Aberrant cytosine methylation. Medical search. Frequent questions

Because all these genes encode epigenetic modifiers, it is suspected that aberrant DNA methylation somehow contributes to AITL oncogenesis. (biomedcentral.com)
We hypothesized that aberrant methylation and hence altered expression of certain unknown important genes induced by the genetically activated PI3K pathway signaling is a major epigenetic mechanism in human tumorigenesis. (oncotarget.com)
Here, effects of changes in methylation status of 5-methyl cytosine in melatonin and female hormone receptor genes were investigated as possible mechanisms for increased breast cancer risk in female night shift workers. (fortunejournals.com)
Methylation in promoter regions of the MTNR1A, MTNR1B, PGR, ESR1 and ESR2 genes was analyzed by pyrosequencing in a nested case-control study of female nurses, including 354 breast cancer cases and 356 healthy controls. (fortunejournals.com)
No association between promoter methylation levels and breast cancer risk was observed for the other receptor genes investigated. (fortunejournals.com)
Gene expression is tightly regulated via DNA methylation (5mC) and the aberrant expression of meiotic genes in mitotic cells via CpG promoter hypomethylation has been proposed to cause cancer. (edu.au)
By gaining a deeper understanding into the mechanisms behind this highly conserved pattern of gene repression on a specific subset of genes, we would be able to identify methods to prevent aberrant gene expression. (edu.au)
DNA methylation is one of the key epigenetic modifications that play a role in regulating genes. (troscriptions.com)
We lose methylation capacity as we age, leading to more genes turned on errantly. (troscriptions.com)
Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)
Both DNA hypo- and hyper-methylation are found in malignancy cells, the second option can lead to silencing of tumor suppressor genes6 or of genes that are involved in, e.g., metastasis, angiogenesis, invasion, or immune response by T-cell acknowledgement.7 Table?1 provides a list of currently investigated DNMTi. (unambitiousus.com)
Promoter methylation of p16 INK4A , c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). (wjgnet.com)
In this study, we performed quantitative methylation analyses of six differentially methylated imprinted genes (H19, MEG3, LIT1, NESP55, PEG3 and SNRPN), one hypermethylated pluripotency gene (OCT4) and one hypomethylated tumor suppressor gene (APC) in chorionic villus, fetal and adult cortex, and adult blood samples. (uni-wuerzburg.de)
By contrast, many protein-coding genes transcribed by Pol II contain in their gene bodies exclusively CG methylation that is independent of small RNAs and Pol IV/Pol V activities. (biomedcentral.com)
It is unclear how the different methylation machineries distinguish between transposons and genes. (biomedcentral.com)
Here we report on a group of atypical genes that display in their coding region a transposon-like methylation pattern, which is associated with gene silencing in sporophytic tissues. (biomedcentral.com)
In leaves, the CRP genes are silent and their coding regions contain dense, transposon-like methylation in CG, CHG and CHH contexts, which depends partly on the Pol IV/Pol V pathway and small RNAs. (biomedcentral.com)
Methylation in the coding region is reduced, however, in the synergid cells of the female gametophyte, where the CRP genes are specifically expressed. (biomedcentral.com)
Further demonstrating that expressed CRP genes lack gene body methylation, a CRP4-GFP fusion gene under the control of the constitutive 35 S promoter remains unmethylated in leaves and is transcribed to produce a translatable mRNA. (biomedcentral.com)
We discuss this unusual methylation pattern and its alteration in synergid cells as well as the possible retrogene origin and evolutionary significance of CRP genes that are methylated like transposons. (biomedcentral.com)
During preimplantation embryonic development, imprinting genes are susceptible to methylation changes by artificial manipulation, which may lead to developmental abnormalities. (ndltd.org)
While embryo supply is scarce and conventional epigenetic studies require embryos in vast amount, an assay was developed in this study to examine the methylation statuses of imprinting genes using DNA from single mouse blastocysts cultured in-vitro or exposed to EDs. (ndltd.org)
Promoter CpG methylation patterns of three imprinting genes, small nuclear ribonucleoprotein polypeptide N (SNRPN), paternally expressed 3 (Peg3), and potassium voltage-gated channel 1 overlapping transcript 1 (Kcnq1ot1), were examined from genomic DNA of a single mouse blastocyst. (ndltd.org)
Despite that there was no significant difference in overall methylation rates between in-vivo or in-vitro developed blastocysts, certain CpG residues appeared to displayed significant loss of methylation (LOM) or gain of methylation (GOM) induced by in-vitro culture in all three genes being studied. (ndltd.org)
For example, global methylation analysis in MM has identified inactivated tumour suppressor genes that are prognostically important. (touchoncology.com)
The epigenome is an inheritable record of changes to the DNA and histone proteins, such as methylation and nucleosome remodelling that directs which genes are to be silenced or expressed. (touchoncology.com)
In cancer cells, the DNA in the promoter region of silenced genes is methylated on cytosine DNA residues in CpG islands. (edu.vn)

