Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair. (wikipedia.org)
Homolog1
The Abelson non receptor tyrosine kinase gene was initial recognized as the mammalian homolog from the oncogenic gene products from the Abelson murine leukemia virus. (pkc-inhibitors.com)
Domain turns ABL1 into an oncogene1
Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (wikipedia.org)
ABL14
The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. (wikipedia.org)
Mutations in the ABL1 gene are associated with chronic myelogenous leukemia (CML). (wikipedia.org)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
Gene2
c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus. (wikipedia.org)
This gene is a partner in a fusion gene with the BCR gene in the Philadelphia chromosome, a characteristic abnormality in chronic myelogenous leukemia (CML) and rarely in some other leukemia forms. (wikipedia.org)
Rous1
Several chimeric murine retroviruses were constructed to test whether the gag sequence of Abelson murine leukemia virus (A-MuLV) could influence the in vitro specificity of two sarcoma-inducing oncogenes: src of Rous sarcoma virus and fps of Fujinami sarcoma virus. (duke.edu)
The tumor cells are clonal and characterized by an increased expression of several cellular oncogenes. (biomedcentral.com)
Expression3
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
In this examine, we set out to analyze the quick expression effects of IM to the,oncogene, separase in BCR ABL beneficial and adverse cells. (pkc-inhibitors.com)
Lymphomas1
Murine models for human AIDS-related B cell lymphomas have been lacking. (biomedcentral.com)
Acute6
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)
This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia that is likely to come back or spread. (clinicaltrialsgps.com)
I. To determine if the administration of post-Induction age-adjusted intrathecal triple therapy (ITT) on a Modified Berlin-Frankfurt-Munster (MBFM) interim maintenance (IM) high-dose methotrexate (IMHDM) backbone will improve 5-year disease-free survival (DFS) of children with high-risk (HR) B-acute lymphoblastic leukemia (ALL) compared to age-adjusted intrathecal (IT) methotrexate (MTX). (clinicaltrialsgps.com)
Around the same time, and building on the observation that the vitamin folic acid could stimulate acute lymphoblastic leukemia (ALL) cells, Farber used folate analogs such as aminopterin and then amethopterin (methotrexate) to treat ALL, in what is often heralded as the first 'rational' drug development approach [ 4 ]. (biomedcentral.com)
Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice. (biomedcentral.com)
Acute myeloid2
It has been found in 5 percent of children and up to 30 percent of adults with B-cell acute lymphoblastic leukemia and very rarely in acute myeloid leukemia. (medlineplus.gov)
High expression of the leukemia-associated gene meningioma-1 ( MN1 ) is frequently found at diagnosis of acute myeloid leukemia (AML) and associates with adverse outcomes. (nih.gov)
Inhibition1
5. Inhibition of Abelson oncogene function by erbstatin analogues. (nih.gov)
Newly diagnosed acute lymphobl1
This phase II clinical trial studies how well dasatinib followed by stem cell transplant works in treating older patients with newly diagnosed acute lymphoblastic leukemia. (uchicagomedicine.org)
Infection3
Viral infection was speculated as a possible underlying cause. (iiarjournals.org)
Results: RNA sequencing did not show any correlation of AVM with viral infection. (iiarjournals.org)
Conclusion: The analysis does not point to the presence of an active viral infection in vascular anomalies. (iiarjournals.org)
Transformation4
4. In vitro transformation of murine pro-B and pre-B cells by v-mpl, a truncated form of a cytokine receptor. (nih.gov)
17. Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain. (nih.gov)
19. Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB. (nih.gov)
QVIRAL ONCOGENES {and other items PAPOVAVIRUS T ANTIGENS POLYOMAs A coneensus is emerging on the role of the various Tf antigens in viral oncogenesis/transformation (part of the game here is to keep the distinctions between these two phenomena in view). (nih.gov)
Virus5
1. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. (nih.gov)
6. Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81. (nih.gov)
8. Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab-MuLV). (nih.gov)
9. Induction by some protein kinase inhibitors of differentiation of a mouse megakaryoblastic cell line established by coinfection with Abelson murine leukemia virus and recombinant SV40 retrovirus. (nih.gov)
16. Viral oncogene expression during differentiation of Abelson virus-infected murine promonocytic leukemia cells. (nih.gov)
Cells1
When mutated, oncogenes have the potential to cause normal cells to become cancerous. (medlineplus.gov)
Cell2
14. Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines. (nih.gov)
15. Introduction of v-abl oncogene induces monocytic differentiation of an IL-3-dependent myeloid progenitor cell line. (nih.gov)
Patients1
Next-generation sequencing has allowed detection of leukemia-associated mutations in patients with TKI resistance in the absence of kinase domain mutations. (journalmc.org)
Analysis1
Materials and Methods: A total of 13 human vascular anomalies and three human skin control tissues were used for viral analysis. (iiarjournals.org)
Cases1
ALL and central nervous system leukemia (CNSL) cases were diagnosed based on the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia (version 1, 2015) ( 16 ). (spandidos-publications.com)
Years1
For years, viral infections have been suspected as one possible cause for the development of VA ( 6 ). (iiarjournals.org)
Small1
In addition, small molecules such as valproic acid have been substituted for the oncogene c-Myc and it has been shown to increase the reprogramming efficiency by 100-fold [ 16 ]. (biomedcentral.com)