• With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. (cdc.gov)
  • The OCP residues, namely: γ-HCH (lindane), heptachlor epoxide isomer, dieldrin, endrin, endrin aldehyde and endrin ketone were found predominantly in seven plant species. (academic-accelerator.com)
  • An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. (lookformedical.com)
  • The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
  • Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (lookformedical.com)
  • The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. (lookformedical.com)
  • 1964). In vitro metabolism by hepatic microsomal enzymes from rats treated 8 days previously with single i.p. doses of 10 or 100 mg/kg of chlordane in corn oil was increased for the 3 drugs reported (hexobarbital, aminopyrine and chlorpromazine). (inchem.org)
  • The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). (cdc.gov)
  • Coumarins and related compounds inhibit vitamin K 1 -2,3 epoxide reductase, preventing vitamin K from being reduced to its active form. (medscape.com)
  • Amyrin isomers are the predominant compounds in tomato fruit wax, with quantities that vary considerably in different cultivars and during the subsequent stages of fruit development. (gerli.com)
  • The chiral Co(salen) complex 3 is an effective catalyst for the asymmetric ring-opening of meso epoxides with benzoic acid. (elsevierpure.com)
  • The beneficial effects of DMF treatment include an increase in renal Nrf2 gene expression, reduction of oxidative stress, decrease in plasma asymmetric dimethylarginine (ADMA) and renal soluble epoxide hydrolase protein levels, increase in the L -arginine-to-ADMA ratio, and activation of genes related to nutrient sensing and autophagy (e.g. (hindawi.com)
  • Medicine.Iupui.Edu/clinpharm/ddis/ of a misuse of drugs and related organic ca?Npfntnd.R 73 rnicrasornal enzymes called epoxide !Zydrases. (stonecottagegardens.com)
  • 1963). Both technical chlordane and one of its pure isomers (gamma-chlordane) have been shown to have stimulating effects on rat liver microsomes for the metabolism of certain drugs (Burns et al. (inchem.org)
  • thus, drugs that inhibit S-isomer metabolism have a greater effect on PT. (medscape.com)
  • Indeed, while the average of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT), predominant specie and its isomers in adipose tissue was 10.02 mg kg -1 in countryside and 6.93 mg kg -1 in the city, it was respectively 0.013 and 0.019 mg kg -1 in milk. (scialert.net)
  • Barriers to non- experimental procedures that are used for culinary or medicinal products and of organic medicinal and phar,naceiuieal chemistry trauma table 19-8 roman numerical nomenclature of penicillins to hydrolysis by esterases and lack of ity when administered .Mphoiericin b should be present in all other antimalarial drugs. (stonecottagegardens.com)
  • Coloration of fruits and vegetables depends on their growthmaturity, concentration of carotenoid isomers, and food processing methods. (fliphtml5.com)
  • Gamma-chlordane is the alpha-chlordane referred to by March (1952) (it is the component present in the highest concentration in technical chlordane), alpha-chlordane is the beta isomer described by March. (inchem.org)
  • Propylene glycol butyl ether â ¥99% Synonym: DOWANOL ® PnB CAS Number 5131-66-8. (dinfashion.com)
  • The biologic activity has been found to be associated with the α-isomer. (wikipedia.org)
  • Both syn-DP and anti-DP isomers were found in all soil and air samples. (bvsalud.org)
  • Osthol showed a significant antileishmanial effect on promastigotes in early hours of exposure with IC 50 of 14.40 µg/mL but suberosin epoxide showed only a weak antileishmanial activity. (ac.ir)
  • This is the first report on the pharmacological activity of suberosin epoxide. (ac.ir)
  • Furthermore, we have also previously observed that DEX + HF induces hypertension concurrently with increases in both renal protein levels and the activity of soluble epoxide hydrolase (SEH) in adult offspring, which is prevented by SEH inhibition [ 10 ]. (hindawi.com)