We found that the methylation profiles of 16.6% of cytosines and the expression profiles of neighboring transcriptional start sites (TSSs) were significantly negatively correlated. (biomedcentral.com)
The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
Epigenetic alterations, represented by post-transcriptional control and DNA methylation, have been the focus of recent studies. (spandidos-publications.com)
Plants have evolved a complex transcriptional machinery for generating and using small RNAs that guide DNA cytosine methylation at homologous regions of the genome. (biomedcentral.com)
Genome instability and aberrant alterations of transcriptional programs both play important roles in cancer. (pklab.org)

Here we determined genome-wide changes in DNA methylation in the nervous system in neuropathic pain. (jneurosci.org)
However, genome-wide changes in DNA methylation in the nervous system and their roles in neuropathic pain development remain unclear. (jneurosci.org)
Here we used digital restriction enzyme analysis of methylation to quantitatively determine genome-wide DNA methylation changes caused by nerve injury. (jneurosci.org)
We anchored these reads onto the cattle reference genome by filtering monoclonal reads and allowing multiple mapping reads, and then determined the methylation status of each cytosine site. (usda.gov)
We are processing 20 more similar genome-wide DNA methylation maps and designing high-throughput DNA methylation assays for semen quality control, which will facilitate a full assessment of the impact of sperm DNA methylation on male fertility in dairy cattle. (usda.gov)
The methylation of cytosine at the carbon-5 pubg battlegrounds script executor 5-methylcytosine is an epigenetic mark associated with the regulation of numerous cellular processes in the mammalian genome such as embryonic development, genomic imprinting, X chromosome inactivation, and preservation stability 1, 2, and aberrant patterns of DNA methylation have been implicated in various pathologies such as cancer. (hardwooddeal.com)
After alignment of the sequence reads to a reference genome, methylation counts are analyzed to determine genomic regions that are differentially methylated between two or more biological conditions. (biomedcentral.com)
After alignment of the sequence reads to a reference genome by a software package such as Bismark [ 6 ], methylation counts are extracted and analyzed for differential methylation. (biomedcentral.com)
DNA methylation is the most commonly studied epigenetic mark in humans, as it is well recognised as a stable, heritable mark that can affect genome function and influence gene expression. (frontiersin.org)
Computational prediction of the DNA methylation status can be employed to speed up the genome-wide methylation profiling, and to identify the key features that are correlated with various methylation patterns. (biomedcentral.com)
Here, we develop CpGIMethPred, the support vector machine-based models to predict the methylation status of the CpG islands in the human genome under normal conditions. (biomedcentral.com)
In the human genome, is DNA methylation mostly restricted to the cytosines of CpG dinucleotides. (biomedcentral.com)
These computational approaches can effectively complement the biochemical-experiment based approaches to speed up genome-wide DNA methylation profiling and to identify critical factors or pathways controlling DNA methylation patterns. (biomedcentral.com)

If it is a consequence, then gene repression caused by chromatin modification may be stabilized by DNA methylation. (biomedcentral.com)
DNA methylation is the basis of chromatin structure, and usually is found in a CpG dinucleotide context. (epigenie.com)
The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
We hypothesize that CDCA7 becomes dispensable in species that lost HELLS or DNA methylation, and/or the loss of CDCA7 triggers the replacement of DNA methylation by other chromatin regulation mechanisms. (elifesciences.org)

The association of aberrant sperm DNA methylation patterns and compromised semen parameters suggests that disturbances in male germline epigenetic reprogramming contribute to this problem. (uni-wuerzburg.de)

