ZidovudineSulfateTabletsDolutegravir and lamivudineEmtricitabineEpzicomNucleosideTriumeqEpivirTabletTrizivirZiagenHypersensitivity reactionRegimenInfection5701DidanosineNevirapineSimplificationNausea2019KivexaPatientsCombinationInfectionsToxicityHAARTPharmacokineticsTake this medicationSubstancesAllergic reactionRegimensTreatmentSevereProductsLiverRisksTriphosphateResistanceAcceptableMedicationsOnce-daily
Zidovudine14
- What is the most important information I should know about abacavir, lamivudine, and zidovudine (Trizivir)? (cigna.com)
- What is abacavir, lamivudine, and zidovudine (Trizivir)? (cigna.com)
- Abacavir, lamivudine, and zidovudine are antiviral medications that prevent human immunodeficiency virus (HIV) from multiplying in your body. (cigna.com)
- Abacavir, lamivudine, and zidovudine (Trizivir) is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). (cigna.com)
- Trizivir (abacavir sulfate, lamivudine, and zidovudine) is a type of antiviral medication called a reverse transcriptase inhibitor used to treat HIV , which causes the acquired immunodeficiency syndrome ( AIDS ). (rxlist.com)
- Lamivudine and zidovudine pass into breast milk. (rxlist.com)
- Serious and sometimes fatal hypersensitivity reactions, with multiple organ involvement, have occurred with abacavir, a component of TRIZIVIR (abacavir, lamivudine, and zidovudine). (rxlist.com)
- This randomized study evaluated the efficacy and tolerability of continued treatment with protease inhibitor plus nucleoside-analogue combination regimens (n = 79) or a change to the simplified regimen of abacavir-lamivudine-zidovudine (n = 84) in patients with suppressed human immunodeficiency virus type 1 (HIV-1) RNA for ⩾6 months who did not have the reverse transcriptase 215 mutation. (uzh.ch)
- The purpose of this study is to determine the safety of and immune response to CsA when given with abacavir sulfate (ABC), lamivudine (3TC), and zidovudine (AZT), (ABC/3TC/AZT) and lopinavir/ritonavir (LPV/r) to HIV infected adults in the early stages of infection. (drugpatentwatch.com)
- A simple, accurate, precise and fully automated method for the simultaneous determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum samples and drug dissolution studies has been developed. (vu.nl)
- Lamivudine is also available in multiple fixed combinations with other antiretroviral agents such as zidovudine, abacavir, tenofovir, efavirenz, nevirapine, dolutegravir and others. (nih.gov)
- The preferred regimen for pregnant women is lopinavir/ritonavir (Kaletra) plus zidovudine/lamivudine (the drugs in Combivir). (hivandhepatitis.com)
- Zidovudine/lamivudine was reclassified from 'alternative' to 'acceptable' overall, but remains the preferred NRTI combination for pregnant women receiving antiretroviral drugs to prevent perinatal HIV transmission. (hivandhepatitis.com)
- Combivir contains zidovudine and lamivudine. (aids.org)
Sulfate2
- Ziagen 20 mg/ml oral solution contains the nucleoside reverse transcriptase inhibitors (NRTI) abacavir (as sulfate). (who.int)
- Our Trizivir (abacavir sulfate, lamivudinc, and zidovudinc) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Tablets6
- LONDON, Aug. 25, 2014 /PRNewswire-HISPANIC PR WIRE/ - On August 22, ViiV Healthcare announced that the US Food and Drug Administration (FDA) approved Triumeq ® (abacavir 600mg, dolutegravir 50mg and lamivudine 300mg) tablets for the treatment of HIV-1 infection. (hispanicprwire.com)
- Abacavir, Dolutegravir,and Lamivudine combination tablets are prescribed to HIV-infected patients. (medindia.net)
- tell your doctor and pharmacist if you are allergic to any medications or any of the ingredients in abacavir tablets or solution. (medlineplus.gov)
- We compared the pharmacokinetics (PK) of once- versus twice-daily lamivudine and abacavir treatment using the World Health Organization recommended weight band dosing of scored adult tablets. (ox.ac.uk)
- The FDA has issued a tentative approval for once-daily abacavir 60 mg/dolutegravir 5 mg/ lamivudine 30 mg tablets for oral suspension to treat HIV-1 infection in pediatric patients weighing 6 kg to less than 25 kg. (pharmacytimes.com)