  • the levo-isomer appears to exert only an antitussive effect. (wikipedia.org)
  • The analysis of DP isomer profiles in different seasons and the calculation of related fugacity fraction showed that anti-DP perhaps easier than syn-DP to migrate from soil to air in summer. (bvsalud.org)
  • In vivo hexobarbital response, measured by sleeping time of mice, 1, 3 and 8 days after single i.p. doses of 25 mg/kg body-weight technical chlordane or gamma-chlordane, showed a decrease (shortened sleeping time), greatest at day 3 but still marked on day 8 (Fouts, 1963). (inchem.org)
  • With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. (cdc.gov)
  • Structures and Environmental Significance of Heptachlor Epoxide Isomers. (epa.gov)
  • What is the total number of isomers, considering both structural and stereoisomers of cyclic ethers with the molecular formula C4H8O? (stackexchange.com)
  • The other isomers can be formed during the synthesis of lindane, and have been used either as fungicides or to synthesize other chemicals. (cdc.gov)
  • 5. An initiator for urethane polyol synthesis using epoxides, and for the polyol in rigid polyurethane foams. (changdechem.com)
  • As the 1,3-cyclohexadiene motif of the latest is oxidized into 2,5-cyclohexadienone, it is assumed that tridachiapyrone B arises from the ring opening of the epoxide (tridachiapyrone C) of tridachiapyrone A. To our knowledge, the synthesis of tridachiapyrone B was not investigated, even though it seems conceivable that the compound's stability to light, air or cytochrome would be higher than its 1,3-cyclohexadiene counterpart. (beilstein-journals.org)
  • For the 189 Mayo Clinic patients initiating warfarin therapy to achieve a target international normalized ratio (INR) in the range of 2.0 to 3.5, we analyzed the CYP2C9 (cytochrome P450 2C9) and VKORC1 (vitamin K epoxide reductase complex, subunit 1) genetic loci to study the relationship among the initial warfarin dose, steady-state dose, time to achieve steady-state dose, variations in INR, and allelic variance. (nih.gov)
  • Warfarin binds to the enzyme vitamin K 2,3-epoxide reductase in liver microsomes, stopping the cycle of vitamin K and reducing gamma-carboxylation of the precursors of vitamin D-dependent pro- and anticoagulant factors. (nih.gov)
  • The example given below illustrates the fate of the C8-hydroperoxide formed from oleic acid (18:1 n-9 or 8-octadecenoic acid) by triplet oxygen oxidation. (gerli.com)
  • Arachidonic acid ( AA ), i.e. 5 Z , 8 Z ,11 Z ,14 Z -eicosatetraenoic acid is an ω-6 fatty acid with four double bonds in the cis configuration (see Cis-trans isomerism ), each located between carbons 5-6, 8-9, 11-12, and 14-15. (thcscience.wiki)
  • trioxatricyclo[22.3.1.0 5,7 ]octacosa-8, 14, 16, 18, 20-pentaene-25-carboxyl ic acid) is an all-trans epoxide polyene amphoteric macrolide antifungal used to treat fungal infections around the eye. (justia.com)
  • The biosynthesis of the rare L -3-nitrotyrosine and L -2-amino-4-hexenoic acid units as well as three pre-tailoring and two post-tailoring steps are probed in the ilamycin biosynthetic machinery through a series of gene inactivation, precursor chemical complementation, isotope-labeled precursor feeding experiments, as well as structural elucidation of three intermediates ( 6 - 8 ) from the respective mutants. (nature.com)
  • First of all, one of the more useful reactions of alkenes is their conversion to epoxides through the use of a peroxyacid like m-chloroperoxybenzoic acid (m-CPBA). (masterorganicchemistry.com)
  • NTP technical report on the toxicology and carcinogenesis studies of glutaraldehyde (CAS no. 111-30-8) in F344/N rats and B6C3F mice (inhalation studies) /National Toxicology Program. (epa.gov)
  • 16. Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues. (nih.gov)
  • Technical grade HCH is a mixture of all four isomers, containing about 64% alpha and 10%-15% gamma isomers. (cdc.gov)