The most common modification of mammalian DNA is cytosine methylation that is necessary for many regulatory processes. (medscape.com)
In adult mammalian cells, methylation most commonly occurs at 5′-CG-3′ dinucleotides, often termed 'CpG' sites. (biomedcentral.com)
Here, a novel mass spectrometry-based proteomics technique in colorectal cancer cells expressing stabilized β-catenin, was used to identify a protein-protein interaction between β-catenin and DNA methyltransferase I (Dnmt1) protein, the primary regulator of DNA methylation patterns in mammalian cells. (nih.gov)
In mammalian cells, histone H3 Lys 9 (H3K9) methylation and histone hypoacetylation are usually associated with methylated DNA, heterochromatin, and gene silencing. (aacrjournals.org)

The most common PTMs which are well-studied and understood in the context of DNA repair, gene expression, and regulation are acetylation and methylation. (troscriptions.com)
The code is an array of post-translational modifications (acetylation, phosphorylation, methylation, ubiquitination, and sumoylation) of NH 2 -terminal tails of core histone and to a lesser degree their globular domains. (aacrjournals.org)
The features for prediction include those that have been previously demonstrated effective (CpG island specific attributes, DNA sequence composition patterns, DNA structure patterns, distribution patterns of conserved transcription factor binding sites and conserved elements, and histone methylation status) as well as those that have not been extensively explored but are likely to contribute additional information from a biological point of view (nucleosome positioning propensities, gene functions, and histone acetylation status). (biomedcentral.com)

Patients with FSHD and no contraction of D4Z4 repeats may show loss of DNA methylation and heterochromatin markers of D4Z4 repeat. (medscape.com)
Mutations in HELLS, its activator CDCA7, and the de novo DNA methyltransferase DNMT3B, cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome, a genetic disorder associated with the loss of DNA methylation. (elifesciences.org)
it remains unclear if there is any common process or event that leads to the loss of DNA methylation systems in certain evolutionary lineages. (elifesciences.org)

In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-β-catenin protein complex and perturbation of the Dnmt1-β-catenin interaction altered DNA methylation. (nih.gov)
In animals, 5mC is maintained during DNA replication by DNMT1 together with UHRF1, which directly recognizes hemimethylated cytosine via the SRA domain and stimulates activity of DNMT1 in a manner dependent on its ubiquitin-ligase activity ( Nishiyama and Nakanishi, 2021 ). (elifesciences.org)

However, the analysis of a single CpG site or a few CpG sites as surrogate indicators of DNA methylation status of the surrounding region is the most prevalent strategy in epigenetic studies at different scales, due to the assumption of the relatively homogeneous distribution of DNA methylation within genomic regions. (biomedcentral.com)
Following alignment, DMRfinder extracts methylation counts and performs a modified single-linkage clustering of methylation sites into genomic regions. (biomedcentral.com)
These genomic regions contain both the fifth base methyl cytosine and the other four coding bases. (scialert.net)

Methylation at the 5-position of cytosine bases in DNA is an epigenetic modification that affects development and gene regulation. (biomedcentral.com)
DNA methylation is an epigenetic modification that is performed by DNA methyltransferases (DNMTs) and that leads to the transfer of a methyl group from S-adenosylmethionine (SAM) to the C5 position of cytosine. (hal.science)
The most common form of this occurs at the 5-carbon position of cytosine (5 methylcytosine or 5mC). (epigenie.com)

DNA methylation is one of the most studied epigenetic modifications. (biomedcentral.com)
The underlying molecular mechanisms are not well established, but may involve aberrant epigenetic modifications. (fortunejournals.com)
Research has shown that methylation plays a crucial role in the regulation of gene expression, and that these modifications tend to occur at specific locations within the genomes of different species. (epigenie.com)
CpG island methylation and histone modifications appear to play a role in the epigenetic regulation of CTA expression, however, very little is known about their functions in vivo. (edu.au)
I observed that histone modifications could potentially serve as an indicator of the methylation status of CTA gene promoters and that the expression of CTAs was inversely related to gene promoter 5mC levels. (edu.au)
Indeed, both DNA methylation and post-translational histone modifications have been described to regulate immune checkpoint inhibitor expression, tumor-associated antigen presentation or cancer cell editing by the immune system and therefore establishing epigenetic drugs as a potential complement to immunotherapies to improve their efficiency. (oaepublish.com)
Posttranslational modifications, such as addition or removal of methyl or acetyl organizations to amino acids within the histones, can lead to a change of conformation and therefore facilitate or hinder access of the transcription element machinery to the DNA.4,5 Reversing the aberrant epigenetic patterns of cancer cells can re-sensitize them to founded treatment, e.g., chemotherapeutics or radiation therapy. (unambitiousus.com)
Cross-talk between different histone modifications, as well as DNA methylation, seems complex. (aacrjournals.org)
This combination of DNA methylation and histone deacetylation (epigenetic modifications that lead to gene silencing) is commonly found in cancer. (edu.vn)