- For HIV infection, lamivudine is available as 150 and 300 mg tablets and as oral solutions under the trade name Epivir. (nih.gov)
Dolutegravir and lamivudine1
- a bioequivalence study of the fixed-dose combination of abacavir, dolutegravir and lamivudine when taken as a single pill compared to the administration of dolutegravir and abacavir/lamivudine as separate pills. (hispanicprwire.com)
Emtricitabine3
- abacavir, elvitegravir/cobicistat/emtricitabine/tenofovir DF. (medscape.com)
- 50 copies/mL) in the dolutegravir and abacavir/lamivudine arm (the separate components of Triumeq) than in the Atripla ®+ (efavirenz, emtricitabine and tenofovir) arm, the most commonly used single-pill regimen. (hispanicprwire.com)
- The revised guidelines include more discussion of the comparative risks and benefits of abacavir/lamivudine and tenofovir/emtricitabine, given that numerous observational and randomized studies since 2008 have produced conflicting data. (hivandhepatitis.com)
Epzicom1
- Darunavir plus abacavir/lamivudine (the drugs in the Epzicom coformulation) was reclassified as an 'alternative' due to additional data. (hivandhepatitis.com)
Nucleoside6
- 1 Triumeq is ViiV Healthcare's first dolutegravir-based fixed-dose combination, offering many people living with HIV the option of a single-pill regimen that combines the integrase strand transfer inhibitor (INSTI) dolutegravir, with the nucleoside reverse transcriptase inhibitors (NRTIs) abacavir and lamivudine. (hispanicprwire.com)
- Abacavir Lamivudine are active ingredients present that are an antiviral agent as well as nucleoside analog that boosts the immunity to fight against HIV infection. (dosepharmacy.com)
- Abamune L contains Abacavir and Lamivudine, which are both nucleoside reverse transcriptase inhibitors (NRTIs). (dosepharmacy.com)
- Abacavir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). (medlineplus.gov)
- Lamivudine is a nucleoside analogue and reverse transcriptase inhibitor used in the therapy of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection. (nih.gov)
- Lamivudine is a rare cause of liver test abnormalities or clinically apparent liver injury in patients with HIV infection without hepatitis B. Although several instances of lactic acidosis with hepatic steatosis and liver failure have been reported in patients receiving lamivudine, in all instances other nucleoside analogues more clearly associated with mitochondrial injury [didanosine, stavudine, zalcitrabine, zidovudine] were also being taken. (nih.gov)
Triumeq1
- Assessment report for Triumeq (dolutegravir/abacavir/lamivudine), ViiV Healthcare UK Limited, 26 June 2014, EMA/580654/2014. (janusinfo.se)
Epivir1
- For HBV infection the recommended dose of lamivudine in adults is 100 mg orally once daily, the drug being available in this dose under the trade name Epivir-HBV. (nih.gov)
Tablet2
- Lamivudine 150mg Tablet (Lamip. (magicinepharma.com)
- Abacavir comes as a tablet and a solution (liquid) to take by mouth. (medlineplus.gov)
Trizivir1
- TRIZIVIR is contraindicated in patients with a prior hypersensitivity reaction to abacavir and in HLA B*5701-positive patients [see CONTRAINDICATIONS , WARNINGS AND PRECAUTIONS ]. (rxlist.com)
Ziagen1
- https://www.ema.europa.eu/en/medicines/human/EPAR/ziagen). (who.int)
Hypersensitivity reaction3
- The most serious safety concern is a hypersensitivity reaction to abacavir. (who.int)
- People with a gene called HLA-B*5701 are more likely to get a hypersensitivity reaction to abacavir. (who.int)
- Additionally, patients who have previously had a hypersensitivity reaction to Abacavir should not take this medication. (dosepharmacy.com)
Regimen1
- Reference to the expanded information is crucial for addressing factors that may be of particular importance when individualizing a patient's treatment, such as loss of bone mineral density with a regimen that includes tenofovir disoproxil fumarate and the conflicting data on cardiac risk with abacavir (see guideline section Specific Factors to Consider and Discuss With Patients ). (hivguidelines.org)
Infection9
- Abamune L contains Abacavir/Lamivudine is used for slowing down the progression of HIV infection which can lead to AIDS and other related illnesses. (dosepharmacy.com)
