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  • tumorigenesis
  • Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal fibroblasts isolated from Spalax possess tumor-suppressive activity. (nih.gov)
  • Evidence that tumorigenesis is a multistage process first emerged from experiments showing that wounding of skin previously treated with coal tar resulted in tumor formation at the wound site (1). (springer.com)
  • Carcinoma
  • On the other hand, PKC activator 12-o-teradecanoyl phorbol-13-acetate enhanced the HSV-1-induced syncytium formation in A431 epidermoid carcinoma cells, suggesting that PKC activation promotes the development of multinucleated giant cells in herpetic muco-cutaneous lesions. (nii.ac.jp)
  • residues
  • Microinjection of antibody directed against CENP-E ( 13 , 14 ) and expression of N-terminal deletion mutants of CENP-E lacking 800 or more N-terminal residues, including the motor domain ( 9 , 13 ), produced a similar failure of the minority of chromosomes to achieve metaphase alignment. (pnas.org)
  • The HSV-1 proteins which have phosphorylated tyrosine residues and suppressed by tyrphostin 9 most significantly were the products of the UL47 gene, the tegument proteins VP13/14. (nii.ac.jp)
  • Yoshiaki
  • Publications] Yoshiaki Yura: 'Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1' Archives of Virology. (nii.ac.jp)
  • infection
  • It has been shown that a number of proteins of herpes simplex virus type 1 (HSV- 1) are phosphorylated and HSV-1 encodes viral PKs, but the role of phosphorylation of viral proteins in HSV-1 infection has not been clarified. (nii.ac.jp)
  • Molecular
  • Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). (curehunter.com)
  • inhibitors
  • In the present study, the effects of PK inhibitors including protein tyrosine kinase (PTK) inhibitors, genistein and tyrphostin, and protein kinase C (PKC) inhibitor, 1-(5-isoquinoline- sulfonyl)-2-methylpiperazine (H-7), on the replication of HSV-1 and phosphorylation of viral proteins were examined. (nii.ac.jp)
  • cells
  • Depletion of CENP-E from cultured human cells using antisense oligonucleotides or RNAi causes prolonged cell-cycle delay in mitosis that is characterized by an intact bipolar mitotic spindle with several chromosomes clustered close to either spindle pole ( 10 , 11 ). (pnas.org)
  • Further
  • This hypothesis was further strengthened by the finding that CENP-E could stimulate the kinase activity of BubR1 in a microtubule-sensitive manner ( 8 , 9 ). (pnas.org)
  • protein
  • kinesin-7) is a kinetochore-associated kinesin motor protein with an essential and exclusive role in metaphase chromosome alignment and satisfaction of the mitotic checkpoint ( 1 ). (pnas.org)
  • CENP-E is a large dimeric protein consisting of an N-terminal kinesin motor domain tethered to a globular C-terminal domain through an extended coiled-coil rod domain ( 2 , 3 ). (pnas.org)
  • similar
  • Subsequent experiments in which physical trauma was replaced by the application of chemical irritants not intrinsically tumorigenic yielded similar results (2,3). (springer.com)