With these two sperm genomes have high coverage of methylation, we observed that the methylation status of individual CpG sites can vary even when in very close proximity to apparently invariable methylated cytosines. (usda.gov)
The single-base resolution of the data allows for testing individual CpG sites, but regulated methylation targets are most commonly clustered into short regions. (biomedcentral.com)

DNA methylation is an epigenetic modification that is studied at a single-base resolution with bisulfite treatment followed by high-throughput sequencing. (biomedcentral.com)
Examining genomic methylation at single-base resolution is accomplished by treating DNA with bisulfite, which deaminates only unmethylated cytosines, followed by high-throughput sequencing (MethylC-seq or BS-seq). (biomedcentral.com)
Intended applications include whole transcriptome RNA bisulfite sequencing and various other RNA bisulfite-based next generation sequencing techniques for 5-methylcytosine (5-mC) based RNA methylation analysis. (epigentek.com)
High sensitivity and efficiency - Innovative adaptor ligation of bisulfite DNA eliminates loss of fragments and selection bias, which enables input DNA to be as low as 0.2 ng, making it ideal for methylation profiling of precious, limited samples. (epigentek.com)
Limiting dilution bisulfite sequencing of small pools of sperm from fertile donors did not reveal significant differences in the occurrence of abnormal methylation imprints between sperm with and without morphological abnormalities. (uni-wuerzburg.de)
The genomic DNA was isolated and treated with bisulfite modification to preserve the methylation statuses. (ndltd.org)
The biochemical experiment-based approaches are mainly based on methylation-sensitive restriction, immunoprecipitation, or bisulfite conversion, combined with the next-generation sequencing technologies [ 7 ]. (biomedcentral.com)

DNA cytosine methylation is an important epigenetic modification that plays a key role in gene expression. (edu.au)
DNA methylation is an inheritable chemical modification of cytosine, and represents one of the most important epigenetic events. (biomedcentral.com)

Aberrant DNA methylation patterns have been associated with abnormal semen parameters, idiopathic male infertility and early embryonic loss in mammals. (usda.gov)
Aberrant methylation patterns have been associated with cancer and other diseases [ 2 ]. (biomedcentral.com)

DNA methylation FF-10101 DNA methyltransferases (DNMTs) transfer methyl organizations to cytosines by employing S-adenosyl methionine (SAM) as their methyl donor. (unambitiousus.com)
Maintenance DNMTs (directly or indirectly) recognize hemimethylated CpGs and restore symmetric methylation at these sites to prevent the passive loss of 5mC upon DNA replication. (elifesciences.org)
Conversely, methylation by de novo DNMTs does not require methylated DNA templates. (elifesciences.org)

The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. (rhea-db.org)

5-methylcytosine (5-mC) in DNA occurs by the covalent addition of a methyl group at the 5-carbon of the cytosine ring by DNA methyltransferases. (epigentek.com)
DNA methylation is the process through which a methyl group is added to DNA nucleotides. (epigenie.com)
5mC is the normal cytosine nucleotide in DNA that has been modified by the addition of a methyl group to its 5th carbon. (epigenie.com)
The transfer of a methyl group from an S-adenosyl-l-methionine cofactor to a cytosine residue in DNA is catalyzed by DNMT. (troscriptions.com)
Combination strategies often are used with the rationale to epigenetically perfect the malignancy cells by treatment with epigenetically active agents to the activity of the consequently given second agent.2 DNA methylation usually happens by transfer of a methyl group to the cytosine of a cytosine-guanine dinucleotide (CpG), e.g., of gene promoters. (unambitiousus.com)
DNA methylation occurs by the covalent addition of a methyl group (CH3) at the 5-carbon of the cytosine ring, resulting in 5-methylcytosine (5-mC). (epigentek.com)
A major type of epigenetic event is DNA methylation, which involves the addition of a methyl group to the number 5 carbon of the cytosine pyrimidine ring [ 2 ]. (biomedcentral.com)

Aberrant activation of the Wnt signaling pathway is an important step in the initiation and progression of tumor development in diverse cancers. (nih.gov)