- Buy Abacavir Lamivudine Online, which is a prescribed medication to treat human immunodeficiency virus (HIV) infection. (dosepharmacy.com)
- Abacavir/Lamivudine is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection in adults, adolescents and children weighing at least 25 kg before initiating treatment with abacavir. (globelapharma.com)
- Abacavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. (medlineplus.gov)
- Abacavir helps to control HIV infection but does not cure it. (medlineplus.gov)
- Abacavir is also used in combination with other antiviral medications to prevent HIV infection in people who have been exposed to it. (medlineplus.gov)
- Lamivudine is indicated for the treatment of HBV infection as a single agent and for HIV infection in combination with other HIV medications. (nih.gov)
- The recommended dose of lamivudine for HIV infection in adults is 150 mg twice daily or 300 mg once daily. (nih.gov)
- Lamivudine was approved by the FDA for HIV infection in 1995 and for HBV infection in 1998. (nih.gov)
57016
- You should not take this medicine if you have ever had an allergic reaction to any medicine that contains abacavir, or if you have a gene variation called HLA-B*5701 allele. (cigna.com)
- Therefore, screening for carriage of the HLA-B*5701 allele is recommended in any HIV-infected patient without prior exposure to abacavir. (who.int)
- Screening is also recommended prior to re-initiation of abacavir in patients of unknown HLA-B*5701 status who have previously tolerated abacavir. (who.int)
- Before initiating treatment with abacavir-containing products, screening for the presence of a genetic marker, the HLA-B*5701 allele, should be performed in any HIV-infected patient, irrespective of racial origin. (hispanicprwire.com)
- Products containing abacavir should not be used in patients known to carry the HLA-B*5701 allele. (hispanicprwire.com)
- Patients who have had positive genetic tests for the HLA-B*5701 allele should not be given abacavir or fixed- dose combinations containing abacavir because HLA-B*5701 predisposes patients to life-threatening hypersensitivity reactions. (cdc.gov)
Didanosine1
- Didanosine/lamivudine was removed as a dual-NRTI option for initial therapy due to lack of clinical trial experience and greater toxicity than other available options. (hivandhepatitis.com)
Nevirapine1
- Patients already receiving HAART lamivudine/nevirapine (57%), emtric- and a challenge to clinicians, and it may were excluded. (who.int)
Simplification1
- Simplification to Abacavir/Lamivudine + Atazanavir Maintains Viral Suppression and Improves Bone and Renal Biomarkers in ASSURE, a Randomized, Open Label, Non-Inferiority Trial. (aidshealth.org)
Nausea1
- Side effects of lamivudine are uncommon but may include headache, nausea, fatigue diarrhea and cough. (nih.gov)
20191
- The use of abacavir (sales data Sweden 2019) has been considered to result in insignificant environmental risk. (janusinfo.se)
Kivexa2
- Brand/Proprietary Drug Name: Kivexa® What Medicine is used for: Kivexa® is a combination of two antiretroviral agents (abacavir and lamivudine). (snec.com.sg)
- Fass environmental information for Kivexa (abacavir, lamivudine) from GlaxoSmithKline (downloaded 2021-10-27). (janusinfo.se)
Patients5
- About 5 % of the patients treated with abacavir develop this reaction. (who.int)
- Abamune L should not be taken by patients who have a hypersensitivity or allergy to Abacavir or Lamivudine. (dosepharmacy.com)
- Elevations in serum ALT levels occur in a proportion of patients with chronic hepatitis B treated with lamivudine. (nih.gov)
- DHHS concludes that abacavir/lamivudine 'remains a good alternative dual-NRTI option for some ART-naive patients. (hivandhepatitis.com)
- Le nombre de patients en surpoids ou obèses s'est fortement accru. (who.int)
Combination1
- Abacavir/dolutegravir/lamivudine, a combination with abacavir and lamivudine is also available. (wikipedia.org)
Infections1
- Although abacavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. (medlineplus.gov)
Toxicity2
- ribavirin increases toxicity of abacavir by Other (see comment). (medscape.com)
- Abacavir has low chronic toxicity. (janusinfo.se)