  • The clinically available warfarin preparations consist of a racemic mixture of equal amounts of 2 distinct S and R isomers, the former being 4-times more potent as anticoagulant and more susceptible to drug interaction. (nih.gov)
  • The gamma isomer, commonly known as lindane, can be used as an insecticide and has been used to kill soil-dwelling and plant-eating insects. (cdc.gov)
  • The V(max) of EET hydrolysis by rat intact RBCs (2.35 +/- 0.24 pmol/min/10(8) RBCs for 14,15-trans-EET) decreased by approximately 2 to 3-fold sequentially from 14,15-, 11,12- to 8,9-EETs for both cis- and trans-isomers. (nih.gov)
  • Incubation of EETs with recombinant murine soluble epoxide hydrolase (sEH) yielded the same geometric and regio preferences of EET hydrolysis as with rat intact RBCs. (nih.gov)
  • The principal epoxide hydrolase activity for EET hydrolysis (approximately 90%) is present in the erythrocyte cytosol. (nih.gov)
  • Preferred hydrolysis of 14,15-EETs and trans-epoxides characterizes sEH activity in RBCs that regulates the hydrolysis and release of cis- and trans-EETs in the circulation. (nih.gov)
  • Effect of a Subsurface Sediment on Hydrolysis of Haloalkanes and Epoxides. (epa.gov)
  • 1978). The intermediate formation of an epoxide has been postulated but not proven (Jones, 1975). (inchem.org)
  • R.sub.2, R.sub.3, R.sub.4 and R.sub.5 =identical or different aliphatic hydrocarbon radicals having 1 to 8 C atoms, or the phenyl radical n=2 to 5, and m=8 to 30. (everypatent.com)
  • 7. Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. (nih.gov)
  • However, carotenoid profiling of loquat flesh indicated trans -β-cryptoxanthin, followed by trans -β-carotene and 5,8-epoxy-β-carotene to be the most predominant carotenoids. (biomedcentral.com)
  • Column chromatography of an active fraction gave C_1 and C_2 inhibitors, so called (±)-p-menthane-3,8-cis-diol and (±)-p-menthane-3,8-trans-diol, respectively. (go.jp)
  • The biological activity of cis isomers was much higher than that of trans isomers. (go.jp)
  • Meanwhile, the construction of quaternary carbon stereocenter(s) is, at present, a distinct challenge in modern synthetic chemistry [8-11] . (beilstein-journals.org)
  • 10. A coating agent according to claim 1, wherein the coating agent comprises as the crosslinking component at least one polar epoxide based on a reaction product of melamine resin with acrylamide with subsequent epoxidation of the acrylic double bond. (everypatent.com)
  • The invention relates to a thermoplastic polyurethane matrix resin composition, comprising at least one C3-8 alkane diol, at least one alkoxylated aromatic diol and at least one polyisocyanate. (justia.com)
  • The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide. (justia.com)
  • the S isomer has, however, an average half-life shorter than the R isomer. (nih.gov)
  • The formation of M3 in HLM with atropisomer 1 was approximately twice as much as that with atropisomer 2, whereas formation of M4 with atropisomer 1 was 8- to 12-fold greater than that with atropisomer 2. (aspetjournals.org)
  • 15. DNA cleavage and 8-hydroxydeoxyguanosine formation caused by tamoxifen derivatives in vitro. (nih.gov)
  • From the chemical structure of Atazanavir sulfate it is evident that it has four chiral centres which result in total of 16 possible stereo-isomers. (who.int)
  • HCH isomers, particularly alpha and gamma have been detected widely in air, soil, water, and sediment as a result of historic production and use. (cdc.gov)
  • However, in research, it is necessary to distinguish between Estragole as a single substance or in the complex herbal extract form (8). (vetmedmosul.com)
  • Regarding nutraceutical properties of fruit carotenoids, a significant number of studies depicted their beneficial effect to the promotion of health, including the prevention and/or treatment of chronic and cardiovascular diseases [ 8 ]. (biomedcentral.com)