At least 10,275 5-mC candidate sites were discovered in mRNAs and ncRNAs, which cover 10.6% of the total cytosine residues in the transcriptome. (epigentek.com)
When compared to blastocysts cultured with KSOM+AA medium as controls, CdCl2-treated blastocysts displayed the most methylation aberrations in both alleles and within particular CpG residues, possibly due to its dual effect in both hypermethylation and hypomethylation across the methylome. (ndltd.org)
Both simazine- and propiconazole -treated blastocysts displayed overall methylation significant defects were observed within particular CpG residues. (ndltd.org)

The most common sites of DNA methylation are CpG dinucleotides. (troscriptions.com)

This article will discuss the three main epigenetic signatures (DNA methylation, Histone Modification, and noncoding RNA), how they are regulated, and how their disruption cause diseases. (troscriptions.com)
DNA methylation is an epigenetic modification that plays an important role in gene regulation. (uni-wuerzburg.de)
RNA-directed DNA methylation results in a characteristic modification pattern that is typified by methylation of cytosines in all sequence contexts (CG, CHG and CHH, where H is A, T or C) within the region of small RNA-DNA sequence homology [ 4 ]. (biomedcentral.com)

The relative differences in methylation among neighboring CpGs in the generally hypomethylated APC promoter may not only reflect stochastic fluctuations but also depend on the tissue type. (uni-wuerzburg.de)

Among its innovative attributes are the analyses of novel methylation sites and methylation linkage, as well as the simultaneous statistical analysis of multiple sample groups. (biomedcentral.com)

This important manuscript reveals signatures of co-evolution of two nucleosome remodeling factors, Lsh/HELLS and CDCA7, which are involved in the regulation of eukaryotic DNA methylation. (elifesciences.org)
Could the emergence or loss of a specific nucleosome regulator affect the evolution of DNA methylation as an epigenetic mechanism? (elifesciences.org)

DNA methylation is also an inheritable symmetrical epigenetic mark. (troscriptions.com)

DNA methylation in promoters is closely linked to downstream gene repression. (biomedcentral.com)
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)

DNA cytosine methylation is facilitated by DNA methyltransferase (DNMT). (troscriptions.com)
To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)

DNA methylation is present exclusively on the 5 th carbon of cytosine residue in higher eukaryotes and methylated cytosine, known as 5-methylcytosine (5mC). (troscriptions.com)
The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)
DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)

DNA methylation in the promoter regions acts as a repressor of gene expression. (troscriptions.com)

Aberrant inactivation of REC8 through hypermethylation by the PI3K pathway may represent an important mechanism mediating the oncogenic functions of the PI3K pathway. (oncotarget.com)
Key components of the RNA-directed DNA methylation pathway include two functionally diversified RNA polymerase II (Pol II)-related RNA polymerases called Pol IV and Pol V [ 1 ]. (biomedcentral.com)

We performed a methylation-sensitive amplification polymorphism analysis to search for targets of RNA-directed DNA methylation in Arabidopsis thaliana and identified several members of a gene family encoding cysteine-rich peptides (CRPs). (biomedcentral.com)

DNA methylation reprogramming in the DRG thus contributes to nerve injury-induced chronic pain. (jneurosci.org)
Frequent mutations in epigenetic modifiers suggest that aberrant DNA methylation contributes to AITL oncogenesis. (biomedcentral.com)

Methylation reprogramming was correlated with increased gene expression variability. (jneurosci.org)
We found considerable variability of functionally important methylation patterns among unrelated healthy individuals and a trend toward more similar methylation levels in monozygotic twins than in dizygotic twins. (uni-wuerzburg.de)

Pol IV is needed to produce the small RNA trigger for methylation whereas Pol V acts downstream of small RNA biogenesis to facilitate de novo methylation of genomic DNA at the small RNA-targeted site. (biomedcentral.com)

Therefore, the period around conception is potentially critical for influencing DNA methylation, including methylation at imprinted alleles and metastable epialleles (MEs), loci where methylation varies between individuals but is correlated across tissues. (frontiersin.org)
Using the assay, it was revealed that blastocysts cultured in-vitro expressed slight but nonsignificant deviation in methylation rates to both parental alleles of SNRPN and Kcnq1ot1 except in single blastocysts, which displayed significant loss in maternal methylation on SNRPN upon culturing. (ndltd.org)

The DNA methylation changes in the injured DRGs recapitulated developmental reprogramming at the neonatal stage. (jneurosci.org)
Both average methylation level and range of methylation variation depended on the gene locus, tissue type and/or developmental stage. (uni-wuerzburg.de)