HAART1
- Lamivudine is currently used in many HAART regimens but is now rarely used to treat hepatitis B because of a high rate of antiviral resistance when it is used as monotherapy as well as the availability of more potent agents with a higher barrier to resistance. (nih.gov)
Pharmacokinetics1
- Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial. (ox.ac.uk)
Take this medication1
- Do not take this medication if you have had a previous allergic reaction to abacavir or any other medication containing abacavir. (medlineplus.gov)
Substances1
- Dolutegravir, abacavir or lamivudine are not PBT substances. (janusinfo.se)
Allergic reaction5
- Abacavir may cause a serious or life-threatening allergic reaction. (medlineplus.gov)
- Some people may be more likely to have an allergic reaction to abacavir based on their heredity or genetic make-up. (medlineplus.gov)
- Your doctor will order a lab test to determine if you are more likely to have an allergic reaction to abacavir. (medlineplus.gov)
- If your doctor tells you to stop taking abacavir because you had an allergic reaction, never take abacavir or a medication containing abacavir again. (medlineplus.gov)
- If you stop taking abacavir or skip doses, your condition may become more difficult to treat, or you could have an allergic reaction when restarting the medication (See Important Warning section). (medlineplus.gov)
Regimens2
- C(max) was 76% (lamivudine) and 64% (abacavir) higher on once-daily regimens. (ox.ac.uk)
- CONCLUSIONS: In children aged 3-12 years, AUC(0-24) of lamivudine and abacavir were bioequivalent on once- and twice-daily regimens. (ox.ac.uk)
Treatment2
- Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) and a Warning Card when you begin treatment with abacavir and each time you refill your prescription. (medlineplus.gov)
- DHHS demoted abacavir/lamivudine from'preferred' to 'alternative' status in 2008 due to concerns that abacavir may increase the risk of cardiovascular problems and may not be as effective for people with high pre-treatment viral load. (hivandhepatitis.com)
Severe1
- Finally, withdrawal flares occur between 4 and 12 weeks after stopping lamivudine and can be severe, symptomatic and even lead to clinical decompensation, acute liver failure and either death or need for emergency liver transplantation. (nih.gov)
Products1
- The products include Abacavir/Dolutegravir/Lamivudine, Lisaftoclax (APG-2575), Zuranolone (Zurzuvae), Ebola Zaire Vaccine. (pharmacytimes.com)
Liver1
- Lamivudine is a very rare cause of clinically apparent drug induced liver injury, but is associated with flares of underlying hepatitis B during therapy or with abrupt withdrawal. (nih.gov)
Risks1
- Talk to your doctor about the risks of taking abacavir. (medlineplus.gov)
Triphosphate3
- Abacavir- Converted inside cells to carbovir triphosphate, its active metabolite. (unboundmedicine.com)
- Lamivudine- After intracellular conversion to its active form (lamivudine-5-triphosphate), inhibits viral DNA synthesis by inhibiting the enzyme reverse transcriptase. (unboundmedicine.com)
- Lamivudine is phosphorylated intracellularly to the triphosphate which competes with the naturally occurring cytidine triphosphate for incorporation into the growing HIV or HBV DNA chain by the viral polymerase, thereby inhibiting polymerase (or reverse transcriptase) activity and causing chain termination. (nih.gov)
Resistance1
- An exacerbation of hepatitis also typically occurs after development of lamivudine resistance, a few weeks or months after the initial appearance of the mutant HBV strain and rise in HBV DNA levels (Case 2). (nih.gov)
Acceptable1
- For both children and caregivers, once-daily dosing of lamivudine plus abacavir was highly acceptable and strongly preferred over twice-daily. (ox.ac.uk)
Medications1
- Tell your doctor and pharmacist if you are allergic to abacavir or any other medications that contain abacavir. (medlineplus.gov)
Once-daily1
- Once-daily dosing of abacavir and lamivudine could provide an alternative dosing strategy for HIV-1-infected children, with high acceptability and strong preference suggesting the potential for improved adherence. (ox.ac.uk)