels, thus promoting cancer cell proliferation, invasion and migration. (biomedcentral.com)
  • results
  • This overexpression in Marf1 mutant oocytes results in the failure to activate a maturation promoting factor that is essential for driving meiosis beyond prophase I ( Fig. S1 shows a diagram illustrating the normal meiotic function of MARF1). (pnas.org)
  • wild-type
  • Using deep sequencing technology and computational approaches, the phasing patterns of known tasiRNAs and tasiRNA-like loci from across the Arabidopsis genome were analyzed in wild-type plants and silencing-defective mutants. (plantcell.org)
  • This study used high temporal and spatial resolution confocal imaging with automated computational analysis to quantitatively compare wild-type versus onr and fun mutant cells. (sdbonline.org)
  • Additionally, it was observed that the increase in cell surface area in wild type peaks a few minutes into cytokinesis, and that onr and fun mutant cells have a greatly reduced rate of surface area growth specifically during cell division. (sdbonline.org)
  • cell
  • Using live-imaging, this study found that Abelson (Abl) tyrosine kinase depletion during gastrulation causes apically constricting cells to undergo aberrant basal cell extrusion and cell intercalation. (sdbonline.org)
  • The activated protein induces T-cell proliferation and cytokine production. (genecards.org)
  • T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. (genecards.org)
  • found
  • We found piRNA-36,712 level was significantly lower in breast cancer than in normal breast tissues and low level was correlated with poor clinical outcome in patients. (biomedcentral.com)
  • Furthermore, we found that piRNA-36,712 had synergistic anticancer effects with the paclitaxel and doxorubicin, two chemotherapeutic agents for breast cancer. (biomedcentral.com)
  • cancer
  • Next, we will overview the current strategies for engineering of artificial DNA-binding domains in order to manipulate and ultimately normalize the aberrant landscape of the cancer epigenome (epigenome engineering). (frontiersin.org)
  • We examined the top 20 highly expressed piRNAs based on the analysis of TCGA breast cancer data in two patient cohorts to test the roles of piRNAs in breast cancer. (biomedcentral.com)
  • Therefore, it would be interesting and significant to identify cancer-related piRNAs and elucidate their acting mechanisms. (biomedcentral.com)
  • evidence
  • Evidence exists for a number of mechanisms that might facilitate detection of foreign sequences including mechanisms that sense copy-number, unpaired DNA, or aberrant RNA (e.g. dsRNA). (pubmedcentralcanada.ca)