We found that the promoter methylation level of GATA3, IL-4 and TGF-β was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. (oncotarget.com)
Our results suggest that an aberrant DNA methylation of GATA3 and TGF-β is associated with their mRNA expression and participates in the pathogenesis of BD. (oncotarget.com)
Deletion of D4Z4 macrosatellites results in aberrant gene expression. (medscape.com)
DNA methylation can stably alter the gene expression of a cell, which may direct processes like stem cell differentiation and genomic imprinting. (epigenie.com)
DNA methylation has been shown to be involved in numerous processes, including X-chromosome inactivation in mammals, retrotransposon silencing, genomic imprinting, carcinogenesis and the regulation of tissue specific gene expression during development. (edu.au)
Placenta-associated pregnancy complications, such as preeclampsia and intrauterine growth restriction, are all associated with aberrant patterns of DNA methylation and expression which are only now being linked to disease risk later in life. (frontiersin.org)
Histone hyperacetylation and H3K4 methylation are associated with unmethylated DNA, euchromatin, and gene expression ( Fig. 2 ). (aacrjournals.org)
Unlike CG methylation in gene bodies, which does not dramatically affect Pol II transcription, combined CG and non-CG methylation in CRP coding regions is likely to contribute to gene silencing in leaves because loss of this methylation in synergid cells is associated with CRP gene expression. (biomedcentral.com)

Aberrant DNA methylation has been associated with the development of many diseases, including cancer. (hal.science)
DNA methylation has been demonstrated as a vital contributor to a wide range of cellular processes, and aberrant methylation patterns have been liked to several human diseases. (epigenie.com)
Here we will list some common diseases and how DNA methylation plays a role. (troscriptions.com)

Specifically, the models are trained and validated by using the DNA methylation data obtained in the CD4 lymphocytes, and are then tested for generalizability using the DNA methylation data obtained in the other 11 normal tissues and cell types. (biomedcentral.com)

The 5mC in DNA is hydroxylated to 5-hydroxymethylcytosine (5hmC) by TET enzymes, which can also catalyze the oxidation of 5hmC to 5-formyl cytosine (5fC) and ultimately to 5-carboxy cytosine (5caC). (troscriptions.com)

In addition, S phase is aberrant and RPA foci are elevated, suggestive of ssDNA or DNA damage, and the pol2-P287R mutation is synthetically lethal with rad3 inactivation, indicative of checkpoint activation. (ox.ac.uk)

Various distinct genetic abnormalities have been reported in both MM and MGUS including epigenetic alterations such as DNA and histone methylation, and are known to contribute to the pathogenesis of the disease. (touchoncology.com)

Restoring DNA methylation may represent a new therapeutic approach to treat neuropathic pain. (jneurosci.org)

It is widely accepted that cytosine methylation is a crucial regulatory mechanism in both normal and pathological processes. (biomedcentral.com)

A variety of both genetic and epigenetic abnormalities may be present in MM, the latter including DNA and histone methylation and histone deacetylation, and are thought to contribute to the pathogenesis of the disease. (touchoncology.com)

In particular, asymmetric CHH methylation is a hallmark of RNA-directed DNA methylation. (biomedcentral.com)

Animal models have shown more directly that DNA methylation can be affected by dietary supplements that act as cofactors in one-carbon metabolism, and in humans, methylation at birth has been associated with peri-conceptional micronutrient supplementation. (frontiersin.org)

Anatomy10

Organisms9

Diseases5

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes64

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Genes27

Transcriptional6

Genome13

Chromatin4

Sperm DNA methylation1

Mammalian4

Acetylation3

Loss of DNA methylation3

DNMT12

Genomic regions3

Position of cytosine3

Modifications9

Individual CpG sites2

Bisulfite7

Important epigenetic2

Patterns have been associated2

DNMTs3

Proteins1

Methyl group7

Tumor1

Residues3

Dinucleotides1

Modification3

CpGs1

Analyses1

Nucleosome2

Inheritable1

Promoters2

Methyltransferase2

Eukaryotes3

Promoter regions1

Pathway2

Targets1

Contributes2

Variability2

Novo1

Alleles2

Developmental2

Expression8

Diseases3

Tissues1

Enzymes1

Inactivation1

Alterations1

Therapeutic1

Crucial1

Abnormalities1

Hallmark1

Metabolism1